<?xml version="1.0" encoding="US-ASCII" standalone="no"?>
    <!-- Field: Doc-Info; Name: Generator; Value: GoFiler Complete; Version: 6.5b -->
    <!-- Field: Doc-Info; Name: VendorURI; Value: https://www.novaworks.com -->
    <!-- Field: Doc-Info; Name: Status; Value: 0x00000000 -->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#Cover" roleURI="http://portagebiotech.com/role/Cover" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StatementsOfFinancialPosition" roleURI="http://portagebiotech.com/role/StatementsOfFinancialPosition" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StatementsOfOperationsAndOtherComprehensiveIncomeLoss" roleURI="http://portagebiotech.com/role/StatementsOfOperationsAndOtherComprehensiveIncomeLoss" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StatementsOfChangesInEquityDeficit" roleURI="http://portagebiotech.com/role/StatementsOfChangesInEquityDeficit" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StatementsOfCashFlows" roleURI="http://portagebiotech.com/role/StatementsOfCashFlows" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#NatureOfOperations" roleURI="http://portagebiotech.com/role/NatureOfOperations" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#GoingConcern" roleURI="http://portagebiotech.com/role/GoingConcern" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#BasisOfPresentation" roleURI="http://portagebiotech.com/role/BasisOfPresentation" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SignificantAccountingPolicies" roleURI="http://portagebiotech.com/role/SignificantAccountingPolicies" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PrepaidExpensesOtherReceivablesAndOtherAssets" roleURI="http://portagebiotech.com/role/PrepaidExpensesOtherReceivablesAndOtherAssets" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#Stablecoin" roleURI="http://portagebiotech.com/role/Stablecoin" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#DigitalAssets" roleURI="http://portagebiotech.com/role/DigitalAssets" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PropertyPlantAndEquipmentAndRight-of-useAssets" roleURI="http://portagebiotech.com/role/PropertyPlantAndEquipmentAndRight-of-useAssets" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#InvestmentInCompedica" roleURI="http://portagebiotech.com/role/InvestmentInCompedica" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiability" roleURI="http://portagebiotech.com/role/WarrantLiability" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PutRightLiabilityAndTonPayable" roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayable" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#AccountsPayableAndAccruedLiabilities" roleURI="http://portagebiotech.com/role/AccountsPayableAndAccruedLiabilities" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LeaseLiability" roleURI="http://portagebiotech.com/role/LeaseLiability" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#BitgoPrimeLoan" roleURI="http://portagebiotech.com/role/BitgoPrimeLoan" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#IncomeTaxes" roleURI="http://portagebiotech.com/role/IncomeTaxes" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CapitalStockAndReserves" roleURI="http://portagebiotech.com/role/CapitalStockAndReserves" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserve" roleURI="http://portagebiotech.com/role/StockOptionReserve" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LossPerShare" roleURI="http://portagebiotech.com/role/LossPerShare" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CommitmentsAndContingentLiabilities" roleURI="http://portagebiotech.com/role/CommitmentsAndContingentLiabilities" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#RelatedPartyTransactions" roleURI="http://portagebiotech.com/role/RelatedPartyTransactions" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#FinancialInstrumentsAndRiskManagement" roleURI="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagement" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SegmentReporting" roleURI="http://portagebiotech.com/role/SegmentReporting" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CapitalManagement" roleURI="http://portagebiotech.com/role/CapitalManagement" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#Non-controllingInterest" roleURI="http://portagebiotech.com/role/Non-controllingInterest" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SubsequentEvents" roleURI="http://portagebiotech.com/role/SubsequentEvents" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SignificantAccountingPoliciesPolicies" roleURI="http://portagebiotech.com/role/SignificantAccountingPoliciesPolicies" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SignificantAccountingPoliciesTables" roleURI="http://portagebiotech.com/role/SignificantAccountingPoliciesTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PrepaidExpensesOtherReceivablesAndOtherAssetsTables" roleURI="http://portagebiotech.com/role/PrepaidExpensesOtherReceivablesAndOtherAssetsTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StablecoinTables" roleURI="http://portagebiotech.com/role/StablecoinTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#DigitalAssetsTables" roleURI="http://portagebiotech.com/role/DigitalAssetsTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PropertyPlantAndEquipmentAndRight-of-useAssetsTables" roleURI="http://portagebiotech.com/role/PropertyPlantAndEquipmentAndRight-of-useAssetsTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#InvestmentInCompedicaTables" roleURI="http://portagebiotech.com/role/InvestmentInCompedicaTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiabilityTables" roleURI="http://portagebiotech.com/role/WarrantLiabilityTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PutRightLiabilityAndTonPayableTables" roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#AccountsPayableAndAccruedLiabilitiesTables" roleURI="http://portagebiotech.com/role/AccountsPayableAndAccruedLiabilitiesTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LeaseLiabilityTables" roleURI="http://portagebiotech.com/role/LeaseLiabilityTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#IncomeTaxesTables" roleURI="http://portagebiotech.com/role/IncomeTaxesTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CapitalStockAndReservesTables" roleURI="http://portagebiotech.com/role/CapitalStockAndReservesTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserveTables" roleURI="http://portagebiotech.com/role/StockOptionReserveTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LossPerShareTables" roleURI="http://portagebiotech.com/role/LossPerShareTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#RelatedPartyTransactionsTables" roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#FinancialInstrumentsAndRiskManagementTables" roleURI="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SegmentReportingTables" roleURI="http://portagebiotech.com/role/SegmentReportingTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#Non-controllingInterestTables" roleURI="http://portagebiotech.com/role/Non-controllingInterestTables" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#GoingConcernDetailsNarrative" roleURI="http://portagebiotech.com/role/GoingConcernDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#BasisOfPresentationDetailsNarrative" roleURI="http://portagebiotech.com/role/BasisOfPresentationDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SignificantAccountingPoliciesDetails" roleURI="http://portagebiotech.com/role/SignificantAccountingPoliciesDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SignificantAccountingPoliciesDetailsNarrative" roleURI="http://portagebiotech.com/role/SignificantAccountingPoliciesDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PrepaidExpensesAndOtherReceivablesDetails" roleURI="http://portagebiotech.com/role/PrepaidExpensesAndOtherReceivablesDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PrepaidExpensesOtherReceivablesAndOtherAssetsDetailsNarrative" roleURI="http://portagebiotech.com/role/PrepaidExpensesOtherReceivablesAndOtherAssetsDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StablecoinDetails" roleURI="http://portagebiotech.com/role/StablecoinDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StablecoinDetails1" roleURI="http://portagebiotech.com/role/StablecoinDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#DigitalAssetsDetails" roleURI="http://portagebiotech.com/role/DigitalAssetsDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#DigitalAssetsDetails1" roleURI="http://portagebiotech.com/role/DigitalAssetsDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#DigitalAssetsDetails2" roleURI="http://portagebiotech.com/role/DigitalAssetsDetails2" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#ReceivablesDigitalAssetsDetails" roleURI="http://portagebiotech.com/role/ReceivablesDigitalAssetsDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#DigitalAssetsDetailsNarrative" roleURI="http://portagebiotech.com/role/DigitalAssetsDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PropertyPlantAndEquipmentAndRight-of-useAssetsDetails" roleURI="http://portagebiotech.com/role/PropertyPlantAndEquipmentAndRight-of-useAssetsDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#InvestmentInCompedicaDetails" roleURI="http://portagebiotech.com/role/InvestmentInCompedicaDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#InvestmentInCompedicaDetailsNarrative" roleURI="http://portagebiotech.com/role/InvestmentInCompedicaDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiabilityDetails" roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiabilityDetails1" roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiabilityDetails2" roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails2" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiabilityDetails3" roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails3" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiabilityDetails4" roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails4" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#WarrantLiabilityDetailsNarrative" roleURI="http://portagebiotech.com/role/WarrantLiabilityDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PutRightLiabilityAndTonPayableDetails" roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PutRightLiabilityAndTonPayableDetails1" roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PutRightLiabilityAndTonPayableDetails2" roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails2" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#PutRightLiabilityAndTonPayableDetailsNarrative" roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#AccountsPayableAndAccruedLiabilitiesDetails" roleURI="http://portagebiotech.com/role/AccountsPayableAndAccruedLiabilitiesDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LeaseLiabilityDetails" roleURI="http://portagebiotech.com/role/LeaseLiabilityDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LeaseLiabilityDetailsNarrative" roleURI="http://portagebiotech.com/role/LeaseLiabilityDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#BitgoPrimeLoanDetailsNarrative" roleURI="http://portagebiotech.com/role/BitgoPrimeLoanDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#IncomeTaxesDetails" roleURI="http://portagebiotech.com/role/IncomeTaxesDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#IncomeTaxesDetails1" roleURI="http://portagebiotech.com/role/IncomeTaxesDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#IncomeTaxesDetails2" roleURI="http://portagebiotech.com/role/IncomeTaxesDetails2" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#IncomeTaxesDetailsNarrative" roleURI="http://portagebiotech.com/role/IncomeTaxesDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CapitalStockAndReservesDetails" roleURI="http://portagebiotech.com/role/CapitalStockAndReservesDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CapitalStockAndReservesDetailsNarrative" roleURI="http://portagebiotech.com/role/CapitalStockAndReservesDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserveDetails" roleURI="http://portagebiotech.com/role/StockOptionReserveDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserveDetails1" roleURI="http://portagebiotech.com/role/StockOptionReserveDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserveDetails2" roleURI="http://portagebiotech.com/role/StockOptionReserveDetails2" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserveDetails3" roleURI="http://portagebiotech.com/role/StockOptionReserveDetails3" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserveDetails4" roleURI="http://portagebiotech.com/role/StockOptionReserveDetails4" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#StockOptionReserveDetailsNarrative" roleURI="http://portagebiotech.com/role/StockOptionReserveDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LossPerShareDetails" roleURI="http://portagebiotech.com/role/LossPerShareDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#LossPerShareDetails1" roleURI="http://portagebiotech.com/role/LossPerShareDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CommitmentsAndContingentLiabilitiesDetailsNarrative" roleURI="http://portagebiotech.com/role/CommitmentsAndContingentLiabilitiesDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#RelatedPartyTransactionsDetails" roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#RelatedPartyTransactionsDetails1" roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#RelatedPartyTransactionsDetails3" roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetails3" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#RelatedPartyTransactionsDetailsNarrative" roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#FinancialInstrumentsAndRiskManagementDetails" roleURI="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#FinancialInstrumentsAndRiskManagementDetails1" roleURI="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementDetails1" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#SegmentReportingDetails" roleURI="http://portagebiotech.com/role/SegmentReportingDetails" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#CapitalManagementDetailsNarrative" roleURI="http://portagebiotech.com/role/CapitalManagementDetailsNarrative" />
    <link:roleRef xlink:type="simple" xlink:href="ptgef-20260331.xsd#Non-controllingInterestDetails" roleURI="http://portagebiotech.com/role/Non-controllingInterestDetails" />
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/Cover" xlink:title="00000001 - Document - Cover">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract" xlink:label="loc_deiCoverAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesTable" xlink:label="loc_deiEntityAddressesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiCoverAbstract" xlink:to="loc_deiEntityAddressesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesLineItems" xlink:label="loc_deiEntityAddressesLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesTable" xlink:to="loc_deiEntityAddressesLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesAddressTypeAxis" xlink:label="loc_deiEntityAddressesAddressTypeAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesTable" xlink:to="loc_deiEntityAddressesAddressTypeAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AddressTypeDomain" xlink:label="loc_deiAddressTypeDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesAddressTypeAxis" xlink:to="loc_deiAddressTypeDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_BusinessContactMember" xlink:label="loc_deiBusinessContactMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiAddressTypeDomain" xlink:to="loc_deiBusinessContactMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:label="loc_deiDocumentType" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentType" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:label="loc_deiAmendmentFlag" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiAmendmentFlag" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentDescription" xlink:label="loc_deiAmendmentDescription" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiAmendmentDescription" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentRegistrationStatement" xlink:label="loc_deiDocumentRegistrationStatement" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentRegistrationStatement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentAnnualReport" xlink:label="loc_deiDocumentAnnualReport" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentAnnualReport" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentQuarterlyReport" xlink:label="loc_deiDocumentQuarterlyReport" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentQuarterlyReport" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentTransitionReport" xlink:label="loc_deiDocumentTransitionReport" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentTransitionReport" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentShellCompanyReport" xlink:label="loc_deiDocumentShellCompanyReport" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentShellCompanyReport" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentShellCompanyEventDate" xlink:label="loc_deiDocumentShellCompanyEventDate" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentShellCompanyEventDate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodStartDate" xlink:label="loc_deiDocumentPeriodStartDate" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentPeriodStartDate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_deiDocumentPeriodEndDate" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentPeriodEndDate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_deiDocumentFiscalPeriodFocus" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentFiscalPeriodFocus" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_deiDocumentFiscalYearFocus" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentFiscalYearFocus" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_deiCurrentFiscalYearEndDate" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiCurrentFiscalYearEndDate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:label="loc_deiEntityFileNumber" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityFileNumber" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:label="loc_deiEntityRegistrantName" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityRegistrantName" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:label="loc_deiEntityCentralIndexKey" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityCentralIndexKey" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityPrimarySicNumber" xlink:label="loc_deiEntityPrimarySicNumber" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityPrimarySicNumber" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:label="loc_deiEntityTaxIdentificationNumber" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityTaxIdentificationNumber" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="loc_deiEntityIncorporationStateCountryCode" />
      <link:presentationArc order="190" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityIncorporationStateCountryCode" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:label="loc_deiEntityAddressAddressLine1" />
      <link:presentationArc order="200" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityAddressAddressLine1" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2" xlink:label="loc_deiEntityAddressAddressLine2" />
      <link:presentationArc order="210" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityAddressAddressLine2" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine3" xlink:label="loc_deiEntityAddressAddressLine3" />
      <link:presentationArc order="220" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityAddressAddressLine3" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown" xlink:label="loc_deiEntityAddressCityOrTown" />
      <link:presentationArc order="230" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityAddressCityOrTown" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince" xlink:label="loc_deiEntityAddressStateOrProvince" />
      <link:presentationArc order="240" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityAddressStateOrProvince" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCountry" xlink:label="loc_deiEntityAddressCountry" />
      <link:presentationArc order="250" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityAddressCountry" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:label="loc_deiEntityAddressPostalZipCode" />
      <link:presentationArc order="260" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityAddressPostalZipCode" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CountryRegion" xlink:label="loc_deiCountryRegion" />
      <link:presentationArc order="270" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiCountryRegion" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:label="loc_deiCityAreaCode" />
      <link:presentationArc order="280" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiCityAreaCode" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:label="loc_deiLocalPhoneNumber" />
      <link:presentationArc order="290" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiLocalPhoneNumber" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Extension" xlink:label="loc_deiExtension" />
      <link:presentationArc order="300" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiExtension" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:label="loc_deiWrittenCommunications" />
      <link:presentationArc order="310" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiWrittenCommunications" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:label="loc_deiSolicitingMaterial" />
      <link:presentationArc order="320" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiSolicitingMaterial" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:label="loc_deiPreCommencementTenderOffer" />
      <link:presentationArc order="330" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiPreCommencementTenderOffer" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:label="loc_deiPreCommencementIssuerTenderOffer" />
      <link:presentationArc order="340" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiPreCommencementIssuerTenderOffer" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle" xlink:label="loc_deiSecurity12bTitle" />
      <link:presentationArc order="350" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiSecurity12bTitle" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_NoTradingSymbolFlag" xlink:label="loc_deiNoTradingSymbolFlag" />
      <link:presentationArc order="360" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiNoTradingSymbolFlag" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:label="loc_deiTradingSymbol" />
      <link:presentationArc order="370" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiTradingSymbol" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:label="loc_deiSecurityExchangeName" />
      <link:presentationArc order="380" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiSecurityExchangeName" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12gTitle" xlink:label="loc_deiSecurity12gTitle" />
      <link:presentationArc order="390" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiSecurity12gTitle" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityReportingObligation" xlink:label="loc_deiSecurityReportingObligation" />
      <link:presentationArc order="400" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiSecurityReportingObligation" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AnnualInformationForm" xlink:label="loc_deiAnnualInformationForm" />
      <link:presentationArc order="410" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiAnnualInformationForm" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AuditedAnnualFinancialStatements" xlink:label="loc_deiAuditedAnnualFinancialStatements" />
      <link:presentationArc order="420" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiAuditedAnnualFinancialStatements" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_deiEntityWellKnownSeasonedIssuer" />
      <link:presentationArc order="430" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityWellKnownSeasonedIssuer" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_deiEntityVoluntaryFilers" />
      <link:presentationArc order="440" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityVoluntaryFilers" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_deiEntityCurrentReportingStatus" />
      <link:presentationArc order="450" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityCurrentReportingStatus" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInteractiveDataCurrent" xlink:label="loc_deiEntityInteractiveDataCurrent" />
      <link:presentationArc order="460" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityInteractiveDataCurrent" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFilerCategory" xlink:label="loc_deiEntityFilerCategory" />
      <link:presentationArc order="470" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityFilerCategory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitySmallBusiness" xlink:label="loc_deiEntitySmallBusiness" />
      <link:presentationArc order="480" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntitySmallBusiness" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_deiEntityEmergingGrowthCompany" />
      <link:presentationArc order="490" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityEmergingGrowthCompany" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod" xlink:label="loc_deiEntityExTransitionPeriod" />
      <link:presentationArc order="500" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityExTransitionPeriod" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentAccountingStandard" xlink:label="loc_deiDocumentAccountingStandard" />
      <link:presentationArc order="510" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentAccountingStandard" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_OtherReportingStandardItemNumber" xlink:label="loc_deiOtherReportingStandardItemNumber" />
      <link:presentationArc order="520" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiOtherReportingStandardItemNumber" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityShellCompany" xlink:label="loc_deiEntityShellCompany" />
      <link:presentationArc order="530" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityShellCompany" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityPublicFloat" xlink:label="loc_deiEntityPublicFloat" />
      <link:presentationArc order="540" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityPublicFloat" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityBankruptcyProceedingsReportingCurrent" xlink:label="loc_deiEntityBankruptcyProceedingsReportingCurrent" />
      <link:presentationArc order="550" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityBankruptcyProceedingsReportingCurrent" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_deiEntityCommonStockSharesOutstanding" />
      <link:presentationArc order="560" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiEntityCommonStockSharesOutstanding" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentsIncorporatedByReferenceTextBlock" xlink:label="loc_deiDocumentsIncorporatedByReferenceTextBlock" />
      <link:presentationArc order="570" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentsIncorporatedByReferenceTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_ContactPersonnelName" xlink:label="loc_deiContactPersonnelName" />
      <link:presentationArc order="580" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiContactPersonnelName" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_IcfrAuditorAttestationFlag" xlink:label="loc_deiIcfrAuditorAttestationFlag" />
      <link:presentationArc order="590" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiIcfrAuditorAttestationFlag" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFinStmtErrorCorrectionFlag" xlink:label="loc_deiDocumentFinStmtErrorCorrectionFlag" />
      <link:presentationArc order="600" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiDocumentFinStmtErrorCorrectionFlag" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AuditorFirmId" xlink:label="loc_deiAuditorFirmId" />
      <link:presentationArc order="610" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiAuditorFirmId" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AuditorName" xlink:label="loc_deiAuditorName" />
      <link:presentationArc order="620" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiAuditorName" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AuditorLocation" xlink:label="loc_deiAuditorLocation" />
      <link:presentationArc order="630" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_deiEntityAddressesLineItems" xlink:to="loc_deiAuditorLocation" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StatementsOfFinancialPosition" xlink:title="00000002 - Statement - Consolidated Statements of Financial Position">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfFinancialPositionAbstract" xlink:label="loc_ifrs-fullStatementOfFinancialPositionAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AssetsAbstract" xlink:label="loc_ifrs-fullAssetsAbstract" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullAssetsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssetsAbstract" xlink:label="loc_ifrs-fullCurrentAssetsAbstract" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullAssetsAbstract" xlink:to="loc_ifrs-fullCurrentAssetsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalents" xlink:label="loc_ifrs-fullCashAndCashEquivalents" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullCashAndCashEquivalents" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RestrictedCashAndCashEquivalents" xlink:label="loc_ifrs-fullRestrictedCashAndCashEquivalents" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullRestrictedCashAndCashEquivalents" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccountsReceivable" xlink:label="loc_ptgefAccountsReceivable" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ptgefAccountsReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Stablecoin" xlink:label="loc_ptgefStablecoin" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ptgefStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsAtFairValueTonCurrent" xlink:label="loc_ptgefDigitalAssetsAtFairValueTonCurrent" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ptgefDigitalAssetsAtFairValueTonCurrent" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentReceivables" xlink:label="loc_ifrs-fullTradeAndOtherCurrentReceivables" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullTradeAndOtherCurrentReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAssets" xlink:label="loc_ifrs-fullCurrentAssets" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullCurrentAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssetsAbstract" xlink:label="loc_ifrs-fullNoncurrentAssetsAbstract" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullNoncurrentAssetsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsAtFairValueTonNetOfCurrentPortion" xlink:label="loc_ptgefDigitalAssetsAtFairValueTonNetOfCurrentPortion" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ptgefDigitalAssetsAtFairValueTonNetOfCurrentPortion" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RightofuseAssets" xlink:label="loc_ifrs-fullRightofuseAssets" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullRightofuseAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipment" xlink:label="loc_ifrs-fullPropertyPlantAndEquipment" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullPropertyPlantAndEquipment" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_EquipmentDeposits" xlink:label="loc_ptgefEquipmentDeposits" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ptgefEquipmentDeposits" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherAssets" xlink:label="loc_ifrs-fullOtherAssets" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullOtherAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentAssets" xlink:label="loc_ifrs-fullNoncurrentAssets" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentAssetsAbstract" xlink:to="loc_ifrs-fullNoncurrentAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Assets" xlink:label="loc_ifrs-fullAssets" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullAssetsAbstract" xlink:to="loc_ifrs-fullAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAndLiabilitiesAbstract" xlink:label="loc_ifrs-fullEquityAndLiabilitiesAbstract" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullEquityAndLiabilitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilitiesAbstract" xlink:label="loc_ifrs-fullCurrentLiabilitiesAbstract" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullEquityAndLiabilitiesAbstract" xlink:to="loc_ifrs-fullCurrentLiabilitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TradeAndOtherCurrentPayables" xlink:label="loc_ifrs-fullTradeAndOtherCurrentPayables" />
      <link:presentationArc order="190" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentLiabilitiesAbstract" xlink:to="loc_ifrs-fullTradeAndOtherCurrentPayables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonPayableToSettlePutRightsExercised" xlink:label="loc_ptgefTonPayableToSettlePutRightsExercised" />
      <link:presentationArc order="200" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentLiabilitiesAbstract" xlink:to="loc_ptgefTonPayableToSettlePutRightsExercised" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLeaseLiabilities" xlink:label="loc_ifrs-fullCurrentLeaseLiabilities" />
      <link:presentationArc order="210" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentLiabilitiesAbstract" xlink:to="loc_ifrs-fullCurrentLeaseLiabilities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightLiability" xlink:label="loc_ptgefPutRightLiability" />
      <link:presentationArc order="220" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentLiabilitiesAbstract" xlink:to="loc_ptgefPutRightLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentLiabilities" xlink:label="loc_ifrs-fullCurrentLiabilities" />
      <link:presentationArc order="230" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCurrentLiabilitiesAbstract" xlink:to="loc_ifrs-fullCurrentLiabilities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilitiesAbstract" xlink:label="loc_ifrs-fullNoncurrentLiabilitiesAbstract" />
      <link:presentationArc order="240" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullEquityAndLiabilitiesAbstract" xlink:to="loc_ifrs-fullNoncurrentLiabilitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLeaseLiabilities" xlink:label="loc_ifrs-fullNoncurrentLeaseLiabilities" />
      <link:presentationArc order="250" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNoncurrentLiabilitiesAbstract" xlink:to="loc_ifrs-fullNoncurrentLeaseLiabilities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentWarrantLiability" xlink:label="loc_ifrs-fullNoncurrentWarrantLiability" />
      <link:presentationArc order="260" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNoncurrentLiabilitiesAbstract" xlink:to="loc_ifrs-fullNoncurrentWarrantLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncurrentLiabilities" xlink:label="loc_ifrs-fullNoncurrentLiabilities" />
      <link:presentationArc order="270" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNoncurrentLiabilitiesAbstract" xlink:to="loc_ifrs-fullNoncurrentLiabilities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Liabilities" xlink:label="loc_ifrs-fullLiabilities" />
      <link:presentationArc order="280" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNoncurrentLiabilitiesAbstract" xlink:to="loc_ifrs-fullLiabilities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CommitmentsAndContingentLiabilities" xlink:label="loc_ptgefCommitmentsAndContingentLiabilities" />
      <link:presentationArc order="290" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ptgefCommitmentsAndContingentLiabilities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAbstract" xlink:label="loc_ifrs-fullEquityAbstract" />
      <link:presentationArc order="300" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullEquityAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IssuedCapital" xlink:label="loc_ifrs-fullIssuedCapital" />
      <link:presentationArc order="310" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullIssuedCapital" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherReserves" xlink:label="loc_ifrs-fullOtherReserves" />
      <link:presentationArc order="320" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullOtherReserves" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RetainedEarnings" xlink:label="loc_ifrs-fullRetainedEarnings" />
      <link:presentationArc order="330" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullRetainedEarnings" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TreasuryShares" xlink:label="loc_ifrs-fullTreasuryShares" />
      <link:presentationArc order="340" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullTreasuryShares" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParent" xlink:label="loc_ifrs-fullEquityAttributableToOwnersOfParent" />
      <link:presentationArc order="350" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullEquityAttributableToOwnersOfParent" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncontrollingInterests" xlink:label="loc_ifrs-fullNoncontrollingInterests" />
      <link:presentationArc order="360" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullNoncontrollingInterests" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity" xlink:label="loc_ifrs-fullEquity" />
      <link:presentationArc order="370" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullEquity" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAndLiabilities" xlink:label="loc_ifrs-fullEquityAndLiabilities" />
      <link:presentationArc order="380" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfFinancialPositionAbstract" xlink:to="loc_ifrs-fullEquityAndLiabilities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StatementsOfOperationsAndOtherComprehensiveIncomeLoss" xlink:title="00000003 - Statement - Consolidated Statements of Operations and Other Comprehensive Income (Loss)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeStatementAbstract" xlink:label="loc_ifrs-fullIncomeStatementAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Revenue" xlink:label="loc_ifrs-fullRevenue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullRevenue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossAbstract" xlink:label="loc_ifrs-fullProfitLossAbstract" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullProfitLossAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense" xlink:label="loc_ifrs-fullResearchAndDevelopmentExpense" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullResearchAndDevelopmentExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GeneralAndAdministrativeExpense" xlink:label="loc_ifrs-fullGeneralAndAdministrativeExpense" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullGeneralAndAdministrativeExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DepreciationExpense" xlink:label="loc_ifrs-fullDepreciationExpense" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullDepreciationExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities" xlink:label="loc_ifrs-fullProfitLossFromOperatingActivities" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullProfitLossFromOperatingActivities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainsLossesOnChangeInFairValueOfWarrants" xlink:label="loc_ptgefGainsLossesOnChangeInFairValueOfWarrants" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefGainsLossesOnChangeInFairValueOfWarrants" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" xlink:label="loc_ptgefChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfPutRightsNetOfRedemptions" xlink:label="loc_ptgefChangeInFairValueOfPutRightsNetOfRedemptions" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefChangeInFairValueOfPutRightsNetOfRedemptions" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRevaluationOfDigitalAssets" xlink:label="loc_ptgefLossOnRevaluationOfDigitalAssets" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefLossOnRevaluationOfDigitalAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRevaluationOfDigitalAssetReceivables" xlink:label="loc_ptgefLossOnRevaluationOfDigitalAssetReceivables" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefLossOnRevaluationOfDigitalAssetReceivables" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossOnSaleOfDigitalAssets" xlink:label="loc_ptgefRealizedLossOnSaleOfDigitalAssets" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefRealizedLossOnSaleOfDigitalAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossOnNovationOfDigitalAssetsToInvestor" xlink:label="loc_ptgefRealizedLossOnNovationOfDigitalAssetsToInvestor" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefRealizedLossOnNovationOfDigitalAssetsToInvestor" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnSettlementWithParexelIoxCro" xlink:label="loc_ptgefGainOnSettlementWithParexelIoxCro" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefGainOnSettlementWithParexelIoxCro" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRegisteredDirectOffering" xlink:label="loc_ptgefLossOnRegisteredDirectOffering" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefLossOnRegisteredDirectOffering" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OfferingCosts" xlink:label="loc_ptgefOfferingCosts" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefOfferingCosts" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossIoxIprd" xlink:label="loc_ptgefImpairmentLossIoxIprd" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefImpairmentLossIoxIprd" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossTarusIprd" xlink:label="loc_ptgefImpairmentLossTarusIprd" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefImpairmentLossTarusIprd" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossStimunity" xlink:label="loc_ptgefImpairmentLossStimunity" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefImpairmentLossStimunity" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossSaugatuck" xlink:label="loc_ptgefImpairmentLossSaugatuck" />
      <link:presentationArc order="190" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefImpairmentLossSaugatuck" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CommitmentFeeUnderCommittedPurchaseAgreement" xlink:label="loc_ptgefCommitmentFeeUnderCommittedPurchaseAgreement" />
      <link:presentationArc order="200" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefCommitmentFeeUnderCommittedPurchaseAgreement" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnDissolutionOfInvestmentInAssociate" xlink:label="loc_ptgefGainOnDissolutionOfInvestmentInAssociate" />
      <link:presentationArc order="210" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefGainOnDissolutionOfInvestmentInAssociate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainFromSaleOfInvestmentInPublicCompany" xlink:label="loc_ptgefGainFromSaleOfInvestmentInPublicCompany" />
      <link:presentationArc order="220" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefGainFromSaleOfInvestmentInPublicCompany" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossInvestmentInCompedica" xlink:label="loc_ptgefImpairmentLossInvestmentInCompedica" />
      <link:presentationArc order="230" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefImpairmentLossInvestmentInCompedica" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRevaluationOfInvestmentInCompedica" xlink:label="loc_ptgefLossOnRevaluationOfInvestmentInCompedica" />
      <link:presentationArc order="240" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefLossOnRevaluationOfInvestmentInCompedica" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:label="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" />
      <link:presentationArc order="250" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnSettlementOfTonPayable" xlink:label="loc_ptgefGainOnSettlementOfTonPayable" />
      <link:presentationArc order="260" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefGainOnSettlementOfTonPayable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnSettlementOfPutRightLiability" xlink:label="loc_ptgefLossOnSettlementOfPutRightLiability" />
      <link:presentationArc order="270" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefLossOnSettlementOfPutRightLiability" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss" xlink:label="loc_ifrs-fullGainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss" />
      <link:presentationArc order="280" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullGainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DepreciationAndAmortisationExpense" xlink:label="loc_ifrs-fullDepreciationAndAmortisationExpense" />
      <link:presentationArc order="290" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullDepreciationAndAmortisationExpense" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnExtinguishmentOfDebt" xlink:label="loc_ptgefGainOnExtinguishmentOfDebt" />
      <link:presentationArc order="300" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefGainOnExtinguishmentOfDebt" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ShareOfLossesFromEquityMethodInvestment" xlink:label="loc_ptgefShareOfLossesFromEquityMethodInvestment" />
      <link:presentationArc order="310" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ptgefShareOfLossesFromEquityMethodInvestment" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossBeforeTax" xlink:label="loc_ifrs-fullProfitLossBeforeTax" />
      <link:presentationArc order="320" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullProfitLossBeforeTax" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations" xlink:label="loc_ifrs-fullIncomeTaxExpenseContinuingOperations" />
      <link:presentationArc order="330" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullIncomeTaxExpenseContinuingOperations" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss" xlink:label="loc_ifrs-fullProfitLoss" />
      <link:presentationArc order="340" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAbstract" xlink:to="loc_ifrs-fullProfitLoss" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherComprehensiveIncomeAbstract" xlink:label="loc_ifrs-fullOtherComprehensiveIncomeAbstract" />
      <link:presentationArc order="350" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullOtherComprehensiveIncomeAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetUnrealizedLossOnInvestments" xlink:label="loc_ptgefNetUnrealizedLossOnInvestments" />
      <link:presentationArc order="360" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullOtherComprehensiveIncomeAbstract" xlink:to="loc_ptgefNetUnrealizedLossOnInvestments" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComprehensiveIncome" xlink:label="loc_ifrs-fullComprehensiveIncome" />
      <link:presentationArc order="370" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullOtherComprehensiveIncomeAbstract" xlink:to="loc_ifrs-fullComprehensiveIncome" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossAttributableToAbstract" xlink:label="loc_ifrs-fullProfitLossAttributableToAbstract" />
      <link:presentationArc order="380" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullProfitLossAttributableToAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossAttributableToOwnersOfParent" xlink:label="loc_ifrs-fullProfitLossAttributableToOwnersOfParent" />
      <link:presentationArc order="390" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAttributableToAbstract" xlink:to="loc_ifrs-fullProfitLossAttributableToOwnersOfParent" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossAttributableToNoncontrollingInterests" xlink:label="loc_ifrs-fullProfitLossAttributableToNoncontrollingInterests" />
      <link:presentationArc order="400" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullProfitLossAttributableToAbstract" xlink:to="loc_ifrs-fullProfitLossAttributableToNoncontrollingInterests" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToAbstract" xlink:label="loc_ifrs-fullComprehensiveIncomeAttributableToAbstract" />
      <link:presentationArc order="410" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullComprehensiveIncomeAttributableToAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToOwnersOfParent" xlink:label="loc_ifrs-fullComprehensiveIncomeAttributableToOwnersOfParent" />
      <link:presentationArc order="420" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComprehensiveIncomeAttributableToAbstract" xlink:to="loc_ifrs-fullComprehensiveIncomeAttributableToOwnersOfParent" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComprehensiveIncomeAttributableToNoncontrollingInterests" xlink:label="loc_ifrs-fullComprehensiveIncomeAttributableToNoncontrollingInterests" />
      <link:presentationArc order="430" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComprehensiveIncomeAttributableToAbstract" xlink:to="loc_ifrs-fullComprehensiveIncomeAttributableToNoncontrollingInterests" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EarningsPerShareAbstract" xlink:label="loc_ifrs-fullEarningsPerShareAbstract" />
      <link:presentationArc order="440" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullEarningsPerShareAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_BasicEarningsLossPerShare" xlink:label="loc_ifrs-fullBasicEarningsLossPerShare" />
      <link:presentationArc order="450" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullBasicEarningsLossPerShare" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DilutedEarningsLossPerShare" xlink:label="loc_ifrs-fullDilutedEarningsLossPerShare" />
      <link:presentationArc order="460" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullDilutedEarningsLossPerShare" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WeightedAverageSharesAndAdjustedWeightedAverageSharesAbstract" xlink:label="loc_ifrs-fullWeightedAverageSharesAndAdjustedWeightedAverageSharesAbstract" />
      <link:presentationArc order="470" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullWeightedAverageSharesAndAdjustedWeightedAverageSharesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WeightedAverageShares" xlink:label="loc_ifrs-fullWeightedAverageShares" />
      <link:presentationArc order="480" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullWeightedAverageShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustedWeightedAverageShares" xlink:label="loc_ifrs-fullAdjustedWeightedAverageShares" />
      <link:presentationArc order="490" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullAdjustedWeightedAverageShares" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StatementsOfChangesInEquityDeficit" xlink:title="00000004 - Statement - Consolidated Statements of Changes in Equity (Deficit)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityAbstract" xlink:label="loc_ifrs-fullStatementOfChangesInEquityAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComponentsOfEquityAxis" xlink:label="loc_ifrs-fullComponentsOfEquityAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullComponentsOfEquityAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ComponentsOfEquityDomain" xlink:label="loc_ifrs-fullComponentsOfEquityDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ifrs-fullComponentsOfEquityDomain" order="80" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IssuedCapitalMember" xlink:label="loc_ifrs-fullIssuedCapitalMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ifrs-fullIssuedCapitalMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StockOptionReserveMember" xlink:label="loc_ptgefStockOptionReserveMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ptgefStockOptionReserveMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TreasuryStockMember" xlink:label="loc_ptgefTreasuryStockMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ptgefTreasuryStockMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccumulatedOtherComprehensiveIncomeLossMember" xlink:label="loc_ptgefAccumulatedOtherComprehensiveIncomeLossMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ptgefAccumulatedOtherComprehensiveIncomeLossMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RetainedEarningsMember" xlink:label="loc_ifrs-fullRetainedEarningsMember" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ifrs-fullRetainedEarningsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EquityAttributableToOwnersOfParentMember" xlink:label="loc_ifrs-fullEquityAttributableToOwnersOfParentMember" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ifrs-fullEquityAttributableToOwnersOfParentMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncontrollingInterestsMember" xlink:label="loc_ifrs-fullNoncontrollingInterestsMember" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullComponentsOfEquityAxis" xlink:to="loc_ifrs-fullNoncontrollingInterestsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity" xlink:label="loc_ifrs-fullEquity" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullEquity" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NumberOfSharesOutstanding" xlink:label="loc_ifrs-fullNumberOfSharesOutstanding" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNumberOfSharesOutstanding" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BalanceApril12022PresplitShares" xlink:label="loc_ptgefBalanceApril12022PresplitShares" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefBalanceApril12022PresplitShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:label="loc_ifrs-fullIncreaseDecreaseThroughSharebasedPaymentTransactions" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullIncreaseDecreaseThroughSharebasedPaymentTransactions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderRegisteredDirectOffering" xlink:label="loc_ptgefSharesIssuedUnderRegisteredDirectOffering" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderRegisteredDirectOffering" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderRegisteredDirectOfferingShares" xlink:label="loc_ptgefSharesIssuedUnderRegisteredDirectOfferingShares" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderRegisteredDirectOfferingShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedRelatedToAtmAgreementNetOfShareIssuanceCosts" xlink:label="loc_ptgefSharesIssuedRelatedToAtmAgreementNetOfShareIssuanceCosts" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedRelatedToAtmAgreementNetOfShareIssuanceCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedRelatedToAtmAgreementNetOfShareIssuanceCostsShares" xlink:label="loc_ptgefSharesIssuedRelatedToAtmAgreementNetOfShareIssuanceCostsShares" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedRelatedToAtmAgreementNetOfShareIssuanceCostsShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedOrAccruedForServices" xlink:label="loc_ptgefSharesIssuedOrAccruedForServices" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedOrAccruedForServices" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedOrAccruedForServicesShares" xlink:label="loc_ptgefSharesIssuedOrAccruedForServicesShares" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedOrAccruedForServicesShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedPursuantToDistributionOfRestrictedStockUnits" xlink:label="loc_ptgefSharesIssuedPursuantToDistributionOfRestrictedStockUnits" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedPursuantToDistributionOfRestrictedStockUnits" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedPursuantToDistributionOfRestrictedStockUnitsShares" xlink:label="loc_ptgefSharesIssuedPursuantToDistributionOfRestrictedStockUnitsShares" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedPursuantToDistributionOfRestrictedStockUnitsShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DerecognitionOfInvestmentInPublicCompany" xlink:label="loc_ptgefDerecognitionOfInvestmentInPublicCompany" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDerecognitionOfInvestmentInPublicCompany" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetUnrealizedLossOnInvestments" xlink:label="loc_ptgefNetUnrealizedLossOnInvestments" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNetUnrealizedLossOnInvestments" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromContinuingOperations" xlink:label="loc_ifrs-fullProfitLossFromContinuingOperations" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullProfitLossFromContinuingOperations" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CorrectionOfPriorPeriodOverstatedSharebasedCompensationExpense" xlink:label="loc_ptgefCorrectionOfPriorPeriodOverstatedSharebasedCompensationExpense" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefCorrectionOfPriorPeriodOverstatedSharebasedCompensationExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderPrivatePlacementNetOfShareIssuanceCosts" xlink:label="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCosts" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsShares" xlink:label="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsShares" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrefundedWarrantsExercised" xlink:label="loc_ptgefPrefundedWarrantsExercised" />
      <link:presentationArc order="190" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPrefundedWarrantsExercised" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrefundedWarrantsExercisedShares" xlink:label="loc_ptgefPrefundedWarrantsExercisedShares" />
      <link:presentationArc order="200" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPrefundedWarrantsExercisedShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AdditionalRoundUpSharesIssuedForFractionalSharesInConnectionWith1for20ReverseStockSplit" xlink:label="loc_ptgefAdditionalRoundUpSharesIssuedForFractionalSharesInConnectionWith1for20ReverseStockSplit" />
      <link:presentationArc order="210" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAdditionalRoundUpSharesIssuedForFractionalSharesInConnectionWith1for20ReverseStockSplit" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AdditionalRoundUpSharesIssuedForFractionalSharesInConnectionWith1for20ReverseStockSplitShares" xlink:label="loc_ptgefAdditionalRoundUpSharesIssuedForFractionalSharesInConnectionWith1for20ReverseStockSplitShares" />
      <link:presentationArc order="220" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAdditionalRoundUpSharesIssuedForFractionalSharesInConnectionWith1for20ReverseStockSplitShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedForAccruedBonuses" xlink:label="loc_ptgefSharesIssuedForAccruedBonuses" />
      <link:presentationArc order="230" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedForAccruedBonuses" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedAccruedForBonusesShares" xlink:label="loc_ptgefSharesIssuedAccruedForBonusesShares" />
      <link:presentationArc order="240" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedAccruedForBonusesShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsAndPutRights" xlink:label="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsAndPutRights" />
      <link:presentationArc order="250" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsAndPutRights" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsAndPutRightsShares" xlink:label="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsAndPutRightsShares" />
      <link:presentationArc order="260" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderPrivatePlacementNetOfShareIssuanceCostsAndPutRightsShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedRelatingToAcquisitionOfCompedica" xlink:label="loc_ptgefSharesIssuedRelatingToAcquisitionOfCompedica" />
      <link:presentationArc order="270" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedRelatingToAcquisitionOfCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedRelatingToAcquisitionOfCompedicaShares" xlink:label="loc_ptgefSharesIssuedRelatingToAcquisitionOfCompedicaShares" />
      <link:presentationArc order="280" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedRelatingToAcquisitionOfCompedicaShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderRegisteredDirectOfferingNetOfShareIssuanceCosts" xlink:label="loc_ptgefSharesIssuedUnderRegisteredDirectOfferingNetOfShareIssuanceCosts" />
      <link:presentationArc order="290" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderRegisteredDirectOfferingNetOfShareIssuanceCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedUnderRegisteredDirectOfferingNetOfShareIssuanceCostsShares" xlink:label="loc_ptgefSharesIssuedUnderRegisteredDirectOfferingNetOfShareIssuanceCostsShares" />
      <link:presentationArc order="300" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedUnderRegisteredDirectOfferingNetOfShareIssuanceCostsShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExerciseOfPrefundedWarrants" xlink:label="loc_ptgefExerciseOfPrefundedWarrants" />
      <link:presentationArc order="310" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExerciseOfPrefundedWarrants" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExerciseOfPrefundedWarrantsShares" xlink:label="loc_ptgefExerciseOfPrefundedWarrantsShares" />
      <link:presentationArc order="320" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExerciseOfPrefundedWarrantsShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedica" xlink:label="loc_ptgefTreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedica" />
      <link:presentationArc order="330" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedicaShares" xlink:label="loc_ptgefTreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedicaShares" />
      <link:presentationArc order="340" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedicaShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightsExercisedAndReturnOfShares" xlink:label="loc_ptgefPutRightsExercisedAndReturnOfShares" />
      <link:presentationArc order="350" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPutRightsExercisedAndReturnOfShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightsExercisedAndReturnShares" xlink:label="loc_ptgefPutRightsExercisedAndReturnShares" />
      <link:presentationArc order="360" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPutRightsExercisedAndReturnShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Equity" xlink:label="loc_ifrs-fullEquity_2" />
      <link:presentationArc order="370" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullEquity_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NumberOfSharesOutstanding" xlink:label="loc_ifrs-fullNumberOfSharesOutstanding_2" />
      <link:presentationArc order="380" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNumberOfSharesOutstanding_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StatementsOfCashFlows" xlink:title="00000005 - Statement - Consolidated Statements of Cash Flows">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfCashFlowsAbstract" xlink:label="loc_ifrs-fullStatementOfCashFlowsAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfReconciliationOfChangesInIntangibleAssetsAndGoodwillTable" xlink:label="loc_ifrs-fullDisclosureOfReconciliationOfChangesInIntangibleAssetsAndGoodwillTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfCashFlowsAbstract" xlink:to="loc_ifrs-fullDisclosureOfReconciliationOfChangesInIntangibleAssetsAndGoodwillTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfReconciliationOfChangesInIntangibleAssetsAndGoodwillTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfIntangibleAssetsAndGoodwillAxis" xlink:label="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfReconciliationOfChangesInIntangibleAssetsAndGoodwillTable" xlink:to="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfIntangibleAssetsAndGoodwillDomain" xlink:label="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillAxis" xlink:to="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IOxIPRDMember" xlink:label="loc_ptgefIOxIPRDMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillDomain" xlink:to="loc_ptgefIOxIPRDMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TarusIPRDMember" xlink:label="loc_ptgefTarusIPRDMember" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillDomain" xlink:to="loc_ptgefTarusIPRDMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StimunityMember" xlink:label="loc_ptgefStimunityMember" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillDomain" xlink:to="loc_ptgefStimunityMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SaugatuckMember" xlink:label="loc_ptgefSaugatuckMember" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfIntangibleAssetsAndGoodwillDomain" xlink:to="loc_ptgefSaugatuckMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract" xlink:label="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLoss" xlink:label="loc_ifrs-fullProfitLoss" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ifrs-fullProfitLoss" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:label="loc_ifrs-fullAdjustmentsForReconcileProfitLossAbstract" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ifrs-fullAdjustmentsForReconcileProfitLossAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments" xlink:label="loc_ifrs-fullAdjustmentsForSharebasedPayments" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullAdjustmentsForReconcileProfitLossAbstract" xlink:to="loc_ifrs-fullAdjustmentsForSharebasedPayments" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" xlink:label="loc_ptgefChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullAdjustmentsForReconcileProfitLossAbstract" xlink:to="loc_ptgefChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRegisteredDirectOffering" xlink:label="loc_ptgefLossOnRegisteredDirectOffering" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullAdjustmentsForReconcileProfitLossAbstract" xlink:to="loc_ptgefLossOnRegisteredDirectOffering" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OfferingCosts" xlink:label="loc_ptgefOfferingCosts" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullAdjustmentsForReconcileProfitLossAbstract" xlink:to="loc_ptgefOfferingCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ImpairmentLoss" xlink:label="loc_ifrs-fullImpairmentLoss" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullAdjustmentsForReconcileProfitLossAbstract" xlink:to="loc_ifrs-fullImpairmentLoss" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CommitmentFeeUnderCommittedPurchaseAgreement" xlink:label="loc_ptgefCommitmentFeeUnderCommittedPurchaseAgreement" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefCommitmentFeeUnderCommittedPurchaseAgreement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnDissolutionOfInvestmentInAssociate" xlink:label="loc_ptgefGainOnDissolutionOfInvestmentInAssociate" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefGainOnDissolutionOfInvestmentInAssociate" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainFromSaleOfInvestmentInPublicCompany" xlink:label="loc_ptgefGainFromSaleOfInvestmentInPublicCompany" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefGainFromSaleOfInvestmentInPublicCompany" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInDeferredTaxLiabilityAsset" xlink:label="loc_ifrs-fullIncreaseDecreaseInDeferredTaxLiabilityAsset" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ifrs-fullIncreaseDecreaseInDeferredTaxLiabilityAsset" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UnrealizedLossOnChangeInFairValueOfDigitalAssets" xlink:label="loc_ptgefUnrealizedLossOnChangeInFairValueOfDigitalAssets" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefUnrealizedLossOnChangeInFairValueOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UnrealizedLossOnChangeInFairValueOfDigitalAssetReceivables" xlink:label="loc_ptgefUnrealizedLossOnChangeInFairValueOfDigitalAssetReceivables" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefUnrealizedLossOnChangeInFairValueOfDigitalAssetReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossOnSaleOfDigitalAssets" xlink:label="loc_ptgefRealizedLossOnSaleOfDigitalAssets" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefRealizedLossOnSaleOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossOnNovationOfDigitalAssetReceivables" xlink:label="loc_ptgefRealizedLossOnNovationOfDigitalAssetReceivables" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefRealizedLossOnNovationOfDigitalAssetReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnImpairmentInvestmentInCompedica" xlink:label="loc_ptgefLossOnImpairmentInvestmentInCompedica" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefLossOnImpairmentInvestmentInCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRemeasurementOfInvestmentInCompedica" xlink:label="loc_ptgefLossOnRemeasurementOfInvestmentInCompedica" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefLossOnRemeasurementOfInvestmentInCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfWarrantLiability" xlink:label="loc_ptgefChangeInFairValueOfWarrantLiability" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefChangeInFairValueOfWarrantLiability" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfPutRightsNetOfRedemptions" xlink:label="loc_ptgefChangeInFairValueOfPutRightsNetOfRedemptions" />
      <link:presentationArc order="190" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefChangeInFairValueOfPutRightsNetOfRedemptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossFromEquityMethodInvestment" xlink:label="loc_ptgefLossFromEquityMethodInvestment" />
      <link:presentationArc order="200" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefLossFromEquityMethodInvestment" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:label="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" />
      <link:presentationArc order="210" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnSettlementOfTonPayable" xlink:label="loc_ptgefGainOnSettlementOfTonPayable" />
      <link:presentationArc order="220" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefGainOnSettlementOfTonPayable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnExerciseOfPutRightLiability" xlink:label="loc_ptgefLossOnExerciseOfPutRightLiability" />
      <link:presentationArc order="230" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefLossOnExerciseOfPutRightLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnExtinguishmentOfDebt" xlink:label="loc_ptgefLossOnExtinguishmentOfDebt" />
      <link:presentationArc order="240" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefLossOnExtinguishmentOfDebt" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NoncashInterestExpense" xlink:label="loc_ptgefNoncashInterestExpense" />
      <link:presentationArc order="250" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefNoncashInterestExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnSettlementWithParexelIoxCro" xlink:label="loc_ptgefGainOnSettlementWithParexelIoxCro" />
      <link:presentationArc order="260" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefGainOnSettlementWithParexelIoxCro" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExpensesSettledUsingStablecoin" xlink:label="loc_ptgefExpensesSettledUsingStablecoin" />
      <link:presentationArc order="270" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefExpensesSettledUsingStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DividendsReceived" xlink:label="loc_ifrs-fullDividendsReceived" />
      <link:presentationArc order="280" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ifrs-fullDividendsReceived" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ShareOfLossInAssociate" xlink:label="loc_ptgefShareOfLossInAssociate" />
      <link:presentationArc order="290" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefShareOfLossInAssociate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueOfSharesIssuedForServices" xlink:label="loc_ptgefFairValueOfSharesIssuedForServices" />
      <link:presentationArc order="300" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefFairValueOfSharesIssuedForServices" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DepreciationAndAmortizations" xlink:label="loc_ptgefDepreciationAndAmortizations" />
      <link:presentationArc order="310" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefDepreciationAndAmortizations" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetChangeInWorkingCapitalComponentsAbstract" xlink:label="loc_ptgefNetChangeInWorkingCapitalComponentsAbstract" />
      <link:presentationArc order="320" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="loc_ptgefNetChangeInWorkingCapitalComponentsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInTradeAccountReceivable" xlink:label="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInTradeAccountReceivable" />
      <link:presentationArc order="330" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNetChangeInWorkingCapitalComponentsAbstract" xlink:to="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInTradeAccountReceivable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInPrepaidExpenses" xlink:label="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInPrepaidExpenses" />
      <link:presentationArc order="340" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNetChangeInWorkingCapitalComponentsAbstract" xlink:to="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInPrepaidExpenses" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherAssets" xlink:label="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInOtherAssets" />
      <link:presentationArc order="350" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNetChangeInWorkingCapitalComponentsAbstract" xlink:to="loc_ifrs-fullAdjustmentsForDecreaseIncreaseInOtherAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:label="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInTradeAccountPayable" />
      <link:presentationArc order="360" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNetChangeInWorkingCapitalComponentsAbstract" xlink:to="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities" xlink:label="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInOtherLiabilities" />
      <link:presentationArc order="370" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNetChangeInWorkingCapitalComponentsAbstract" xlink:to="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInOtherLiabilities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:label="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" />
      <link:presentationArc order="380" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCashFlowsFromUsedInOperatingActivities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" xlink:label="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" />
      <link:presentationArc order="390" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromSalesOfInvestmentProperty" xlink:label="loc_ifrs-fullProceedsFromSalesOfInvestmentProperty" />
      <link:presentationArc order="400" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ifrs-fullProceedsFromSalesOfInvestmentProperty" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PurchasesOfStablecoin" xlink:label="loc_ptgefPurchasesOfStablecoin" />
      <link:presentationArc order="410" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ptgefPurchasesOfStablecoin" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PurchasesOfDigitalAssets" xlink:label="loc_ptgefPurchasesOfDigitalAssets" />
      <link:presentationArc order="420" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ptgefPurchasesOfDigitalAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SalesOfStablecoin" xlink:label="loc_ptgefSalesOfStablecoin" />
      <link:presentationArc order="430" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ptgefSalesOfStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SalesOfDigitalAssets" xlink:label="loc_ptgefSalesOfDigitalAssets" />
      <link:presentationArc order="440" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ptgefSalesOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:label="loc_ifrs-fullPurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" />
      <link:presentationArc order="450" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ifrs-fullPurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_EquipmentDeposit" xlink:label="loc_ptgefEquipmentDeposit" />
      <link:presentationArc order="460" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ptgefEquipmentDeposit" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CashPaidForInvestmentInCompedica" xlink:label="loc_ptgefCashPaidForInvestmentInCompedica" />
      <link:presentationArc order="470" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="loc_ptgefCashPaidForInvestmentInCompedica" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:label="loc_ifrs-fullCashFlowsFromUsedInInvestingActivities" />
      <link:presentationArc order="480" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCashFlowsFromUsedInInvestingActivities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" xlink:label="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" />
      <link:presentationArc order="490" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProceedsFromExerciseOfPrefundedWarrants" xlink:label="loc_ptgefProceedsFromExerciseOfPrefundedWarrants" />
      <link:presentationArc order="500" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefProceedsFromExerciseOfPrefundedWarrants" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProceedsFromSharesIssuedUnderPrivatePlacement" xlink:label="loc_ptgefProceedsFromSharesIssuedUnderPrivatePlacement" />
      <link:presentationArc order="510" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefProceedsFromSharesIssuedUnderPrivatePlacement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProceedsFromRegisteredDirectOffering" xlink:label="loc_ptgefProceedsFromRegisteredDirectOffering" />
      <link:presentationArc order="520" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefProceedsFromRegisteredDirectOffering" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProceedsFromSharesIssuedUnderAtmAndCommittedPurchaseAgreement" xlink:label="loc_ptgefProceedsFromSharesIssuedUnderAtmAndCommittedPurchaseAgreement" />
      <link:presentationArc order="530" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefProceedsFromSharesIssuedUnderAtmAndCommittedPurchaseAgreement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PaymentsForShareIssueCosts" xlink:label="loc_ifrs-fullPaymentsForShareIssueCosts" />
      <link:presentationArc order="540" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ifrs-fullPaymentsForShareIssueCosts" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightIssuanceCosts" xlink:label="loc_ptgefPutRightIssuanceCosts" />
      <link:presentationArc order="550" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefPutRightIssuanceCosts" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:label="loc_ifrs-fullPaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" />
      <link:presentationArc order="560" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ifrs-fullPaymentsOfLeaseLiabilitiesClassifiedAsFinancingActivities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PaymentsOnExternalDebt" xlink:label="loc_ptgefPaymentsOnExternalDebt" />
      <link:presentationArc order="570" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefPaymentsOnExternalDebt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DeferredFinancingCosts" xlink:label="loc_ptgefDeferredFinancingCosts" />
      <link:presentationArc order="580" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefDeferredFinancingCosts" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LoanTerminationFee" xlink:label="loc_ptgefLoanTerminationFee" />
      <link:presentationArc order="590" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefLoanTerminationFee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesFromRSUDistribution" xlink:label="loc_ptgefSharesFromRSUDistribution" />
      <link:presentationArc order="600" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="loc_ptgefSharesFromRSUDistribution" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:label="loc_ifrs-fullCashFlowsFromUsedInFinancingActivities" />
      <link:presentationArc order="610" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCashFlowsFromUsedInFinancingActivities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalents" xlink:label="loc_ifrs-fullIncreaseDecreaseInCashAndCashEquivalents" />
      <link:presentationArc order="620" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullIncreaseDecreaseInCashAndCashEquivalents" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentRestrictedCashAndCashEquivalents" xlink:label="loc_ifrs-fullCurrentRestrictedCashAndCashEquivalents" />
      <link:presentationArc order="630" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCurrentRestrictedCashAndCashEquivalents" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentRestrictedCashAndCashEquivalents" xlink:label="loc_ifrs-fullCurrentRestrictedCashAndCashEquivalents_2" />
      <link:presentationArc order="640" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCurrentRestrictedCashAndCashEquivalents_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SupplementalCashFlowInformationsAbstract" xlink:label="loc_ptgefSupplementalCashFlowInformationsAbstract" />
      <link:presentationArc order="650" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSupplementalCashFlowInformationsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CashPaidForInterest" xlink:label="loc_ptgefCashPaidForInterest" />
      <link:presentationArc order="660" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefSupplementalCashFlowInformationsAbstract" xlink:to="loc_ptgefCashPaidForInterest" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NoncashInvestingItemsAbstract" xlink:label="loc_ptgefNoncashInvestingItemsAbstract" />
      <link:presentationArc order="670" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNoncashInvestingItemsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExchangeOfStimunityConvertibleNoteForStimunitySharesAtFairValue" xlink:label="loc_ptgefExchangeOfStimunityConvertibleNoteForStimunitySharesAtFairValue" />
      <link:presentationArc order="680" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefExchangeOfStimunityConvertibleNoteForStimunitySharesAtFairValue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CapitalExpendituresIncludedInAccountsPayable" xlink:label="loc_ptgefCapitalExpendituresIncludedInAccountsPayable" />
      <link:presentationArc order="690" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefCapitalExpendituresIncludedInAccountsPayable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RightToUseAssetAcquired" xlink:label="loc_ptgefRightToUseAssetAcquired" />
      <link:presentationArc order="700" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefRightToUseAssetAcquired" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LeaseLiabilityIncurred" xlink:label="loc_ptgefLeaseLiabilityIncurred" />
      <link:presentationArc order="710" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefLeaseLiabilityIncurred" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContributionOfDigitalAssets" xlink:label="loc_ptgefContributionOfDigitalAssets" />
      <link:presentationArc order="720" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefContributionOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContributionOfStablecoin" xlink:label="loc_ptgefContributionOfStablecoin" />
      <link:presentationArc order="730" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefContributionOfStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContributionOfDigitalAssetsReceivable" xlink:label="loc_ptgefContributionOfDigitalAssetsReceivable" />
      <link:presentationArc order="740" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefContributionOfDigitalAssetsReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContributionOfStablecoinReceivable" xlink:label="loc_ptgefContributionOfStablecoinReceivable" />
      <link:presentationArc order="750" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefContributionOfStablecoinReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ValueOfSharesUsedToPurchaseInterestInCompedica" xlink:label="loc_ptgefValueOfSharesUsedToPurchaseInterestInCompedica" />
      <link:presentationArc order="760" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefValueOfSharesUsedToPurchaseInterestInCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedica" xlink:label="loc_ptgefTreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedica" />
      <link:presentationArc order="770" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefTreasuryStockObtainedInExchangeForReturnOfInvestmentInterestToCompedica" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightsIssuedToInvestors" xlink:label="loc_ptgefPutRightsIssuedToInvestors" />
      <link:presentationArc order="780" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefPutRightsIssuedToInvestors" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ShareIssuanceCostsSettledInCompanyStock" xlink:label="loc_ptgefShareIssuanceCostsSettledInCompanyStock" />
      <link:presentationArc order="790" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefShareIssuanceCostsSettledInCompanyStock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ShareIssuanceCostsSettledInWarrantsOnCompanysStock" xlink:label="loc_ptgefShareIssuanceCostsSettledInWarrantsOnCompanysStock" />
      <link:presentationArc order="800" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefShareIssuanceCostsSettledInWarrantsOnCompanysStock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SettlementOfPutRightLiabilityUsingStablecoinReceivable" xlink:label="loc_ptgefSettlementOfPutRightLiabilityUsingStablecoinReceivable" />
      <link:presentationArc order="810" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefSettlementOfPutRightLiabilityUsingStablecoinReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExerciseOfPutRights" xlink:label="loc_ptgefExerciseOfPutRights" />
      <link:presentationArc order="820" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefExerciseOfPutRights" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SettlementOfPutRightLiabilityUsingDigitalAssetReceivables" xlink:label="loc_ptgefSettlementOfPutRightLiabilityUsingDigitalAssetReceivables" />
      <link:presentationArc order="830" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefSettlementOfPutRightLiabilityUsingDigitalAssetReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ReceiptOfDigitalAssetsReceivableTonTokens" xlink:label="loc_ptgefReceiptOfDigitalAssetsReceivableTonTokens" />
      <link:presentationArc order="840" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefReceiptOfDigitalAssetsReceivableTonTokens" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StablecoinUsedToPurchaseDigitalAssets" xlink:label="loc_ptgefStablecoinUsedToPurchaseDigitalAssets" />
      <link:presentationArc order="850" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefStablecoinUsedToPurchaseDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SaleOfDigitalAssetsSettledInStablecoin" xlink:label="loc_ptgefSaleOfDigitalAssetsSettledInStablecoin" />
      <link:presentationArc order="860" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefSaleOfDigitalAssetsSettledInStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExchangeOfBitcoinForTonTokens" xlink:label="loc_ptgefExchangeOfBitcoinForTonTokens" />
      <link:presentationArc order="870" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefExchangeOfBitcoinForTonTokens" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExternalDebtProceedsReceivedInStablecoin" xlink:label="loc_ptgefExternalDebtProceedsReceivedInStablecoin" />
      <link:presentationArc order="880" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefExternalDebtProceedsReceivedInStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PaymentsOnExternalDebtUsingDigitalAssets" xlink:label="loc_ptgefPaymentsOnExternalDebtUsingDigitalAssets" />
      <link:presentationArc order="890" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashInvestingItemsAbstract" xlink:to="loc_ptgefPaymentsOnExternalDebtUsingDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NoncashOperatingActivitiesAbstract" xlink:label="loc_ptgefNoncashOperatingActivitiesAbstract" />
      <link:presentationArc order="900" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNoncashOperatingActivitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrepaidExpensesObtainedInExchangeForStablecoin" xlink:label="loc_ptgefPrepaidExpensesObtainedInExchangeForStablecoin" />
      <link:presentationArc order="910" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefNoncashOperatingActivitiesAbstract" xlink:to="loc_ptgefPrepaidExpensesObtainedInExchangeForStablecoin" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/NatureOfOperations" xlink:title="999006 - Disclosure - NATURE OF OPERATIONS">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureNatureOfOperationsAbstract" xlink:label="loc_ptgefDisclosureNatureOfOperationsAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NatureOfOperationsExplanatory" xlink:label="loc_ptgefNatureOfOperationsExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureNatureOfOperationsAbstract" xlink:to="loc_ptgefNatureOfOperationsExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/GoingConcern" xlink:title="999007 - Disclosure - GOING CONCERN">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfGoingConcernExplanatory" xlink:label="loc_ifrs-fullDisclosureOfGoingConcernExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfGoingConcernExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/BasisOfPresentation" xlink:title="999008 - Disclosure - BASIS OF PRESENTATION">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfBasisOfConsolidationExplanatory" xlink:label="loc_ifrs-fullDisclosureOfBasisOfConsolidationExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfBasisOfConsolidationExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SignificantAccountingPolicies" xlink:title="999009 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSignificantAccountingPoliciesAbstract" xlink:label="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory" xlink:label="loc_ptgefDisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PrepaidExpensesOtherReceivablesAndOtherAssets" xlink:title="999010 - Disclosure - PREPAID EXPENSES, OTHER RECEIVABLES, AND OTHER ASSETS">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfOtherAssetsExplanatory" xlink:label="loc_ifrs-fullDisclosureOfOtherAssetsExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfOtherAssetsExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/Stablecoin" xlink:title="999011 - Disclosure - STABLECOIN">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureStablecoinAbstract" xlink:label="loc_ptgefDisclosureStablecoinAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfStablecoinExplanatory" xlink:label="loc_ptgefDisclosureOfStablecoinExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureStablecoinAbstract" xlink:to="loc_ptgefDisclosureOfStablecoinExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/DigitalAssets" xlink:title="999012 - Disclosure - DIGITAL ASSETS">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureDigitalAssetsAbstract" xlink:label="loc_ptgefDisclosureDigitalAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfDigitalAssetsExplanatory" xlink:label="loc_ptgefDisclosureOfDigitalAssetsExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefDisclosureOfDigitalAssetsExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PropertyPlantAndEquipmentAndRight-of-useAssets" xlink:title="999013 - Disclosure - PROPERTY, PLANT, AND EQUIPMENT AND RIGHT-OF-USE ASSETS">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" xlink:label="loc_ptgefDisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PropertyPlantAndEquipmentAndRightOfUseAssetsTextBlock" xlink:label="loc_ptgefPropertyPlantAndEquipmentAndRightOfUseAssetsTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" xlink:to="loc_ptgefPropertyPlantAndEquipmentAndRightOfUseAssetsTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/InvestmentInCompedica" xlink:title="999014 - Disclosure - INVESTMENT IN COMPEDICA">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfInvestmentPropertyExplanatory" xlink:label="loc_ifrs-fullDisclosureOfInvestmentPropertyExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfInvestmentPropertyExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiability" xlink:title="999015 - Disclosure - WARRANT LIABILITY">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfWarrantLiabilityExplanatory" xlink:label="loc_ptgefDisclosureOfWarrantLiabilityExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ptgefDisclosureOfWarrantLiabilityExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PutRightLiabilityAndTonPayable" xlink:title="999016 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePutRightLiabilityAndTonPayableAbstract" xlink:label="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOPutRightLiabilityAndTonPayableExplanatory" xlink:label="loc_ptgefDisclosureOPutRightLiabilityAndTonPayableExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefDisclosureOPutRightLiabilityAndTonPayableExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/AccountsPayableAndAccruedLiabilities" xlink:title="999017 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:label="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccountsPayableAndAccruedLiabilitiesTextBlock" xlink:label="loc_ptgefAccountsPayableAndAccruedLiabilitiesTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccountsPayableAndAccruedLiabilitiesTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LeaseLiability" xlink:title="999018 - Disclosure - LEASE LIABILITY">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureLeaseLiabilityAbstract" xlink:label="loc_ptgefDisclosureLeaseLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfLeaseLiabilityExplanatory" xlink:label="loc_ptgefDisclosureOfLeaseLiabilityExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefDisclosureOfLeaseLiabilityExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/BitgoPrimeLoan" xlink:title="999019 - Disclosure - BITGO PRIME LOAN">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureBitgoPrimeLoanAbstract" xlink:label="loc_ptgefDisclosureBitgoPrimeLoanAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfBitgoPrimeLoanExplanatory" xlink:label="loc_ptgefDisclosureOfBitgoPrimeLoanExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureBitgoPrimeLoanAbstract" xlink:to="loc_ptgefDisclosureOfBitgoPrimeLoanExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/IncomeTaxes" xlink:title="999020 - Disclosure - INCOME TAXES">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfIncomeTaxExplanatory" xlink:label="loc_ifrs-fullDisclosureOfIncomeTaxExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfIncomeTaxExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CapitalStockAndReserves" xlink:title="999021 - Disclosure - CAPITAL STOCK AND RESERVES">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureCapitalStockAndReservesAbstract" xlink:label="loc_ptgefDisclosureCapitalStockAndReservesAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CapitalStockAndReservesTextBlock" xlink:label="loc_ptgefCapitalStockAndReservesTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalStockAndReservesAbstract" xlink:to="loc_ptgefCapitalStockAndReservesTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserve" xlink:title="999022 - Disclosure - STOCK OPTION RESERVE">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory" xlink:label="loc_ifrs-fullDisclosureOfSharebasedPaymentArrangementsExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfSharebasedPaymentArrangementsExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LossPerShare" xlink:title="999023 - Disclosure - LOSS PER SHARE">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeStatementAbstract" xlink:label="loc_ifrs-fullIncomeStatementAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_EarningsPerShareExplanatory" xlink:label="loc_ifrs-fullEarningsPerShareExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullEarningsPerShareExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CommitmentsAndContingentLiabilities" xlink:title="999024 - Disclosure - COMMITMENTS AND CONTINGENT LIABILITIES">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory" xlink:label="loc_ifrs-fullDisclosureOfCommitmentsAndContingentLiabilitiesExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfCommitmentsAndContingentLiabilitiesExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/RelatedPartyTransactions" xlink:title="999025 - Disclosure - RELATED PARTY TRANSACTIONS">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfRelatedPartyExplanatory" xlink:label="loc_ifrs-fullDisclosureOfRelatedPartyExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfRelatedPartyExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagement" xlink:title="999026 - Disclosure - FINANCIAL INSTRUMENTS AND RISK MANAGEMENT">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:label="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfFinancialInstrumentsAndRiskManagementExplanatory" xlink:label="loc_ptgefDisclosureOfFinancialInstrumentsAndRiskManagementExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:to="loc_ptgefDisclosureOfFinancialInstrumentsAndRiskManagementExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SegmentReporting" xlink:title="999027 - Disclosure - SEGMENT REPORTING">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSegmentReportingAbstract" xlink:label="loc_ptgefDisclosureSegmentReportingAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfSegmentReportingExplanatoryTextBlock" xlink:label="loc_ptgefDisclosureOfSegmentReportingExplanatoryTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSegmentReportingAbstract" xlink:to="loc_ptgefDisclosureOfSegmentReportingExplanatoryTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CapitalManagement" xlink:title="999028 - Disclosure - CAPITAL MANAGEMENT">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureCapitalManagementAbstract" xlink:label="loc_ptgefDisclosureCapitalManagementAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfCapitalManagementExplanatoryTextBlock" xlink:label="loc_ptgefDisclosureOfCapitalManagementExplanatoryTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalManagementAbstract" xlink:to="loc_ptgefDisclosureOfCapitalManagementExplanatoryTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/Non-controllingInterest" xlink:title="999029 - Disclosure - NON-CONTROLLING INTEREST">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfInterestsInOtherEntitiesExplanatory" xlink:label="loc_ifrs-fullDisclosureOfInterestsInOtherEntitiesExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfInterestsInOtherEntitiesExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SubsequentEvents" xlink:title="999030 - Disclosure - SUBSEQUENT EVENTS">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory" xlink:label="loc_ifrs-fullDisclosureOfEventsAfterReportingPeriodExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfEventsAfterReportingPeriodExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SignificantAccountingPoliciesPolicies" xlink:title="999031 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Policies)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSignificantAccountingPoliciesAbstract" xlink:label="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForImpairmentOfFinancialAssetsExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForCashAndCashEquivalentsExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForCashAndCashEquivalentsExplanatory" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForCashAndCashEquivalentsExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForImpairmentOfIndefiniteLifeIntangibleAssetsOtherThanGoodwillExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForImpairmentOfIndefiniteLifeIntangibleAssetsOtherThanGoodwillExplanatory" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForImpairmentOfIndefiniteLifeIntangibleAssetsOtherThanGoodwillExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForEarningsPerShareExplanatory" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForEarningsPerShareExplanatory" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForEarningsPerShareExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForInvestmentInPrivateCompaniesExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForInvestmentInPrivateCompaniesExplanatory" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForInvestmentInPrivateCompaniesExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForInvestmentInAssociates" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForInvestmentInAssociates" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForInvestmentInAssociates" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForContingentLiabilitiesExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForContingentLiabilitiesExplanatory" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForContingentLiabilitiesExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForFairValueMeasurementExplanatory" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForFairValueMeasurementExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfAccountingPolicyForIncomeTaxExplanatory" xlink:label="loc_ifrs-fullDescriptionOfAccountingPolicyForIncomeTaxExplanatory" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDescriptionOfAccountingPolicyForIncomeTaxExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyFoStablecoinExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyFoStablecoinExplanatory" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyFoStablecoinExplanatory" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForDigitalAssetsExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForDigitalAssetsExplanatory" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForDigitalAssetsExplanatory" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForRevenueFromContractsWithCustomersExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForRevenueFromContractsWithCustomersExplanatory" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForRevenueFromContractsWithCustomersExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForAccountsReceivableExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForAccountsReceivableExplanatory" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForAccountsReceivableExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForExpectedCreditLossesExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForExpectedCreditLossesExplanatory" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForExpectedCreditLossesExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfPolicyForPropertyPlantAndEquipmentExplanatory" xlink:label="loc_ptgefDescriptionOfPolicyForPropertyPlantAndEquipmentExplanatory" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfPolicyForPropertyPlantAndEquipmentExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfAccountingPolicyForAdoptionOfNewStandardsExplanatory" xlink:label="loc_ptgefDescriptionOfAccountingPolicyForAdoptionOfNewStandardsExplanatory" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefDescriptionOfAccountingPolicyForAdoptionOfNewStandardsExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SignificantAccountingPoliciesTables" xlink:title="999032 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSignificantAccountingPoliciesAbstract" xlink:label="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareExplanatory2023" xlink:label="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareExplanatory2023" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareExplanatory2023" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PrepaidExpensesOtherReceivablesAndOtherAssetsTables" xlink:title="999033 - Disclosure - PREPAID EXPENSES, OTHER RECEIVABLES, AND OTHER ASSETS (Tables)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfDetailedInformationAboutPrepaidExpensesAndOtherReceivableTableTextBlock" xlink:label="loc_ptgefDisclosureOfDetailedInformationAboutPrepaidExpensesAndOtherReceivableTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefDisclosureOfDetailedInformationAboutPrepaidExpensesAndOtherReceivableTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StablecoinTables" xlink:title="999034 - Disclosure - STABLECOIN (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureStablecoinAbstract" xlink:label="loc_ptgefDisclosureStablecoinAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfStablecoinTableTextBlock" xlink:label="loc_ptgefDisclosureOfStablecoinTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureStablecoinAbstract" xlink:to="loc_ptgefDisclosureOfStablecoinTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfStablecoinPurchasesTableTextBlock" xlink:label="loc_ptgefDisclosureOfStablecoinPurchasesTableTextBlock" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureStablecoinAbstract" xlink:to="loc_ptgefDisclosureOfStablecoinPurchasesTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/DigitalAssetsTables" xlink:title="999035 - Disclosure - DIGITAL ASSETS (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureDigitalAssetsAbstract" xlink:label="loc_ptgefDisclosureDigitalAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfDigitalAssetsTableTextBlock" xlink:label="loc_ptgefScheduleOfDigitalAssetsTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefScheduleOfDigitalAssetsTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfDigitalAssetsPurchasesTableTextBlock" xlink:label="loc_ptgefScheduleOfDigitalAssetsPurchasesTableTextBlock" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefScheduleOfDigitalAssetsPurchasesTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SeheduleOfTonTokensTableTextBlock" xlink:label="loc_ptgefSeheduleOfTonTokensTableTextBlock" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefSeheduleOfTonTokensTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfReceivablesDigitalAssetsTableXextBlock" xlink:label="loc_ptgefScheduleOfReceivablesDigitalAssetsTableXextBlock" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefScheduleOfReceivablesDigitalAssetsTableXextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PropertyPlantAndEquipmentAndRight-of-useAssetsTables" xlink:title="999036 - Disclosure - PROPERTY, PLANT, AND EQUIPMENT AND RIGHT-OF-USE ASSETS (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" xlink:label="loc_ptgefDisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfDetailedInformationAboutPropertyPlantAndEquipmentExplanatory" xlink:label="loc_ifrs-fullDisclosureOfDetailedInformationAboutPropertyPlantAndEquipmentExplanatory" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" xlink:to="loc_ifrs-fullDisclosureOfDetailedInformationAboutPropertyPlantAndEquipmentExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/InvestmentInCompedicaTables" xlink:title="999037 - Disclosure - INVESTMENT IN COMPEDICA (Tables)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfInvestmentBalanceTableTextBlock" xlink:label="loc_ptgefScheduleOfInvestmentBalanceTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfInvestmentBalanceTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiabilityTables" xlink:title="999038 - Disclosure - WARRANT LIABILITY (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfWarrantLiabilityTableTextBlock" xlink:label="loc_ptgefScheduleOfWarrantLiabilityTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ptgefScheduleOfWarrantLiabilityTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfFairValueMeasurementExplanatory" xlink:label="loc_ifrs-fullDisclosureOfFairValueMeasurementExplanatory" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ifrs-fullDisclosureOfFairValueMeasurementExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfFairValueMeasurementOfWarrantsExplanatory" xlink:label="loc_ptgefDisclosureOfFairValueMeasurementOfWarrantsExplanatory" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ptgefDisclosureOfFairValueMeasurementOfWarrantsExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfFairValueOfPlacementAgentWarrantsMeasurementExplanatory" xlink:label="loc_ptgefDisclosureOfFairValueOfPlacementAgentWarrantsMeasurementExplanatory" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ptgefDisclosureOfFairValueOfPlacementAgentWarrantsMeasurementExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureOfFairValueMeasurementPlacementAgentExplanatory" xlink:label="loc_ptgefDisclosureOfFairValueMeasurementPlacementAgentExplanatory" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ptgefDisclosureOfFairValueMeasurementPlacementAgentExplanatory" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableTables" xlink:title="999039 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePutRightLiabilityAndTonPayableAbstract" xlink:label="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfFairValueOfThePutRightLiabilityIsEstimatedUsingBlackScholesModelTableTextBlock" xlink:label="loc_ptgefScheduleOfFairValueOfThePutRightLiabilityIsEstimatedUsingBlackScholesModelTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefScheduleOfFairValueOfThePutRightLiabilityIsEstimatedUsingBlackScholesModelTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfPutRightLiabilityTableTextBlock" xlink:label="loc_ptgefScheduleOfPutRightLiabilityTableTextBlock" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefScheduleOfPutRightLiabilityTableTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfTonPayableTableTextBlock" xlink:label="loc_ptgefScheduleOfTonPayableTableTextBlock" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefScheduleOfTonPayableTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/AccountsPayableAndAccruedLiabilitiesTables" xlink:title="999040 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:label="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccountsPayableAndAccruedLiabilitiesTableTextBlock" xlink:label="loc_ptgefAccountsPayableAndAccruedLiabilitiesTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccountsPayableAndAccruedLiabilitiesTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LeaseLiabilityTables" xlink:title="999041 - Disclosure - LEASE LIABILITY (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureLeaseLiabilityAbstract" xlink:label="loc_ptgefDisclosureLeaseLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfLeaseLiabilityTableTextBlock" xlink:label="loc_ptgefScheduleOfLeaseLiabilityTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefScheduleOfLeaseLiabilityTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/IncomeTaxesTables" xlink:title="999042 - Disclosure - INCOME TAXES (Tables)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfIncomeTaxesBenefitTableTextBlock" xlink:label="loc_ptgefScheduleOfIncomeTaxesBenefitTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfIncomeTaxesBenefitTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfReconciliationEffectiveIncomeTaxratesTableTextBlock" xlink:label="loc_ptgefScheduleOfReconciliationEffectiveIncomeTaxratesTableTextBlock" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfReconciliationEffectiveIncomeTaxratesTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfDeferredTaxAssetsTableTextBlock" xlink:label="loc_ptgefScheduleOfDeferredTaxAssetsTableTextBlock" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfDeferredTaxAssetsTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CapitalStockAndReservesTables" xlink:title="999043 - Disclosure - CAPITAL STOCK AND RESERVES (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureCapitalStockAndReservesAbstract" xlink:label="loc_ptgefDisclosureCapitalStockAndReservesAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:label="loc_ptgefScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalStockAndReservesAbstract" xlink:to="loc_ptgefScheduleOfAccumulatedOtherComprehensiveIncomeLossTableTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserveTables" xlink:title="999044 - Disclosure - STOCK OPTION RESERVE (Tables)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfTermsStockOptionReserveTableTextBlock" xlink:label="loc_ptgefScheduleOfTermsStockOptionReserveTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfTermsStockOptionReserveTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:label="loc_ptgefScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfWeightedAverageAssumptionsTableTextBlock" xlink:label="loc_ptgefScheduleOfWeightedAverageAssumptionsTableTextBlock" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfWeightedAverageAssumptionsTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfNumberAndWeightedAverageRemainingContractualLifeOfOutstandingShareOptionsExplanatory" xlink:label="loc_ifrs-fullDisclosureOfNumberAndWeightedAverageRemainingContractualLifeOfOutstandingShareOptionsExplanatory" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfNumberAndWeightedAverageRemainingContractualLifeOfOutstandingShareOptionsExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfShareBasedCompensationStocksOptionsAndStockAppreciationRightsAwardActivityTableTextBlock" xlink:label="loc_ptgefScheduleOfShareBasedCompensationStocksOptionsAndStockAppreciationRightsAwardActivityTableTextBlock" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfShareBasedCompensationStocksOptionsAndStockAppreciationRightsAwardActivityTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LossPerShareTables" xlink:title="999045 - Disclosure - LOSS PER SHARE (Tables)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeStatementAbstract" xlink:label="loc_ifrs-fullIncomeStatementAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfEarningsPerShareTableTextBlock" xlink:label="loc_ptgefScheduleOfEarningsPerShareTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ptgefScheduleOfEarningsPerShareTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfAntiDilutiveEffectTableTextBlock" xlink:label="loc_ptgefScheduleOfAntiDilutiveEffectTableTextBlock" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ptgefScheduleOfAntiDilutiveEffectTableTextBlock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/RelatedPartyTransactionsTables" xlink:title="999046 - Disclosure - RELATED PARTY TRANSACTIONS (Tables)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfCompensationPayableTableTextBlock" xlink:label="loc_ptgefScheduleOfCompensationPayableTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfCompensationPayableTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfAuditorsRemunerationExplanatory" xlink:label="loc_ifrs-fullDisclosureOfAuditorsRemunerationExplanatory" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfAuditorsRemunerationExplanatory" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfOutstandingEquityAwardsTableTextBlock" xlink:label="loc_ptgefScheduleOfOutstandingEquityAwardsTableTextBlock" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfOutstandingEquityAwardsTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementTables" xlink:title="999047 - Disclosure - FINANCIAL INSTRUMENTS AND RISK MANAGEMENT (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:label="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfFinancialAssetsAndFinancialLiabilitiesTableTextBlock" xlink:label="loc_ptgefScheduleOfFinancialAssetsAndFinancialLiabilitiesTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:to="loc_ptgefScheduleOfFinancialAssetsAndFinancialLiabilitiesTableTextBlock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LiabilitiesMeasuredFairValueRecurringBasisTableTextBlock" xlink:label="loc_ptgefLiabilitiesMeasuredFairValueRecurringBasisTableTextBlock" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:to="loc_ptgefLiabilitiesMeasuredFairValueRecurringBasisTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SegmentReportingTables" xlink:title="999048 - Disclosure - SEGMENT REPORTING (Tables)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSegmentReportingAbstract" xlink:label="loc_ptgefDisclosureSegmentReportingAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfSegmentReportingTableTextBlock" xlink:label="loc_ptgefScheduleOfSegmentReportingTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSegmentReportingAbstract" xlink:to="loc_ptgefScheduleOfSegmentReportingTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/Non-controllingInterestTables" xlink:title="999049 - Disclosure - NON-CONTROLLING INTEREST (Tables)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ScheduleOfNoncontrollingInterestTableTextBlock" xlink:label="loc_ptgefScheduleOfNoncontrollingInterestTableTextBlock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefScheduleOfNoncontrollingInterestTableTextBlock" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/GoingConcernDetailsNarrative" xlink:title="999050 - Disclosure - GOING CONCERN (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Cash" xlink:label="loc_ifrs-fullCash" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullCash" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TotalCurrentLiabilities" xlink:label="loc_ptgefTotalCurrentLiabilities" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefTotalCurrentLiabilities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetLossIncome" xlink:label="loc_ptgefNetLossIncome" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefNetLossIncome" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CashUsedInOperatingActivities" xlink:label="loc_ptgefCashUsedInOperatingActivities" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefCashUsedInOperatingActivities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CashCashEquivalents" xlink:label="loc_ptgefCashCashEquivalents" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefCashCashEquivalents" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RestrictedCashOnHand" xlink:label="loc_ptgefRestrictedCashOnHand" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefRestrictedCashOnHand" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/BasisOfPresentationDetailsNarrative" xlink:title="999051 - Disclosure - BASIS OF PRESENTATION (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfSignificantInvestmentsInSubsidiariesTable" xlink:label="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SignificantInvestmentsInSubsidiariesAxis" xlink:label="loc_ifrs-fullSignificantInvestmentsInSubsidiariesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" xlink:to="loc_ifrs-fullSignificantInvestmentsInSubsidiariesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SignificantInvestmentsInSubsidiariesDomain" xlink:label="loc_ifrs-fullSignificantInvestmentsInSubsidiariesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullSignificantInvestmentsInSubsidiariesAxis" xlink:to="loc_ifrs-fullSignificantInvestmentsInSubsidiariesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IOXMember" xlink:label="loc_ptgefIOXMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullSignificantInvestmentsInSubsidiariesDomain" xlink:to="loc_ptgefIOXMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ConsolidatedStructuredEntitiesAxis" xlink:label="loc_ifrs-fullConsolidatedStructuredEntitiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" xlink:to="loc_ifrs-fullConsolidatedStructuredEntitiesAxis" order="20" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ConsolidatedStructuredEntitiesDomain" xlink:label="loc_ifrs-fullConsolidatedStructuredEntitiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullConsolidatedStructuredEntitiesAxis" xlink:to="loc_ifrs-fullConsolidatedStructuredEntitiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SalvaRxMember" xlink:label="loc_ptgefSalvaRxMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullConsolidatedStructuredEntitiesDomain" xlink:to="loc_ptgefSalvaRxMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StimunityMember" xlink:label="loc_ptgefStimunityMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullConsolidatedStructuredEntitiesDomain" xlink:to="loc_ptgefStimunityMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RangeAxis" xlink:label="loc_ifrs-fullRangeAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" xlink:to="loc_ifrs-fullRangeAxis" order="30" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RangeDomain" xlink:label="loc_ifrs-fullRangeDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullRangeAxis" xlink:to="loc_ifrs-fullRangeDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_BottomOfRangeMember" xlink:label="loc_ifrs-fullBottomOfRangeMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullRangeDomain" xlink:to="loc_ifrs-fullBottomOfRangeMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TopOfRangeMember" xlink:label="loc_ifrs-fullTopOfRangeMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullRangeDomain" xlink:to="loc_ifrs-fullTopOfRangeMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GeographicalAreasAxis" xlink:label="loc_ifrs-fullGeographicalAreasAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" xlink:to="loc_ifrs-fullGeographicalAreasAxis" order="40" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GeographicalAreasDomain" xlink:label="loc_ifrs-fullGeographicalAreasDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullGeographicalAreasAxis" xlink:to="loc_ifrs-fullGeographicalAreasDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CountryOfBritishVirginIslandsMember" xlink:label="loc_ptgefCountryOfBritishVirginIslandsMember" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullGeographicalAreasDomain" xlink:to="loc_ptgefCountryOfBritishVirginIslandsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DelawareMember" xlink:label="loc_ptgefDelawareMember" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullGeographicalAreasDomain" xlink:to="loc_ptgefDelawareMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfSignificantInvestmentsInSubsidiariesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="50" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SubsidiariesTwoMember" xlink:label="loc_ptgefSubsidiariesTwoMember" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefSubsidiariesTwoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProportionOfVotingPowerHeldInSubsidiary" xlink:label="loc_ifrs-fullProportionOfVotingPowerHeldInSubsidiary" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullProportionOfVotingPowerHeldInSubsidiary" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProportionOfOwnershipInterestInSubsidiary" xlink:label="loc_ifrs-fullProportionOfOwnershipInterestInSubsidiary" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullProportionOfOwnershipInterestInSubsidiary" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProportionOfOwnershipInterestsHeldByNoncontrollingInterests" xlink:label="loc_ifrs-fullProportionOfOwnershipInterestsHeldByNoncontrollingInterests" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullProportionOfOwnershipInterestsHeldByNoncontrollingInterests" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NoncontrollingInterestIncreasedUponConversion" xlink:label="loc_ptgefNoncontrollingInterestIncreasedUponConversion" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNoncontrollingInterestIncreasedUponConversion" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SignificantAccountingPoliciesDetails" xlink:title="999052 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Details )">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSignificantAccountingPoliciesAbstract" xlink:label="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" xlink:label="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TypesOfAntidilutiveInstrumentsAxis" xlink:label="loc_ifrs-fullTypesOfAntidilutiveInstrumentsAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" xlink:to="loc_ifrs-fullTypesOfAntidilutiveInstrumentsAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TypesOfAntidilutiveInstrumentsDomain" xlink:label="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullTypesOfAntidilutiveInstrumentsAxis" xlink:to="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WarrantsMember" xlink:label="loc_ifrs-fullWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" xlink:to="loc_ifrs-fullWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StockOptionsMember" xlink:label="loc_ptgefStockOptionsMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" xlink:to="loc_ptgefStockOptionsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RestrictedStockUnitsMember" xlink:label="loc_ptgefRestrictedStockUnitsMember" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" xlink:to="loc_ptgefRestrictedStockUnitsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NumberOfPotentialOrdinarySharesThatAreAntidilutiveInPeriodPresented" xlink:label="loc_ifrs-fullNumberOfPotentialOrdinarySharesThatAreAntidilutiveInPeriodPresented" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNumberOfPotentialOrdinarySharesThatAreAntidilutiveInPeriodPresented" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SignificantAccountingPoliciesDetailsNarrative" xlink:title="999053 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSignificantAccountingPoliciesAbstract" xlink:label="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InvestmentProperty" xlink:label="loc_ifrs-fullInvestmentProperty" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ifrs-fullInvestmentProperty" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CashRestrictedForUse" xlink:label="loc_ptgefCashRestrictedForUse" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSignificantAccountingPoliciesAbstract" xlink:to="loc_ptgefCashRestrictedForUse" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PrepaidExpensesAndOtherReceivablesDetails" xlink:title="999054 - Disclosure - PREPAID EXPENSES AND OTHER RECEIVABLES (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentReceivablesFromSaleOfProperties" xlink:label="loc_ifrs-fullCurrentReceivablesFromSaleOfProperties" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullCurrentReceivablesFromSaleOfProperties" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentAdvancesToSuppliers" xlink:label="loc_ifrs-fullCurrentAdvancesToSuppliers" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullCurrentAdvancesToSuppliers" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentPrepaidExpenses" xlink:label="loc_ifrs-fullCurrentPrepaidExpenses" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullCurrentPrepaidExpenses" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrepaidInvestorRelations" xlink:label="loc_ptgefPrepaidInvestorRelations" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefPrepaidInvestorRelations" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TaxDeposits" xlink:label="loc_ptgefTaxDeposits" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefTaxDeposits" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrepaidGpuInfrastructureCosts" xlink:label="loc_ptgefPrepaidGpuInfrastructureCosts" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefPrepaidGpuInfrastructureCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrepaidGpuLeasesShortterm" xlink:label="loc_ptgefPrepaidGpuLeasesShortterm" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefPrepaidGpuLeasesShortterm" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherCurrentReceivables" xlink:label="loc_ifrs-fullOtherCurrentReceivables" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullOtherCurrentReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TotalPrepaidExpensesAndOtherReceivables" xlink:label="loc_ptgefTotalPrepaidExpensesAndOtherReceivables" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefTotalPrepaidExpensesAndOtherReceivables" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PrepaidExpensesOtherReceivablesAndOtherAssetsDetailsNarrative" xlink:title="999055 - Disclosure - PREPAID EXPENSES, OTHER RECEIVABLES, AND OTHER ASSETS (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OtherAssetsLongTermPortion" xlink:label="loc_ptgefOtherAssetsLongTermPortion" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefOtherAssetsLongTermPortion" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SecurityDeposits" xlink:label="loc_ptgefSecurityDeposits" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefSecurityDeposits" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StablecoinDetails" xlink:title="999056 - Disclosure - STABLECOIN (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureStablecoinAbstract" xlink:label="loc_ptgefDisclosureStablecoinAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfFinancialInstrumentsTable" xlink:label="loc_ifrs-fullDisclosureOfFinancialInstrumentsTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureStablecoinAbstract" xlink:to="loc_ifrs-fullDisclosureOfFinancialInstrumentsTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFinancialInstrumentsTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfFinancialInstrumentsAxis" xlink:label="loc_ifrs-fullClassesOfFinancialInstrumentsAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFinancialInstrumentsTable" xlink:to="loc_ifrs-fullClassesOfFinancialInstrumentsAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfFinancialInstrumentsDomain" xlink:label="loc_ifrs-fullClassesOfFinancialInstrumentsDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfFinancialInstrumentsAxis" xlink:to="loc_ifrs-fullClassesOfFinancialInstrumentsDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_USDCMember" xlink:label="loc_ptgefUSDCMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfFinancialInstrumentsDomain" xlink:to="loc_ptgefUSDCMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UsdtMember" xlink:label="loc_ptgefUsdtMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfFinancialInstrumentsDomain" xlink:to="loc_ptgefUsdtMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Stablecoins" xlink:label="loc_ptgefStablecoins" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefStablecoins" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StablecoinDetails1" xlink:title="999057 - Disclosure - STABLECOIN (Details 1)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureStablecoinAbstract" xlink:label="loc_ptgefDisclosureStablecoinAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:label="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureStablecoinAbstract" xlink:to="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_USDCMember" xlink:label="loc_ptgefUSDCMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefUSDCMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UsdtMember" xlink:label="loc_ptgefUsdtMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefUsdtMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TotalMember" xlink:label="loc_ptgefTotalMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefTotalMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetValueAsOfApril1" xlink:label="loc_ptgefDigitalAssetValueAsOfApril1" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetValueAsOfApril1" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContributionOfStablecoin" xlink:label="loc_ptgefContributionOfStablecoin" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefContributionOfStablecoin" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProceedsFromSaleOfDigitalAssets" xlink:label="loc_ptgefProceedsFromSaleOfDigitalAssets" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefProceedsFromSaleOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StablecoinUsedToSettleOperatingCosts" xlink:label="loc_ptgefStablecoinUsedToSettleOperatingCosts" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefStablecoinUsedToSettleOperatingCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StablecoinSold" xlink:label="loc_ptgefStablecoinSold" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefStablecoinSold" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProceedsFromExternalDebtDrawdown" xlink:label="loc_ptgefProceedsFromExternalDebtDrawdown" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefProceedsFromExternalDebtDrawdown" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PurchasesOfStablecoin" xlink:label="loc_ptgefPurchasesOfStablecoin" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPurchasesOfStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StablecoinUsedToPurchaseDigitalAssets" xlink:label="loc_ptgefStablecoinUsedToPurchaseDigitalAssets" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefStablecoinUsedToPurchaseDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StablecoinValueAsOfMarch31" xlink:label="loc_ptgefStablecoinValueAsOfMarch31" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefStablecoinValueAsOfMarch31" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/DigitalAssetsDetails" xlink:title="999058 - Disclosure - DIGITAL ASSETS (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureDigitalAssetsAbstract" xlink:label="loc_ptgefDisclosureDigitalAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ApproximateNumberOfTonTokensHeld" xlink:label="loc_ptgefApproximateNumberOfTonTokensHeld" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefApproximateNumberOfTonTokensHeld" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonTokensFairValueInThousands" xlink:label="loc_ptgefTonTokensFairValueInThousands" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefTonTokensFairValueInThousands" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsFairValueInThousands" xlink:label="loc_ptgefDigitalAssetsFairValueInThousands" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefDigitalAssetsFairValueInThousands" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/DigitalAssetsDetails1" xlink:title="999059 - Disclosure - DIGITAL ASSETS (Details 1)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureDigitalAssetsAbstract" xlink:label="loc_ptgefDisclosureDigitalAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfIntangibleAssetsMaterialToEntityTable" xlink:label="loc_ifrs-fullDisclosureOfIntangibleAssetsMaterialToEntityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ifrs-fullDisclosureOfIntangibleAssetsMaterialToEntityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfIntangibleAssetsMaterialToEntityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IntangibleAssetsMaterialToEntityAxis" xlink:label="loc_ifrs-fullIntangibleAssetsMaterialToEntityAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfIntangibleAssetsMaterialToEntityTable" xlink:to="loc_ifrs-fullIntangibleAssetsMaterialToEntityAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IntangibleAssetsMaterialToEntityDomain" xlink:label="loc_ifrs-fullIntangibleAssetsMaterialToEntityDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIntangibleAssetsMaterialToEntityAxis" xlink:to="loc_ifrs-fullIntangibleAssetsMaterialToEntityDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TONMember" xlink:label="loc_ptgefTONMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIntangibleAssetsMaterialToEntityDomain" xlink:to="loc_ptgefTONMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BITCOINMember" xlink:label="loc_ptgefBITCOINMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIntangibleAssetsMaterialToEntityDomain" xlink:to="loc_ptgefBITCOINMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TotalMember" xlink:label="loc_ptgefTotalMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIntangibleAssetsMaterialToEntityDomain" xlink:to="loc_ptgefTotalMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetValueAsOfApril1" xlink:label="loc_ptgefDigitalAssetValueAsOfApril1" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetValueAsOfApril1" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContributionOfDigitalAssets" xlink:label="loc_ptgefContributionOfDigitalAssets" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefContributionOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UnrealizedLossesOnDigitalAssetsRecognizedInStatementOfOperations" xlink:label="loc_ptgefUnrealizedLossesOnDigitalAssetsRecognizedInStatementOfOperations" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefUnrealizedLossesOnDigitalAssetsRecognizedInStatementOfOperations" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsSold" xlink:label="loc_ptgefDigitalAssetsSold" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetsSold" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PaymentsOnExternalDebtUsingDigitalAssets" xlink:label="loc_ptgefPaymentsOnExternalDebtUsingDigitalAssets" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPaymentsOnExternalDebtUsingDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetPurchases" xlink:label="loc_ptgefDigitalAssetPurchases" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetPurchases" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ReceiptOfDigitalAssetsReceivable" xlink:label="loc_ptgefReceiptOfDigitalAssetsReceivable" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefReceiptOfDigitalAssetsReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossGainOnSaleOfDigitalAssets" xlink:label="loc_ptgefRealizedLossGainOnSaleOfDigitalAssets" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefRealizedLossGainOnSaleOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossOnNovationOfDigitalAssetsToInvestor" xlink:label="loc_ptgefRealizedLossOnNovationOfDigitalAssetsToInvestor" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefRealizedLossOnNovationOfDigitalAssetsToInvestor" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RevenueReceivedInDigitalAssets" xlink:label="loc_ptgefRevenueReceivedInDigitalAssets" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefRevenueReceivedInDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TokensUsedToSettlePutRights" xlink:label="loc_ptgefTokensUsedToSettlePutRights" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTokensUsedToSettlePutRights" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsExchanged" xlink:label="loc_ptgefDigitalAssetsExchanged" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetsExchanged" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsTransacted" xlink:label="loc_ptgefDigitalAssetsTransacted" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetsTransacted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetValueAsOfMarch31" xlink:label="loc_ptgefDigitalAssetValueAsOfMarch31" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetValueAsOfMarch31" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/DigitalAssetsDetails2" xlink:title="999060 - Disclosure - DIGITAL ASSETS (Details 2)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureDigitalAssetsAbstract" xlink:label="loc_ptgefDisclosureDigitalAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CapitalFutureMinimumPaymentsRemainderOfFiscalYear" xlink:label="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfFiscalYear" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfFiscalYear" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CapitalFutureMinimumPaymentsRemainderOfSecondYear" xlink:label="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfSecondYear" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfSecondYear" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CapitalFutureMinimumPaymentsRemainderOfThirdYear" xlink:label="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfThirdYear" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfThirdYear" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CapitalFutureMinimumPaymentsRemainderOfTotalYear" xlink:label="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfTotalYear" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefCapitalFutureMinimumPaymentsRemainderOfTotalYear" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/ReceivablesDigitalAssetsDetails" xlink:title="999061 - Disclosure - RECEIVABLES DIGITAL ASSETS (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureDigitalAssetsAbstract" xlink:label="loc_ptgefDisclosureDigitalAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:label="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_USD1Member" xlink:label="loc_ptgefUSD1Member" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefUSD1Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LockedTonMember" xlink:label="loc_ptgefLockedTonMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefLockedTonMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TotalMember" xlink:label="loc_ptgefTotalMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefTotalMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetValueAsOfApril1" xlink:label="loc_ptgefDigitalAssetValueAsOfApril1" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetValueAsOfApril1" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContributionOfDigitalAssetAndStablecoinReceivables" xlink:label="loc_ptgefContributionOfDigitalAssetAndStablecoinReceivables" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefContributionOfDigitalAssetAndStablecoinReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfDigitalAssetsReceivable" xlink:label="loc_ptgefChangeInFairValueOfDigitalAssetsReceivable" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefChangeInFairValueOfDigitalAssetsReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ReceiptOfDigitalAssetReceivables" xlink:label="loc_ptgefReceiptOfDigitalAssetReceivables" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefReceiptOfDigitalAssetReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TokensUsedToSettlePutRights" xlink:label="loc_ptgefTokensUsedToSettlePutRights" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTokensUsedToSettlePutRights" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StablecoinValueAsOfSeptember30" xlink:label="loc_ptgefStablecoinValueAsOfSeptember30" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefStablecoinValueAsOfSeptember30" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/DigitalAssetsDetailsNarrative" xlink:title="999062 - Disclosure - DIGITAL ASSETS (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureDigitalAssetsAbstract" xlink:label="loc_ptgefDisclosureDigitalAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssets" xlink:label="loc_ptgefDigitalAssets" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonTokensReceivable" xlink:label="loc_ptgefTonTokensReceivable" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefTonTokensReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonTokensReceivableShares" xlink:label="loc_ptgefTonTokensReceivableShares" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefTonTokensReceivableShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TokensArePayable" xlink:label="loc_ptgefTokensArePayable" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureDigitalAssetsAbstract" xlink:to="loc_ptgefTokensArePayable" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PropertyPlantAndEquipmentAndRight-of-useAssetsDetails" xlink:title="999063 - Disclosure - PROPERTY, PLANT, AND EQUIPMENT AND RIGHT-OF-USE ASSETS (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" xlink:label="loc_ptgefDisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfPropertyPlantAndEquipmentTable" xlink:label="loc_ifrs-fullDisclosureOfPropertyPlantAndEquipmentTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePropertyPlantAndEquipmentAndRightofuseAssetsAbstract" xlink:to="loc_ifrs-fullDisclosureOfPropertyPlantAndEquipmentTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfPropertyPlantAndEquipmentTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis" xlink:label="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfPropertyPlantAndEquipmentTable" xlink:to="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfPropertyPlantAndEquipmentDomain" xlink:label="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentAxis" xlink:to="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GPUsMember" xlink:label="loc_ptgefGPUsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentDomain" xlink:to="loc_ptgefGPUsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GPUDepositsMember" xlink:label="loc_ptgefGPUDepositsMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentDomain" xlink:to="loc_ptgefGPUDepositsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RightOfUseAssetMember" xlink:label="loc_ptgefRightOfUseAssetMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentDomain" xlink:to="loc_ptgefRightOfUseAssetMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TotalMember" xlink:label="loc_ptgefTotalMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfPropertyPlantAndEquipmentDomain" xlink:to="loc_ptgefTotalMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets" xlink:label="loc_ifrs-fullPropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullPropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdditionsToRightofuseAssets" xlink:label="loc_ifrs-fullAdditionsToRightofuseAssets" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullAdditionsToRightofuseAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisposalsPropertyPlantAndEquipment" xlink:label="loc_ifrs-fullDisposalsPropertyPlantAndEquipment" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDisposalsPropertyPlantAndEquipment" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets" xlink:label="loc_ifrs-fullPropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets_2" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullPropertyPlantAndEquipmentCarryingAmountAtCostOfRevaluedAssets_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccumulatedDepreciationPropertyPlantAndEquipment" xlink:label="loc_ptgefAccumulatedDepreciationPropertyPlantAndEquipment" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAccumulatedDepreciationPropertyPlantAndEquipment" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FixedAssetDepreciation" xlink:label="loc_ptgefFixedAssetDepreciation" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefFixedAssetDepreciation" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FixedAssetDisposals" xlink:label="loc_ptgefFixedAssetDisposals" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefFixedAssetDisposals" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccumulatedDepreciationPropertyPlantAndEquipment" xlink:label="loc_ptgefAccumulatedDepreciationPropertyPlantAndEquipment_2" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAccumulatedDepreciationPropertyPlantAndEquipment_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PropertyPlantAndEquipment" xlink:label="loc_ifrs-fullPropertyPlantAndEquipment" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullPropertyPlantAndEquipment" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/InvestmentInCompedicaDetails" xlink:title="999064 - Disclosure - INVESTMENT IN COMPEDICA (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BalanceAsOfApril1" xlink:label="loc_ptgefBalanceAsOfApril1" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefBalanceAsOfApril1" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_InitialInvestmentInCompedica" xlink:label="loc_ptgefInitialInvestmentInCompedica" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefInitialInvestmentInCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossFromEquityMethodInvestment" xlink:label="loc_ptgefLossFromEquityMethodInvestment" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefLossFromEquityMethodInvestment" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnImpairment" xlink:label="loc_ptgefLossOnImpairment" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefLossOnImpairment" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfInvestmentInCompedica" xlink:label="loc_ptgefChangeInFairValueOfInvestmentInCompedica" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefChangeInFairValueOfInvestmentInCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ReturnOfInvestmentInterestToCompedica" xlink:label="loc_ptgefReturnOfInvestmentInterestToCompedica" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefReturnOfInvestmentInterestToCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_InvestmentInCompedicaAsOfMarch31" xlink:label="loc_ptgefInvestmentInCompedicaAsOfMarch31" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefInvestmentInCompedicaAsOfMarch31" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/InvestmentInCompedicaDetailsNarrative" xlink:title="999065 - Disclosure - INVESTMENT IN COMPEDICA (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedReimbursementOtherProvisions" xlink:label="loc_ifrs-fullExpectedReimbursementOtherProvisions" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullExpectedReimbursementOtherProvisions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ImpairmentLoss" xlink:label="loc_ifrs-fullImpairmentLoss" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullImpairmentLoss" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOnInvestmentInCompedica" xlink:label="loc_ptgefChangeInFairValueOnInvestmentInCompedica" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefChangeInFairValueOnInvestmentInCompedica" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiabilityDetails" xlink:title="999066 - Disclosure - WARRANT LIABILITY (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ClassBWarrantsMember" xlink:label="loc_ptgefClassBWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefClassBWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ClassCWarrantsMember" xlink:label="loc_ptgefClassCWarrantsMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefClassCWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PlacementAgentWarrantsMember" xlink:label="loc_ptgefPlacementAgentWarrantsMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefPlacementAgentWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueOfWarrantsAtIssuanceExercisePrice" xlink:label="loc_ptgefFairValueOfWarrantsAtIssuanceExercisePrice" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefFairValueOfWarrantsAtIssuanceExercisePrice" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueOfWarrantsShares" xlink:label="loc_ptgefFairValueOfWarrantsShares" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefFairValueOfWarrantsShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueOfWarrantsAmount" xlink:label="loc_ptgefFairValueOfWarrantsAmount" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefFairValueOfWarrantsAmount" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfWarrantLiabilityAmount" xlink:label="loc_ptgefChangeInFairValueOfWarrantLiabilityAmount" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefChangeInFairValueOfWarrantLiabilityAmount" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WarrantsLiabilityShares" xlink:label="loc_ptgefWarrantsLiabilityShares" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefWarrantsLiabilityShares" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WarrantsLiabilityFairValue" xlink:label="loc_ptgefWarrantsLiabilityFairValue" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefWarrantsLiabilityFairValue" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WarrantsLiabilityShares" xlink:label="loc_ptgefWarrantsLiabilityShares_2" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefWarrantsLiabilityShares_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WarrantsLiabilityFairValue" xlink:label="loc_ptgefWarrantsLiabilityFairValue_2" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefWarrantsLiabilityFairValue_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiabilityDetails1" xlink:title="999067 - Disclosure - WARRANT LIABILITY (Details 1)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SeriesBWarrantsMember" xlink:label="loc_ptgefSeriesBWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefSeriesBWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExercisePriceFairValue" xlink:label="loc_ptgefExercisePriceFairValue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExercisePriceFairValue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharePriceFairvalue" xlink:label="loc_ptgefSharePriceFairvalue" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharePriceFairvalue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OptionLifeShareOptions" xlink:label="loc_ptgefOptionLifeShareOptions" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOptionLifeShareOptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted" xlink:label="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiabilityDetails2" xlink:title="999068 - Disclosure - WARRANT LIABILITY (Details 2)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SeriesCWarrantsMember" xlink:label="loc_ptgefSeriesCWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefSeriesCWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExercisePriceFairValue" xlink:label="loc_ptgefExercisePriceFairValue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExercisePriceFairValue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharePriceFairvalue" xlink:label="loc_ptgefSharePriceFairvalue" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharePriceFairvalue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OptionLifeShareOptions" xlink:label="loc_ptgefOptionLifeShareOptions" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOptionLifeShareOptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted" xlink:label="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiabilityDetails3" xlink:title="999069 - Disclosure - WARRANT LIABILITY (Details 3)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PlacementAgentWarrantsMember" xlink:label="loc_ptgefPlacementAgentWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefPlacementAgentWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExercisePriceFairValue" xlink:label="loc_ptgefExercisePriceFairValue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExercisePriceFairValue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharePriceFairvalue" xlink:label="loc_ptgefSharePriceFairvalue" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharePriceFairvalue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OptionLifeShareOptions" xlink:label="loc_ptgefOptionLifeShareOptions" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOptionLifeShareOptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted" xlink:label="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiabilityDetails4" xlink:title="999070 - Disclosure - WARRANT LIABILITY (Details 4)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PlacementAgentWarrantsMember" xlink:label="loc_ptgefPlacementAgentWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefPlacementAgentWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PlacementAgentsWarrantsMember" xlink:label="loc_ptgefPlacementAgentsWarrantsMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefPlacementAgentsWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExercisePriceFairValue" xlink:label="loc_ptgefExercisePriceFairValue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExercisePriceFairValue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharePriceFairvalue" xlink:label="loc_ptgefSharePriceFairvalue" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharePriceFairvalue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OptionLifeShareOptions" xlink:label="loc_ptgefOptionLifeShareOptions" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOptionLifeShareOptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted" xlink:label="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/WarrantLiabilityDetailsNarrative" xlink:title="999071 - Disclosure - WARRANT LIABILITY (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureWarrantLiabilityAbstract" xlink:label="loc_ptgefDisclosureWarrantLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureWarrantLiabilityAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SeiesBWarrantsMember" xlink:label="loc_ptgefSeiesBWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefSeiesBWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SeiesCWarrantsMember" xlink:label="loc_ptgefSeiesCWarrantsMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefSeiesCWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PlacementAgentWarrantsMember" xlink:label="loc_ptgefPlacementAgentWarrantsMember" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefPlacementAgentWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PlacementAgentWarrants2026Member" xlink:label="loc_ptgefPlacementAgentWarrants2026Member" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefPlacementAgentWarrants2026Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueOfWarrantPerShare" xlink:label="loc_ptgefFairValueOfWarrantPerShare" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefFairValueOfWarrantPerShare" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails" xlink:title="999072 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePutRightLiabilityAndTonPayableAbstract" xlink:label="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonTokenVolatilityMember" xlink:label="loc_ptgefTonTokenVolatilityMember" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefTonTokenVolatilityMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExercisePriceOfOutstandingShareOptions2019" xlink:label="loc_ifrs-fullExercisePriceOfOutstandingShareOptions2019" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExercisePriceOfOutstandingShareOptions2019" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019" xlink:label="loc_ifrs-fullWeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullWeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightLiabilityemainingTermInYears" xlink:label="loc_ptgefPutRightLiabilityemainingTermInYears" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPutRightLiabilityemainingTermInYears" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted" xlink:label="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonTokenPrice" xlink:label="loc_ptgefTonTokenPrice" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTonTokenPrice" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LockedTonTokenDiscountForLackOfMarketabilityRate" xlink:label="loc_ptgefLockedTonTokenDiscountForLackOfMarketabilityRate" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefLockedTonTokenDiscountForLackOfMarketabilityRate" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails1" xlink:title="999073 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details 1)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePutRightLiabilityAndTonPayableAbstract" xlink:label="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BalanceOfPutRightLiability" xlink:label="loc_ptgefBalanceOfPutRightLiability" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefBalanceOfPutRightLiability" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DecreaseThroughRightToConsiderationBecomingUnconditionalContractAssets" xlink:label="loc_ifrs-fullDecreaseThroughRightToConsiderationBecomingUnconditionalContractAssets" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ifrs-fullDecreaseThroughRightToConsiderationBecomingUnconditionalContractAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GainsLossesOnChangeInFairValueOfDerivatives" xlink:label="loc_ifrs-fullGainsLossesOnChangeInFairValueOfDerivatives" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ifrs-fullGainsLossesOnChangeInFairValueOfDerivatives" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromExerciseOfOptions" xlink:label="loc_ifrs-fullProceedsFromExerciseOfOptions" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ifrs-fullProceedsFromExerciseOfOptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SettlementOfDwfMaasLimitedPutRight" xlink:label="loc_ptgefSettlementOfDwfMaasLimitedPutRight" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefSettlementOfDwfMaasLimitedPutRight" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnExerciseOfPutRightLiability" xlink:label="loc_ptgefLossOnExerciseOfPutRightLiability" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefLossOnExerciseOfPutRightLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightLiabilityEndingBalance" xlink:label="loc_ptgefPutRightLiabilityEndingBalance" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefPutRightLiabilityEndingBalance" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails2" xlink:title="999074 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details 2)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePutRightLiabilityAndTonPayableAbstract" xlink:label="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BalanceOfTonPayable" xlink:label="loc_ptgefBalanceOfTonPayable" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefBalanceOfTonPayable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExerciseOfSideLetterPutRightPayable" xlink:label="loc_ptgefExerciseOfSideLetterPutRightPayable" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefExerciseOfSideLetterPutRightPayable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:label="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnSettlementOfTonPayable" xlink:label="loc_ptgefGainOnSettlementOfTonPayable" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefGainOnSettlementOfTonPayable" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SettlementOfPutRightLiabilityUsingDigitalAssets" xlink:label="loc_ptgefSettlementOfPutRightLiabilityUsingDigitalAssets" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefSettlementOfPutRightLiabilityUsingDigitalAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonPayableEndingBalanceAsOfMarch31" xlink:label="loc_ptgefTonPayableEndingBalanceAsOfMarch31" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefTonPayableEndingBalanceAsOfMarch31" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetailsNarrative" xlink:title="999075 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosurePutRightLiabilityAndTonPayableAbstract" xlink:label="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TreasuryManagementAgreementDescription" xlink:label="loc_ptgefTreasuryManagementAgreementDescription" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefTreasuryManagementAgreementDescription" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentInterestReceivable" xlink:label="loc_ifrs-fullCurrentInterestReceivable" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ifrs-fullCurrentInterestReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueOfContribution" xlink:label="loc_ptgefFairValueOfContribution" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefFairValueOfContribution" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Usd1Receivable" xlink:label="loc_ptgefUsd1Receivable" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefUsd1Receivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnExercise" xlink:label="loc_ptgefLossOnExercise" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefLossOnExercise" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OutstandingContingentPutOptionsFairValue" xlink:label="loc_ptgefOutstandingContingentPutOptionsFairValue" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefOutstandingContingentPutOptionsFairValue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RemeasurementChangeInFairValue" xlink:label="loc_ptgefRemeasurementChangeInFairValue" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosurePutRightLiabilityAndTonPayableAbstract" xlink:to="loc_ptgefRemeasurementChangeInFairValue" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/AccountsPayableAndAccruedLiabilitiesDetails" xlink:title="999076 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:label="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccountsPayable" xlink:label="loc_ptgefAccountsPayable" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccountsPayable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccruedOtherProfessionalFees" xlink:label="loc_ptgefAccruedOtherProfessionalFees" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccruedOtherProfessionalFees" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccruedAccountingAndAuditingFees" xlink:label="loc_ptgefAccruedAccountingAndAuditingFees" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccruedAccountingAndAuditingFees" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccruedBonusesAndOtherPayrollrelatedExpenses" xlink:label="loc_ptgefAccruedBonusesAndOtherPayrollrelatedExpenses" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccruedBonusesAndOtherPayrollrelatedExpenses" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccruedCRO" xlink:label="loc_ptgefAccruedCRO" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccruedCRO" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProfessionalFeesExpenses" xlink:label="loc_ptgefProfessionalFeesExpenses" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefProfessionalFeesExpenses" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccruedClinicalAndRdServices" xlink:label="loc_ptgefAccruedClinicalAndRdServices" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccruedClinicalAndRdServices" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CapitalExpenditures" xlink:label="loc_ptgefCapitalExpenditures" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefCapitalExpenditures" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OtherAccruedExpenses" xlink:label="loc_ptgefOtherAccruedExpenses" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefOtherAccruedExpenses" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccountsPayableAndAccruedLiabilityNet" xlink:label="loc_ptgefAccountsPayableAndAccruedLiabilityNet" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureAccountsPayableAndAccruedLiabilitiesAbstract" xlink:to="loc_ptgefAccountsPayableAndAccruedLiabilityNet" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LeaseLiabilityDetails" xlink:title="999077 - Disclosure - LEASE LIABILITY (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureLeaseLiabilityAbstract" xlink:label="loc_ptgefDisclosureLeaseLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LeaseLiabilityFutureMinimumPaymentsDue" xlink:label="loc_ptgefLeaseLiabilityFutureMinimumPaymentsDue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefLeaseLiabilityFutureMinimumPaymentsDue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LeaseLiabilityFutureMinimumPaymentsYearTwoDue" xlink:label="loc_ptgefLeaseLiabilityFutureMinimumPaymentsYearTwoDue" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefLeaseLiabilityFutureMinimumPaymentsYearTwoDue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LeaseLiabilityFutureMinimumPaymentsYearDue" xlink:label="loc_ptgefLeaseLiabilityFutureMinimumPaymentsYearDue" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefLeaseLiabilityFutureMinimumPaymentsYearDue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Interest" xlink:label="loc_ptgefInterest" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefInterest" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TotalLeaseLiability" xlink:label="loc_ptgefTotalLeaseLiability" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefTotalLeaseLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LeaseLiabilityCurrent" xlink:label="loc_ptgefLeaseLiabilityCurrent" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefLeaseLiabilityCurrent" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LeaseLiabilityNoncurrent" xlink:label="loc_ptgefLeaseLiabilityNoncurrent" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefLeaseLiabilityNoncurrent" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LeaseLiabilityDetailsNarrative" xlink:title="999078 - Disclosure - LEASE LIABILITY (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureLeaseLiabilityAbstract" xlink:label="loc_ptgefDisclosureLeaseLiabilityAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Commencement" xlink:label="loc_ptgefCommencement" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefCommencement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PurchasePriceLeaseLiability" xlink:label="loc_ptgefPurchasePriceLeaseLiability" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefPurchasePriceLeaseLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PurchaseEquipmentPayment" xlink:label="loc_ptgefPurchaseEquipmentPayment" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureLeaseLiabilityAbstract" xlink:to="loc_ptgefPurchaseEquipmentPayment" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/BitgoPrimeLoanDetailsNarrative" xlink:title="999079 - Disclosure - BITGO PRIME LOAN (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureBitgoPrimeLoanAbstract" xlink:label="loc_ptgefDisclosureBitgoPrimeLoanAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_MasterLoanAgreementDescription" xlink:label="loc_ptgefMasterLoanAgreementDescription" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureBitgoPrimeLoanAbstract" xlink:to="loc_ptgefMasterLoanAgreementDescription" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/IncomeTaxesDetails" xlink:title="999080 - Disclosure - INCOME TAXES (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentTaxExpenseIncomeAndAdjustmentsForCurrentTaxOfPriorPeriodsAbstract" xlink:label="loc_ifrs-fullCurrentTaxExpenseIncomeAndAdjustmentsForCurrentTaxOfPriorPeriodsAbstract" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullCurrentTaxExpenseIncomeAndAdjustmentsForCurrentTaxOfPriorPeriodsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CurrentTaxOnProfitsForYear" xlink:label="loc_ptgefCurrentTaxOnProfitsForYear" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefCurrentTaxOnProfitsForYear" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AdjustmentsForCurrentTaxOfPriorPeriods" xlink:label="loc_ptgefAdjustmentsForCurrentTaxOfPriorPeriods" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefAdjustmentsForCurrentTaxOfPriorPeriods" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CurrentTaxExpenseIncome" xlink:label="loc_ifrs-fullCurrentTaxExpenseIncome" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullCurrentTaxExpenseIncome" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DeferredTaxExpenseIncomeAbstract" xlink:label="loc_ifrs-fullDeferredTaxExpenseIncomeAbstract" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDeferredTaxExpenseIncomeAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DecreaseIncreaseInDeferredTaxAssets" xlink:label="loc_ptgefDecreaseIncreaseInDeferredTaxAssets" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefDecreaseIncreaseInDeferredTaxAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ProfitLossFromContinuingOperation" xlink:label="loc_ptgefProfitLossFromContinuingOperation" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefProfitLossFromContinuingOperation" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/IncomeTaxesDetails1" xlink:title="999081 - Disclosure - INCOME TAXES (Details 1)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IncomeLossOnOrdinaryActivitiesBeforeTax" xlink:label="loc_ptgefIncomeLossOnOrdinaryActivitiesBeforeTax" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefIncomeLossOnOrdinaryActivitiesBeforeTax" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TaxUsingBviTaxRate" xlink:label="loc_ptgefTaxUsingBviTaxRate" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefTaxUsingBviTaxRate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_EffectOfTaxRatesInOtherCountries" xlink:label="loc_ptgefEffectOfTaxRatesInOtherCountries" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefEffectOfTaxRatesInOtherCountries" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DerecognitionOfDeferredTaxAssets" xlink:label="loc_ptgefDerecognitionOfDeferredTaxAssets" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefDerecognitionOfDeferredTaxAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NondeductibleExpenses" xlink:label="loc_ptgefNondeductibleExpenses" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefNondeductibleExpenses" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UtilizationOfLossesNotPreviouslyBenefitted" xlink:label="loc_ptgefUtilizationOfLossesNotPreviouslyBenefitted" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefUtilizationOfLossesNotPreviouslyBenefitted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IncomeTaxEffectsRelatedToEquityCompensation" xlink:label="loc_ptgefIncomeTaxEffectsRelatedToEquityCompensation" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefIncomeTaxEffectsRelatedToEquityCompensation" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ForeignCurrencyEffectAndOther" xlink:label="loc_ptgefForeignCurrencyEffectAndOther" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefForeignCurrencyEffectAndOther" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IncomeTaxExpense" xlink:label="loc_ptgefIncomeTaxExpense" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefIncomeTaxExpense" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/IncomeTaxesDetails2" xlink:title="999082 - Disclosure - INCOME TAXES (Details 2)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DeferredTaxAssetsAbstract" xlink:label="loc_ptgefDeferredTaxAssetsAbstract" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefDeferredTaxAssetsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DeferredTaxAssetsNetOperatingLossCarryforward" xlink:label="loc_ptgefDeferredTaxAssetsNetOperatingLossCarryforward" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDeferredTaxAssetsAbstract" xlink:to="loc_ptgefDeferredTaxAssetsNetOperatingLossCarryforward" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StockbasedCompensation" xlink:label="loc_ptgefStockbasedCompensation" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDeferredTaxAssetsAbstract" xlink:to="loc_ptgefStockbasedCompensation" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ReservesAndAccruals" xlink:label="loc_ptgefReservesAndAccruals" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDeferredTaxAssetsAbstract" xlink:to="loc_ptgefReservesAndAccruals" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NetDeferredTaxAssets" xlink:label="loc_ifrs-fullNetDeferredTaxAssets" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDeferredTaxAssetsAbstract" xlink:to="loc_ifrs-fullNetDeferredTaxAssets" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DeferredTaxAssetNotRecognized" xlink:label="loc_ptgefDeferredTaxAssetNotRecognized" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDeferredTaxAssetsAbstract" xlink:to="loc_ptgefDeferredTaxAssetNotRecognized" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetDeferredTaxAsset" xlink:label="loc_ptgefNetDeferredTaxAsset" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDeferredTaxAssetsAbstract" xlink:to="loc_ptgefNetDeferredTaxAsset" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/IncomeTaxesDetailsNarrative" xlink:title="999083 - Disclosure - INCOME TAXES (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForUnrealisedForeignExchangeLossesGains" xlink:label="loc_ifrs-fullAdjustmentsForUnrealisedForeignExchangeLossesGains" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullAdjustmentsForUnrealisedForeignExchangeLossesGains" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UkLossCarryForwards" xlink:label="loc_ptgefUkLossCarryForwards" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefUkLossCarryForwards" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DeferredTaxAssets" xlink:label="loc_ifrs-fullDeferredTaxAssets" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDeferredTaxAssets" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CapitalStockAndReservesDetails" xlink:title="999084 - Disclosure - CAPITAL STOCK AND RESERVES (Details )">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureCapitalStockAndReservesAbstract" xlink:label="loc_ptgefDisclosureCapitalStockAndReservesAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_StatementOfChangesInEquityTable" xlink:label="loc_ifrs-fullStatementOfChangesInEquityTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalStockAndReservesAbstract" xlink:to="loc_ifrs-fullStatementOfChangesInEquityTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullStatementOfChangesInEquityTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PlacementAgentWarrantsMember" xlink:label="loc_ptgefPlacementAgentWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefPlacementAgentWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExercisePriceFairValue" xlink:label="loc_ptgefExercisePriceFairValue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExercisePriceFairValue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharePriceFairvalue" xlink:label="loc_ptgefSharePriceFairvalue" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharePriceFairvalue" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OptionLifeShareOptions" xlink:label="loc_ptgefOptionLifeShareOptions" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOptionLifeShareOptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted" xlink:label="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CapitalStockAndReservesDetailsNarrative" xlink:title="999085 - Disclosure - CAPITAL STOCK AND RESERVES (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureCapitalStockAndReservesAbstract" xlink:label="loc_ptgefDisclosureCapitalStockAndReservesAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfOffsettingOfFinancialAssetsTable" xlink:label="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalStockAndReservesAbstract" xlink:to="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CounterpartiesAxis" xlink:label="loc_ifrs-fullCounterpartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" xlink:to="loc_ifrs-fullCounterpartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CounterpartiesDomain" xlink:label="loc_ifrs-fullCounterpartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCounterpartiesAxis" xlink:to="loc_ifrs-fullCounterpartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ATMMember" xlink:label="loc_ptgefATMMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCounterpartiesDomain" xlink:to="loc_ptgefATMMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalAxis" xlink:label="loc_ifrs-fullClassesOfShareCapitalAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" xlink:to="loc_ifrs-fullClassesOfShareCapitalAxis" order="20" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ClassesOfShareCapitalDomain" xlink:label="loc_ifrs-fullClassesOfShareCapitalDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalAxis" xlink:to="loc_ifrs-fullClassesOfShareCapitalDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SeriesAWarrantsAndPreFundedWarrantsMember" xlink:label="loc_ptgefSeriesAWarrantsAndPreFundedWarrantsMember" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullClassesOfShareCapitalDomain" xlink:to="loc_ptgefSeriesAWarrantsAndPreFundedWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SaleOfStock" xlink:label="loc_ptgefSaleOfStock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSaleOfStock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AggregateProceeds" xlink:label="loc_ptgefAggregateProceeds" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAggregateProceeds" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesPrice" xlink:label="loc_ptgefSharesPrice" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesPrice" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WarrantsToPurchase" xlink:label="loc_ptgefWarrantsToPurchase" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefWarrantsToPurchase" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PurchasePrice" xlink:label="loc_ptgefPurchasePrice" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPurchasePrice" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GrossProceeds" xlink:label="loc_ptgefGrossProceeds" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGrossProceeds" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Cash" xlink:label="loc_ifrs-fullCash" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCash" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DgitalAssets" xlink:label="loc_ptgefDgitalAssets" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDgitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OrdinarySharesIssued" xlink:label="loc_ptgefOrdinarySharesIssued" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOrdinarySharesIssued" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfSharesSold" xlink:label="loc_ptgefNumberOfSharesSold" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfSharesSold" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetProceeds" xlink:label="loc_ptgefNetProceeds" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNetProceeds" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TreasuryStock" xlink:label="loc_ptgefTreasuryStock" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTreasuryStock" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AggregateOfferingOrdinaryShares" xlink:label="loc_ptgefAggregateOfferingOrdinaryShares" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAggregateOfferingOrdinaryShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Proceedsfromexerciseofwarrant" xlink:label="loc_ptgefProceedsfromexerciseofwarrant" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefProceedsfromexerciseofwarrant" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProceedsFromExerciseOfWarrants" xlink:label="loc_ifrs-fullProceedsFromExerciseOfWarrants" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullProceedsFromExerciseOfWarrants" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NumberOfSharesIssued" xlink:label="loc_ifrs-fullNumberOfSharesIssued" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNumberOfSharesIssued" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncreaseDecreaseInNumberOfSharesOutstanding" xlink:label="loc_ifrs-fullIncreaseDecreaseInNumberOfSharesOutstanding" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullIncreaseDecreaseInNumberOfSharesOutstanding" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AdditionalSharesIssued" xlink:label="loc_ptgefAdditionalSharesIssued" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAdditionalSharesIssued" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WarrantsPurchase" xlink:label="loc_ptgefWarrantsPurchase" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefWarrantsPurchase" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WarrantsPerShare" xlink:label="loc_ptgefWarrantsPerShare" />
      <link:presentationArc order="190" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefWarrantsPerShare" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserveDetails" xlink:title="999086 - Disclosure - STOCK OPTION RESERVE (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StockOptionReserve" xlink:label="loc_ptgefStockOptionReserve" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefStockOptionReserve" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForSharebasedPayments" xlink:label="loc_ifrs-fullAdjustmentsForSharebasedPayments" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullAdjustmentsForSharebasedPayments" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CorrectionOfPriorPeriodOverstatedSharebasedCompensationsExpense" xlink:label="loc_ptgefCorrectionOfPriorPeriodOverstatedSharebasedCompensationsExpense" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefCorrectionOfPriorPeriodOverstatedSharebasedCompensationsExpense" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StockOptionReserve" xlink:label="loc_ptgefStockOptionReserve_2" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefStockOptionReserve_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserveDetails1" xlink:title="999087 - Disclosure - STOCK OPTION RESERVE (Details 1)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfDefinedBenefitPlansTable" xlink:label="loc_ifrs-fullDisclosureOfDefinedBenefitPlansTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfDefinedBenefitPlansTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfDefinedBenefitPlansTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DefinedBenefitPlansAxis" xlink:label="loc_ifrs-fullDefinedBenefitPlansAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfDefinedBenefitPlansTable" xlink:to="loc_ifrs-fullDefinedBenefitPlansAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DefinedBenefitPlansDomain" xlink:label="loc_ifrs-fullDefinedBenefitPlansDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDefinedBenefitPlansAxis" xlink:to="loc_ifrs-fullDefinedBenefitPlansDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PBI2021EquityIncentivePlanMember" xlink:label="loc_ptgefPBI2021EquityIncentivePlanMember" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDefinedBenefitPlansDomain" xlink:to="loc_ptgefPBI2021EquityIncentivePlanMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfOutstandingShareOption" xlink:label="loc_ptgefNumberOfOutstandingShareOption" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfOutstandingShareOption" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfShareOptionsGrantedInSharebasedPaymentsArrangement" xlink:label="loc_ptgefNumberOfShareOptionsGrantedInSharebasedPaymentsArrangement" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfShareOptionsGrantedInSharebasedPaymentsArrangement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfShareOptionsExpiredOrForfeitedInSharebasedPaymentsArrangement" xlink:label="loc_ptgefNumberOfShareOptionsExpiredOrForfeitedInSharebasedPaymentsArrangement" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfShareOptionsExpiredOrForfeitedInSharebasedPaymentsArrangement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfOutstandingShareOption" xlink:label="loc_ptgefNumberOfOutstandingShareOption_2" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfOutstandingShareOption_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfShareOptionsExercisableInSharebasedPaymentsArrangements" xlink:label="loc_ptgefNumberOfShareOptionsExercisableInSharebasedPaymentsArrangements" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfShareOptionsExercisableInSharebasedPaymentsArrangements" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfShareOptionsAvailableForFutureAwardsSharebasedPaymentsArrangement" xlink:label="loc_ptgefNumberOfShareOptionsAvailableForFutureAwardsSharebasedPaymentsArrangement" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfShareOptionsAvailableForFutureAwardsSharebasedPaymentsArrangement" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserveDetails2" xlink:title="999088 - Disclosure - STOCK OPTION RESERVE (Details 2)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfFairValueMeasurementOfAssetsTable" xlink:label="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MeasurementAxis" xlink:label="loc_ifrs-fullMeasurementAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" xlink:to="loc_ifrs-fullMeasurementAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MeasurementDomain" xlink:label="loc_ifrs-fullMeasurementDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullMeasurementAxis" xlink:to="loc_ifrs-fullMeasurementDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StockOptionGrantedMember" xlink:label="loc_ptgefStockOptionGrantedMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullMeasurementDomain" xlink:to="loc_ptgefStockOptionGrantedMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DescriptionOfGrantPriceShareOptionsGranted" xlink:label="loc_ptgefDescriptionOfGrantPriceShareOptionsGranted" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDescriptionOfGrantPriceShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OptionLifeShareOptionsGranted" xlink:label="loc_ptgefOptionLifeShareOptionsGranted" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOptionLifeShareOptionsGranted" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:label="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDescriptionOfExpectedVolatilityShareOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ExpectedDividendAsPercentageShareOptionsGranted" xlink:label="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullExpectedDividendAsPercentageShareOptionsGranted" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserveDetails3" xlink:title="999089 - Disclosure - STOCK OPTION RESERVE (Details 3)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019" xlink:label="loc_ifrs-fullWeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullWeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WeightedAverageRemainingContractualLifeOfOutstandingShareOptions2019" xlink:label="loc_ifrs-fullWeightedAverageRemainingContractualLifeOfOutstandingShareOptions2019" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullWeightedAverageRemainingContractualLifeOfOutstandingShareOptions2019" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserveDetails4" xlink:title="999090 - Disclosure - STOCK OPTION RESERVE (Details 4)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfQuantitativeInformationAboutFinancialInstrumentsThatHaveYetToTransitionToAlternativeBenchmarkRateTable" xlink:label="loc_ifrs-fullDisclosureOfQuantitativeInformationAboutFinancialInstrumentsThatHaveYetToTransitionToAlternativeBenchmarkRateTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfQuantitativeInformationAboutFinancialInstrumentsThatHaveYetToTransitionToAlternativeBenchmarkRateTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfQuantitativeInformationAboutFinancialInstrumentsThatHaveYetToTransitionToAlternativeBenchmarkRateTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestRateBenchmarksAxis" xlink:label="loc_ifrs-fullInterestRateBenchmarksAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfQuantitativeInformationAboutFinancialInstrumentsThatHaveYetToTransitionToAlternativeBenchmarkRateTable" xlink:to="loc_ifrs-fullInterestRateBenchmarksAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestRateBenchmarksDomain" xlink:label="loc_ifrs-fullInterestRateBenchmarksDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksAxis" xlink:to="loc_ifrs-fullInterestRateBenchmarksDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_January132021Member" xlink:label="loc_ptgefJanuary132021Member" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefJanuary132021Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_January192022Member" xlink:label="loc_ptgefJanuary192022Member" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefJanuary192022Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_February152022Member" xlink:label="loc_ptgefFebruary152022Member" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefFebruary152022Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_June82022Member" xlink:label="loc_ptgefJune82022Member" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefJune82022Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_July272022Member" xlink:label="loc_ptgefJuly272022Member" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefJuly272022Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_March302023Member" xlink:label="loc_ptgefMarch302023Member" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefMarch302023Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_March72025Member" xlink:label="loc_ptgefMarch72025Member" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefMarch72025Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_July272026Member" xlink:label="loc_ptgefJuly272026Member" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefJuly272026Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_March112026Member" xlink:label="loc_ptgefMarch112026Member" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullInterestRateBenchmarksDomain" xlink:to="loc_ptgefMarch112026Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExpirationDate" xlink:label="loc_ptgefExpirationDate" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExpirationDate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExercisePrice" xlink:label="loc_ptgefExercisePrice" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExercisePrice" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ShareOptions" xlink:label="loc_ptgefShareOptions" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefShareOptions" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/StockOptionReserveDetailsNarrative" xlink:title="999091 - Disclosure - STOCK OPTION RESERVE (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" xlink:label="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TypesOfAntidilutiveInstrumentsAxis" xlink:label="loc_ifrs-fullTypesOfAntidilutiveInstrumentsAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" xlink:to="loc_ifrs-fullTypesOfAntidilutiveInstrumentsAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TypesOfAntidilutiveInstrumentsDomain" xlink:label="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullTypesOfAntidilutiveInstrumentsAxis" xlink:to="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_RestrictedShareUnitsMember" xlink:label="loc_ifrs-fullRestrictedShareUnitsMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullTypesOfAntidilutiveInstrumentsDomain" xlink:to="loc_ifrs-fullRestrictedShareUnitsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MeasurementAxis" xlink:label="loc_ifrs-fullMeasurementAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfInstrumentsWithPotentialFutureDilutiveEffectNotIncludedInCalculationOfDilutedEarningsPerShareTable" xlink:to="loc_ifrs-fullMeasurementAxis" order="20" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_MeasurementDomain" xlink:label="loc_ifrs-fullMeasurementDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullMeasurementAxis" xlink:to="loc_ifrs-fullMeasurementDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_VestedStockOptionMember" xlink:label="loc_ptgefVestedStockOptionMember" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullMeasurementDomain" xlink:to="loc_ptgefVestedStockOptionMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AuthorizedGrantOptionPurchaseShares" xlink:label="loc_ptgefAuthorizedGrantOptionPurchaseShares" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAuthorizedGrantOptionPurchaseShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesIssuedGrantedRsu" xlink:label="loc_ptgefSharesIssuedGrantedRsu" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesIssuedGrantedRsu" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NumberOfSharesIssued" xlink:label="loc_ifrs-fullNumberOfSharesIssued" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNumberOfSharesIssued" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberOfSharesExercise" xlink:label="loc_ptgefNumberOfSharesExercise" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberOfSharesExercise" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharesRepurchasedIntoTreasuryEmployeePayrollTaxes" xlink:label="loc_ptgefSharesRepurchasedIntoTreasuryEmployeePayrollTaxes" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharesRepurchasedIntoTreasuryEmployeePayrollTaxes" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationSharebasedPayment" xlink:label="loc_ifrs-fullKeyManagementPersonnelCompensationSharebasedPayment" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullKeyManagementPersonnelCompensationSharebasedPayment" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharebasedCompensationExpense" xlink:label="loc_ptgefSharebasedCompensationExpense" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSharebasedCompensationExpense" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ReversalOfSharebasedCompensation" xlink:label="loc_ptgefReversalOfSharebasedCompensation" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefReversalOfSharebasedCompensation" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ShareBasedCompensationExpenseUnvestedShareOptions" xlink:label="loc_ptgefShareBasedCompensationExpenseUnvestedShareOptions" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefShareBasedCompensationExpenseUnvestedShareOptions" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LossPerShareDetails" xlink:title="999092 - Disclosure - LOSS PER SHARE (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeStatementAbstract" xlink:label="loc_ifrs-fullIncomeStatementAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WeightedAverageSharesOutstandingDiluted" xlink:label="loc_ptgefWeightedAverageSharesOutstandingDiluted" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ptgefWeightedAverageSharesOutstandingDiluted" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustedWeightedAverageShares" xlink:label="loc_ifrs-fullAdjustedWeightedAverageShares" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullAdjustedWeightedAverageShares" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossPerShareBasic" xlink:label="loc_ptgefLossPerShareBasic" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ptgefLossPerShareBasic" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossPerShareDiluted" xlink:label="loc_ptgefLossPerShareDiluted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ptgefLossPerShareDiluted" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/LossPerShareDetails1" xlink:title="999093 - Disclosure - LOSS PER SHARE (Details 1)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_IncomeStatementAbstract" xlink:label="loc_ifrs-fullIncomeStatementAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:label="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullIncomeStatementAbstract" xlink:to="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WarrantsMember" xlink:label="loc_ifrs-fullWarrantsMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ifrs-fullWarrantsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StockOptionsMember" xlink:label="loc_ptgefStockOptionsMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefStockOptionsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RestrictedStockUnitsMember" xlink:label="loc_ptgefRestrictedStockUnitsMember" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefRestrictedStockUnitsMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AntidilutiveEffectOnLossPerShare" xlink:label="loc_ptgefAntidilutiveEffectOnLossPerShare" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefAntidilutiveEffectOnLossPerShare" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CommitmentsAndContingentLiabilitiesDetailsNarrative" xlink:title="999094 - Disclosure - COMMITMENTS AND CONTINGENT LIABILITIES (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfOffsettingOfFinancialAssetsTable" xlink:label="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CounterpartiesAxis" xlink:label="loc_ifrs-fullCounterpartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfOffsettingOfFinancialAssetsTable" xlink:to="loc_ifrs-fullCounterpartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CounterpartiesDomain" xlink:label="loc_ifrs-fullCounterpartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCounterpartiesAxis" xlink:to="loc_ifrs-fullCounterpartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CROMember" xlink:label="loc_ptgefCROMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCounterpartiesDomain" xlink:to="loc_ptgefCROMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CROAgreementMember" xlink:label="loc_ptgefCROAgreementMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCounterpartiesDomain" xlink:to="loc_ptgefCROAgreementMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ServiceFees" xlink:label="loc_ptgefServiceFees" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefServiceFees" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BudgetCosts" xlink:label="loc_ptgefBudgetCosts" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefBudgetCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GrossProceeds" xlink:label="loc_ptgefGrossProceeds" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGrossProceeds" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_UnbilledServices" xlink:label="loc_ptgefUnbilledServices" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefUnbilledServices" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ForfeitedAdvancedPayments" xlink:label="loc_ptgefForfeitedAdvancedPayments" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefForfeitedAdvancedPayments" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetGain" xlink:label="loc_ptgefNetGain" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNetGain" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:label="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInTradeAccountPayable" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullAdjustmentsForIncreaseDecreaseInTradeAccountPayable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrepaidExpensesAndOtherReceivables" xlink:label="loc_ptgefPrepaidExpensesAndOtherReceivables" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPrepaidExpensesAndOtherReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ContractualPayments" xlink:label="loc_ptgefContractualPayments" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefContractualPayments" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SecurityDeposits" xlink:label="loc_ptgefSecurityDeposits" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSecurityDeposits" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetworkingEquipmentCost" xlink:label="loc_ptgefNetworkingEquipmentCost" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNetworkingEquipmentCost" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Deposit" xlink:label="loc_ptgefDeposit" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDeposit" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/RelatedPartyTransactionsDetails" xlink:title="999095 - Disclosure - RELATED PARTY TRANSACTIONS (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ShorttermEmployeeBenefitsExpense" xlink:label="loc_ifrs-fullShorttermEmployeeBenefitsExpense" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullShorttermEmployeeBenefitsExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_PostemploymentBenefitExpenseInProfitOrLoss" xlink:label="loc_ifrs-fullPostemploymentBenefitExpenseInProfitOrLoss" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullPostemploymentBenefitExpenseInProfitOrLoss" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_OtherLongtermBenefits" xlink:label="loc_ifrs-fullOtherLongtermBenefits" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullOtherLongtermBenefits" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_TerminationBenefitsExpense" xlink:label="loc_ifrs-fullTerminationBenefitsExpense" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullTerminationBenefitsExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SharebasedPaymentCompensation" xlink:label="loc_ptgefSharebasedPaymentCompensation" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefSharebasedPaymentCompensation" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_KeyManagementPersonnelCompensationPostemploymentBenefits" xlink:label="loc_ifrs-fullKeyManagementPersonnelCompensationPostemploymentBenefits" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullKeyManagementPersonnelCompensationPostemploymentBenefits" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/RelatedPartyTransactionsDetails1" xlink:title="999096 - Disclosure - RELATED PARTY TRANSACTIONS (Details 1)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:label="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_MichaelTerpinMember" xlink:label="loc_ptgefMichaelTerpinMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefMichaelTerpinMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FDanielSicilianoMember" xlink:label="loc_ptgefFDanielSicilianoMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefFDanielSicilianoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GregoryHBaileyMDMember" xlink:label="loc_ptgefGregoryHBaileyMDMember" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefGregoryHBaileyMDMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_JamesMellonMember" xlink:label="loc_ptgefJamesMellonMember" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefJamesMellonMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_StevenMintzMember" xlink:label="loc_ptgefStevenMintzMember" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefStevenMintzMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_JeanChristopheRenondinMDMember" xlink:label="loc_ptgefJeanChristopheRenondinMDMember" />
      <link:presentationArc order="230" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefJeanChristopheRenondinMDMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_JustinStebbingMDPhDMember" xlink:label="loc_ptgefJustinStebbingMDPhDMember" />
      <link:presentationArc order="290" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefJustinStebbingMDPhDMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LindaKozickMember" xlink:label="loc_ptgefLindaKozickMember" />
      <link:presentationArc order="350" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefLindaKozickMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_MarkSimonMember" xlink:label="loc_ptgefMarkSimonMember" />
      <link:presentationArc order="410" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefMarkSimonMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RobertGlassmanMember" xlink:label="loc_ptgefRobertGlassmanMember" />
      <link:presentationArc order="470" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefRobertGlassmanMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BrittanyKaiserMember" xlink:label="loc_ptgefBrittanyKaiserMember" />
      <link:presentationArc order="550" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefBrittanyKaiserMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_EnzoVillaniMember" xlink:label="loc_ptgefEnzoVillaniMember" />
      <link:presentationArc order="570" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefEnzoVillaniMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_WesLevittMember" xlink:label="loc_ptgefWesLevittMember" />
      <link:presentationArc order="590" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefWesLevittMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_YuryMitinMember" xlink:label="loc_ptgefYuryMitinMember" />
      <link:presentationArc order="600" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefYuryMitinMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AlexanderPickettMember" xlink:label="loc_ptgefAlexanderPickettMember" />
      <link:presentationArc order="620" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAlexanderPickettMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IanWaltersMember" xlink:label="loc_ptgefIanWaltersMember" />
      <link:presentationArc order="660" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefIanWaltersMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AndreaParkMember" xlink:label="loc_ptgefAndreaParkMember" />
      <link:presentationArc order="720" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAndreaParkMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AllanShawMember" xlink:label="loc_ptgefAllanShawMember" />
      <link:presentationArc order="760" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAllanShawMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RobertKramerMember" xlink:label="loc_ptgefRobertKramerMember" />
      <link:presentationArc order="820" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefRobertKramerMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BrianWileyMember" xlink:label="loc_ptgefBrianWileyMember" />
      <link:presentationArc order="880" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefBrianWileyMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_JustinFairchildMember" xlink:label="loc_ptgefJustinFairchildMember" />
      <link:presentationArc order="940" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefJustinFairchildMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SignificantInvestmentsInAssociatesAxis" xlink:label="loc_ifrs-fullSignificantInvestmentsInAssociatesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullSignificantInvestmentsInAssociatesAxis" order="20" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_SignificantInvestmentsInAssociatesDomain" xlink:label="loc_ifrs-fullSignificantInvestmentsInAssociatesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullSignificantInvestmentsInAssociatesAxis" xlink:to="loc_ifrs-fullSignificantInvestmentsInAssociatesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DirectorCompensationMember" xlink:label="loc_ptgefDirectorCompensationMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullSignificantInvestmentsInAssociatesDomain" xlink:to="loc_ptgefDirectorCompensationMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExecutiveOfficerCompensationMember" xlink:label="loc_ptgefExecutiveOfficerCompensationMember" />
      <link:presentationArc order="540" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullSignificantInvestmentsInAssociatesDomain" xlink:to="loc_ptgefExecutiveOfficerCompensationMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FeeAndCommissionExpense" xlink:label="loc_ifrs-fullFeeAndCommissionExpense" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullFeeAndCommissionExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_FeeAndCommissionIncome" xlink:label="loc_ifrs-fullFeeAndCommissionIncome" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullFeeAndCommissionIncome" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TransactionClosingBonus" xlink:label="loc_ptgefTransactionClosingBonus" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTransactionClosingBonus" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SecuritiesUnderOptionsGranted" xlink:label="loc_ptgefSecuritiesUnderOptionsGranted" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSecuritiesUnderOptionsGranted" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NumberOfSharesIssued" xlink:label="loc_ifrs-fullNumberOfSharesIssued" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNumberOfSharesIssued" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OtherCompensation" xlink:label="loc_ptgefOtherCompensation" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOtherCompensation" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CompensationFromThirdPartiesForItemsOfPropertyPlantAndEquipment" xlink:label="loc_ifrs-fullCompensationFromThirdPartiesForItemsOfPropertyPlantAndEquipment" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCompensationFromThirdPartiesForItemsOfPropertyPlantAndEquipment" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/RelatedPartyTransactionsDetails3" xlink:title="999097 - Disclosure - RELATED PARTY TRANSACTIONS (Details 3)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:label="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AlexanderPickettMember" xlink:label="loc_ptgefAlexanderPickettMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAlexanderPickettMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AlexanderPickettTwoMember" xlink:label="loc_ptgefAlexanderPickettTwoMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAlexanderPickettTwoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IanBWaltersMember" xlink:label="loc_ptgefIanBWaltersMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefIanBWaltersMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IanBWaltersTwoMember" xlink:label="loc_ptgefIanBWaltersTwoMember" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefIanBWaltersTwoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IanBWaltersThreeMember" xlink:label="loc_ptgefIanBWaltersThreeMember" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefIanBWaltersThreeMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AndreaEParkMember" xlink:label="loc_ptgefAndreaEParkMember" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAndreaEParkMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AndreaEParkTwoMember" xlink:label="loc_ptgefAndreaEParkTwoMember" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAndreaEParkTwoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AllanShawMember" xlink:label="loc_ptgefAllanShawMember" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAllanShawMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AllanShawTwoMember" xlink:label="loc_ptgefAllanShawTwoMember" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAllanShawTwoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AllanShawThreeMember" xlink:label="loc_ptgefAllanShawThreeMember" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefAllanShawThreeMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RobertKramerMember" xlink:label="loc_ptgefRobertKramerMember" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefRobertKramerMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RobertKramerTwoMember" xlink:label="loc_ptgefRobertKramerTwoMember" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefRobertKramerTwoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RobertKramerThreeMember" xlink:label="loc_ptgefRobertKramerThreeMember" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefRobertKramerThreeMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BrianWileyMember" xlink:label="loc_ptgefBrianWileyMember" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefBrianWileyMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BrianWileyTwoMember" xlink:label="loc_ptgefBrianWileyTwoMember" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefBrianWileyTwoMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_BrittanyKaiserMember" xlink:label="loc_ptgefBrittanyKaiserMember" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefBrittanyKaiserMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_EnzoVillaniMember" xlink:label="loc_ptgefEnzoVillaniMember" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefEnzoVillaniMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_YuryMitinMember" xlink:label="loc_ptgefYuryMitinMember" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefYuryMitinMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GrantDate" xlink:label="loc_ptgefGrantDate" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGrantDate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_AdjustedWeightedAverageShares" xlink:label="loc_ifrs-fullAdjustedWeightedAverageShares" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullAdjustedWeightedAverageShares" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberofSecuritiesUnderlyingUnexercisedOptionsUnExercisable" xlink:label="loc_ptgefNumberofSecuritiesUnderlyingUnexercisedOptionsUnExercisable" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberofSecuritiesUnderlyingUnexercisedOptionsUnExercisable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ExercisePrices" xlink:label="loc_ptgefExercisePrices" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefExercisePrices" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OptionExpirationDate" xlink:label="loc_ptgefOptionExpirationDate" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOptionExpirationDate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NumberofShareUnitsofStockThetHaveNotVested" xlink:label="loc_ptgefNumberofShareUnitsofStockThetHaveNotVested" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNumberofShareUnitsofStockThetHaveNotVested" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_MarketValueNumberofShareUnitsofStockThetHaveNotVested" xlink:label="loc_ptgefMarketValueNumberofShareUnitsofStockThetHaveNotVested" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefMarketValueNumberofShareUnitsofStockThetHaveNotVested" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/RelatedPartyTransactionsDetailsNarrative" xlink:title="999098 - Disclosure - RELATED PARTY TRANSACTIONS (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SaleOfStock" xlink:label="loc_ptgefSaleOfStock" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefSaleOfStock" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AggregateProceeds" xlink:label="loc_ptgefAggregateProceeds" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefAggregateProceeds" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Decentranet" xlink:label="loc_ptgefDecentranet" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ptgefDecentranet" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementDetails" xlink:title="999099 - Disclosure - - FINANCIAL INSTRUMENTS AND RISK MANAGEMENT (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:label="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfFairValueMeasurementOfAssetsTable" xlink:label="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:to="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LevelsOfFairValueHierarchyAxis" xlink:label="loc_ifrs-fullLevelsOfFairValueHierarchyAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFairValueMeasurementOfAssetsTable" xlink:to="loc_ifrs-fullLevelsOfFairValueHierarchyAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_LevelsOfFairValueHierarchyDomain" xlink:label="loc_ifrs-fullLevelsOfFairValueHierarchyDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullLevelsOfFairValueHierarchyAxis" xlink:to="loc_ifrs-fullLevelsOfFairValueHierarchyDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AmortizedCostMember" xlink:label="loc_ptgefAmortizedCostMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullLevelsOfFairValueHierarchyDomain" xlink:to="loc_ptgefAmortizedCostMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueToOtherComprehensiveIncomeMember" xlink:label="loc_ptgefFairValueToOtherComprehensiveIncomeMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullLevelsOfFairValueHierarchyDomain" xlink:to="loc_ptgefFairValueToOtherComprehensiveIncomeMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_FairValueThroughProfitOrLossMember" xlink:label="loc_ptgefFairValueThroughProfitOrLossMember" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullLevelsOfFairValueHierarchyDomain" xlink:to="loc_ptgefFairValueThroughProfitOrLossMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfFinancialAssetsAbstract" xlink:label="loc_ifrs-fullCategoriesOfFinancialAssetsAbstract" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCategoriesOfFinancialAssetsAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CashAndCashEquivalents" xlink:label="loc_ifrs-fullCashAndCashEquivalents" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialAssetsAbstract" xlink:to="loc_ifrs-fullCashAndCashEquivalents" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Stablecoin" xlink:label="loc_ptgefStablecoin" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialAssetsAbstract" xlink:to="loc_ptgefStablecoin" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PrepaidExpensesAndOtherReceivable" xlink:label="loc_ptgefPrepaidExpensesAndOtherReceivable" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialAssetsAbstract" xlink:to="loc_ptgefPrepaidExpensesAndOtherReceivable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfFinancialLiabilitiesAbstract" xlink:label="loc_ifrs-fullCategoriesOfFinancialLiabilitiesAbstract" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullCategoriesOfFinancialLiabilitiesAbstract" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_AccountsPayableAndAccruedLiabilities" xlink:label="loc_ptgefAccountsPayableAndAccruedLiabilities" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialLiabilitiesAbstract" xlink:to="loc_ptgefAccountsPayableAndAccruedLiabilities" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonPayableToSettlePutRightsExercised" xlink:label="loc_ptgefTonPayableToSettlePutRightsExercised" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialLiabilitiesAbstract" xlink:to="loc_ptgefTonPayableToSettlePutRightsExercised" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightLiability" xlink:label="loc_ptgefPutRightLiability" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialLiabilitiesAbstract" xlink:to="loc_ptgefPutRightLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WarrantLiability" xlink:label="loc_ifrs-fullWarrantLiability" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialLiabilitiesAbstract" xlink:to="loc_ifrs-fullWarrantLiability" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LeaseLiabilityCurrentAndNoncurrent" xlink:label="loc_ptgefLeaseLiabilityCurrentAndNoncurrent" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfFinancialLiabilitiesAbstract" xlink:to="loc_ptgefLeaseLiabilityCurrentAndNoncurrent" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementDetails1" xlink:title="999100 - Disclosure - FINANCIAL INSTRUMENTS AND RISK MANAGEMENT (Details 1)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:label="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfFinancialAssetsThatAreEitherPastDueOrImpairedTable" xlink:label="loc_ifrs-fullDisclosureOfFinancialAssetsThatAreEitherPastDueOrImpairedTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureFinancialInstrumentsAndRiskManagementAbstract" xlink:to="loc_ifrs-fullDisclosureOfFinancialAssetsThatAreEitherPastDueOrImpairedTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFinancialAssetsThatAreEitherPastDueOrImpairedTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ImpairmentOfFinancialAssetsAxis" xlink:label="loc_ifrs-fullImpairmentOfFinancialAssetsAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfFinancialAssetsThatAreEitherPastDueOrImpairedTable" xlink:to="loc_ifrs-fullImpairmentOfFinancialAssetsAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ImpairmentOfFinancialAssetsDomain" xlink:label="loc_ifrs-fullImpairmentOfFinancialAssetsDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullImpairmentOfFinancialAssetsAxis" xlink:to="loc_ifrs-fullImpairmentOfFinancialAssetsDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Level1Member" xlink:label="loc_ptgefLevel1Member" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullImpairmentOfFinancialAssetsDomain" xlink:to="loc_ptgefLevel1Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Level2Member" xlink:label="loc_ptgefLevel2Member" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullImpairmentOfFinancialAssetsDomain" xlink:to="loc_ptgefLevel2Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_Level3Member" xlink:label="loc_ptgefLevel3Member" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullImpairmentOfFinancialAssetsDomain" xlink:to="loc_ptgefLevel3Member" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsAtFairValueTonLiquid" xlink:label="loc_ptgefDigitalAssetsAtFairValueTonLiquid" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetsAtFairValueTonLiquid" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalAssetsAtFairValueTonLocked" xlink:label="loc_ptgefDigitalAssetsAtFairValueTonLocked" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefDigitalAssetsAtFairValueTonLocked" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_TonPayableToSettlePutRightsExercised" xlink:label="loc_ptgefTonPayableToSettlePutRightsExercised" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefTonPayableToSettlePutRightsExercised" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightLiability" xlink:label="loc_ptgefPutRightLiability" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefPutRightLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_WarrantLiability" xlink:label="loc_ifrs-fullWarrantLiability" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullWarrantLiability" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/SegmentReportingDetails" xlink:title="999101 - Disclosure - SEGMENT REPORTING (Details)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureSegmentReportingAbstract" xlink:label="loc_ptgefDisclosureSegmentReportingAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:label="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureSegmentReportingAbstract" xlink:to="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DigitalComputeMember" xlink:label="loc_ptgefDigitalComputeMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefDigitalComputeMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImmunoOncologyMember" xlink:label="loc_ptgefImmunoOncologyMember" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefImmunoOncologyMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_Revenue" xlink:label="loc_ifrs-fullRevenue" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullRevenue" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossAbstract" xlink:label="loc_ifrs-fullProfitLossAbstract" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullProfitLossAbstract" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ResearchAndDevelopmentExpense" xlink:label="loc_ifrs-fullResearchAndDevelopmentExpense" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullResearchAndDevelopmentExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_GeneralAndAdministrativeExpense" xlink:label="loc_ifrs-fullGeneralAndAdministrativeExpense" />
      <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullGeneralAndAdministrativeExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DepreciationAndAmortisationExpense" xlink:label="loc_ifrs-fullDepreciationAndAmortisationExpense" />
      <link:presentationArc order="40" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullDepreciationAndAmortisationExpense" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_ProfitLossFromOperatingActivities" xlink:label="loc_ifrs-fullProfitLossFromOperatingActivities" />
      <link:presentationArc order="50" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullProfitLossFromOperatingActivities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainsLossesOnChangeInFairValueOfWarrants" xlink:label="loc_ptgefGainsLossesOnChangeInFairValueOfWarrants" />
      <link:presentationArc order="60" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGainsLossesOnChangeInFairValueOfWarrants" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" xlink:label="loc_ptgefChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" />
      <link:presentationArc order="70" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefChangeInFairValueOfDeferredPurchasePricePayableTarusAndDeferredObligationIoxMilestone" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfPutRightsNetOfRedemptions" xlink:label="loc_ptgefChangeInFairValueOfPutRightsNetOfRedemptions" />
      <link:presentationArc order="80" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefChangeInFairValueOfPutRightsNetOfRedemptions" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRevaluationOfDigitalAssets" xlink:label="loc_ptgefLossOnRevaluationOfDigitalAssets" />
      <link:presentationArc order="90" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefLossOnRevaluationOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRevaluationOfDigitalAssetReceivables" xlink:label="loc_ptgefLossOnRevaluationOfDigitalAssetReceivables" />
      <link:presentationArc order="100" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefLossOnRevaluationOfDigitalAssetReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossOnSaleOfDigitalAssets" xlink:label="loc_ptgefRealizedLossOnSaleOfDigitalAssets" />
      <link:presentationArc order="110" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefRealizedLossOnSaleOfDigitalAssets" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_RealizedLossOnNovationOfDigitalAssetReceivables" xlink:label="loc_ptgefRealizedLossOnNovationOfDigitalAssetReceivables" />
      <link:presentationArc order="120" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefRealizedLossOnNovationOfDigitalAssetReceivables" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnSettlementWithParexelIoxCro" xlink:label="loc_ptgefGainOnSettlementWithParexelIoxCro" />
      <link:presentationArc order="130" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGainOnSettlementWithParexelIoxCro" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRegisteredDirectOffering" xlink:label="loc_ptgefLossOnRegisteredDirectOffering" />
      <link:presentationArc order="140" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefLossOnRegisteredDirectOffering" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_OfferingCosts" xlink:label="loc_ptgefOfferingCosts" />
      <link:presentationArc order="150" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefOfferingCosts" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossIoxIprd" xlink:label="loc_ptgefImpairmentLossIoxIprd" />
      <link:presentationArc order="160" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefImpairmentLossIoxIprd" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossTarusIprd" xlink:label="loc_ptgefImpairmentLossTarusIprd" />
      <link:presentationArc order="170" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefImpairmentLossTarusIprd" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossStimunity" xlink:label="loc_ptgefImpairmentLossStimunity" />
      <link:presentationArc order="180" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefImpairmentLossStimunity" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossSaugatuck" xlink:label="loc_ptgefImpairmentLossSaugatuck" />
      <link:presentationArc order="190" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefImpairmentLossSaugatuck" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CommitmentFeeUnderCommittedPurchaseAgreement" xlink:label="loc_ptgefCommitmentFeeUnderCommittedPurchaseAgreement" />
      <link:presentationArc order="200" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefCommitmentFeeUnderCommittedPurchaseAgreement" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnDissolutionOfInvestmentInAssociate" xlink:label="loc_ptgefGainOnDissolutionOfInvestmentInAssociate" />
      <link:presentationArc order="210" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGainOnDissolutionOfInvestmentInAssociate" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainFromSaleOfInvestmentInPublicCompany" xlink:label="loc_ptgefGainFromSaleOfInvestmentInPublicCompany" />
      <link:presentationArc order="220" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGainFromSaleOfInvestmentInPublicCompany" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ImpairmentLossInvestmentInCompedica" xlink:label="loc_ptgefImpairmentLossInvestmentInCompedica" />
      <link:presentationArc order="230" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefImpairmentLossInvestmentInCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnRevaluationOfInvestmentInCompedica" xlink:label="loc_ptgefLossOnRevaluationOfInvestmentInCompedica" />
      <link:presentationArc order="240" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefLossOnRevaluationOfInvestmentInCompedica" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:label="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" />
      <link:presentationArc order="250" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefChangeInFairValueOfTonPayableToSettlePutRightsExercised" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnSettlementOfTonPayable" xlink:label="loc_ptgefGainOnSettlementOfTonPayable" />
      <link:presentationArc order="260" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGainOnSettlementOfTonPayable" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnSettlementOfPutRightLiability" xlink:label="loc_ptgefLossOnSettlementOfPutRightLiability" />
      <link:presentationArc order="270" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefLossOnSettlementOfPutRightLiability" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NetForeignExchangeGain" xlink:label="loc_ifrs-fullNetForeignExchangeGain" />
      <link:presentationArc order="280" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNetForeignExchangeGain" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_InterestExpenseIncomeDefinedBenefitPlans" xlink:label="loc_ifrs-fullInterestExpenseIncomeDefinedBenefitPlans" />
      <link:presentationArc order="290" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullInterestExpenseIncomeDefinedBenefitPlans" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_LossOnExtinguishmentOfDebt" xlink:label="loc_ptgefLossOnExtinguishmentOfDebt" />
      <link:presentationArc order="300" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefLossOnExtinguishmentOfDebt" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_GainOnExtinguishmentOfDebt" xlink:label="loc_ptgefGainOnExtinguishmentOfDebt" />
      <link:presentationArc order="310" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefGainOnExtinguishmentOfDebt" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_ShareOfLossesFromEquityMethodInvestment" xlink:label="loc_ptgefShareOfLossesFromEquityMethodInvestment" />
      <link:presentationArc order="320" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefShareOfLossesFromEquityMethodInvestment" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SegmentLossBeforeBenefitForIncomeTaxes" xlink:label="loc_ptgefSegmentLossBeforeBenefitForIncomeTaxes" />
      <link:presentationArc order="330" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSegmentLossBeforeBenefitForIncomeTaxes" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IncomeTaxBenefit" xlink:label="loc_ptgefIncomeTaxBenefit" />
      <link:presentationArc order="340" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefIncomeTaxBenefit" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SegmentNetLoss" xlink:label="loc_ptgefSegmentNetLoss" />
      <link:presentationArc order="350" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefSegmentNetLoss" xlink:type="arc" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/CapitalManagementDetailsNarrative" xlink:title="999102 - Disclosure - CAPITAL MANAGEMENT (Details Narrative)">
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_DisclosureCapitalManagementAbstract" xlink:label="loc_ptgefDisclosureCapitalManagementAbstract" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PayablesAndAccruedExpense" xlink:label="loc_ptgefPayablesAndAccruedExpense" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalManagementAbstract" xlink:to="loc_ptgefPayablesAndAccruedExpense" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_PutRightLiabilities" xlink:label="loc_ptgefPutRightLiabilities" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalManagementAbstract" xlink:to="loc_ptgefPutRightLiabilities" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_CurrentAsset" xlink:label="loc_ptgefCurrentAsset" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefDisclosureCapitalManagementAbstract" xlink:to="loc_ptgefCurrentAsset" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" />
    </link:presentationLink>
    <link:presentationLink xlink:type="extended" xlink:role="http://portagebiotech.com/role/Non-controllingInterestDetails" xlink:title="999103 - Disclosure - NON-CONTROLLING INTEREST (Details)">
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NotesAndOtherExplanatoryInformationAbstract" xlink:label="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_DisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:label="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullNotesAndOtherExplanatoryInformationAbstract" xlink:to="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" order="100" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_IfrsStatementLineItems" xlink:label="loc_ptgefIfrsStatementLineItems" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ptgefIfrsStatementLineItems" order="200" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullDisclosureOfTransactionsBetweenRelatedPartiesTable" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" order="10" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_CategoriesOfRelatedPartiesDomain" xlink:label="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" />
      <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesAxis" xlink:to="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" order="0" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_SaugatuckMember" xlink:label="loc_ptgefSaugatuckMember" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ifrs-fullCategoriesOfRelatedPartiesDomain" xlink:to="loc_ptgefSaugatuckMember" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncontrollingInterests" xlink:label="loc_ifrs-fullNoncontrollingInterests" />
      <link:presentationArc order="0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNoncontrollingInterests" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" />
      <link:loc xlink:type="locator" xlink:href="ptgef-20260331.xsd#ptgef_NetLossAttributableToNoncontrollingInterest" xlink:label="loc_ptgefNetLossAttributableToNoncontrollingInterest" />
      <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ptgefNetLossAttributableToNoncontrollingInterest" xlink:type="arc" />
      <link:loc xlink:type="locator" xlink:href="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd#ifrs-full_NoncontrollingInterests" xlink:label="loc_ifrs-fullNoncontrollingInterests_2" />
      <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ptgefIfrsStatementLineItems" xlink:to="loc_ifrs-fullNoncontrollingInterests_2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" />
    </link:presentationLink>
</link:linkbase>
