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        <link:roleType roleURI="http://portagebiotech.com/role/DigitalAssetsDetails" id="DigitalAssetsDetails">
          <link:definition>999058 - Disclosure - DIGITAL ASSETS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/DigitalAssetsDetails1" id="DigitalAssetsDetails1">
          <link:definition>999059 - Disclosure - DIGITAL ASSETS (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/DigitalAssetsDetails2" id="DigitalAssetsDetails2">
          <link:definition>999060 - Disclosure - DIGITAL ASSETS (Details 2)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/ReceivablesDigitalAssetsDetails" id="ReceivablesDigitalAssetsDetails">
          <link:definition>999061 - Disclosure - RECEIVABLES DIGITAL ASSETS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://portagebiotech.com/role/DigitalAssetsDetailsNarrative" id="DigitalAssetsDetailsNarrative">
          <link:definition>999062 - Disclosure - DIGITAL ASSETS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://portagebiotech.com/role/PropertyPlantAndEquipmentAndRight-of-useAssetsDetails" id="PropertyPlantAndEquipmentAndRight-of-useAssetsDetails">
          <link:definition>999063 - Disclosure - PROPERTY, PLANT, AND EQUIPMENT AND RIGHT-OF-USE ASSETS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://portagebiotech.com/role/InvestmentInCompedicaDetails" id="InvestmentInCompedicaDetails">
          <link:definition>999064 - Disclosure - INVESTMENT IN COMPEDICA (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://portagebiotech.com/role/InvestmentInCompedicaDetailsNarrative" id="InvestmentInCompedicaDetailsNarrative">
          <link:definition>999065 - Disclosure - INVESTMENT IN COMPEDICA (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails" id="WarrantLiabilityDetails">
          <link:definition>999066 - Disclosure - WARRANT LIABILITY (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails1" id="WarrantLiabilityDetails1">
          <link:definition>999067 - Disclosure - WARRANT LIABILITY (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails2" id="WarrantLiabilityDetails2">
          <link:definition>999068 - Disclosure - WARRANT LIABILITY (Details 2)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails3" id="WarrantLiabilityDetails3">
          <link:definition>999069 - Disclosure - WARRANT LIABILITY (Details 3)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/WarrantLiabilityDetails4" id="WarrantLiabilityDetails4">
          <link:definition>999070 - Disclosure - WARRANT LIABILITY (Details 4)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/WarrantLiabilityDetailsNarrative" id="WarrantLiabilityDetailsNarrative">
          <link:definition>999071 - Disclosure - WARRANT LIABILITY (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails" id="PutRightLiabilityAndTonPayableDetails">
          <link:definition>999072 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails1" id="PutRightLiabilityAndTonPayableDetails1">
          <link:definition>999073 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetails2" id="PutRightLiabilityAndTonPayableDetails2">
          <link:definition>999074 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details 2)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/PutRightLiabilityAndTonPayableDetailsNarrative" id="PutRightLiabilityAndTonPayableDetailsNarrative">
          <link:definition>999075 - Disclosure - PUT RIGHT LIABILITY AND TON PAYABLE (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/AccountsPayableAndAccruedLiabilitiesDetails" id="AccountsPayableAndAccruedLiabilitiesDetails">
          <link:definition>999076 - Disclosure - ACCOUNTS PAYABLE AND ACCRUED LIABILITIES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/LeaseLiabilityDetails" id="LeaseLiabilityDetails">
          <link:definition>999077 - Disclosure - LEASE LIABILITY (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/LeaseLiabilityDetailsNarrative" id="LeaseLiabilityDetailsNarrative">
          <link:definition>999078 - Disclosure - LEASE LIABILITY (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/BitgoPrimeLoanDetailsNarrative" id="BitgoPrimeLoanDetailsNarrative">
          <link:definition>999079 - Disclosure - BITGO PRIME LOAN (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/IncomeTaxesDetails" id="IncomeTaxesDetails">
          <link:definition>999080 - Disclosure - INCOME TAXES (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/IncomeTaxesDetails1" id="IncomeTaxesDetails1">
          <link:definition>999081 - Disclosure - INCOME TAXES (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/IncomeTaxesDetails2" id="IncomeTaxesDetails2">
          <link:definition>999082 - Disclosure - INCOME TAXES (Details 2)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/IncomeTaxesDetailsNarrative" id="IncomeTaxesDetailsNarrative">
          <link:definition>999083 - Disclosure - INCOME TAXES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/CapitalStockAndReservesDetails" id="CapitalStockAndReservesDetails">
          <link:definition>999084 - Disclosure - CAPITAL STOCK AND RESERVES (Details )</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/CapitalStockAndReservesDetailsNarrative" id="CapitalStockAndReservesDetailsNarrative">
          <link:definition>999085 - Disclosure - CAPITAL STOCK AND RESERVES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/StockOptionReserveDetails" id="StockOptionReserveDetails">
          <link:definition>999086 - Disclosure - STOCK OPTION RESERVE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/StockOptionReserveDetails1" id="StockOptionReserveDetails1">
          <link:definition>999087 - Disclosure - STOCK OPTION RESERVE (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/StockOptionReserveDetails2" id="StockOptionReserveDetails2">
          <link:definition>999088 - Disclosure - STOCK OPTION RESERVE (Details 2)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/StockOptionReserveDetails3" id="StockOptionReserveDetails3">
          <link:definition>999089 - Disclosure - STOCK OPTION RESERVE (Details 3)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/StockOptionReserveDetails4" id="StockOptionReserveDetails4">
          <link:definition>999090 - Disclosure - STOCK OPTION RESERVE (Details 4)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/StockOptionReserveDetailsNarrative" id="StockOptionReserveDetailsNarrative">
          <link:definition>999091 - Disclosure - STOCK OPTION RESERVE (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/LossPerShareDetails" id="LossPerShareDetails">
          <link:definition>999092 - Disclosure - LOSS PER SHARE (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/LossPerShareDetails1" id="LossPerShareDetails1">
          <link:definition>999093 - Disclosure - LOSS PER SHARE (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/CommitmentsAndContingentLiabilitiesDetailsNarrative" id="CommitmentsAndContingentLiabilitiesDetailsNarrative">
          <link:definition>999094 - Disclosure - COMMITMENTS AND CONTINGENT LIABILITIES (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetails" id="RelatedPartyTransactionsDetails">
          <link:definition>999095 - Disclosure - RELATED PARTY TRANSACTIONS (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetails1" id="RelatedPartyTransactionsDetails1">
          <link:definition>999096 - Disclosure - RELATED PARTY TRANSACTIONS (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetails3" id="RelatedPartyTransactionsDetails3">
          <link:definition>999097 - Disclosure - RELATED PARTY TRANSACTIONS (Details 3)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/RelatedPartyTransactionsDetailsNarrative" id="RelatedPartyTransactionsDetailsNarrative">
          <link:definition>999098 - Disclosure - RELATED PARTY TRANSACTIONS (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementDetails" id="FinancialInstrumentsAndRiskManagementDetails">
          <link:definition>999099 - Disclosure - - FINANCIAL INSTRUMENTS AND RISK MANAGEMENT (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/FinancialInstrumentsAndRiskManagementDetails1" id="FinancialInstrumentsAndRiskManagementDetails1">
          <link:definition>999100 - Disclosure - FINANCIAL INSTRUMENTS AND RISK MANAGEMENT (Details 1)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://portagebiotech.com/role/SegmentReportingDetails" id="SegmentReportingDetails">
          <link:definition>999101 - Disclosure - SEGMENT REPORTING (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://portagebiotech.com/role/CapitalManagementDetailsNarrative" id="CapitalManagementDetailsNarrative">
          <link:definition>999102 - Disclosure - CAPITAL MANAGEMENT (Details Narrative)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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          <link:definition>999103 - Disclosure - NON-CONTROLLING INTEREST (Details)</link:definition>
          <link:usedOn>link:presentationLink</link:usedOn>
          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:linkbaseRef xlink:type="simple" xlink:href="ptgef-20260331_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Definition Links" />
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    <element id="ptgef_ChangeInFairValueOfWarrantLiabilityAmount" name="ChangeInFairValueOfWarrantLiabilityAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_WarrantsLiabilityShares" name="WarrantsLiabilityShares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_WarrantsLiabilityFairValue" name="WarrantsLiabilityFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ExercisePriceFairValue" name="ExercisePriceFairValue" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SharePriceFairvalue" name="SharePriceFairvalue" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_OptionLifeShareOptions" name="OptionLifeShareOptions" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_FairValueOfWarrantPerShare" name="FairValueOfWarrantPerShare" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PutRightLiabilityemainingTermInYears" name="PutRightLiabilityemainingTermInYears" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_TonTokenPrice" name="TonTokenPrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LockedTonTokenDiscountForLackOfMarketabilityRate" name="LockedTonTokenDiscountForLackOfMarketabilityRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_BalanceOfPutRightLiability" name="BalanceOfPutRightLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SettlementOfDwfMaasLimitedPutRight" name="SettlementOfDwfMaasLimitedPutRight" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PutRightLiabilityEndingBalance" name="PutRightLiabilityEndingBalance" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_BalanceOfTonPayable" name="BalanceOfTonPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ExerciseOfSideLetterPutRightPayable" name="ExerciseOfSideLetterPutRightPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SettlementOfPutRightLiabilityUsingDigitalAssets" name="SettlementOfPutRightLiabilityUsingDigitalAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_TonPayableEndingBalanceAsOfMarch31" name="TonPayableEndingBalanceAsOfMarch31" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_TreasuryManagementAgreementDescription" name="TreasuryManagementAgreementDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_FairValueOfContribution" name="FairValueOfContribution" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_Usd1Receivable" name="Usd1Receivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LossOnExercise" name="LossOnExercise" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_OutstandingContingentPutOptionsFairValue" name="OutstandingContingentPutOptionsFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_RemeasurementChangeInFairValue" name="RemeasurementChangeInFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccountsPayable" name="AccountsPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccruedOtherProfessionalFees" name="AccruedOtherProfessionalFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccruedAccountingAndAuditingFees" name="AccruedAccountingAndAuditingFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccruedBonusesAndOtherPayrollrelatedExpenses" name="AccruedBonusesAndOtherPayrollrelatedExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccruedCRO" name="AccruedCRO" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ProfessionalFeesExpenses" name="ProfessionalFeesExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccruedClinicalAndRdServices" name="AccruedClinicalAndRdServices" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_CapitalExpenditures" name="CapitalExpenditures" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_OtherAccruedExpenses" name="OtherAccruedExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccountsPayableAndAccruedLiabilityNet" name="AccountsPayableAndAccruedLiabilityNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LeaseLiabilityFutureMinimumPaymentsDue" name="LeaseLiabilityFutureMinimumPaymentsDue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LeaseLiabilityFutureMinimumPaymentsYearTwoDue" name="LeaseLiabilityFutureMinimumPaymentsYearTwoDue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LeaseLiabilityFutureMinimumPaymentsYearDue" name="LeaseLiabilityFutureMinimumPaymentsYearDue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_Interest" name="Interest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_TotalLeaseLiability" name="TotalLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LeaseLiabilityCurrent" name="LeaseLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LeaseLiabilityNoncurrent" name="LeaseLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_Commencement" name="Commencement" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PurchasePriceLeaseLiability" name="PurchasePriceLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PurchaseEquipmentPayment" name="PurchaseEquipmentPayment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_MasterLoanAgreementDescription" name="MasterLoanAgreementDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_CurrentTaxOnProfitsForYear" name="CurrentTaxOnProfitsForYear" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AdjustmentsForCurrentTaxOfPriorPeriods" name="AdjustmentsForCurrentTaxOfPriorPeriods" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DecreaseIncreaseInDeferredTaxAssets" name="DecreaseIncreaseInDeferredTaxAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ProfitLossFromContinuingOperation" name="ProfitLossFromContinuingOperation" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_IncomeLossOnOrdinaryActivitiesBeforeTax" name="IncomeLossOnOrdinaryActivitiesBeforeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_TaxUsingBviTaxRate" name="TaxUsingBviTaxRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_EffectOfTaxRatesInOtherCountries" name="EffectOfTaxRatesInOtherCountries" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DerecognitionOfDeferredTaxAssets" name="DerecognitionOfDeferredTaxAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NondeductibleExpenses" name="NondeductibleExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_UtilizationOfLossesNotPreviouslyBenefitted" name="UtilizationOfLossesNotPreviouslyBenefitted" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_IncomeTaxEffectsRelatedToEquityCompensation" name="IncomeTaxEffectsRelatedToEquityCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ForeignCurrencyEffectAndOther" name="ForeignCurrencyEffectAndOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_IncomeTaxExpense" name="IncomeTaxExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DeferredTaxAssetsAbstract" name="DeferredTaxAssetsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DeferredTaxAssetsNetOperatingLossCarryforward" name="DeferredTaxAssetsNetOperatingLossCarryforward" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_StockbasedCompensation" name="StockbasedCompensation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ReservesAndAccruals" name="ReservesAndAccruals" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DeferredTaxAssetNotRecognized" name="DeferredTaxAssetNotRecognized" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NetDeferredTaxAsset" name="NetDeferredTaxAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_UkLossCarryForwards" name="UkLossCarryForwards" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SaleOfStock" name="SaleOfStock" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AggregateProceeds" name="AggregateProceeds" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SharesPrice" name="SharesPrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_WarrantsToPurchase" name="WarrantsToPurchase" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PurchasePrice" name="PurchasePrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_GrossProceeds" name="GrossProceeds" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DgitalAssets" name="DgitalAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_OrdinarySharesIssued" name="OrdinarySharesIssued" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberOfSharesSold" name="NumberOfSharesSold" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NetProceeds" name="NetProceeds" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_TreasuryStock" name="TreasuryStock" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AggregateOfferingOrdinaryShares" name="AggregateOfferingOrdinaryShares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_Proceedsfromexerciseofwarrant" name="Proceedsfromexerciseofwarrant" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AdditionalSharesIssued" name="AdditionalSharesIssued" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_WarrantsPurchase" name="WarrantsPurchase" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_WarrantsPerShare" name="WarrantsPerShare" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_StockOptionReserve" name="StockOptionReserve" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_CorrectionOfPriorPeriodOverstatedSharebasedCompensationsExpense" name="CorrectionOfPriorPeriodOverstatedSharebasedCompensationsExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberOfOutstandingShareOption" name="NumberOfOutstandingShareOption" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberOfShareOptionsGrantedInSharebasedPaymentsArrangement" name="NumberOfShareOptionsGrantedInSharebasedPaymentsArrangement" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberOfShareOptionsExpiredOrForfeitedInSharebasedPaymentsArrangement" name="NumberOfShareOptionsExpiredOrForfeitedInSharebasedPaymentsArrangement" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberOfShareOptionsExercisableInSharebasedPaymentsArrangements" name="NumberOfShareOptionsExercisableInSharebasedPaymentsArrangements" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberOfShareOptionsAvailableForFutureAwardsSharebasedPaymentsArrangement" name="NumberOfShareOptionsAvailableForFutureAwardsSharebasedPaymentsArrangement" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DescriptionOfGrantPriceShareOptionsGranted" name="DescriptionOfGrantPriceShareOptionsGranted" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_OptionLifeShareOptionsGranted" name="OptionLifeShareOptionsGranted" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ExpirationDate" name="ExpirationDate" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ExercisePrice" name="ExercisePrice" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ShareOptions" name="ShareOptions" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AuthorizedGrantOptionPurchaseShares" name="AuthorizedGrantOptionPurchaseShares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SharesIssuedGrantedRsu" name="SharesIssuedGrantedRsu" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberOfSharesExercise" name="NumberOfSharesExercise" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SharesRepurchasedIntoTreasuryEmployeePayrollTaxes" name="SharesRepurchasedIntoTreasuryEmployeePayrollTaxes" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SharebasedCompensationExpense" name="SharebasedCompensationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ReversalOfSharebasedCompensation" name="ReversalOfSharebasedCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ShareBasedCompensationExpenseUnvestedShareOptions" name="ShareBasedCompensationExpenseUnvestedShareOptions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_WeightedAverageSharesOutstandingDiluted" name="WeightedAverageSharesOutstandingDiluted" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LossPerShareBasic" name="LossPerShareBasic" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LossPerShareDiluted" name="LossPerShareDiluted" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AntidilutiveEffectOnLossPerShare" name="AntidilutiveEffectOnLossPerShare" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ServiceFees" name="ServiceFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_BudgetCosts" name="BudgetCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_UnbilledServices" name="UnbilledServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ForfeitedAdvancedPayments" name="ForfeitedAdvancedPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NetGain" name="NetGain" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PrepaidExpensesAndOtherReceivables" name="PrepaidExpensesAndOtherReceivables" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ContractualPayments" name="ContractualPayments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NetworkingEquipmentCost" name="NetworkingEquipmentCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_Deposit" name="Deposit" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SharebasedPaymentCompensation" name="SharebasedPaymentCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_TransactionClosingBonus" name="TransactionClosingBonus" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SecuritiesUnderOptionsGranted" name="SecuritiesUnderOptionsGranted" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_OtherCompensation" name="OtherCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_GrantDate" name="GrantDate" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberofSecuritiesUnderlyingUnexercisedOptionsUnExercisable" name="NumberofSecuritiesUnderlyingUnexercisedOptionsUnExercisable" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_ExercisePrices" name="ExercisePrices" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_OptionExpirationDate" name="OptionExpirationDate" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NumberofShareUnitsofStockThetHaveNotVested" name="NumberofShareUnitsofStockThetHaveNotVested" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_MarketValueNumberofShareUnitsofStockThetHaveNotVested" name="MarketValueNumberofShareUnitsofStockThetHaveNotVested" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_Decentranet" name="Decentranet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PrepaidExpensesAndOtherReceivable" name="PrepaidExpensesAndOtherReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_AccountsPayableAndAccruedLiabilities" name="AccountsPayableAndAccruedLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_LeaseLiabilityCurrentAndNoncurrent" name="LeaseLiabilityCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DigitalAssetsAtFairValueTonLiquid" name="DigitalAssetsAtFairValueTonLiquid" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_DigitalAssetsAtFairValueTonLocked" name="DigitalAssetsAtFairValueTonLocked" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SegmentLossBeforeBenefitForIncomeTaxes" name="SegmentLossBeforeBenefitForIncomeTaxes" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_IncomeTaxBenefit" name="IncomeTaxBenefit" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_SegmentNetLoss" name="SegmentNetLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PayablesAndAccruedExpense" name="PayablesAndAccruedExpense" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_PutRightLiabilities" name="PutRightLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_CurrentAsset" name="CurrentAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ptgef_NetLossAttributableToNoncontrollingInterest" name="NetLossAttributableToNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
