<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Fri Jul 17 19:42:38 UTC 2026 -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:xbrldt="http://xbrl.org/2005/xbrldt">
  <roleRef xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#IndividualsOnly" roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly"/>
  <roleRef xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#PvpAdjustmentsOnly" roleURI="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly"/>
  <roleRef xlink:type="simple" xlink:href="cgc-20260331.xsd#cgc_r_AdditionalDimensions" roleURI="http://www.canopygrowth.com/role/AdditionalDimensions"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>
  <definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_AllIndividualsMember"/>
    <loc xlink:type="locator" xlink:label="cgc_MrMongeauMember" xlink:href="cgc-20260331.xsd#cgc_MrMongeauMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="cgc_MrMongeauMember" order="2" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="cgc_MrKleinMember" xlink:href="cgc-20260331.xsd#cgc_MrKleinMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="cgc_MrKleinMember" order="4" xbrldt:closed="true"/>
  </definitionLink>
  <definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ecd_EqtyAwrdsAdjsMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_EqtyAwrdsAdjsMember"/>
    <loc xlink:type="locator" xlink:label="cgc_FairValueOfAwardsGrantedDuringAnyPriorFYThatWereForfeitedDuringApplicableFYDeterminedAsOfPriorFYEndMember" xlink:href="cgc-20260331.xsd#cgc_FairValueOfAwardsGrantedDuringAnyPriorFYThatWereForfeitedDuringApplicableFYDeterminedAsOfPriorFYEndMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsMember" xlink:to="cgc_FairValueOfAwardsGrantedDuringAnyPriorFYThatWereForfeitedDuringApplicableFYDeterminedAsOfPriorFYEndMember" order="1" xbrldt:closed="true"/>
  </definitionLink>
<!-- [WMV7][na3jlVt1Xq44ord1y2L3MGYCFiENzNTSZhBnWCiepXe11jQE3+yOVuO6leN7Ppe1UnUL+Q/dScZCMKd3IhReuVzIRrtSjYTxI5BtObB22Jn5kRAwZG/o3uc5WBpbfhsmaT7PvrBIQpwuOGYPs1vfUFs+MxYEeMBqVH3lk2zaqSXza8hyZ8kz4KYCc1SFPzlEDZysJ4IbRAWes67ybQFIXrUkv/nPy4EF0aNeWsHa5lCktrzd9c+YtWAwS3w/2VSPEDWpJl8QIoZtO8PsMYMVYJYaSfuSpKWe2bVSAs8SGQYnsDjSxXV/zVev0QkA] CSR-->
  <definitionLink xlink:role="http://www.canopygrowth.com/role/AdditionalDimensions" xlink:type="extended"/>
</linkbase>
