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      id="x_9946864c-14db-4ee4-afad-5c467147f4f8">&lt;span style="color:#000000;font-family:Times New Roman;font-size:16pt;font-variant:small-caps;"&gt;Federated Hermes Total Return Bond Fund&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:9pt;font-weight:bold;"&gt;A Portfolio of Federated Hermes Total Return Series, Inc.&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:9pt;font-weight:bold;text-transform:uppercase;"&gt;CLASS A SHARES (TICKER TLRAX)&lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:9pt;font-weight:bold;text-transform:uppercase;"&gt;CLASS C SHARES (TICKER TLRCX)&lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:9pt;font-weight:bold;text-transform:uppercase;"&gt;CLASS R SHARES (TICKER FTRKX)&lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:9pt;font-weight:bold;text-transform:uppercase;"&gt;INSTITUTIONAL SHARES (TICKER FTRBX)&lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:9pt;font-weight:bold;text-transform:uppercase;"&gt;SERVICE SHARES (TICKER FTRFX)&lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:9pt;font-weight:bold;text-transform:uppercase;"&gt;CLASS R6 SHARES (TICKER FTRLX)&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8.5pt;font-weight:bold;text-transform:uppercase;"&gt;SUPPLEMENT TO SUMMARY PROSPECTUS AND PROSPECTUS DATED JANUARY 31, 2026&lt;/span&gt;&lt;span style="color:#000000;font-family:Times New Roman;font-size:9.9pt;"&gt;Effective September 30, 2026, the Fund may invest up to 35% of its total assets in noninvestment-grade debt securities. As such, effective September 30, 2026, please replace the third sentence under &#x201c;What are the Fund&#x2019;s Main Investment Strategies&#x201d; in the Summary Prospectus and Prospectus and the first sentence of the third paragraph under &#x201c;What are the Fund&#x2019;s Investment Strategies?&#x201d; with the following sentence:&lt;/span&gt;&lt;span style="color:#000000;font-family:Times New Roman;font-size:9.9pt;"&gt;&#x201c;The Fund may invest up to 35% of its total assets in noninvestment-grade securities (otherwise known as &#x201c;junk bonds&#x201d;).&#x201d;  &lt;/span&gt;&lt;span style="color:#000000;font-family:Times New Roman;font-size:9.9pt;"&gt;July 16, 2026&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;Federated Hermes Total Return Bond Fund&lt;/span&gt;
&lt;br/&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;Federated Hermes Funds&lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;4000 Ericsson Drive  &lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;Warrendale, PA 15086-7561&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;Contact us at&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;font-weight:bold;line-height:9pt;"&gt;  &lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;font-weight:bold;"&gt;FederatedHermes.com/us&lt;/span&gt;
&lt;br/&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;or call 1-800-341-7400.&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;Federated Securities Corp., Distributor&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;Q457303 (7/26)&lt;/span&gt;&lt;span style="color:#000000;font-family:Arial;font-size:8pt;"&gt;&#xa9;  2026 Federated Hermes, Inc.&lt;/span&gt;</oef:SupplementToProspectusTextBlock>
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