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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <name>United Therapeutics Corp.</name>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <name>uniQure NV</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ORIC Pharmaceuticals, Inc.</name>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <name>Waters Corp.</name>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <fairValLevel>1</fairValLevel>
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        <name>Adaptive Biotechnologies Corp.</name>
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        <curCd>USD</curCd>
        <valUSD>28429440.00000000</valUSD>
        <pctVal>0.478547151851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Veracyte, Inc.</name>
        <lei>529900ESWZRHXOW27Z37</lei>
        <title>Veracyte, Inc.</title>
        <cusip>92337F107</cusip>
        <identifiers>
          <isin value="US92337F1075"/>
          <other otherDesc="Inhouse Asset ID" value="SBFTWZY08"/>
        </identifiers>
        <balance>453231.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15559420.23000000</valUSD>
        <pctVal>0.261908649467</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7691842.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Anavex Life Sciences Corp.</name>
        <lei>549300K1I5L8COCQ8W36</lei>
        <title>Anavex Life Sciences Corp.</title>
        <cusip>032797300</cusip>
        <identifiers>
          <isin value="US0327973006"/>
          <other otherDesc="Inhouse Asset ID" value="032797300"/>
        </identifiers>
        <balance>489509.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4356630.10000000</valUSD>
        <pctVal>0.073334294520</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3730746.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akouos, Inc.</name>
        <lei>N/A</lei>
        <title>Akouos, Inc., CVR</title>
        <cusip>009CVR036</cusip>
        <identifiers>
          <isin value="US009CVR0361"/>
          <other otherDesc="Inhouse Asset ID" value="009CVR036"/>
        </identifiers>
        <balance>157087.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1.57000000</valUSD>
        <pctVal>0.000000026427</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Right"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1.09890000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Terns Pharmaceuticals, Inc.</name>
        <lei>254900S1ZDQMF4MYP709</lei>
        <title>Terns Pharmaceuticals, Inc.</title>
        <cusip>880881107</cusip>
        <identifiers>
          <isin value="US8808811074"/>
          <other otherDesc="Inhouse Asset ID" value="880881107"/>
        </identifiers>
        <balance>408459.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3067527.09000000</valUSD>
        <pctVal>0.051635078008</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="598404.31000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OmniAb Operations, Inc.</name>
        <lei>N/A</lei>
        <title>OmniAb, Inc., 12.50 Earnout Shares</title>
        <cusip>68218J202</cusip>
        <identifiers>
          <isin value="US68218J2024"/>
          <other otherDesc="Inhouse Asset ID" value="68218J202"/>
        </identifiers>
        <balance>46839.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.47000000</valUSD>
        <pctVal>0.000000007911</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Right"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neumora Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Neumora Therapeutics, Inc.</title>
        <cusip>640979100</cusip>
        <identifiers>
          <isin value="US6409791000"/>
          <other otherDesc="Inhouse Asset ID" value="640979100"/>
        </identifiers>
        <balance>408119.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>742776.58000000</valUSD>
        <pctVal>0.012503011554</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>
        
        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="541349.90000000"/>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      
      
      
      <explntrNote note="This amendment reflects updates to the Securities on Loan information reported in Item C.12.c. The values have now been corrected to ensure accurate reporting." noteItem="C.12.c"/>
      <explntrNote note="Monthly returns presented in B.5.a have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>
      
      
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-09-30</ncom:dateSigned>
      <ncom:nameOfApplicant>iShares Trust</ncom:nameOfApplicant>
      <ncom:signature>Chuck Pulsfort</ncom:signature>
      <ncom:signerName>Chuck Pulsfort</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
