<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019f5cf7-9efe-73ca-b644-9a2cbb02a1da,g:99849938-85f4-46c4-9fbb-0ee43eb99d01-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://tarsusrx.com/role/Cover" xlink:type="simple" xlink:href="tars-20260713.xsd#Cover"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019f5cf7-9efe-7300-a4d5-cfa6c16bfc46" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_019f5cf7-9efe-7bdb-b350-68163b375a20" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f5cf7-9efe-7300-a4d5-cfa6c16bfc46" xlink:to="loc_dei_DocumentInformationTable_019f5cf7-9efe-7bdb-b350-68163b375a20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_019f5cf7-9efe-779f-b51f-5bcd9576d4ca" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_019f5cf7-9efe-7bdb-b350-68163b375a20" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_019f5cf7-9efe-779f-b51f-5bcd9576d4ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_019f5cf7-9efe-725a-b505-c24113f33a2b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AddressTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_019f5cf7-9efe-779f-b51f-5bcd9576d4ca" xlink:to="loc_dei_AddressTypeDomain_019f5cf7-9efe-725a-b505-c24113f33a2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_FormerAddressMember_019f5cf7-9efe-7234-8f27-f3591cf6f2ed" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_FormerAddressMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_AddressTypeDomain_019f5cf7-9efe-725a-b505-c24113f33a2b" xlink:to="loc_dei_FormerAddressMember_019f5cf7-9efe-7234-8f27-f3591cf6f2ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_019f5cf7-9efe-7bdb-b350-68163b375a20" xlink:to="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019f5cf7-9efe-79c5-8dde-c4d17e95372d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_DocumentType_019f5cf7-9efe-79c5-8dde-c4d17e95372d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019f5cf7-9efe-7856-a27b-61ca43f5c30e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_DocumentPeriodEndDate_019f5cf7-9efe-7856-a27b-61ca43f5c30e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019f5cf7-9efe-78f9-ae74-81233d585d7d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityRegistrantName_019f5cf7-9efe-78f9-ae74-81233d585d7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019f5cf7-9efe-7326-9447-79af535756e5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019f5cf7-9efe-7326-9447-79af535756e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019f5cf7-9efe-7d5d-91ce-9211dde268e9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityFileNumber_019f5cf7-9efe-7d5d-91ce-9211dde268e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019f5cf7-9efe-7b83-b4d3-51ff995ca622" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityTaxIdentificationNumber_019f5cf7-9efe-7b83-b4d3-51ff995ca622" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019f5cf7-9efe-7100-9c51-f82871b0b0b2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityAddressAddressLine1_019f5cf7-9efe-7100-9c51-f82871b0b0b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019f5cf7-9efe-7124-9b00-5ab44f25288f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityAddressAddressLine2_019f5cf7-9efe-7124-9b00-5ab44f25288f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019f5cf7-9efe-7a81-8a3f-945be84215e9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityAddressCityOrTown_019f5cf7-9efe-7a81-8a3f-945be84215e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019f5cf7-9efe-74a1-9d0b-ed8b3ec1525c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityAddressStateOrProvince_019f5cf7-9efe-74a1-9d0b-ed8b3ec1525c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019f5cf7-9efe-72e1-bc43-fb0f6855bcd3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityAddressPostalZipCode_019f5cf7-9efe-72e1-bc43-fb0f6855bcd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019f5cf7-9efe-7fc7-98da-687b15a88be0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_CityAreaCode_019f5cf7-9efe-7fc7-98da-687b15a88be0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019f5cf7-9efe-767e-93d2-7833bfe35b06" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_LocalPhoneNumber_019f5cf7-9efe-767e-93d2-7833bfe35b06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019f5cf7-9efe-7ff9-a22e-fa3be566fe4f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_WrittenCommunications_019f5cf7-9efe-7ff9-a22e-fa3be566fe4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019f5cf7-9efe-7e54-95cc-7f92bf97079c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_SolicitingMaterial_019f5cf7-9efe-7e54-95cc-7f92bf97079c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019f5cf7-9efe-7caf-8bc7-47314e941bd8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_PreCommencementTenderOffer_019f5cf7-9efe-7caf-8bc7-47314e941bd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019f5cf7-9efe-783b-affc-3652180ae5f1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019f5cf7-9efe-783b-affc-3652180ae5f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019f5cf7-9efe-7294-9070-dc6dcc15998d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_Security12bTitle_019f5cf7-9efe-7294-9070-dc6dcc15998d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019f5cf7-9efe-766b-a246-9e21ffe92aed" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_TradingSymbol_019f5cf7-9efe-766b-a246-9e21ffe92aed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019f5cf7-9efe-7246-b400-d2cfe6b672b7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_SecurityExchangeName_019f5cf7-9efe-7246-b400-d2cfe6b672b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019f5cf7-9efe-7318-85eb-bb910ac57628" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityEmergingGrowthCompany_019f5cf7-9efe-7318-85eb-bb910ac57628" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019f5cf7-9efe-7683-be46-90c5079f08de" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_EntityCentralIndexKey_019f5cf7-9efe-7683-be46-90c5079f08de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019f5cf7-9efe-7fac-bf2e-d732e0f7e00f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019f5cf7-9efe-7f18-8507-37ca4a3b7f3d" xlink:to="loc_dei_AmendmentFlag_019f5cf7-9efe-7fac-bf2e-d732e0f7e00f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
