<?xml version="1.0" encoding="utf-8"?>
<!--XBRL document created with Toppan Merrill Bridge  11.3.0.1 -->
<!--Based on XBRL 2.1-->
<!--Created on: 6/24/2026 5:38:08 PM-->
<!--Modified on: 6/24/2026 5:38:08 PM-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt">
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DocumentDocumentAndEntityInformation" roleURI="http://www.abbvie.com/role/DocumentDocumentAndEntityInformation" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#StatementStatementsOfNetAssetsAvailableForBenefits" roleURI="http://www.abbvie.com/role/StatementStatementsOfNetAssetsAvailableForBenefits" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#StatementStatementOfChangesInNetAssetsAvailableForBenefits" roleURI="http://www.abbvie.com/role/StatementStatementOfChangesInNetAssetsAvailableForBenefits" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlan" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlan" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureSummaryOfSignificantAccountingPolicies" roleURI="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPolicies" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureInvestments" roleURI="http://www.abbvie.com/role/DisclosureInvestments" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureRelatedPartyAndPartyInInterestTransactions" roleURI="http://www.abbvie.com/role/DisclosureRelatedPartyAndPartyInInterestTransactions" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosurePlanTermination" roleURI="http://www.abbvie.com/role/DisclosurePlanTermination" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureTaxStatus" roleURI="http://www.abbvie.com/role/DisclosureTaxStatus" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureSubsequentEvents" roleURI="http://www.abbvie.com/role/DisclosureSubsequentEvents" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYear" roleURI="http://www.abbvie.com/role/DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYear" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureSummaryOfSignificantAccountingPoliciesPolicies" roleURI="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesPolicies" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlanTables" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlanTables" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureSummaryOfSignificantAccountingPoliciesTables" roleURI="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesTables" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureInvestmentsTables" roleURI="http://www.abbvie.com/role/DisclosureInvestmentsTables" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlanMergersDetails" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlanMergersDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlanContributionsAndVestingDetails" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlanContributionsAndVestingDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlanEmployerAnnualContributionDetails" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlanEmployerAnnualContributionDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlanVestingDetails" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlanVestingDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlanDistributionsDetails" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlanDistributionsDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureDescriptionOfPlanNotesReceivableFromParticipantsDetails" roleURI="http://www.abbvie.com/role/DisclosureDescriptionOfPlanNotesReceivableFromParticipantsDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureSummaryOfSignificantAccountingPoliciesInvestmentValuationDetails" roleURI="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesInvestmentValuationDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureSummaryOfSignificantAccountingPoliciesNotesReceivableFromParticipantsDetails" roleURI="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesNotesReceivableFromParticipantsDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureInvestmentsDetails" roleURI="http://www.abbvie.com/role/DisclosureInvestmentsDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureRelatedPartyAndPartyInInterestTransactionsDetails" roleURI="http://www.abbvie.com/role/DisclosureRelatedPartyAndPartyInInterestTransactionsDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureTaxStatusDetails" roleURI="http://www.abbvie.com/role/DisclosureTaxStatusDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYearDetails" roleURI="http://www.abbvie.com/role/DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYearDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="abbv-20251231.xsd#DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYearDefaultDetails" roleURI="http://www.abbvie.com/role/DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYearDefaultDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <link:roleRef roleURI="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-roles-2026.xsd#eedm1" xlink:type="simple" />
  <link:roleRef roleURI="http://www.abbvie.com/role/DisclosureStandardAndCustomAxisDomainDefaults" xlink:href="abbv-20251231.xsd#DisclosureStandardAndCustomAxisDomainDefaults" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" />
  <link:arcroleRef arcroleURI="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd#wider-narrower" />
  <link:definitionLink xlink:role="http://www.abbvie.com/role/DisclosureStandardAndCustomAxisDomainDefaults" xlink:type="extended" xlink:title="99900 - Disclosure - Standard And Custom Axis Domain Defaults">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis_1" xlink:title="dei_LegalEntityAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain_1" xlink:title="dei_EntityDomain_1" />
    <link:definitionArc xlink:type="arc" xlink:from="dei_LegalEntityAxis_1" xlink:to="dei_EntityDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:dei_LegalEntityAxis_1 To dei_EntityDomain_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis_1" xlink:title="us-gaap_BusinessAcquisitionAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain_1" xlink:title="us-gaap_BusinessAcquisitionAcquireeDomain_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_BusinessAcquisitionAxis_1" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:us-gaap_BusinessAcquisitionAxis_1 To us-gaap_BusinessAcquisitionAcquireeDomain_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementScenarioAxis" xlink:label="srt_StatementScenarioAxis_1" xlink:title="srt_StatementScenarioAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="srt_ScenarioUnspecifiedDomain_1" xlink:title="srt_ScenarioUnspecifiedDomain_1" />
    <link:definitionArc xlink:type="arc" xlink:from="srt_StatementScenarioAxis_1" xlink:to="srt_ScenarioUnspecifiedDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:srt_StatementScenarioAxis_1 To srt_ScenarioUnspecifiedDomain_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis_1" xlink:title="srt_RangeAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember_1" xlink:title="srt_RangeMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="srt_RangeAxis_1" xlink:to="srt_RangeMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:srt_RangeAxis_1 To srt_RangeMember_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanVestingAxis" xlink:label="abbv_EmployeeBenefitPlanVestingAxis_1" xlink:title="abbv_EmployeeBenefitPlanVestingAxis_1" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanVestingDomain" xlink:label="abbv_EmployeeBenefitPlanVestingDomain_1" xlink:title="abbv_EmployeeBenefitPlanVestingDomain_1" />
    <link:definitionArc xlink:type="arc" xlink:from="abbv_EmployeeBenefitPlanVestingAxis_1" xlink:to="abbv_EmployeeBenefitPlanVestingDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:abbv_EmployeeBenefitPlanVestingAxis_1 To abbv_EmployeeBenefitPlanVestingDomain_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis_1" xlink:title="us-gaap_FairValueByFairValueHierarchyLevelAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1" xlink:title="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis_1" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:us-gaap_FairValueByFairValueHierarchyLevelAxis_1 To us-gaap_FairValueMeasurementsFairValueHierarchyDomain_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis_1" xlink:title="us-gaap_InvestmentTypeAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_1" xlink:title="us-gaap_InvestmentTypeCategorizationMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeAxis_1" xlink:to="us-gaap_InvestmentTypeCategorizationMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:us-gaap_InvestmentTypeAxis_1 To us-gaap_InvestmentTypeCategorizationMember_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis_1" xlink:title="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain_1" xlink:title="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis_1" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis_1 To us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain_1" order="1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameAxis" xlink:label="us-gaap_InvestmentIssuerNameAxis_1" xlink:title="us-gaap_InvestmentIssuerNameAxis_1" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_1" xlink:title="us-gaap_InvestmentIssuerNameDomain_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameAxis_1" xlink:to="us-gaap_InvestmentIssuerNameDomain_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:title="definition:us-gaap_InvestmentIssuerNameAxis_1 To us-gaap_InvestmentIssuerNameDomain_1" order="1" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:type="extended" xlink:title="SRT Extensible Enumeration Domain Members">
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_4" xlink:title="us-gaap_InvestmentTypeCategorizationMember_4" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" xlink:label="us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember_2" xlink:title="us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember_2" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeCategorizationMember_4" xlink:to="us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember_2" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentTypeCategorizationMember_4 To us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember_2" order="4" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_5" xlink:title="us-gaap_InvestmentTypeCategorizationMember_5" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EbpNonemployerCommonStockMember" xlink:label="us-gaap-ebp_EbpNonemployerCommonStockMember_1" xlink:title="us-gaap-ebp_EbpNonemployerCommonStockMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeCategorizationMember_5" xlink:to="us-gaap-ebp_EbpNonemployerCommonStockMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentTypeCategorizationMember_5 To us-gaap-ebp_EbpNonemployerCommonStockMember_1" order="5" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_6" xlink:title="us-gaap_InvestmentTypeCategorizationMember_6" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestBearingDepositsMember" xlink:label="us-gaap_InterestBearingDepositsMember_1" xlink:title="us-gaap_InterestBearingDepositsMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeCategorizationMember_6" xlink:to="us-gaap_InterestBearingDepositsMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentTypeCategorizationMember_6 To us-gaap_InterestBearingDepositsMember_1" order="6" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_7" xlink:title="us-gaap_InvestmentTypeCategorizationMember_7" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MoneyMarketFundsMember" xlink:label="us-gaap_MoneyMarketFundsMember_1" xlink:title="us-gaap_MoneyMarketFundsMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeCategorizationMember_7" xlink:to="us-gaap_MoneyMarketFundsMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentTypeCategorizationMember_7 To us-gaap_MoneyMarketFundsMember_1" order="7" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_8" xlink:title="us-gaap_InvestmentTypeCategorizationMember_8" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MutualFundMember" xlink:label="us-gaap_MutualFundMember_1" xlink:title="us-gaap_MutualFundMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeCategorizationMember_8" xlink:to="us-gaap_MutualFundMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentTypeCategorizationMember_8 To us-gaap_MutualFundMember_1" order="8" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_9" xlink:title="us-gaap_InvestmentTypeCategorizationMember_9" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" xlink:label="us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember_1" xlink:title="us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeCategorizationMember_9" xlink:to="us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentTypeCategorizationMember_9 To us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember_1" order="9" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember_10" xlink:title="us-gaap_InvestmentTypeCategorizationMember_10" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:label="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember_1" xlink:title="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentTypeCategorizationMember_10" xlink:to="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentTypeCategorizationMember_10 To us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember_1" order="10" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_2" xlink:title="us-gaap_InvestmentIssuerNameDomain_2" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_AbbvieIncMember" xlink:label="abbv_AbbvieIncMember_1" xlink:title="abbv_AbbvieIncMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_2" xlink:to="abbv_AbbvieIncMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_2 To abbv_AbbvieIncMember_1" order="2" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_3" xlink:title="us-gaap_InvestmentIssuerNameDomain_3" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_AbbottLaboratoriesMember" xlink:label="abbv_AbbottLaboratoriesMember_1" xlink:title="abbv_AbbottLaboratoriesMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_3" xlink:to="abbv_AbbottLaboratoriesMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_3 To abbv_AbbottLaboratoriesMember_1" order="3" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_4" xlink:title="us-gaap_InvestmentIssuerNameDomain_4" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_AmericanFundsEuropacificGrowthFundClassR6Member" xlink:label="abbv_AmericanFundsEuropacificGrowthFundClassR6Member_2" xlink:title="abbv_AmericanFundsEuropacificGrowthFundClassR6Member_2" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_4" xlink:to="abbv_AmericanFundsEuropacificGrowthFundClassR6Member_2" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_4 To abbv_AmericanFundsEuropacificGrowthFundClassR6Member_2" order="4" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_5" xlink:title="us-gaap_InvestmentIssuerNameDomain_5" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_VanguardFederalMoneyMarketMember" xlink:label="abbv_VanguardFederalMoneyMarketMember_1" xlink:title="abbv_VanguardFederalMoneyMarketMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_5" xlink:to="abbv_VanguardFederalMoneyMarketMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_5 To abbv_VanguardFederalMoneyMarketMember_1" order="5" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_6" xlink:title="us-gaap_InvestmentIssuerNameDomain_6" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_CapitalGroupEuropacificGrowthTrustClassU2Member" xlink:label="abbv_CapitalGroupEuropacificGrowthTrustClassU2Member_1" xlink:title="abbv_CapitalGroupEuropacificGrowthTrustClassU2Member_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_6" xlink:to="abbv_CapitalGroupEuropacificGrowthTrustClassU2Member_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_6 To abbv_CapitalGroupEuropacificGrowthTrustClassU2Member_1" order="7" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_7" xlink:title="us-gaap_InvestmentIssuerNameDomain_7" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_CapitalGroupGrowthFundOfAmericaClassU4Member" xlink:label="abbv_CapitalGroupGrowthFundOfAmericaClassU4Member_2" xlink:title="abbv_CapitalGroupGrowthFundOfAmericaClassU4Member_2" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_7" xlink:to="abbv_CapitalGroupGrowthFundOfAmericaClassU4Member_2" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_7 To abbv_CapitalGroupGrowthFundOfAmericaClassU4Member_2" order="8" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_8" xlink:title="us-gaap_InvestmentIssuerNameDomain_8" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_CapitalGroupWashingtonMutualInvestorsTrustClassU3Member" xlink:label="abbv_CapitalGroupWashingtonMutualInvestorsTrustClassU3Member_1" xlink:title="abbv_CapitalGroupWashingtonMutualInvestorsTrustClassU3Member_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_8" xlink:to="abbv_CapitalGroupWashingtonMutualInvestorsTrustClassU3Member_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_8 To abbv_CapitalGroupWashingtonMutualInvestorsTrustClassU3Member_1" order="9" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_9" xlink:title="us-gaap_InvestmentIssuerNameDomain_9" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_FiamCorePlusCollectiveInvestmentTrustClassUMember" xlink:label="abbv_FiamCorePlusCollectiveInvestmentTrustClassUMember_1" xlink:title="abbv_FiamCorePlusCollectiveInvestmentTrustClassUMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_9" xlink:to="abbv_FiamCorePlusCollectiveInvestmentTrustClassUMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_9 To abbv_FiamCorePlusCollectiveInvestmentTrustClassUMember_1" order="10" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_10" xlink:title="us-gaap_InvestmentIssuerNameDomain_10" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_GalliardStableReturnFundWMember" xlink:label="abbv_GalliardStableReturnFundWMember_1" xlink:title="abbv_GalliardStableReturnFundWMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_10" xlink:to="abbv_GalliardStableReturnFundWMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_10 To abbv_GalliardStableReturnFundWMember_1" order="11" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_11" xlink:title="us-gaap_InvestmentIssuerNameDomain_11" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_GalliardManagedIncomeFundCoreMember" xlink:label="abbv_GalliardManagedIncomeFundCoreMember_1" xlink:title="abbv_GalliardManagedIncomeFundCoreMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_11" xlink:to="abbv_GalliardManagedIncomeFundCoreMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_11 To abbv_GalliardManagedIncomeFundCoreMember_1" order="12" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_12" xlink:title="us-gaap_InvestmentIssuerNameDomain_12" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2025SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2025SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2025SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_12" xlink:to="abbv_StateStreetTargetRetirement2025SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_12 To abbv_StateStreetTargetRetirement2025SecuritiesLendingSeriesFundClassIvMember_1" order="13" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_13" xlink:title="us-gaap_InvestmentIssuerNameDomain_13" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2030SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2030SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2030SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_13" xlink:to="abbv_StateStreetTargetRetirement2030SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_13 To abbv_StateStreetTargetRetirement2030SecuritiesLendingSeriesFundClassIvMember_1" order="14" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_14" xlink:title="us-gaap_InvestmentIssuerNameDomain_14" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2035SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2035SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2035SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_14" xlink:to="abbv_StateStreetTargetRetirement2035SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_14 To abbv_StateStreetTargetRetirement2035SecuritiesLendingSeriesFundClassIvMember_1" order="15" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_15" xlink:title="us-gaap_InvestmentIssuerNameDomain_15" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2040SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2040SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2040SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_15" xlink:to="abbv_StateStreetTargetRetirement2040SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_15 To abbv_StateStreetTargetRetirement2040SecuritiesLendingSeriesFundClassIvMember_1" order="16" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_16" xlink:title="us-gaap_InvestmentIssuerNameDomain_16" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2045SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2045SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2045SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_16" xlink:to="abbv_StateStreetTargetRetirement2045SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_16 To abbv_StateStreetTargetRetirement2045SecuritiesLendingSeriesFundClassIvMember_1" order="17" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_17" xlink:title="us-gaap_InvestmentIssuerNameDomain_17" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2050SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2050SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2050SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_17" xlink:to="abbv_StateStreetTargetRetirement2050SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_17 To abbv_StateStreetTargetRetirement2050SecuritiesLendingSeriesFundClassIvMember_1" order="18" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_18" xlink:title="us-gaap_InvestmentIssuerNameDomain_18" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2055SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2055SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2055SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_18" xlink:to="abbv_StateStreetTargetRetirement2055SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_18 To abbv_StateStreetTargetRetirement2055SecuritiesLendingSeriesFundClassIvMember_1" order="19" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_19" xlink:title="us-gaap_InvestmentIssuerNameDomain_19" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2060SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2060SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2060SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_19" xlink:to="abbv_StateStreetTargetRetirement2060SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_19 To abbv_StateStreetTargetRetirement2060SecuritiesLendingSeriesFundClassIvMember_1" order="20" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_20" xlink:title="us-gaap_InvestmentIssuerNameDomain_20" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2065SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2065SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2065SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_20" xlink:to="abbv_StateStreetTargetRetirement2065SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_20 To abbv_StateStreetTargetRetirement2065SecuritiesLendingSeriesFundClassIvMember_1" order="21" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_21" xlink:title="us-gaap_InvestmentIssuerNameDomain_21" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirement2070SecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirement2070SecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirement2070SecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_21" xlink:to="abbv_StateStreetTargetRetirement2070SecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_21 To abbv_StateStreetTargetRetirement2070SecuritiesLendingSeriesFundClassIvMember_1" order="22" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_22" xlink:title="us-gaap_InvestmentIssuerNameDomain_22" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetTargetRetirementIncomeSecuritiesLendingSeriesFundClassIvMember" xlink:label="abbv_StateStreetTargetRetirementIncomeSecuritiesLendingSeriesFundClassIvMember_1" xlink:title="abbv_StateStreetTargetRetirementIncomeSecuritiesLendingSeriesFundClassIvMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_22" xlink:to="abbv_StateStreetTargetRetirementIncomeSecuritiesLendingSeriesFundClassIvMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_22 To abbv_StateStreetTargetRetirementIncomeSecuritiesLendingSeriesFundClassIvMember_1" order="23" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_23" xlink:title="us-gaap_InvestmentIssuerNameDomain_23" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetGlobalAllcapEquityExUsIndexSecuritiesLendingSeriesFundClassXMember" xlink:label="abbv_StateStreetGlobalAllcapEquityExUsIndexSecuritiesLendingSeriesFundClassXMember_1" xlink:title="abbv_StateStreetGlobalAllcapEquityExUsIndexSecuritiesLendingSeriesFundClassXMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_23" xlink:to="abbv_StateStreetGlobalAllcapEquityExUsIndexSecuritiesLendingSeriesFundClassXMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_23 To abbv_StateStreetGlobalAllcapEquityExUsIndexSecuritiesLendingSeriesFundClassXMember_1" order="24" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_24" xlink:title="us-gaap_InvestmentIssuerNameDomain_24" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetSP500IndexSecuritiesLendingSeriesFundClassXMember" xlink:label="abbv_StateStreetSP500IndexSecuritiesLendingSeriesFundClassXMember_1" xlink:title="abbv_StateStreetSP500IndexSecuritiesLendingSeriesFundClassXMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_24" xlink:to="abbv_StateStreetSP500IndexSecuritiesLendingSeriesFundClassXMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_24 To abbv_StateStreetSP500IndexSecuritiesLendingSeriesFundClassXMember_1" order="25" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_25" xlink:title="us-gaap_InvestmentIssuerNameDomain_25" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetUsBondIndexSecuritiesLendingSeriesFundClassXMember" xlink:label="abbv_StateStreetUsBondIndexSecuritiesLendingSeriesFundClassXMember_1" xlink:title="abbv_StateStreetUsBondIndexSecuritiesLendingSeriesFundClassXMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_25" xlink:to="abbv_StateStreetUsBondIndexSecuritiesLendingSeriesFundClassXMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_25 To abbv_StateStreetUsBondIndexSecuritiesLendingSeriesFundClassXMember_1" order="26" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_26" xlink:title="us-gaap_InvestmentIssuerNameDomain_26" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_StateStreetUsExtendedMarketIndexSecuritiesLendingSeriesFundClassXMember" xlink:label="abbv_StateStreetUsExtendedMarketIndexSecuritiesLendingSeriesFundClassXMember_1" xlink:title="abbv_StateStreetUsExtendedMarketIndexSecuritiesLendingSeriesFundClassXMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_26" xlink:to="abbv_StateStreetUsExtendedMarketIndexSecuritiesLendingSeriesFundClassXMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_26 To abbv_StateStreetUsExtendedMarketIndexSecuritiesLendingSeriesFundClassXMember_1" order="27" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_27" xlink:title="us-gaap_InvestmentIssuerNameDomain_27" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_WellingtonCifIiSmidCapResearchClassS5Member" xlink:label="abbv_WellingtonCifIiSmidCapResearchClassS5Member_1" xlink:title="abbv_WellingtonCifIiSmidCapResearchClassS5Member_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_27" xlink:to="abbv_WellingtonCifIiSmidCapResearchClassS5Member_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_27 To abbv_WellingtonCifIiSmidCapResearchClassS5Member_1" order="28" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_28" xlink:title="us-gaap_InvestmentIssuerNameDomain_28" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_CapitalGroupWashingtonMutualInvestmentTrustClassU3Member" xlink:label="abbv_CapitalGroupWashingtonMutualInvestmentTrustClassU3Member_1" xlink:title="abbv_CapitalGroupWashingtonMutualInvestmentTrustClassU3Member_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_28" xlink:to="abbv_CapitalGroupWashingtonMutualInvestmentTrustClassU3Member_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_28 To abbv_CapitalGroupWashingtonMutualInvestmentTrustClassU3Member_1" order="30" priority="0" />
    <link:loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIssuerNameDomain" xlink:label="us-gaap_InvestmentIssuerNameDomain_29" xlink:title="us-gaap_InvestmentIssuerNameDomain_29" />
    <link:loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_GalliardStableReturnFundXMember" xlink:label="abbv_GalliardStableReturnFundXMember_1" xlink:title="abbv_GalliardStableReturnFundXMember_1" />
    <link:definitionArc xlink:type="arc" xlink:from="us-gaap_InvestmentIssuerNameDomain_29" xlink:to="abbv_GalliardStableReturnFundXMember_1" use="optional" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:title="definition:us-gaap_InvestmentIssuerNameDomain_29 To abbv_GalliardStableReturnFundXMember_1" order="31" priority="0" />
  </link:definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DocumentDocumentAndEntityInformation" xlink:type="extended" xlink:title="00090 - Document - Document and Entity Information" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationTable" xlink:label="dei_DocumentInformationTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="dei_DocumentInformationTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationLineItems" xlink:label="dei_DocumentInformationLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentInformationTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType" xlink:label="dei_DocumentType" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentType" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityRegistrantName" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber" xlink:label="dei_EntityTaxIdentificationNumber" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityTaxIdentificationNumber" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey" xlink:label="dei_EntityCentralIndexKey" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityCentralIndexKey" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag" xlink:label="dei_AmendmentFlag" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_AmendmentFlag" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/StatementStatementsOfNetAssetsAvailableForBenefits" xlink:type="extended" xlink:title="00100 - Statement - STATEMENTS OF NET ASSETS AVAILABLE FOR BENEFITS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanCash" xlink:label="us-gaap-ebp_EmployeeBenefitPlanCash" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanCash" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanEmployerContributionReceivable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanEmployerContributionReceivable" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanEmployerContributionReceivable" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanTransactionPendingInvestment" xlink:label="abbv_EmployeeBenefitPlanTransactionPendingInvestment" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:to="abbv_EmployeeBenefitPlanTransactionPendingInvestment" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAsset" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAsset" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAsset" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:label="us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccruedExpense" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccruedExpense" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAccruedExpense" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanParticipantLiability" xlink:label="us-gaap-ebp_EmployeeBenefitPlanParticipantLiability" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanParticipantLiability" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanLiability" xlink:label="us-gaap-ebp_EmployeeBenefitPlanLiability" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanLiability" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/StatementStatementOfChangesInNetAssetsAvailableForBenefits" xlink:type="extended" xlink:title="00200 - Statement - STATEMENT OF CHANGES IN NET ASSETS AVAILABLE FOR BENEFITS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContributionAbstract" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContributionAbstract" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContributionAbstract" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContribution" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContribution" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContributionAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContribution" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionExcludingRollover" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionExcludingRollover" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContributionAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionExcludingRollover" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionRollover" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionRollover" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContributionAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionRollover" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContribution" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContribution" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContributionAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForContribution" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestmentAbstract" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestmentAbstract" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestmentAbstract" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForUnrealizedGainLossOnInvestment" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForUnrealizedGainLossOnInvestment" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestmentAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForUnrealizedGainLossOnInvestment" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestAndDividendIncomeOnInvestment" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestAndDividendIncomeOnInvestment" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestmentAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestAndDividendIncomeOnInvestment" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestmentAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncrease" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncrease" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncrease" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseAbstract" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseAbstract" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseAbstract" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForOtherExpense" xlink:label="abbv_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForOtherExpense" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseAbstract" xlink:to="abbv_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForOtherExpense" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitTransferToFromExternalPlan" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitTransferToFromExternalPlan" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitTransferToFromExternalPlan" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreasePostTransfersToPlan" xlink:label="abbv_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreasePostTransfersToPlan" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseAbstract" xlink:to="abbv_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreasePostTransfersToPlan" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlan" xlink:type="extended" xlink:title="10101 - Disclosure - DESCRIPTION OF THE PLAN" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPolicies" xlink:type="extended" xlink:title="10201 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureInvestments" xlink:type="extended" xlink:title="10301 - Disclosure - INVESTMENTS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanInvestmentsInEmployerCommonStockTextBlock" xlink:label="abbv_EmployeeBenefitPlanInvestmentsInEmployerCommonStockTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="abbv_EmployeeBenefitPlanInvestmentsInEmployerCommonStockTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureRelatedPartyAndPartyInInterestTransactions" xlink:type="extended" xlink:title="10401 - Disclosure - RELATED-PARTY AND PARTY-IN-INTEREST TRANSACTIONS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosurePlanTermination" xlink:type="extended" xlink:title="10501 - Disclosure - PLAN TERMINATION" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanPlanTerminationTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanPlanTerminationTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanPlanTerminationTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureTaxStatus" xlink:type="extended" xlink:title="10601 - Disclosure - TAX STATUS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureSubsequentEvents" xlink:type="extended" xlink:title="10701 - Disclosure - SUBSEQUENT EVENTS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EbpSubsequentEventTable" xlink:label="us-gaap-ebp_EbpSubsequentEventTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EbpSubsequentEventTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EbpSubsequentEventLineItems" xlink:label="us-gaap-ebp_EbpSubsequentEventLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EbpSubsequentEventLineItems" xlink:to="us-gaap-ebp_EbpSubsequentEventTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSubsequentEventTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanSubsequentEventTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EbpSubsequentEventLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanSubsequentEventTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYear" xlink:type="extended" xlink:title="10801 - Disclosure - SCHEDULE H, LINE 4i - SCHEDULE OF ASSETS (HELD AT END OF YEAR)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended" xlink:title="20202 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanIncomeRecognitionPolicyTextBlock" xlink:label="abbv_EmployeeBenefitPlanIncomeRecognitionPolicyTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="abbv_EmployeeBenefitPlanIncomeRecognitionPolicyTextBlock" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanPaymentToParticipantPolicyTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanPaymentToParticipantPolicyTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="7" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanPaymentToParticipantPolicyTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlanTables" xlink:type="extended" xlink:title="30103 - Disclosure - DESCRIPTION OF THE PLAN (Tables)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanContributionTableTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanContributionTableTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanContributionTableTextBlock" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanVestingPercentageTableTextBlock" xlink:label="abbv_EmployeeBenefitPlanVestingPercentageTableTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanVestingPercentageTableTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesTables" xlink:type="extended" xlink:title="30203 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureInvestmentsTables" xlink:type="extended" xlink:title="30303 - Disclosure - INVESTMENTS (Tables)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanInvestmentInEmployerCommonStockTableTextBlock" xlink:label="abbv_EmployeeBenefitPlanInvestmentInEmployerCommonStockTableTextBlock" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="abbv_EmployeeBenefitPlanInvestmentInEmployerCommonStockTableTextBlock" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlanMergersDetails" xlink:type="extended" xlink:title="40101 - Disclosure - DESCRIPTION OF THE PLAN - Mergers (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="us-gaap_BusinessAcquisitionAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_ImmunogenIncMember" xlink:label="abbv_ImmunogenIncMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="abbv_ImmunogenIncMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_CerevelTherapeuticsLlcMember" xlink:label="abbv_CerevelTherapeuticsLlcMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="abbv_CerevelTherapeuticsLlcMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_NimbleTherapeuticsIncMember" xlink:label="abbv_NimbleTherapeuticsIncMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="abbv_NimbleTherapeuticsIncMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitTransferToFromExternalPlan" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitTransferToFromExternalPlan" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitTransferToFromExternalPlan" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlanContributionsAndVestingDetails" xlink:type="extended" xlink:title="40102 - Disclosure - DESCRIPTION OF THE PLAN - Contributions and Vesting (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="srt_RangeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="srt_RangeAxis" xlink:to="srt_RangeMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="srt_RangeMember" xlink:to="srt_MinimumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="srt_RangeMember" xlink:to="srt_MaximumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementScenarioAxis" xlink:label="srt_StatementScenarioAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="srt_StatementScenarioAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="srt_ScenarioUnspecifiedDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="srt_StatementScenarioAxis" xlink:to="srt_ScenarioUnspecifiedDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeesNotCoveredUnderAspPlusMember" xlink:label="abbv_EmployeesNotCoveredUnderAspPlusMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_EmployeesNotCoveredUnderAspPlusMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeesCoveredUnderAspPlusMember" xlink:label="abbv_EmployeesCoveredUnderAspPlusMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_EmployeesCoveredUnderAspPlusMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanParticipantContributionPercentage" xlink:label="abbv_EmployeeBenefitPlanParticipantContributionPercentage" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanParticipantContributionPercentage" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" xlink:label="us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanEmployerContributionMatchingPercentage" xlink:label="us-gaap-ebp_EmployeeBenefitPlanEmployerContributionMatchingPercentage" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanEmployerContributionMatchingPercentage" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanNumberOfPubliclyTradedCompanies" xlink:label="abbv_EmployeeBenefitPlanNumberOfPubliclyTradedCompanies" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanNumberOfPubliclyTradedCompanies" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanNumberOfSharesExchangedPerSharesHeld" xlink:label="abbv_EmployeeBenefitPlanNumberOfSharesExchangedPerSharesHeld" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanNumberOfSharesExchangedPerSharesHeld" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanEmployerCommonStockDividendDistributionPeriod" xlink:label="abbv_EmployeeBenefitPlanEmployerCommonStockDividendDistributionPeriod" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="7" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanEmployerCommonStockDividendDistributionPeriod" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanNumberOfConsecutiveBreakYears" xlink:label="abbv_EmployeeBenefitPlanNumberOfConsecutiveBreakYears" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="8" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanNumberOfConsecutiveBreakYears" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanSeverancePeriod" xlink:label="abbv_EmployeeBenefitPlanSeverancePeriod" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="9" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanSeverancePeriod" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanForfeitedNonvestedAccountDecreaseForEmployerContribution" xlink:label="us-gaap-ebp_EmployeeBenefitPlanForfeitedNonvestedAccountDecreaseForEmployerContribution" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="10" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanForfeitedNonvestedAccountDecreaseForEmployerContribution" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanForfeitedNonvestedAccount" xlink:label="us-gaap-ebp_EmployeeBenefitPlanForfeitedNonvestedAccount" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="11" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanForfeitedNonvestedAccount" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlanEmployerAnnualContributionDetails" xlink:type="extended" xlink:title="40103 - Disclosure - DESCRIPTION OF THE PLAN - Employer Annual Contribution (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementScenarioAxis" xlink:label="srt_StatementScenarioAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="srt_StatementScenarioAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="srt_ScenarioUnspecifiedDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="srt_StatementScenarioAxis" xlink:to="srt_ScenarioUnspecifiedDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_YearsOfAgeAndYearsOfServiceLessThan30Member" xlink:label="abbv_YearsOfAgeAndYearsOfServiceLessThan30Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_YearsOfAgeAndYearsOfServiceLessThan30Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_YearsOfAgeAndYearsOfServiceBetween30And39Member" xlink:label="abbv_YearsOfAgeAndYearsOfServiceBetween30And39Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_YearsOfAgeAndYearsOfServiceBetween30And39Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_YearsOfAgeAndYearsOfServiceBetween40And49Member" xlink:label="abbv_YearsOfAgeAndYearsOfServiceBetween40And49Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_YearsOfAgeAndYearsOfServiceBetween40And49Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_YearsOfAgeAndYearsOfServiceBetween50And59Member" xlink:label="abbv_YearsOfAgeAndYearsOfServiceBetween50And59Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_YearsOfAgeAndYearsOfServiceBetween50And59Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_YearsOfAgeAndYearsOfServiceBetween60And69Member" xlink:label="abbv_YearsOfAgeAndYearsOfServiceBetween60And69Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_YearsOfAgeAndYearsOfServiceBetween60And69Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_YearsOfAgeAndYearsOfService70OrMoreMember" xlink:label="abbv_YearsOfAgeAndYearsOfService70OrMoreMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="abbv_YearsOfAgeAndYearsOfService70OrMoreMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanEmployerAnnualContributionForAspPlusCoveredEmployees" xlink:label="abbv_EmployeeBenefitPlanEmployerAnnualContributionForAspPlusCoveredEmployees" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanEmployerAnnualContributionForAspPlusCoveredEmployees" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlanVestingDetails" xlink:type="extended" xlink:title="40104 - Disclosure - DESCRIPTION OF THE PLAN - Vesting (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanVestingAxis" xlink:label="abbv_EmployeeBenefitPlanVestingAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="abbv_EmployeeBenefitPlanVestingAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanVestingDomain" xlink:label="abbv_EmployeeBenefitPlanVestingDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="abbv_EmployeeBenefitPlanVestingAxis" xlink:to="abbv_EmployeeBenefitPlanVestingDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceLessThanTwoYearsMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceLessThanTwoYearsMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceLessThanTwoYearsMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceTwoYearsOrMoreMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceTwoYearsOrMoreMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceTwoYearsOrMoreMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceLessThanOneYearMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceLessThanOneYearMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceLessThanOneYearMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceOneYearMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceOneYearMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceOneYearMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceTwoYearsMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceTwoYearsMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceTwoYearsMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceThreeYearsMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceThreeYearsMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceThreeYearsMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceFourYearsMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceFourYearsMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="7" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceFourYearsMember" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanYearsOfVestingServiceFiveYearsOrMoreMember" xlink:label="abbv_EmployeeBenefitPlanYearsOfVestingServiceFiveYearsOrMoreMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="8" xlink:from="abbv_EmployeeBenefitPlanVestingDomain" xlink:to="abbv_EmployeeBenefitPlanYearsOfVestingServiceFiveYearsOrMoreMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanMatchingContributionVestingPercentage" xlink:label="abbv_EmployeeBenefitPlanMatchingContributionVestingPercentage" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanMatchingContributionVestingPercentage" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanAnnualContributionVestingPercentage" xlink:label="abbv_EmployeeBenefitPlanAnnualContributionVestingPercentage" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanAnnualContributionVestingPercentage" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlanDistributionsDetails" xlink:type="extended" xlink:title="40105 - Disclosure - DESCRIPTION OF THE PLAN - Distributions (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EbpEmployeesAgeOfParticipantsMinimumDistributionCommencement" xlink:label="abbv_EbpEmployeesAgeOfParticipantsMinimumDistributionCommencement" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EbpEmployeesAgeOfParticipantsMinimumDistributionCommencement" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureDescriptionOfPlanNotesReceivableFromParticipantsDetails" xlink:type="extended" xlink:title="40106 - Disclosure - DESCRIPTION OF THE PLAN - Notes Receivable from Participants (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="srt_RangeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="srt_RangeAxis" xlink:to="srt_RangeMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="srt_RangeMember" xlink:to="srt_MinimumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="srt_RangeMember" xlink:to="srt_MaximumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMinimumBorrowingAmount" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMinimumBorrowingAmount" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMinimumBorrowingAmount" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanNumberOfLoansPerParticipant" xlink:label="abbv_EmployeeBenefitPlanNumberOfLoansPerParticipant" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanNumberOfLoansPerParticipant" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanNoteReceivableFromParticipantMaximumTerm" xlink:label="abbv_EmployeeBenefitPlanNoteReceivableFromParticipantMaximumTerm" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanNoteReceivableFromParticipantMaximumTerm" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanNoteReceivableFromParticipantMaximumTermIfProceedsUsedToPurchasePrimaryResidence" xlink:label="abbv_EmployeeBenefitPlanNoteReceivableFromParticipantMaximumTermIfProceedsUsedToPurchasePrimaryResidence" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="7" xlink:from="us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:to="abbv_EmployeeBenefitPlanNoteReceivableFromParticipantMaximumTermIfProceedsUsedToPurchasePrimaryResidence" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesInvestmentValuationDetails" xlink:type="extended" xlink:title="40201 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Investment Valuation (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:to="us-gaap_FairValueByFairValueHierarchyLevelAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="us-gaap_FairValueInputsLevel1Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_FairValueInputsLevel1Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:to="us-gaap_InvestmentTypeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap_InvestmentTypeAxis" xlink:to="us-gaap_InvestmentTypeCategorizationMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestBearingDepositsMember" xlink:label="us-gaap_InterestBearingDepositsMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_InterestBearingDepositsMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember" xlink:label="us-gaap_CommonStockMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_CommonStockMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MutualFundMember" xlink:label="us-gaap_MutualFundMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_MutualFundMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" xlink:label="us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:label="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureSummaryOfSignificantAccountingPoliciesNotesReceivableFromParticipantsDetails" xlink:type="extended" xlink:title="40202 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Notes Receivable from Participants (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAllowanceForCreditLoss" xlink:label="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAllowanceForCreditLoss" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAllowanceForCreditLoss" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureInvestmentsDetails" xlink:type="extended" xlink:title="40301 - Disclosure - INVESTMENTS (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="us-gaap_InvestmentTypeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap_InvestmentTypeAxis" xlink:to="us-gaap_InvestmentTypeCategorizationMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" xlink:label="us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanEmployerMember" xlink:label="abbv_EmployeeBenefitPlanEmployerMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" xlink:to="abbv_EmployeeBenefitPlanEmployerMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentNumberOfShares" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentNumberOfShares" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentNumberOfShares" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanFairValuePerShareOrUnit" xlink:label="abbv_EmployeeBenefitPlanFairValuePerShareOrUnit" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="abbv_EmployeeBenefitPlanFairValuePerShareOrUnit" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureRelatedPartyAndPartyInInterestTransactionsDetails" xlink:type="extended" xlink:title="40401 - Disclosure - RELATED-PARTY AND PARTY-IN-INTEREST TRANSACTIONS (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="us-gaap_InvestmentTypeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap_InvestmentTypeAxis" xlink:to="us-gaap_InvestmentTypeCategorizationMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" xlink:label="us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestAxis" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EmployeeBenefitPlanEmployerMember" xlink:label="abbv_EmployeeBenefitPlanEmployerMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestDomain" xlink:to="abbv_EmployeeBenefitPlanEmployerMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForDividendIncomeOnInvestment" xlink:label="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForDividendIncomeOnInvestment" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForDividendIncomeOnInvestment" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureTaxStatusDetails" xlink:type="extended" xlink:title="40601 - Disclosure - TAX STATUS (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxDeterminationLetterObtained" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxDeterminationLetterObtained" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanTaxDeterminationLetterObtained" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxDeterminationLetterDate" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxDeterminationLetterDate" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanTaxDeterminationLetterDate" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxQualificationStatusExtensibleEnumeration" xlink:label="us-gaap-ebp_EmployeeBenefitPlanTaxQualificationStatusExtensibleEnumeration" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanTaxQualificationStatusExtensibleEnumeration" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYearDetails" xlink:type="extended" xlink:title="40801 - Disclosure - SCHEDULE H, LINE 4i - SCHEDULE OF ASSETS (HELD AT END OF YEAR) (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="srt_RangeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="srt_RangeAxis" xlink:to="srt_RangeMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="srt_RangeMember" xlink:to="srt_MaximumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="srt_RangeMember" xlink:to="srt_MinimumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="us-gaap_InvestmentTypeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap_InvestmentTypeAxis" xlink:to="us-gaap_InvestmentTypeCategorizationMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestBearingDepositsMember" xlink:label="us-gaap_InterestBearingDepositsMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_InterestBearingDepositsMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:label="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIdentifierAxis" xlink:label="us-gaap_InvestmentIdentifierAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="us-gaap_InvestmentIdentifierAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber" xlink:label="dei_EntityTaxIdentificationNumber" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="dei_EntityTaxIdentificationNumber" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanPlanNumber" xlink:label="us-gaap-ebp_EmployeeBenefitPlanPlanNumber" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanPlanNumber" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentIssuerNameExtensibleEnumeration" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentIssuerNameExtensibleEnumeration" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentIssuerNameExtensibleEnumeration" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentTypeExtensibleEnumeration" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentTypeExtensibleEnumeration" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentTypeExtensibleEnumeration" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="7" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" xlink:label="us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="8" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="9" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentPartyInInterest" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentPartyInInterest" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="10" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentPartyInInterest" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustParticipationStatusExtensibleEnumeration" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustParticipationStatusExtensibleEnumeration" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="11" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustParticipationStatusExtensibleEnumeration" priority="1" use="optional" />
  </definitionLink>
  <definitionLink xlink:role="http://www.abbvie.com/role/DisclosureScheduleHLine4iScheduleOfAssetsHeldAtEndOfYearDefaultDetails" xlink:type="extended" xlink:title="40801 - Disclosure - SCHEDULE H, LINE 4i - SCHEDULE OF ASSETS (HELD AT END OF YEAR) Default (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:label="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="dei_LegalEntityAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="dei_LegalEntityAxis" xlink:to="dei_EntityDomain" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP001Member" xlink:label="abbv_EBP001Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP001Member" use="optional" />
    <loc xlink:type="locator" xlink:href="abbv-20251231.xsd#abbv_EBP002Member" xlink:label="abbv_EBP002Member" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="dei_EntityDomain" xlink:to="abbv_EBP002Member" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="srt_RangeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember" xlink:label="srt_RangeMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="srt_RangeAxis" xlink:to="srt_RangeMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="srt_RangeMember" xlink:to="srt_MaximumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="srt_RangeMember" xlink:to="srt_MinimumMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="us-gaap_InvestmentTypeAxis" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" order="1" xlink:from="us-gaap_InvestmentTypeAxis" xlink:to="us-gaap_InvestmentTypeCategorizationMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestBearingDepositsMember" xlink:label="us-gaap_InterestBearingDepositsMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="1" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_InterestBearingDepositsMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:label="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:label="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" order="1" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber" xlink:label="dei_EntityTaxIdentificationNumber" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="2" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="dei_EntityTaxIdentificationNumber" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanPlanNumber" xlink:label="us-gaap-ebp_EmployeeBenefitPlanPlanNumber" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="3" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanPlanNumber" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentIssuerNameExtensibleEnumeration" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentIssuerNameExtensibleEnumeration" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="4" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentIssuerNameExtensibleEnumeration" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentTypeExtensibleEnumeration" xlink:label="us-gaap-ebp_EmployeeBenefitPlanInvestmentTypeExtensibleEnumeration" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="5" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanInvestmentTypeExtensibleEnumeration" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="6" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="7" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" xlink:label="us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="8" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="9" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentPartyInInterest" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentPartyInInterest" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="10" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentPartyInInterest" priority="1" use="optional" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustParticipationStatusExtensibleEnumeration" xlink:label="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustParticipationStatusExtensibleEnumeration" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" order="11" xlink:from="us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:to="us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustParticipationStatusExtensibleEnumeration" priority="1" use="optional" />
  </definitionLink>
</link:linkbase>
