<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019f3d54-e12b-7e51-b431-92c0638aeb08,g:73f7cd18-bbdb-41b9-925a-40d10f74498d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.modernatx.com/role/Cover" xlink:type="simple" xlink:href="mrna-20260706.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.modernatx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019f3d54-e12b-73b9-80d4-5013855d6177" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_DocumentType_019f3d54-e12b-73b9-80d4-5013855d6177" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019f3d54-e12b-71a6-a38b-5e11544354d9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_DocumentPeriodEndDate_019f3d54-e12b-71a6-a38b-5e11544354d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019f3d54-e12b-71fd-a3cf-3088532a8047" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityRegistrantName_019f3d54-e12b-71fd-a3cf-3088532a8047" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019f3d54-e12b-7db3-aa44-41fc93319aa4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019f3d54-e12b-7db3-aa44-41fc93319aa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019f3d54-e12b-7c19-a449-fd12e54dcc2f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityFileNumber_019f3d54-e12b-7c19-a449-fd12e54dcc2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019f3d54-e12b-7295-83d7-ad9456b26d8b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityTaxIdentificationNumber_019f3d54-e12b-7295-83d7-ad9456b26d8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019f3d54-e12b-7353-9b85-c131d1d98edf" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityAddressAddressLine1_019f3d54-e12b-7353-9b85-c131d1d98edf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019f3d54-e12b-7ffe-9c12-3c649d00dd0a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityAddressCityOrTown_019f3d54-e12b-7ffe-9c12-3c649d00dd0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019f3d54-e12b-70cf-8f05-dfdd992946db" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityAddressStateOrProvince_019f3d54-e12b-70cf-8f05-dfdd992946db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019f3d54-e12b-7900-9ce3-2a33d53a13da" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityAddressPostalZipCode_019f3d54-e12b-7900-9ce3-2a33d53a13da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019f3d54-e12b-78dc-b4bc-390b0d324a59" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_CityAreaCode_019f3d54-e12b-78dc-b4bc-390b0d324a59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019f3d54-e12b-78fb-8574-e50337d7baff" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_LocalPhoneNumber_019f3d54-e12b-78fb-8574-e50337d7baff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019f3d54-e12b-79c8-b540-c5afe696b66d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_WrittenCommunications_019f3d54-e12b-79c8-b540-c5afe696b66d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019f3d54-e12b-7867-b223-2e11249add98" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_SolicitingMaterial_019f3d54-e12b-7867-b223-2e11249add98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019f3d54-e12b-73a3-96fb-b4ffe53f5e7d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_PreCommencementTenderOffer_019f3d54-e12b-73a3-96fb-b4ffe53f5e7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019f3d54-e12b-7cc2-8681-42a85aabf07d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019f3d54-e12b-7cc2-8681-42a85aabf07d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019f3d54-e12b-74e9-a1e1-f8e4699ade46" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_Security12bTitle_019f3d54-e12b-74e9-a1e1-f8e4699ade46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019f3d54-e12b-7bcf-84a2-e6f64601323d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_TradingSymbol_019f3d54-e12b-7bcf-84a2-e6f64601323d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019f3d54-e12b-7648-a9ec-2a9a7d763e27" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_SecurityExchangeName_019f3d54-e12b-7648-a9ec-2a9a7d763e27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019f3d54-e12b-76b7-b2e6-d3d95c125ea7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityEmergingGrowthCompany_019f3d54-e12b-76b7-b2e6-d3d95c125ea7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019f3d54-e12b-7c4c-a8f3-2d030445f051" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_EntityCentralIndexKey_019f3d54-e12b-7c4c-a8f3-2d030445f051" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019f3d54-e12b-7507-bc19-97513db66d34" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019f3d54-e12b-7a0f-b9f3-81861b0c07da" xlink:to="loc_dei_AmendmentFlag_019f3d54-e12b-7507-bc19-97513db66d34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
