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  <xsd:element id="nvo_EBPMinimumAgeForSuperMakeupContributions" name="EBPMinimumAgeForSuperMakeupContributions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPMinimumAgeOfParticipantRequiredToMakeMakeupContribution" name="EBPMinimumAgeOfParticipantRequiredToMakeMakeupContribution" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPMinimumAgeOfParticipantsRequiredToReceivePreretirementDistributions" name="EBPMinimumAgeOfParticipantsRequiredToReceivePreretirementDistributions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPMinimumServicePeriodToBeEligibleForParticipation" name="EBPMinimumServicePeriodToBeEligibleForParticipation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPMutualFundFeesTextBlock" name="EBPMutualFundFeesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPParticipantContributionAutomaticDeferralRateIncreaseEachYear" name="EBPParticipantContributionAutomaticDeferralRateIncreaseEachYear" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPParticipantContributionAutomaticDeferralRateMinimumPercentageDeferredToTriggerYearlyIncrease" name="EBPParticipantContributionAutomaticDeferralRateMinimumPercentageDeferredToTriggerYearlyIncrease" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPParticipantContributionAutomaticDeferralRatePercentToTriggerAnnualReenrollment" name="EBPParticipantContributionAutomaticDeferralRatePercentToTriggerAnnualReenrollment" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPParticipantContributionMaximumContribution" name="EBPParticipantContributionMaximumContribution" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPParticipantContributionPosttaxMaximumAnnualCompensationToTotalCompensationPercentage" name="EBPParticipantContributionPosttaxMaximumAnnualCompensationToTotalCompensationPercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPPercentVestingUponTermination" name="EBPPercentVestingUponTermination" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPScheduleOfAssetsTextBlock" name="EBPScheduleOfAssetsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPScheduleOfVestingTableTextBlock" name="EBPScheduleOfVestingTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPTaxStatusDividendWithholdTaxRefundReceived" name="EBPTaxStatusDividendWithholdTaxRefundReceived" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPTaxStatusWithholdingTaxPaid" name="EBPTaxStatusWithholdingTaxPaid" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPVestingPercentageInLessThanOneYearOfService" name="EBPVestingPercentageInLessThanOneYearOfService" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPVestingPercentageInYearOneOfService" name="EBPVestingPercentageInYearOneOfService" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPVestingPercentageInYearThreeOfService" name="EBPVestingPercentageInYearThreeOfService" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_EBPVestingPercentageInYearTwoOfService" name="EBPVestingPercentageInYearTwoOfService" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_LoanForPrimaryResidenceMember" name="LoanForPrimaryResidenceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_MutualFundsCommonStockAndMoneyMarketFundsMember" name="MutualFundsCommonStockAndMoneyMarketFundsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="nvo_NovoNordiskASMember" name="NovoNordiskASMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_PolicyTable" name="PolicyTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-note-1-description-of-plan-tables" name="statement-statement-note-1-description-of-plan-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-note-1-description-of-plan-vesting-schedule-details" name="statement-statement-note-1-description-of-plan-vesting-schedule-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-note-3-fair-value-measurements-assets-at-fair-value-details" name="statement-statement-note-3-fair-value-measurements-assets-at-fair-value-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-note-3-fair-value-measurements-assets-at-fair-value-details16F49CD4-D91E-4311-A84D-7660132875F7" name="statement-statement-note-3-fair-value-measurements-assets-at-fair-value-details16F49CD4-D91E-4311-A84D-7660132875F7" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-note-3-fair-value-measurements-assets-at-fair-value-details5E9F1FA8-6A60-4D98-95F0-DEB71DEAFB3B" name="statement-statement-note-3-fair-value-measurements-assets-at-fair-value-details5E9F1FA8-6A60-4D98-95F0-DEB71DEAFB3B" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-note-3-fair-value-measurements-tables" name="statement-statement-note-3-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-schedule-h-line-4i-schedule-of-assets-held-at-end-of-year-2-details" name="statement-statement-schedule-h-line-4i-schedule-of-assets-held-at-end-of-year-2-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-schedule-h-line-4i-schedule-of-assets-held-at-end-of-year-details" name="statement-statement-schedule-h-line-4i-schedule-of-assets-held-at-end-of-year-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-schedule-h-line-4i-schedule-of-assets-held-at-end-of-year-tables" name="statement-statement-schedule-h-line-4i-schedule-of-assets-held-at-end-of-year-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="nvo_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
