<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created with Toppan Merrill Bridge  11.3.0.1 -->
<!--Based on XBRL 2.1-->
<!--Created on: 6/24/2026 1:16:50 AM-->
<!--Modified on: 6/24/2026 1:16:50 AM-->
<link:linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink">
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#StatementCondensedConsolidatedBalanceSheets" roleURI="http://www.liminatuspharma.com/role/StatementCondensedConsolidatedBalanceSheets" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#StatementCondensedConsolidatedStatementsOfCashFlows" roleURI="http://www.liminatuspharma.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#StatementConsolidatedBalanceSheets" roleURI="http://www.liminatuspharma.com/role/StatementConsolidatedBalanceSheets" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#StatementConsolidatedStatementsOfOperations" roleURI="http://www.liminatuspharma.com/role/StatementConsolidatedStatementsOfOperations" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#StatementConsolidatedStatementsOfCashFlows" roleURI="http://www.liminatuspharma.com/role/StatementConsolidatedStatementsOfCashFlows" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#DisclosureIncomeTaxesIncomeTaxProvisionDetailss" roleURI="http://www.liminatuspharma.com/role/DisclosureIncomeTaxesIncomeTaxProvisionDetailss" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#DisclosureIncomeTaxesReconciliationOfIncomeTaxRateDetailss" roleURI="http://www.liminatuspharma.com/role/DisclosureIncomeTaxesReconciliationOfIncomeTaxRateDetailss" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="limn-20260331.xsd#DisclosureIncomeTaxesDeferredTaxAssetsAndLiabilitiesDetailss" roleURI="http://www.liminatuspharma.com/role/DisclosureIncomeTaxesDeferredTaxAssetsAndLiabilitiesDetailss" xmlns="http://www.xbrl.org/2003/linkbase" />
  <link:roleRef roleURI="http://www.liminatuspharma.com/role/DisclosureFairValueMeasurementsChangesInFairValueOfLevel3Details" xlink:type="simple" xlink:href="limn-20260331.xsd#DisclosureFairValueMeasurementsChangesInFairValueOfLevel3Details" />
  <link:roleRef roleURI="http://www.liminatuspharma.com/role/DisclosureFairValueMeasurementsDetails" xlink:type="simple" xlink:href="limn-20260331.xsd#DisclosureFairValueMeasurementsDetails" />
  <link:roleRef roleURI="http://www.liminatuspharma.com/role/DisclosureFairValueMeasurementsTables" xlink:type="simple" xlink:href="limn-20260331.xsd#DisclosureFairValueMeasurementsTables" />
  <link:roleRef roleURI="http://www.liminatuspharma.com/role/DisclosureFairValueMeasurements" xlink:type="simple" xlink:href="limn-20260331.xsd#DisclosureFairValueMeasurements" />
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item" />
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/StatementCondensedConsolidatedBalanceSheets" xlink:type="extended" xlink:title="1100100 - Statement - Condensed Consolidated Balance Sheets" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_AssetsCurrent_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Cash" xlink:label="us-gaap_Cash_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639178606082987389" xlink:to="us-gaap_Cash_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NotesAndLoansReceivableNetCurrent" xlink:label="us-gaap_NotesAndLoansReceivableNetCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639178606082987389" xlink:to="us-gaap_NotesAndLoansReceivableNetCurrent_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredCostsCurrent" xlink:label="us-gaap_DeferredCostsCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639178606082987389" xlink:to="us-gaap_DeferredCostsCurrent_639178606082987389" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639178606082987389" xlink:to="us-gaap_PrepaidExpenseAndOtherAssetsCurrent_639178606082987389" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsNoncurrent" xlink:label="us-gaap_AssetsNoncurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_AssetsNoncurrent_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherReceivableAfterAllowanceForCreditLossNoncurrent" xlink:label="us-gaap_OtherReceivableAfterAllowanceForCreditLossNoncurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsNoncurrent_639178606082987389" xlink:to="us-gaap_OtherReceivableAfterAllowanceForCreditLossNoncurrent_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsNoncurrent_639178606082987389" xlink:to="us-gaap_PropertyPlantAndEquipmentNet_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities" xlink:label="us-gaap_Liabilities_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_Liabilities_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Liabilities_639178606082987389" xlink:to="us-gaap_LiabilitiesCurrent_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639178606082987389" xlink:to="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_AccruedInterestCurrent" xlink:label="limn_AccruedInterestCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639178606082987389" xlink:to="limn_AccruedInterestCurrent_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="us-gaap_OtherLiabilitiesCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639178606082987389" xlink:to="us-gaap_OtherLiabilitiesCurrent_639178606082987389" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermBorrowings" xlink:label="us-gaap_ShortTermBorrowings_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639178606082987389" xlink:to="us-gaap_ShortTermBorrowings_639178606082987389" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_DeferredUnderwritingFeesPayableInCashCurrent" xlink:label="limn_DeferredUnderwritingFeesPayableInCashCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639178606082987389" xlink:to="limn_DeferredUnderwritingFeesPayableInCashCurrent_639178606082987389" order="5" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_CommonStockPayable" xlink:label="limn_CommonStockPayable_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639178606082987389" xlink:to="limn_CommonStockPayable_639178606082987389" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="us-gaap_WarrantsAndRightsOutstanding_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Liabilities_639178606082987389" xlink:to="us-gaap_WarrantsAndRightsOutstanding_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="us-gaap_CommitmentsAndContingencies_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_CommitmentsAndContingencies_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity" xlink:label="us-gaap_StockholdersEquity_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_StockholdersEquity_639178606082987389" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue" xlink:label="us-gaap_PreferredStockValue_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639178606082987389" xlink:to="us-gaap_PreferredStockValue_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue" xlink:label="us-gaap_CommonStockValue_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639178606082987389" xlink:to="us-gaap_CommonStockValue_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="us-gaap_AdditionalPaidInCapital_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639178606082987389" xlink:to="us-gaap_AdditionalPaidInCapital_639178606082987389" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639178606082987389" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit_639178606082987389" order="4" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" xlink:type="extended" xlink:title="1100400 - Statement - Condensed Consolidated Statements of Cash Flows" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="us-gaap_ProfitLoss_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_ForgivenessOfUnrelatedVendorPayable" xlink:label="limn_ForgivenessOfUnrelatedVendorPayable_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="limn_ForgivenessOfUnrelatedVendorPayable_639178606082987389" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_OtherReceivableWriteOff" xlink:label="limn_OtherReceivableWriteOff_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="limn_OtherReceivableWriteOff_639178606082987389" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation" xlink:label="us-gaap_Depreciation_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="us-gaap_Depreciation_639178606082987389" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue" xlink:label="limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue_639178606082987389" order="5" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="us-gaap_FairValueAdjustmentOfWarrants_639178606082987389" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_FairValueOfCommonStockIssuanceForContingentLiability" xlink:label="limn_FairValueOfCommonStockIssuanceForContingentLiability_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="limn_FairValueOfCommonStockIssuanceForContingentLiability_639178606082987389" order="7" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDueFromRelatedPartiesCurrent" xlink:label="us-gaap_IncreaseDecreaseInDueFromRelatedPartiesCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="us-gaap_IncreaseDecreaseInDueFromRelatedPartiesCurrent_639178606082987389" order="8" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_639178606082987389" order="9" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_639178606082987389" order="10" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_IncreaseDecreaseInAccruedInterestToRelatedPartyCurrent" xlink:label="limn_IncreaseDecreaseInAccruedInterestToRelatedPartyCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="limn_IncreaseDecreaseInAccruedInterestToRelatedPartyCurrent_639178606082987389" order="11" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_IncreaseDecreaseInAccruedMaintenanceFeesCurrent" xlink:label="limn_IncreaseDecreaseInAccruedMaintenanceFeesCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="limn_IncreaseDecreaseInAccruedMaintenanceFeesCurrent_639178606082987389" order="12" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_IncreaseDecreaseInDueToResearchAndDevelopmentPartnerCurrent" xlink:label="limn_IncreaseDecreaseInDueToResearchAndDevelopmentPartnerCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="limn_IncreaseDecreaseInDueToResearchAndDevelopmentPartnerCurrent_639178606082987389" order="13" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDueToRelatedPartiesCurrent" xlink:label="us-gaap_IncreaseDecreaseInDueToRelatedPartiesCurrent_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639178606082987389" xlink:to="us-gaap_IncreaseDecreaseInDueToRelatedPartiesCurrent_639178606082987389" order="14" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInInvestingActivities_639178606082987389" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireLoansReceivable" xlink:label="us-gaap_PaymentsToAcquireLoansReceivable_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities_639178606082987389" xlink:to="us-gaap_PaymentsToAcquireLoansReceivable_639178606082987389" order="1" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities_639178606082987389" xlink:to="us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_639178606082987389" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInFinancingActivities_639178606082987389" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement" xlink:label="us-gaap_ProceedsFromIssuanceOfPrivatePlacement_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_639178606082987389" xlink:to="us-gaap_ProceedsFromIssuanceOfPrivatePlacement_639178606082987389" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities" xlink:label="us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_639178606082987389" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_639178606082987389" xlink:to="us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_639178606082987389" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromShortTermDebt" xlink:label="us-gaap_ProceedsFromShortTermDebt_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_639178606082987389" xlink:to="us-gaap_ProceedsFromShortTermDebt_639178606083179918" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfShortTermDebt" xlink:label="us-gaap_RepaymentsOfShortTermDebt_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_639178606082987389" xlink:to="us-gaap_RepaymentsOfShortTermDebt_639178606083179918" order="4" use="optional" weight="-1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/StatementConsolidatedBalanceSheets" xlink:type="extended" xlink:title="1200100 - Statement - Consolidated Balance Sheets" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent_1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_1" xlink:to="us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_639178606083179918" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_AccruedInterestCurrent" xlink:label="limn_AccruedInterestCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_1" xlink:to="limn_AccruedInterestCurrent_639178606083179918" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="us-gaap_OtherLiabilitiesCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_1" xlink:to="us-gaap_OtherLiabilitiesCurrent_639178606083179918" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermBorrowings" xlink:label="us-gaap_ShortTermBorrowings_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_1" xlink:to="us-gaap_ShortTermBorrowings_639178606083179918" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_AccruedMaintenanceFeeCurrent" xlink:label="limn_AccruedMaintenanceFeeCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_1" xlink:to="limn_AccruedMaintenanceFeeCurrent_639178606083179918" order="5" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_DeferredUnderwritingFeesPayableInCashCurrent" xlink:label="limn_DeferredUnderwritingFeesPayableInCashCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_1" xlink:to="limn_DeferredUnderwritingFeesPayableInCashCurrent_639178606083179918" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_CommonStockPayable" xlink:label="limn_CommonStockPayable_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_1" xlink:to="limn_CommonStockPayable_639178606083179918" order="7" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/StatementConsolidatedStatementsOfOperations" xlink:type="extended" xlink:title="1200200 - Statement - Consolidated Statements of Operations" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss" xlink:label="us-gaap_OperatingIncomeLoss_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss" xlink:to="us-gaap_OperatingIncomeLoss_639178606083179918" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses" xlink:label="us-gaap_OperatingExpenses_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingIncomeLoss_639178606083179918" xlink:to="us-gaap_OperatingExpenses_639178606083179918" order="1" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="us-gaap_GeneralAndAdministrativeExpense_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_639178606083179918" xlink:to="us-gaap_GeneralAndAdministrativeExpense_639178606083179918" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="us-gaap_ResearchAndDevelopmentExpense_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_639178606083179918" xlink:to="us-gaap_ResearchAndDevelopmentExpense_639178606083179918" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="us-gaap_NonoperatingIncomeExpense_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss" xlink:to="us-gaap_NonoperatingIncomeExpense_639178606083179918" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating" xlink:label="us-gaap_InterestExpenseNonoperating_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense_639178606083179918" xlink:to="us-gaap_InterestExpenseNonoperating_639178606083179918" order="1" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="us-gaap_InvestmentIncomeInterest_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense_639178606083179918" xlink:to="us-gaap_InvestmentIncomeInterest_639178606083179918" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_ForgivenessOfUnrelatedVendorPayable" xlink:label="limn_ForgivenessOfUnrelatedVendorPayable_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense_639178606083179918" xlink:to="limn_ForgivenessOfUnrelatedVendorPayable_639178606083179918" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue" xlink:label="limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense_639178606083179918" xlink:to="limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue_639178606083179918" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense_639178606083179918" xlink:to="us-gaap_FairValueAdjustmentOfWarrants_639178606083179918" order="5" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_GainLossOnIssuanceOfCommonStockForWarrants" xlink:label="limn_GainLossOnIssuanceOfCommonStockForWarrants_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense_639178606083179918" xlink:to="limn_GainLossOnIssuanceOfCommonStockForWarrants_639178606083179918" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_FairValueOfCommonStockIssuanceForContingentLiability" xlink:label="limn_FairValueOfCommonStockIssuanceForContingentLiability_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NonoperatingIncomeExpense_639178606083179918" xlink:to="limn_FairValueOfCommonStockIssuanceForContingentLiability_639178606083179918" order="7" use="optional" weight="-1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/StatementConsolidatedStatementsOfCashFlows" xlink:type="extended" xlink:title="1200400 - Statement - Consolidated Statements of Cash Flows" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDueToRelatedPartiesCurrent" xlink:label="us-gaap_IncreaseDecreaseInDueToRelatedPartiesCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="us-gaap_IncreaseDecreaseInDueToRelatedPartiesCurrent_639178606083179918" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_IncreaseDecreaseInAccruedMaintenanceFeesCurrent" xlink:label="limn_IncreaseDecreaseInAccruedMaintenanceFeesCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_IncreaseDecreaseInAccruedMaintenanceFeesCurrent_639178606083179918" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_IncreaseDecreaseInDueToResearchAndDevelopmentPartnerCurrent" xlink:label="limn_IncreaseDecreaseInDueToResearchAndDevelopmentPartnerCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_IncreaseDecreaseInDueToResearchAndDevelopmentPartnerCurrent_639178606083179918" order="3" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_IncreaseDecreaseInAccruedInterestToRelatedPartyCurrent" xlink:label="limn_IncreaseDecreaseInAccruedInterestToRelatedPartyCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_IncreaseDecreaseInAccruedInterestToRelatedPartyCurrent_639178606083179918" order="4" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_639178606083179918" order="5" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_639178606083179918" order="6" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDueFromRelatedPartiesCurrent" xlink:label="us-gaap_IncreaseDecreaseInDueFromRelatedPartiesCurrent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="us-gaap_IncreaseDecreaseInDueFromRelatedPartiesCurrent_639178606083179918" order="7" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_FairValueOfCommonStockIssuanceForContingentLiability" xlink:label="limn_FairValueOfCommonStockIssuanceForContingentLiability_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_FairValueOfCommonStockIssuanceForContingentLiability_639178606083179918" order="8" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_GainLossOnIssuanceOfCommonStockForWarrants" xlink:label="limn_GainLossOnIssuanceOfCommonStockForWarrants_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_GainLossOnIssuanceOfCommonStockForWarrants_639178606083179918" order="9" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="us-gaap_FairValueAdjustmentOfWarrants_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="us-gaap_FairValueAdjustmentOfWarrants_639178606083179918" order="10" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue" xlink:label="limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_EquitySettlementDeferredUnderwritingFeesEffectOfChangeInFairValue_639178606083179918" order="11" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation" xlink:label="us-gaap_Depreciation_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="us-gaap_Depreciation_639178606083179918" order="12" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_OtherReceivableWriteOff" xlink:label="limn_OtherReceivableWriteOff_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_OtherReceivableWriteOff_639178606083179918" order="13" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_ForgivenessOfUnrelatedVendorPayable" xlink:label="limn_ForgivenessOfUnrelatedVendorPayable_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="limn_ForgivenessOfUnrelatedVendorPayable_639178606083179918" order="14" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_1" xlink:to="us-gaap_ProfitLoss_639178606083179918" order="15" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/DisclosureIncomeTaxesIncomeTaxProvisionDetailss" xlink:type="extended" xlink:title="1240902 - Disclosure - Income Taxes - Income tax provision (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="IncomeTaxExpenseBenefit" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:label="us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="IncomeTaxExpenseBenefit" xlink:to="us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_639178606083179918" order="1" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:label="us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="IncomeTaxExpenseBenefit" xlink:to="us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_639178606083179918" order="2" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/DisclosureIncomeTaxesReconciliationOfIncomeTaxRateDetailss" xlink:type="extended" xlink:title="1240903 - Disclosure - Income Taxes - Reconciliation of income tax rate (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="EffectiveIncomeTaxRateContinuingOperations" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="EffectiveIncomeTaxRateContinuingOperations" xlink:to="us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_639178606083179918" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes" xlink:label="us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="EffectiveIncomeTaxRateContinuingOperations" xlink:to="us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_639178606083179918" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_EffectiveIncomeTaxRateReconciliationGainLossOnExchangeOfCommonStockPercent" xlink:label="limn_EffectiveIncomeTaxRateReconciliationGainLossOnExchangeOfCommonStockPercent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="EffectiveIncomeTaxRateContinuingOperations" xlink:to="limn_EffectiveIncomeTaxRateReconciliationGainLossOnExchangeOfCommonStockPercent_639178606083179918" order="3" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_EffectiveIncomeTaxRateReconciliationFairValueOfCommonStockForContingentLiabilityPercent" xlink:label="limn_EffectiveIncomeTaxRateReconciliationFairValueOfCommonStockForContingentLiabilityPercent_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="EffectiveIncomeTaxRateContinuingOperations" xlink:to="limn_EffectiveIncomeTaxRateReconciliationFairValueOfCommonStockForContingentLiabilityPercent_639178606083179918" order="4" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments" xlink:label="us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="EffectiveIncomeTaxRateContinuingOperations" xlink:to="us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_639178606083179918" order="5" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:label="us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="EffectiveIncomeTaxRateContinuingOperations" xlink:to="us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_639178606083179918" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="IncomeTaxExpenseBenefit" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:label="us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="IncomeTaxExpenseBenefit" xlink:to="us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_639178606083179918" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_EffectiveIncomeTaxRateReconciliationGainLossOnExchangeOfCommonStockAmount" xlink:label="limn_EffectiveIncomeTaxRateReconciliationGainLossOnExchangeOfCommonStockAmount_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="IncomeTaxExpenseBenefit" xlink:to="limn_EffectiveIncomeTaxRateReconciliationGainLossOnExchangeOfCommonStockAmount_639178606083179918" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_EffectiveIncomeTaxRateReconciliationFairValueOfCommonStockForContingentLiabilityAmount" xlink:label="limn_EffectiveIncomeTaxRateReconciliationFairValueOfCommonStockForContingentLiabilityAmount_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="IncomeTaxExpenseBenefit" xlink:to="limn_EffectiveIncomeTaxRateReconciliationFairValueOfCommonStockForContingentLiabilityAmount_639178606083179918" order="3" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:label="us-gaap_IncomeTaxReconciliationOtherAdjustments_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="IncomeTaxExpenseBenefit" xlink:to="us-gaap_IncomeTaxReconciliationOtherAdjustments_639178606083179918" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:label="us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="IncomeTaxExpenseBenefit" xlink:to="us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_639178606083179918" order="5" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.liminatuspharma.com/role/DisclosureIncomeTaxesDeferredTaxAssetsAndLiabilitiesDetailss" xlink:type="extended" xlink:title="1240904 - Disclosure - Income Taxes - Deferred tax assets and liabilities (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="DeferredTaxAssetsNet" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="us-gaap_DeferredTaxAssetsValuationAllowance_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="DeferredTaxAssetsNet" xlink:to="us-gaap_DeferredTaxAssetsValuationAllowance_639178606083179918" order="1" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="us-gaap_DeferredTaxAssetsGross_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="DeferredTaxAssetsNet" xlink:to="us-gaap_DeferredTaxAssetsGross_639178606083179918" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetInterestCarryforward" xlink:label="us-gaap_DeferredTaxAssetInterestCarryforward_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="DeferredTaxAssetsNet" xlink:to="us-gaap_DeferredTaxAssetInterestCarryforward_639178606083179918" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="limn-20260331.xsd#limn_DeferredTaxAssetsStartupExpenses" xlink:label="limn_DeferredTaxAssetsStartupExpenses_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="DeferredTaxAssetsNet" xlink:to="limn_DeferredTaxAssetsStartupExpenses_639178606083179918" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_639178606083179918" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="DeferredTaxAssetsNet" xlink:to="us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_639178606083179918" order="5" use="optional" weight="1" />
  </calculationLink>
</link:linkbase>
