<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ecb52-d825-7695-a76f-cc84d43da089,g:3a891805-f43a-4f3d-94cd-9baa94a88afb-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.pacira.com/role/CoverPage" xlink:type="simple" xlink:href="pcrx-20260628.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.pacira.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019ecb52-d826-7e00-935e-f61c929e878f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_DocumentType_019ecb52-d826-7e00-935e-f61c929e878f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019ecb52-d826-72c0-9210-b23c809dc557" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_DocumentPeriodEndDate_019ecb52-d826-72c0-9210-b23c809dc557" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019ecb52-d826-7428-b494-5a455837bea2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityRegistrantName_019ecb52-d826-7428-b494-5a455837bea2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019ecb52-d826-717f-bdc9-9bd65d3ad53e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019ecb52-d826-717f-bdc9-9bd65d3ad53e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019ecb52-d826-703b-be82-68c98c935bd1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityFileNumber_019ecb52-d826-703b-be82-68c98c935bd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019ecb52-d826-73d3-bc3c-d2182ce1d948" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityTaxIdentificationNumber_019ecb52-d826-73d3-bc3c-d2182ce1d948" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019ecb52-d826-7b5e-afd4-6172f23790b2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityAddressAddressLine1_019ecb52-d826-7b5e-afd4-6172f23790b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019ecb52-d826-7055-bf6a-bb4a360e7f18" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityAddressCityOrTown_019ecb52-d826-7055-bf6a-bb4a360e7f18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019ecb52-d826-7baa-bc30-1826e56c613e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityAddressStateOrProvince_019ecb52-d826-7baa-bc30-1826e56c613e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019ecb52-d826-7dc5-8dcf-b255f579dd24" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityAddressPostalZipCode_019ecb52-d826-7dc5-8dcf-b255f579dd24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019ecb52-d826-7b38-aa91-79e2d09bf4ac" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_CityAreaCode_019ecb52-d826-7b38-aa91-79e2d09bf4ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019ecb52-d826-7194-bf8c-220f945d1d79" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_LocalPhoneNumber_019ecb52-d826-7194-bf8c-220f945d1d79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019ecb52-d826-7340-9cc5-c376035a0731" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_WrittenCommunications_019ecb52-d826-7340-9cc5-c376035a0731" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019ecb52-d826-7a89-8e84-ac245d80822b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_SolicitingMaterial_019ecb52-d826-7a89-8e84-ac245d80822b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019ecb52-d826-7e44-ac89-0386925c8799" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_PreCommencementTenderOffer_019ecb52-d826-7e44-ac89-0386925c8799" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019ecb52-d826-7c6f-b2f1-b0d11b0e0abd" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019ecb52-d826-7c6f-b2f1-b0d11b0e0abd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019ecb52-d826-70f5-8f77-4b14ab1febed" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_Security12bTitle_019ecb52-d826-70f5-8f77-4b14ab1febed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019ecb52-d826-79b5-8198-3d28477d89ff" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_TradingSymbol_019ecb52-d826-79b5-8198-3d28477d89ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019ecb52-d826-79a2-8a09-c262597ca369" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_SecurityExchangeName_019ecb52-d826-79a2-8a09-c262597ca369" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019ecb52-d826-7587-bc47-85d406eda29c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityEmergingGrowthCompany_019ecb52-d826-7587-bc47-85d406eda29c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019ecb52-d826-7696-98cf-fafd17d930c6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_EntityCentralIndexKey_019ecb52-d826-7696-98cf-fafd17d930c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019ecb52-d826-761d-a733-f9662561ca6a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019ecb52-d826-797b-949d-aa1c7a39a271" xlink:to="loc_dei_AmendmentFlag_019ecb52-d826-761d-a733-f9662561ca6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
