FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person *
Patel Samir Rashmikant

(Last) (First) (Middle)
C/O AKARI THERAPEUTICS PLC
401 EAST JACKSON STREET, SUITE 3300

(Street)
TAMPA FL 33602

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Akari Therapeutics Plc [ AKTX ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
07/07/2026
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
American Depositary Shares representing Ordinary Shares 07/07/2026   M   1,209 A $ 8 76,976 I PranaBio Investments LLC
American Depositary Shares representing Ordinary Shares 07/07/2026   M   15,466 A $ 0.0004 92,442 I PranaBio Investments LLC
American Depositary Shares representing Ordinary Shares 07/07/2026   M   5,799 A $ 0.0004 98,241 I PranaBio Investments LLC
American Depositary Shares representing Ordinary Shares               3,566 D  
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Pre-Funded Warrant to purchase American Depositary Shares (1) $ 8 07/07/2026   M   1,209   10/06/2023   (2) American Depositary Shares representing Ordinary Shares 1,209 $ 32 0 I PranaBio Investments LLC
Pre-Funded Warrant to purchase ADSs $ 0.0004 07/07/2026   M   15,466     (3)   (2) American Depositary Shares representing Ordinary Shares 15,466 $ 16.16 (4) 0 I PranaBio Investments LLC
Pre-Funded Warrant to purchase ADSs (5) $ 0.0004 07/07/2026   M   5,799     (3)   (2) American Depositary Shares representing Ordinary Shares 5,799 $ 16.16 (5) 0 I PranaBio Investments LLC
Explanation of Responses:
1. Each American Depositary Share ("ADS") represents 80,000 ordinary shares with a par value of $0.000000005 per ordinary share.
2. The pre-funded warrants remain exercisable until fully exercised.
3. The pre-funded warrants became exercisable upon shareholder approval, which was obtained on March 2, 2026.
4. The combined purchase price per one pre-funded warrant and accompanying Series G Warrant was $16.16.
5. On December 16, 2025, the Reporting Person and the Issuer entered into a note cancellation and exchange agreement, pursuant to which, in exchange for the entire outstanding principal amount and all accrued interest on the Issuer's unsecured promissory note held by the Reporting Person, the Issuer issued to the Reporting Person (i) pre-funded warrants (the "Note Exchange Unregistered Pre-Funded Warrants") to purchase up to 5,799 ADSs, at a purchase price of $16.16 per Note Exchange Unregistered Pre-Funded Warrant, and (ii) warrants to purchase up to 5,799 ADSs.
/s/ Abizer Gaslightwala, as Attorney-in-Fact 07/17/2026
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
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