0001439222 2026-06-15 2026-06-15 0001439222 1 2026-06-15 2026-06-15 iso4217:USD pure shares S-8 S-8 EX-FILING FEES 0001439222 AGIOS PHARMACEUTICALS, INC. N/A false S-8 AGIOS PHARMACEUTICALS, INC. Equity Common Stock, $0.001 par value per share true 2000000 30.59 61180000.00 0.0001381 8448.96 61180000.00 8448.96 0.00 8448.96 (1) In accordance with Rule 416 under the Securities Act of 1933, as amended, this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions. (2) Consists of 2,000,000 additional shares of common stock issuable under the 2023 Stock Incentive Plan, as amended. (3) Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as amended, and based on the average of the high and low sale prices of the registrant's common stock as reported on the Nasdaq Global Select Market on June 15, 2026.