0001813814 2026-06-24 2026-06-24 0001813814 1 2026-06-24 2026-06-24 iso4217:USD pure shares S-3 424B5 EX-FILING FEES 333-280548 0001813814 Definium Therapeutics, Inc. N/A N/A S-3 Definium Therapeutics, Inc. false Equity Common Shares, without par value true 23676471 34.00 805000014.00 0.0001381 111170.50 805000014.00 111170.50 0.00 0.00 111170.50 a) Calculated in accordance with Rule 457(r) under the Securities Act of 1933, as amended (the "Securities Act"). In accordance with Rules 456(b) and 457(r) under the Securities Act, the Registrant initially deferred payment of all of the registration fees for the registration statement on Form S-3 (Registration No. 333-280548), filed on June 28, 2024, other than in connection with $150,000,000 of common shares of the Registrant, without par value (the "Common Shares"), that may be issued and sold from time to time under the prospectus supplement included therein. b) Assumes exercise in full of the underwriters' option to purchase up to 3,088,235 additional Common Shares. 805000014.00 true