The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 11,231,243 292,938 SH SOLE 292,938 0 0
3D SYS CORP DEL COM NEW 88554D205 33,250 11,010 SH SOLE 11,010 0 0
ABBOTT LABORATORIES COM 002824100 1,864,344 20,546 SH SOLE 20,546 0 0
ABBVIE INC COM 00287Y109 16,220,966 64,461 SH SOLE 64,461 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206 2,134,671 345,416 SH SOLE 345,416 0 0
ACHIEVE LIFE SCIENCE INC COM 004468500 9,351,646 1,432,105 SH SOLE 1,432,105 0 0
ADOBE INC COM 00724F101 574,056 2,800 SH Call SOLE 2,800 0 0
ADOBE INC COM 00724F101 487,743 2,379 SH SOLE 2,379 0 0
AGILON HEALTH INC COM NEW 00857U206 903,420 8,429 SH SOLE 8,429 0 0
AGNC INVT CORP COM 00123Q104 1,258,786 115,485 SH SOLE 115,485 0 0
ALIGN TECHNOLOGY INC COM 016255101 11,274,415 66,847 SH SOLE 66,847 0 0
AMERICAN EXPRESS CO COM 025816109 273,306 808 SH SOLE 808 0 0
AMGEN INC COM 031162100 7,595,105 20,974 SH SOLE 20,974 0 0
ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839 1,606,320 71,839 SH SOLE 71,839 0 0
APPLIED MATLS INC COM 038222105 499,593 691 SH SOLE 691 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104 1,159,488 278,723 SH SOLE 278,723 0 0
ARMOUR RESIDENTIAL REIT INC COM SHS 042315705 940,555 53,900 SH SOLE 53,900 0 0
ARTIVA BIOTHERAPEUTICS INC COM 04317A107 983,144 101,355 SH SOLE 101,355 0 0
ASTRAZENECA PLC ORD G0593M107 6,482,729 34,188 SH SOLE 34,188 0 0
AUTODESK INC COM 052769106 229,999 1,183 SH SOLE 1,183 0 0
BENITEC BIOPHARMA INC COM NEW 08205P209 13,454,353 1,005,557 SH SOLE 1,005,557 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 1,332,038 2,662 SH SOLE 2,662 0 0
BEYOND MEAT INC COM 08862E109 37,335 49,780 SH SOLE 49,780 0 0
BIOHAVEN LTD COM G1110E107 15,478,994 1,040,255 SH SOLE 1,040,255 0 0
BLUE OWL CAPITAL INC COM CL A 09581B103 931,875 106,500 SH SOLE 106,500 0 0
BOOKING HOLDINGS INC COM 09857L108 220,126 1,235 SH SOLE 1,235 0 0
BOSTON SCIENTIFIC CORP COM 101137107 640,798 15,014 SH SOLE 15,014 0 0
BRAEMAR HOTELS & RESORTS INC COM 10482B101 395,280 183,000 SH SOLE 183,000 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 508,934 1,356 SH SOLE 1,356 0 0
CARDINAL HEALTH INC COM 14149Y108 6,382,178 26,924 SH SOLE 26,924 0 0
CATERPILLAR INC COM 149123101 594,214 558 SH SOLE 558 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 1,977,116 53,134 SH SOLE 53,134 0 0
CHIMERA INVT CORP COM SHS 16934Q802 680,674 51,025 SH SOLE 51,025 0 0
CIENA CORP COM NEW 171779309 385,580 786 SH SOLE 786 0 0
CISCO SYS INC COM 17275R102 1,985,544 16,904 SH SOLE 16,904 0 0
CLOUDFLARE INC CL A COM 18915M107 467,504 1,906 SH SOLE 1,906 0 0
COCA COLA CO COM 191216100 332,313 4,089 SH SOLE 4,089 0 0
COLGATE PALMOLIVE CO COM 194162103 217,832 2,376 SH SOLE 2,376 0 0
COMCAST CORP NEW CL A 20030N101 396,845 16,385 SH SOLE 16,385 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 1,617,076 114,281 SH SOLE 114,281 0 0
COOPER COS INC COM 216648501 945,281 13,182 SH SOLE 13,182 0 0
CORCEPT THERAPEUTICS INC COM 218352102 2,298,436 26,434 SH SOLE 26,434 0 0
CVS HEALTH CORP COM 126650100 7,354,260 71,090 SH SOLE 71,090 0 0
CYPHERPUNK TECHNOLOGIES INC COM NEW 52187K200 17,132 27,979 SH SOLE 27,979 0 0
DANAHER CORP DEL COM 235851102 8,159,020 42,834 SH SOLE 42,834 0 0
DATADOG INC CL A COM 23804L103 451,204 1,733 SH SOLE 1,733 0 0
DELCATH SYS INC COM NEW 24661P807 3,333,454 264,770 SH SOLE 264,770 0 0
DELL TECHNOLOGIES INC CL C 24703L202 1,368,591 3,172 SH SOLE 3,172 0 0
DYNEX CAP INC COM 26817Q886 1,763,295 134,500 SH SOLE 134,500 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 1,688,707 18,668 SH SOLE 18,668 0 0
ELECTRONIC ARTS INC COM 285512109 244,408 1,192 SH SOLE 1,192 0 0
ELEVANCE HEALTH INC FORMERLY COM 036752103 9,891,393 25,577 SH SOLE 25,577 0 0
ELI LILLY & CO COM 532457108 17,649,612 14,715 SH SOLE 14,715 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 5,194,937 60,540 SH SOLE 60,540 0 0
EXXON MOBIL CORP COM 30231G102 736,374 5,386 SH SOLE 5,386 0 0
EYEPOINT INC COM NEW 30233G209 5,720,629 400,044 SH SOLE 400,044 0 0
FLUOR CORP COM 343412102 326,547 6,233 SH SOLE 6,233 0 0
FORTINET INC COM 34959E109 539,667 3,513 SH SOLE 3,513 0 0
FULCRUM THERAPEUTICS INC COM 359616109 562,886 153,794 SH SOLE 153,794 0 0
FULL HSE RESORTS INC COM 359678109 1,107,630 397,000 SH SOLE 397,000 0 0
GE AEROSPACE COM NEW 369604301 614,038 1,643 SH SOLE 1,643 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107 3,331,080 52,040 SH SOLE 52,040 0 0
GE VERNOVA INC COM 36828A101 439,398 374 SH SOLE 374 0 0
GILEAD SCIENCES INC COM 375558103 10,274,600 81,325 SH SOLE 81,325 0 0
GUARDANT HEALTH INC COM 40131M109 4,136,477 27,571 SH SOLE 27,571 0 0
HOME DEPOT INC COM 437076102 378,778 1,074 SH SOLE 1,074 0 0
ICON PUB LTD CO SHS G4705A100 260,391 1,499 SH SOLE 1,499 0 0
IMMUNIC INC COM NEW 4525EP200 472,243 30,725 SH SOLE 30,725 0 0
INSMED INC COM PAR $.01 457669307 1,512,938 14,190 SH SOLE 14,190 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 1,409,987 5,014 SH SOLE 5,014 0 0
INTUIT COM 461202103 363,312 1,392 SH SOLE 1,392 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 2,979,419 7,492 SH SOLE 7,492 0 0
INVENTIVA SA ADS 46124U107 1,184,966 313,483 SH SOLE 313,483 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 2,209,200 3,000 SH Call SOLE 3,000 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 48,463,582 1,455,800 SH Call SOLE 1,455,800 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 16,208,901 486,900 SH SOLE 486,900 0 0
ISHARES TR CORE US AGGBD ET 464287226 499,032,910 5,041,755 SH SOLE 5,041,755 0 0
ISHARES TR CORE S&P500 ETF 464287200 780,831,656 1,042,652 SH SOLE 1,042,652 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 16,520,903 68,560 SH SOLE 68,560 0 0
JOHNSON & JOHNSON COM 478160104 18,509,080 72,879 SH SOLE 72,879 0 0
KYVERNA THERAPEUTICS INC COM 501976104 1,626,993 182,603 SH SOLE 182,603 0 0
LAM RESEARCH CORP COM NEW 512807306 478,830 1,105 SH SOLE 1,105 0 0
LEONABIO INC COM 04746L203 1,371,874 149,279 SH SOLE 149,279 0 0
MASTERCARD INCORPORATED CL A 57636Q104 809,947 1,577 SH SOLE 1,577 0 0
MERCK & CO INC COM 58933Y105 920,960 7,167 SH SOLE 7,167 0 0
MFA FINL INC COM 55272X607 1,625,459 167,746 SH SOLE 167,746 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 4,488,168 3,349,379 SH SOLE 3,349,379 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 558,694 3,315 SH SOLE 3,315 0 0
NOVO-NORDISK A S ADR 670100205 24,205,769 504,918 SH SOLE 504,918 0 0
NVIDIA CORPORATION COM 67066G104 10,404,680 52,000 SH Call SOLE 52,000 0 0
OCULAR THERAPEUTIX INC COM 67576A100 795,921 81,051 SH SOLE 81,051 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106 946,655 219,387 SH SOLE 219,387 0 0
PACIRA BIOSCIENCES INC COM 695127100 2,107,816 83,083 SH SOLE 83,083 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108 1,402,490 12,021 SH SOLE 12,021 0 0
PALISADE BIO INC COM 696389402 941,635 450,543 SH SOLE 450,543 0 0
PENNYMAC MTG INVT TR COM 70931T103 603,480 53,500 SH SOLE 53,500 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 2,704,547 249,267 SH SOLE 249,267 0 0
PHILIP MORRIS INTL INC COM 718172109 269,375 1,489 SH SOLE 1,489 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 30,880,177 1,272,360 SH SOLE 1,272,360 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103 24,720,821 3,048,190 SH SOLE 3,048,190 0 0
QUALCOMM INC COM 747525103 1,010,986 5,471 SH SOLE 5,471 0 0
QUEST DIAGNOSTICS INC COM 74834L100 10,537,094 49,715 SH SOLE 49,715 0 0
RITHM CAPITAL CORP COM NEW 64828T201 3,864,858 411,593 SH SOLE 411,593 0 0
ROCKWELL AUTOMATION INC COM 773903109 257,442 520 SH SOLE 520 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202 408,911 104,849 SH SOLE 104,849 0 0
SALESFORCE INC COM 79466L302 692,437 4,420 SH SOLE 4,420 0 0
SEAGATE TECHNOLOGY HLDNGS PL ORD SHS G7997R103 955,350 990 SH SOLE 990 0 0
SERVICENOW INC COM 81762P102 553,089 5,571 SH SOLE 5,571 0 0
SIMPLIFY EXCHANGE TRADED FUN CHINA A SHS PLUS 82889N384 12,447,053 428,078 SH SOLE 428,078 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BD ETF 82889N723 42,541,092 2,109,127 SH SOLE 2,109,127 0 0
SIMPLIFY EXCHANGE TRADED FUN PIPE SAND SM ETF 82889N327 3,149,398 91,464 SH SOLE 91,464 0 0
SIMPLIFY EXCHANGE TRADED FUN TARGE 15 ETF 82889N350 15,472,781 624,406 SH SOLE 624,406 0 0
SIMPLIFY EXCHANGE TRADED FUN ANCORATO TARGET 82889N343 2,755,808 116,500 SH SOLE 116,500 0 0
SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657 98,259,364 4,810,740 SH SOLE 4,810,740 0 0
SIMPLIFY EXCHANGE TRADED FUN NATL MUNI BD ETF 82889N442 38,680,150 1,553,376 SH SOLE 1,553,376 0 0
SIMPLIFY EXCHANGE TRADED FUN NEXT INTANGIBLE 82889N475 28,648,214 822,303 SH SOLE 822,303 0 0
SIMPLIFY EXCHANGE TRADED FUN MULTI QIS ALTERN 82889N533 37,864,596 3,777,620 SH SOLE 3,777,620 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQUITY INCOME 82889N301 80,414,767 1,634,812 SH SOLE 1,634,812 0 0
SIMPLIFY EXCHANGE TRADED FUN TREASURY OPT INC 82889N640 39,814,000 1,700,000 SH SOLE 1,700,000 0 0
SIMPLIFY EXCHANGE TRADED FUN GOVT MONE MA ETF 82889N269 4,917,134,712 49,141,862 SH SOLE 49,141,862 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQUI PLUS ETF 82889N228 2,641,000 100,000 SH SOLE 100,000 0 0
SNOWFLAKE INC COM SHS 833445109 422,979 1,662 SH SOLE 1,662 0 0
SPDR GOLD TR GOLD SHS 78463V107 40,766,000 110,000 SH Call SOLE 110,000 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 461,885 1,006 SH SOLE 1,006 0 0
STRYKER CORPORATION COM 863667101 708,390 2,250 SH SOLE 2,250 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 221,232 885 SH SOLE 885 0 0
TESLA INC COM 88160R101 4,467,193 10,621 SH SOLE 10,621 0 0
TG THERAPEUTICS INC COM 88322Q108 1,168,519 21,269 SH SOLE 21,269 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 11,570,887 23,079 SH SOLE 23,079 0 0
UBER TECHNOLOGIES INC COM 90353T100 241,808 3,351 SH SOLE 3,351 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 24,605,042 45,411 SH SOLE 45,411 0 0
UNITEDHEALTH GROUP INC COM 91324P102 17,544,574 42,212 SH SOLE 42,212 0 0
UPSTREAM BIO INC COM 91678A107 429,822 62,113 SH SOLE 62,113 0 0
VANECK BITCOIN ETF SH BEN INT 92189K105 4,392,132 264,427 SH SOLE 264,427 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 5,193,809 10,456 SH SOLE 10,456 0 0
VTEX SHS CL A G9470A102 44,780 11,195 SH SOLE 11,195 0 0
WALMART INC COM 931142103 1,912,961 16,890 SH SOLE 16,890 0 0
WARBY PARKER INC CL A COM 93403J106 17,811,582 587,066 SH SOLE 587,066 0 0
WESTERN DIGITAL CORP COM 958102105 931,892 1,459 SH SOLE 1,459 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206 1,014,684 70,759 SH SOLE 70,759 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 378,366 4,395 SH SOLE 4,395 0 0