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  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/>
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  <xs:element name="ScheduleOfChangesInFinancialLiabilitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfChangesInFinancialLiabilitiesAbstract"/>
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  <xs:element name="ScheduleOfIntangibleAssetsAsOfTheClosingDateOfTheAcquisitionAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfIntangibleAssetsAsOfTheClosingDateOfTheAcquisitionAbstract"/>
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  <xs:element name="ScheduleOfResultsOfSocialProxyAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfResultsOfSocialProxyAbstract"/>
  <xs:element name="ScheduleOfCostOfServiceAndAmortizationOfIntangibleAssetsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfCostOfServiceAndAmortizationOfIntangibleAssetsAbstract"/>
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  <xs:element name="ScheduleOfAssumptionsToEstimateTheWarrantsIssuedAtTheFundRaisingAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfAssumptionsToEstimateTheWarrantsIssuedAtTheFundRaisingAbstract"/>
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  <xs:element name="ScheduleOfNumberOfShareOptionsAndTheirRelatedWeightedAverageExercisePricesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfNumberOfShareOptionsAndTheirRelatedWeightedAverageExercisePricesAbstract"/>
  <xs:element name="ScheduleOfExercisePriceAndRemainingContractualLifeForOptionsOutstandingAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfExercisePriceAndRemainingContractualLifeForOptionsOutstandingAbstract"/>
  <xs:element name="ScheduleOfOutstandingOptionsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfOutstandingOptionsAbstract"/>
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  <xs:element name="SalesAndMarketingExpensesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SalesAndMarketingExpensesAbstract"/>
  <xs:element name="ScheduleOfGeneralAndAdministrativeExpensesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfGeneralAndAdministrativeExpensesAbstract"/>
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  <xs:element name="ScheduleOfWeightedAverageNumberOfOrdinarySharesBasicAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfWeightedAverageNumberOfOrdinarySharesBasicAbstract"/>
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  <xs:element name="LossBeforeIncomeTaxesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_LossBeforeIncomeTaxesAbstract"/>
  <xs:element name="CurrentMarketableSecurities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_CurrentMarketableSecurities"/>
  <xs:element name="WarrantsNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsNet"/>
  <xs:element name="ConvertibleLoanFromShareholderCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ConvertibleLoanFromShareholderCurrent"/>
  <xs:element name="ChangeInFairValueOfFinancialInstruments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ChangeInFairValueOfFinancialInstruments"/>
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  <xs:element name="PercentageofAmortizationCustomerList" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageofAmortizationCustomerList"/>
  <xs:element name="PercentageofAmortizationBrand" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageofAmortizationBrand"/>
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  <xs:element name="FinancialInstrumentsandFinancialRiskManagementScheduleofWarrantSensitivityAnalysisParentheticalsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_FinancialInstrumentsandFinancialRiskManagementScheduleofWarrantSensitivityAnalysisParentheticalsDetailsTable"/>
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  <xs:element name="FairValueOfIssuedWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FairValueOfIssuedWarrants"/>
  <xs:element name="SubsidiariesScheduleofIntangibleAssetsasoftheClosingDateoftheAcquisitionDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_SubsidiariesScheduleofIntangibleAssetsasoftheClosingDateoftheAcquisitionDetailsTable"/>
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  <xs:element name="SocialProxysStandaloneLossForThePeriodFromAcquisition" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SocialProxysStandaloneLossForThePeriodFromAcquisition"/>
  <xs:element name="DiscontinuedOperationsScheduleofLossfromDiscontinuedOperationsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_DiscontinuedOperationsScheduleofLossfromDiscontinuedOperationsDetailsTable"/>
  <xs:element name="OtherAdjustments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OtherAdjustments"/>
  <xs:element name="SocialProxysEquity" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SocialProxysEquity"/>
  <xs:element name="LoanToSocialProxy" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_LoanToSocialProxy"/>
  <xs:element name="DiscontinuedOperationsScheduleofCashFlowsFromtheDiscontinuedOperationsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_DiscontinuedOperationsScheduleofCashFlowsFromtheDiscontinuedOperationsDetailsTable"/>
  <xs:element name="DiscontinuedOperationsScheduleofCashFlowsFromtheDiscontinuedOperationsDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DiscontinuedOperationsScheduleofCashFlowsFromtheDiscontinuedOperationsDetailsLineItems"/>
  <xs:element name="CashandCashEquivalentsScheduleofCashandCashEquivalentsareDenominatedorLinkedDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_CashandCashEquivalentsScheduleofCashandCashEquivalentsareDenominatedorLinkedDetailsTable"/>
  <xs:element name="CashandCashEquivalentsScheduleofCashandCashEquivalentsareDenominatedorLinkedDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_CashandCashEquivalentsScheduleofCashandCashEquivalentsareDenominatedorLinkedDetailsLineItems"/>
  <xs:element name="GainsLossesOnFairValueOnMarketableSecurities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_GainsLossesOnFairValueOnMarketableSecurities"/>
  <xs:element name="FairValueBeforeDisposal" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FairValueBeforeDisposal"/>
  <xs:element name="ProceedsFromSale" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ProceedsFromSale"/>
  <xs:element name="GovernmentAuthorities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_GovernmentAuthorities"/>
  <xs:element name="IntangibleAssetsScheduleofCompositionandMovementDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_IntangibleAssetsScheduleofCompositionandMovementDetailsTable"/>
  <xs:element name="IntangibleAssetsScheduleofCompositionandMovementDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IntangibleAssetsScheduleofCompositionandMovementDetailsLineItems"/>
  <xs:element name="ReclassificationToDiscontinuedOperations" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ReclassificationToDiscontinuedOperations"/>
  <xs:element name="EmployeesAndRelated" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_EmployeesAndRelated"/>
  <xs:element name="TypeOfCurrencyDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_TypeOfCurrencyDomainDomain"/>
  <xs:element name="AccountsPayableScheduleofCarryingAmountofAccountsPayableDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_AccountsPayableScheduleofCarryingAmountofAccountsPayableDetailsTable"/>
  <xs:element name="AccountsPayableScheduleofCarryingAmountofAccountsPayableDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AccountsPayableScheduleofCarryingAmountofAccountsPayableDetailsLineItems"/>
  <xs:element name="WarrantsScheduleofAssumptionstoEstimatetheWarrantsIssuedattheFundRaisingDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_WarrantsScheduleofAssumptionstoEstimatetheWarrantsIssuedattheFundRaisingDetailsTable"/>
  <xs:element name="DateDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DateDomainDomain"/>
  <xs:element name="WarrantsScheduleofOutstandingWarrantsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_WarrantsScheduleofOutstandingWarrantsDetailsTable"/>
  <xs:element name="NumberOfSharesExercisable" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfSharesExercisable"/>
  <xs:element name="IssuanceDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuanceDate"/>
  <xs:element name="ExercisePriceperWarrant" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ExercisePriceperWarrant"/>
  <xs:element name="ShareBasedPaymentScheduleofNumberofShareOptionsandtheirRelatedWeightedAverageExercisePricesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ShareBasedPaymentScheduleofNumberofShareOptionsandtheirRelatedWeightedAverageExercisePricesDetailsTable"/>
  <xs:element name="ShareBasedPaymentScheduleofExercisePriceandRemainingContractualLifeforOptionsOutstandingDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ShareBasedPaymentScheduleofExercisePriceandRemainingContractualLifeforOptionsOutstandingDetailsTable"/>
  <xs:element name="NumberOfOutstandingShareOption" type="xbrli:decimalItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfOutstandingShareOption"/>
  <xs:element name="ShareBasedPaymentScheduleofOutstandingOptionsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ShareBasedPaymentScheduleofOutstandingOptionsDetailsTable"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsPosition" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsPosition"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingExercisePrice" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingExercisePrice"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingValue"/>
  <xs:element name="ShareBasedPaymentScheduleofFairValueforOptionsGrantedDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ShareBasedPaymentScheduleofFairValueforOptionsGrantedDetailsTable"/>
  <xs:element name="ShareBasedPaymentScheduleofFairValueforOptionsGrantedDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ShareBasedPaymentScheduleofFairValueforOptionsGrantedDetailsLineItems"/>
  <xs:element name="FeesRelatedToServiceProviders" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FeesRelatedToServiceProviders"/>
  <xs:element name="GeneralandAdministrativeExpensesScheduleofGeneralandAdministrativeExpensesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_GeneralandAdministrativeExpensesScheduleofGeneralandAdministrativeExpensesDetailsTable"/>
  <xs:element name="GeneralandAdministrativeExpensesScheduleofGeneralandAdministrativeExpensesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_GeneralandAdministrativeExpensesScheduleofGeneralandAdministrativeExpensesDetailsLineItems"/>
  <xs:element name="PatentsAndFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PatentsAndFees"/>
  <xs:element name="RentAndOfficeMaintenance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RentAndOfficeMaintenance"/>
  <xs:element name="FinanceExpensesRevaluationOfMarketableSecurities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FinanceExpensesRevaluationOfMarketableSecurities"/>
  <xs:element name="ExchangeDifferences" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ExchangeDifferences"/>
  <xs:element name="IssuanceCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuanceCosts"/>
  <xs:element name="InterestExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_InterestExpenses"/>
  <xs:element name="RevaluationOfConvertibleLoanFromShareholder" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RevaluationOfConvertibleLoanFromShareholder"/>
  <xs:element name="RevaluationOfWarrantToPurchaseADSs" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RevaluationOfWarrantToPurchaseADSs"/>
  <xs:element name="RevaluationOfWarrantsToPurchaseADSs" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RevaluationOfWarrantsToPurchaseADSs"/>
  <xs:element name="RevaluationMarketableSecurities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RevaluationMarketableSecurities"/>
  <xs:element name="ProfitLossPerShareScheduleofWeightedAverageNumberofOrdinarySharesBasicDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ProfitLossPerShareScheduleofWeightedAverageNumberofOrdinarySharesBasicDetailsTable"/>
  <xs:element name="ProfitLossPerShareScheduleofWeightedAverageNumberofOrdinarySharesBasicDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ProfitLossPerShareScheduleofWeightedAverageNumberofOrdinarySharesBasicDetailsLineItems"/>
  <xs:element name="IssuedOrdinarySharesAtJanuary1" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuedOrdinarySharesAtJanuary1"/>
  <xs:element name="Issued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_Issued"/>
  <xs:element name="AllowanceForDoubtfulDebts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AllowanceForDoubtfulDebts"/>
  <xs:element name="PercentageOfFunctionalCurrency" type="dtr:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfFunctionalCurrency"/>
  <xs:element name="SubsidiariesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_SubsidiariesDetailsTable"/>
  <xs:element name="IssuedWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuedWarrants"/>
  <xs:element name="MeasuredMilestonesPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MeasuredMilestonesPeriod"/>
  <xs:element name="PercentageOfDevelopmentOfNewTechnology" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfDevelopmentOfNewTechnology"/>
  <xs:element name="PercentageOfAttritionRate" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfAttritionRate"/>
  <xs:element name="PercentageOfEBITMargin" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfEBITMargin"/>
  <xs:element name="RoyaltyRatePercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RoyaltyRatePercentage"/>
  <xs:element name="DiscontinuedOperationsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_DiscontinuedOperationsDetailsTable"/>
  <xs:element name="ChangesInCostOfService" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ChangesInCostOfService"/>
  <xs:element name="SalesAndMarketing" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SalesAndMarketing"/>
  <xs:element name="MarketableSecuritiesInterCureLtdDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_MarketableSecuritiesInterCureLtdDetailsTable"/>
  <xs:element name="MarketableSecuritiesInterCureLtdDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MarketableSecuritiesInterCureLtdDetailsLineItems"/>
  <xs:element name="MarketableSecuritiesShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MarketableSecuritiesShare"/>
  <xs:element name="PercentageOfHoldingShare" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfHoldingShare"/>
  <xs:element name="SoldShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SoldShare"/>
  <xs:element name="AgreementDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AgreementDomainDomain"/>
  <xs:element name="IntangibleAssetsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_IntangibleAssetsDetailsTable"/>
  <xs:element name="MilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MilestonePayments"/>
  <xs:element name="MilestonePaymentsAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MilestonePaymentsAmount"/>
  <xs:element name="ApprovalMarketAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ApprovalMarketAmount"/>
  <xs:element name="MarketingApprovalAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MarketingApprovalAmount"/>
  <xs:element name="PercentageOfRoyalties" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfRoyalties"/>
  <xs:element name="PercentageOfSublicenseFees" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfSublicenseFees"/>
  <xs:element name="ExpiryTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ExpiryTerm"/>
  <xs:element name="PriorWrittenNotice" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PriorWrittenNotice"/>
  <xs:element name="LiquidatedDamages" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_LiquidatedDamages"/>
  <xs:element name="RemainingLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RemainingLiability"/>
  <xs:element name="ImpairmentLossCarryingAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ImpairmentLossCarryingAmount"/>
  <xs:element name="AnnualInterest" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AnnualInterest"/>
  <xs:element name="AnnualInterestOnInitialLoanPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AnnualInterestOnInitialLoanPercentage"/>
  <xs:element name="DepositaryShareDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DepositaryShareDomainDomain"/>
  <xs:element name="WarrantsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_WarrantsDetailsTable"/>
  <xs:element name="GrossFundRaised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_GrossFundRaised"/>
  <xs:element name="IssuingADSs" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuingADSs"/>
  <xs:element name="WarrantsToPurchaseShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsToPurchaseShares"/>
  <xs:element name="ExpirePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ExpirePeriod"/>
  <xs:element name="WarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsExercised"/>
  <xs:element name="NumberOfShareExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfShareExercised"/>
  <xs:element name="WarrantsRemainOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsRemainOutstanding"/>
  <xs:element name="NumberOfOrdinarySharesIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfOrdinarySharesIssued"/>
  <xs:element name="ChangeInTheFairValueOfTheWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ChangeInTheFairValueOfTheWarrants"/>
  <xs:element name="ConvertibleLoanfromShareholderDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ConvertibleLoanfromShareholderDetailsTable"/>
  <xs:element name="NumberOfTradingDays" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfTradingDays"/>
  <xs:element name="Discount" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_Discount"/>
  <xs:element name="FairValueOfLoan" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FairValueOfLoan"/>
  <xs:element name="RevaluationLoss" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RevaluationLoss"/>
  <xs:element name="ShareCapitalReservesandAccumulatedDeficitDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ShareCapitalReservesandAccumulatedDeficitDetailsTable"/>
  <xs:element name="ParValuePerShares" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ParValuePerShares"/>
  <xs:element name="FundrraisingRound" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FundrraisingRound"/>
  <xs:element name="IssuanceCostsFinancing" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuanceCostsFinancing"/>
  <xs:element name="DeferredLoss" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DeferredLoss"/>
  <xs:element name="NumberOfWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfWarrantsExercised"/>
  <xs:element name="NumberOfConvertibleLoanConvertedIntoADS" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfConvertibleLoanConvertedIntoADS"/>
  <xs:element name="NamePlanDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NamePlanDomainDomain"/>
  <xs:element name="AwardTypesDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AwardTypesDomainDomain"/>
  <xs:element name="ShareBasedPaymentDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_ShareBasedPaymentDetailsTable"/>
  <xs:element name="ShareBasedPaymentDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ShareBasedPaymentDetailsLineItems"/>
  <xs:element name="SharebasedPaymentAwardRemainingContractualTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SharebasedPaymentAwardRemainingContractualTerm"/>
  <xs:element name="NumberOfShareExercisableInSharebasedPaymentArrangement" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfShareExercisableInSharebasedPaymentArrangement"/>
  <xs:element name="IncreaseOfReserve" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IncreaseOfReserve"/>
  <xs:element name="OptionsReserve" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OptionsReserve"/>
  <xs:element name="RemainingNumberOfOptionsAvailableForGrant" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RemainingNumberOfOptionsAvailableForGrant"/>
  <xs:element name="OptionsExercisableIntoOrdinaryShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OptionsExercisableIntoOrdinaryShares"/>
  <xs:element name="OrdinarySharesExercisePrice" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OrdinarySharesExercisePrice"/>
  <xs:element name="ExtendedExpiryTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ExtendedExpiryTerm"/>
  <xs:element name="NumberOfShareOptionsExercisableSharebasedPaymentArrangement" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfShareOptionsExercisableSharebasedPaymentArrangement"/>
  <xs:element name="ADSIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ADSIssued"/>
  <xs:element name="NumberOfOptionsFullyVested" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfOptionsFullyVested"/>
  <xs:element name="NumberOfOptionsVest" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_NumberOfOptionsVest"/>
  <xs:element name="GeneralandAdministrativeExpensesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_GeneralandAdministrativeExpensesDetailsTable"/>
  <xs:element name="GeneralandAdministrativeExpensesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_GeneralandAdministrativeExpensesDetailsLineItems"/>
  <xs:element name="ContractualLoanInterestRate" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ContractualLoanInterestRate"/>
  <xs:element name="OutstandingLoanBalance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OutstandingLoanBalance"/>
  <xs:element name="TaxesonIncomeDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_TaxesonIncomeDetailsTable"/>
  <xs:element name="BeneficialTaxRatePercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_BeneficialTaxRatePercentage"/>
  <xs:element name="DeferredTaxAssetsCapitalLossCarryforward" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DeferredTaxAssetsCapitalLossCarryforward"/>
  <xs:element name="TransactionsandBalanceswithRelatedPartiesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_TransactionsandBalanceswithRelatedPartiesDetailsTable"/>
  <xs:element name="TransactionsandBalanceswithRelatedPartiesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_TransactionsandBalanceswithRelatedPartiesDetailsLineItems"/>
  <xs:element name="AdministrativeFeeExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AdministrativeFeeExpense"/>
  <xs:element name="PercentageOfInvestment" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfInvestment"/>
  <xs:element name="CurrentMarketableSecuritie" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_CurrentMarketableSecuritie"/>
  <xs:element name="RevaluationGain" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RevaluationGain"/>
  <xs:element name="OtherInvestment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OtherInvestment"/>
  <xs:element name="PercentageOfAnnualRate" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfAnnualRate"/>
  <xs:element name="PercentageOfMarketPrice" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfMarketPrice"/>
  <xs:element name="PotentialOrdinarySharesFromShareOptionsExcludedFromDilutedEarningPerShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PotentialOrdinarySharesFromShareOptionsExcludedFromDilutedEarningPerShare"/>
  <xs:element name="PotentialOrdinarySharesFromWarrantsExcludedFromDilutedEarningPerShare" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PotentialOrdinarySharesFromWarrantsExcludedFromDilutedEarningPerShare"/>
  <xs:element name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="xtlb_SubsequentEventsDetailsTable"/>
  <xs:element name="PrivatePlacement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PrivatePlacement"/>
  <xs:element name="ConvertedLoans" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ConvertedLoans"/>
  <xs:element name="ConversionPrice" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ConversionPrice"/>
  <xs:element name="PercentageOfProposedAcquisition" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfProposedAcquisition"/>
  <xs:element name="PercentageOfSharesIssued" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfSharesIssued"/>
  <xs:element name="PercentageOfConsideration" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfConsideration"/>
  <xs:element name="PercentageOfSharesOutstanding" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfSharesOutstanding"/>
  <xs:element name="PercentageOfAggregate" type="dtr1:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PercentageOfAggregate"/>
  <xs:element name="PurchasePrice" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_PurchasePrice"/>
  <xs:element name="WarrantToTheInvestors" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantToTheInvestors"/>
  <xs:element name="ReducedWarrants" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ReducedWarrants"/>
  <xs:element name="ClosingPrice" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ClosingPrice"/>
  <xs:element name="EquityValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="xtlb_EquityValue"/>
  <xs:element name="AntiDilutionProtectionTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AntiDilutionProtectionTerm"/>
  <xs:element name="WarrantsSharePrice" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsSharePrice"/>
  <xs:element name="LowerFinancingPrice" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_LowerFinancingPrice"/>
  <xs:element name="ExercisableWarrants" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ExercisableWarrants"/>
  <xs:element name="AgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="xtlb_AgreementAxis"/>
  <xs:element name="AwardTypesAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="xtlb_AwardTypesAxis"/>
  <xs:element name="DateAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="xtlb_DateAxis"/>
  <xs:element name="DepositaryShareAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="xtlb_DepositaryShareAxis"/>
  <xs:element name="NamePlanAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="xtlb_NamePlanAxis"/>
  <xs:element name="TypeOfCurrencyAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="xtlb_TypeOfCurrencyAxis"/>
  <xs:element name="WarrantsIssuedAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="xtlb_WarrantsIssuedAxis"/>
  <xs:element name="ADSMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ADSMember"/>
  <xs:element name="AmericanDepositorySharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AmericanDepositorySharesMember"/>
  <xs:element name="AmortizationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AmortizationMember"/>
  <xs:element name="AprilSevenTwoThousandTwentyFiveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AprilSevenTwoThousandTwentyFiveMember"/>
  <xs:element name="August142024Member" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_August142024Member"/>
  <xs:element name="August142024OneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_August142024OneMember"/>
  <xs:element name="BlackScholesModelMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_BlackScholesModelMember"/>
  <xs:element name="ChiefExecutiveOfficerAndDirectorMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ChiefExecutiveOfficerAndDirectorMember"/>
  <xs:element name="ConvertibleLoanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ConvertibleLoanMember"/>
  <xs:element name="DevelopmentAreaAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DevelopmentAreaAMember"/>
  <xs:element name="DistributorMethodMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DistributorMethodMember"/>
  <xs:element name="EventsAfterTheReportingPeriodMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_EventsAfterTheReportingPeriodMember"/>
  <xs:element name="FirstGrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FirstGrantMember"/>
  <xs:element name="ForecastMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ForecastMember"/>
  <xs:element name="ForeignCurrenciesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ForeignCurrenciesMember"/>
  <xs:element name="FormerChiefExecutiveOfficerMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FormerChiefExecutiveOfficerMember"/>
  <xs:element name="FormerOfficerMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_FormerOfficerMember"/>
  <xs:element name="InterCureLtdMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_InterCureLtdMember"/>
  <xs:element name="IsraeliCpiForwardContractsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IsraeliCpiForwardContractsMember"/>
  <xs:element name="IsraeliNewShekelMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IsraeliNewShekelMember"/>
  <xs:element name="IssuedAugust142024DueToFundraisingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuedAugust142024DueToFundraisingMember"/>
  <xs:element name="IssuedAugust142024DueToTheSocialProxyTransactionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuedAugust142024DueToTheSocialProxyTransactionMember"/>
  <xs:element name="IssuedOct92025warrantExerciseMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IssuedOct92025warrantExerciseMember"/>
  <xs:element name="JulySevenTwoThousandTwentyMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_JulySevenTwoThousandTwentyMember"/>
  <xs:element name="JulyTwentyOneTwoThousandTwentyFiveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_JulyTwentyOneTwoThousandTwentyFiveMember"/>
  <xs:element name="LicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_LicenseAgreementMember"/>
  <xs:element name="LoanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_LoanMember"/>
  <xs:element name="MarchSeventeenTwoThousandTwentyFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MarchSeventeenTwoThousandTwentyFourMember"/>
  <xs:element name="MarchTwoTwoThousandTwentyThreeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_MarchTwoTwoThousandTwentyThreeMember"/>
  <xs:element name="OneChiefExecutiveOfficerMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OneChiefExecutiveOfficerMember"/>
  <xs:element name="OneDirectorMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OneDirectorMember"/>
  <xs:element name="OrdinaryShareMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_OrdinaryShareMember"/>
  <xs:element name="RangeOfExercisePricesOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RangeOfExercisePricesOneMember"/>
  <xs:element name="RangeOfExercisePricesThreeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RangeOfExercisePricesThreeMember"/>
  <xs:element name="RangeOfExercisePricesTwoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RangeOfExercisePricesTwoMember"/>
  <xs:element name="RelieffromroyaltyMethodMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_RelieffromroyaltyMethodMember"/>
  <xs:element name="SAASSocialProxyMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SAASSocialProxyMember"/>
  <xs:element name="SecondGrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SecondGrantMember"/>
  <xs:element name="SeriesAWarrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SeriesAWarrantMember"/>
  <xs:element name="SeriesBWarrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SeriesBWarrantMember"/>
  <xs:element name="ShareCapitalReservesAndAccumulatedDeficitMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ShareCapitalReservesAndAccumulatedDeficitMember"/>
  <xs:element name="SocialProxyMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SocialProxyMember"/>
  <xs:element name="SocialProxyTransactionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_SocialProxyTransactionMember"/>
  <xs:element name="StockOptionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_StockOptionsMember"/>
  <xs:element name="ThirdGrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ThirdGrantMember"/>
  <xs:element name="ThreeChiefExecutiveOfficerMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ThreeChiefExecutiveOfficerMember"/>
  <xs:element name="ThreeDirectorMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ThreeDirectorMember"/>
  <xs:element name="TwoDirectorMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_TwoDirectorMember"/>
  <xs:element name="TwoThousandElevenPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_TwoThousandElevenPlanMember"/>
  <xs:element name="UnitedStatesDollarMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_UnitedStatesDollarMember"/>
  <xs:element name="WarrantsIssuedAtTheFundRaisingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsIssuedAtTheFundRaisingMember"/>
  <xs:element name="XTEPOMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_XTEPOMember"/>
  <xs:element name="XTLsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_XTLsMember"/>
  <xs:element name="YedaAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_YedaAgreementMember"/>
  <xs:element name="hCDR1Member" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_hCDR1Member"/>
  <xs:element name="AdjustmentsToReconcileNetLossToNetCashUsedInOperatingActivitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_AdjustmentsToReconcileNetLossToNetCashUsedInOperatingActivitiesAbstract"/>
  <xs:element name="BasisOfPreparationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_BasisOfPreparationAbstract"/>
  <xs:element name="ChangesInOperatingAssetAndLiabilityItemsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ChangesInOperatingAssetAndLiabilityItemsAbstract"/>
  <xs:element name="CostOfServiceAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_CostOfServiceAbstract"/>
  <xs:element name="GeneralAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_GeneralAbstract"/>
  <xs:element name="IncomeAndExpensesNotInvolvingOperatingCashFlowsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_IncomeAndExpensesNotInvolvingOperatingCashFlowsAbstract"/>
  <xs:element name="ProfitLossPerShareAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ProfitLossPerShareAbstract"/>
  <xs:element name="ResearchAndDevelopmentExpensesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ResearchAndDevelopmentExpensesAbstract"/>
  <xs:element name="ScheduleOfAnnualAmortizationRatesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfAnnualAmortizationRatesAbstract"/>
  <xs:element name="ScheduleOfAssumptionsToEstimateTheWarrantsIssuedAtTheFundRaisingLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfAssumptionsToEstimateTheWarrantsIssuedAtTheFundRaisingLineItems"/>
  <xs:element name="ScheduleOfCostOfServiceAndAmortizationOfIntangibleAssetsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfCostOfServiceAndAmortizationOfIntangibleAssetsLineItems"/>
  <xs:element name="ScheduleOfLoansAndCreditFromBankingCorporationsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfLoansAndCreditFromBankingCorporationsAbstract"/>
  <xs:element name="ScheduleOfLossFromDiscontinuedOperationsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfLossFromDiscontinuedOperationsLineItems"/>
  <xs:element name="ScheduleOfOutstandingOptionsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfOutstandingOptionsLineItems"/>
  <xs:element name="ScheduleOfOutstandingWarrantsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfOutstandingWarrantsLineItems"/>
  <xs:element name="ScheduleOfResultsOfSocialProxyLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfResultsOfSocialProxyLineItems"/>
  <xs:element name="ScheduleOfWarrantSensitivityAnalysisLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ScheduleOfWarrantSensitivityAnalysisLineItems"/>
  <xs:element name="ShareBasedPaymentAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_ShareBasedPaymentAbstract"/>
  <xs:element name="TaxesOnIncomeLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_TaxesOnIncomeLineItems"/>
  <xs:element name="WarrantsIssuedAtTheFundRaisingAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsIssuedAtTheFundRaisingAbstract"/>
  <xs:element name="WarrantsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_WarrantsLineItems"/>
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  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="xtlb_DocumentAndEntityInformationAbstract"/>
</xs:schema>
