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Disclosure - Fair value of financial assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Short-term investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Property, plant and equipment, net (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Accrued expenses and other current liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Long-term debt - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Long-term debt - Schedule of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Long-term debt -Schedule of Maturity of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Stockholders’ Equity - Common Stock and Undesignated Preferred Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Stockholders' Equity - Schedule of Pre-funded Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Stockholders' Equity - ATM Program (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Stockholders' Equity - Equity offerings (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Pre-funded Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Stock-based compensation - Classification of expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Stock-based compensation - Additional information (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stock-based compensation - Assumptions to determine grant-date fair value of stock options (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - 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