<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0001950047-26-006116</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001321402</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001437402</issuerCik>
      <issuerName>ARDELYX, INC.</issuerName>
      <secFileNumber>001-36485</secFileNumber>
      <issuerAddress>
        <com:street1>34175 ARDENWOOD BLVD.</com:street1>
        <com:city>FREMONT</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94555</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>510-745-7047</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RAAB MICHAEL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>41666</noOfUnitsSold>
      <aggregateMarketValue>236662.88</aggregateMarketValue>
      <noOfUnitsOutstanding>247029387</noOfUnitsOutstanding>
      <approxSaleDate>06/15/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/15/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>20833</amountOfSecuritiesAcquired>
      <paymentDate>06/15/2026</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/19/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>19734</amountOfSecuritiesAcquired>
      <paymentDate>02/19/2025</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/30/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Purchase Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1099</amountOfSecuritiesAcquired>
      <paymentDate>08/30/2024</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MICHAEL G. RAAB</name>
        <address>
          <com:street1>400 Fifth Avenue Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/21/2026</saleDate>
      <amountOfSecuritiesSold>54748</amountOfSecuritiesSold>
      <grossProceeds>343133.09</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MICHAEL G. RAAB</name>
        <address>
          <com:street1>400 Fifth Avenue Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/15/2026</saleDate>
      <amountOfSecuritiesSold>41666</amountOfSecuritiesSold>
      <grossProceeds>261610.40</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MICHAEL G. RAAB</name>
        <address>
          <com:street1>400 Fifth Avenue Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>04/15/2026</saleDate>
      <amountOfSecuritiesSold>41668</amountOfSecuritiesSold>
      <grossProceeds>261954.22</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MICHAEL G. RAAB</name>
        <address>
          <com:street1>400 Fifth Avenue Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/16/2026</saleDate>
      <amountOfSecuritiesSold>41666</amountOfSecuritiesSold>
      <grossProceeds>243329.44</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>This amendment reduces the aggregate share amount reported on the 6/15/2026 Form 144 to reflect only the actual number of shares sold on 6/15/2026. No further sales will be made under the prior filing.</remarks>
    <noticeSignature>
      <noticeDate>06/17/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/07/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ Michael Raab</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
