<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ecbe5-6dc2-7fb3-92d9-4ed0cf98881b,g:a6fd8470-88b2-4ebd-b0d6-dbb72a102cf5-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:gskpr="http://gsk.com/20260617" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://gsk.com/20260617">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap-ebp/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/ebp/elts/us-gaap-ebp-2025.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="gskpr-20260617_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="gskpr-20260617_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="gskpr-20260617_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="gskpr-20260617_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://gsk.com/role/Cover">
        <link:definition>0000001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementsofNetAssetsAvailableforBenefits" roleURI="http://gsk.com/role/StatementsofNetAssetsAvailableforBenefits">
        <link:definition>0000002 - Statement - Statements of Net Assets Available for Benefits</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementofChangesinNetAssetsAvailableforBenefits" roleURI="http://gsk.com/role/StatementofChangesinNetAssetsAvailableforBenefits">
        <link:definition>0000003 - Statement - Statement of Changes in Net Assets Available for Benefits</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DescriptionofthePlan" roleURI="http://gsk.com/role/DescriptionofthePlan">
        <link:definition>0000004 - Disclosure - Description of the Plan</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofSignificantAccountingPoliciesandRecentAccountingPronouncements" roleURI="http://gsk.com/role/SummaryofSignificantAccountingPoliciesandRecentAccountingPronouncements">
        <link:definition>0000005 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurements" roleURI="http://gsk.com/role/FairValueMeasurements">
        <link:definition>0000006 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedPartyandPartyinInterestTransactions" roleURI="http://gsk.com/role/RelatedPartyandPartyinInterestTransactions">
        <link:definition>0000007 - Disclosure - Related Party and Party in Interest Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PlanTermination" roleURI="http://gsk.com/role/PlanTermination">
        <link:definition>0000008 - Disclosure - Plan Termination</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="TaxStatus" roleURI="http://gsk.com/role/TaxStatus">
        <link:definition>0000009 - Disclosure - Tax Status</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ReconciliationtoForm5500" roleURI="http://gsk.com/role/ReconciliationtoForm5500">
        <link:definition>0000010 - Disclosure - Reconciliation to Form 5500</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RisksandUncertainties" roleURI="http://gsk.com/role/RisksandUncertainties">
        <link:definition>0000011 - Disclosure - Risks and Uncertainties</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEvents" roleURI="http://gsk.com/role/SubsequentEvents">
        <link:definition>0000012 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ScheduleHLine4iScheduleofAssetsHeldatEndofYear" roleURI="http://gsk.com/role/ScheduleHLine4iScheduleofAssetsHeldatEndofYear">
        <link:definition>0000013 - Disclosure - Schedule H, Line 4i - Schedule of Assets (Held at End of Year)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofSignificantAccountingPoliciesandRecentAccountingPronouncementsPolicies" roleURI="http://gsk.com/role/SummaryofSignificantAccountingPoliciesandRecentAccountingPronouncementsPolicies">
        <link:definition>0000014 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsTables" roleURI="http://gsk.com/role/FairValueMeasurementsTables">
        <link:definition>0000015 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ReconciliationtoForm5500Tables" roleURI="http://gsk.com/role/ReconciliationtoForm5500Tables">
        <link:definition>0000016 - Disclosure - Reconciliation to Form 5500 (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RisksandUncertaintiesTables" roleURI="http://gsk.com/role/RisksandUncertaintiesTables">
        <link:definition>0000017 - Disclosure - Risks and Uncertainties (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DescriptionofthePlanDetails" roleURI="http://gsk.com/role/DescriptionofthePlanDetails">
        <link:definition>0000018 - Disclosure - Description of the Plan (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofSignificantAccountingPoliciesandRecentAccountingPronouncementsDetails" roleURI="http://gsk.com/role/SummaryofSignificantAccountingPoliciesandRecentAccountingPronouncementsDetails">
        <link:definition>0000019 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsFairvaluehierarchyDetails" roleURI="http://gsk.com/role/FairValueMeasurementsFairvaluehierarchyDetails">
        <link:definition>0000020 - Disclosure - Fair Value Measurements - Fair value hierarchy (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsInvestmentsmeasuredatfairvaluebasedonNAVDetails" roleURI="http://gsk.com/role/FairValueMeasurementsInvestmentsmeasuredatfairvaluebasedonNAVDetails">
        <link:definition>0000021 - Disclosure - Fair Value Measurements - Investments measured at fair value based on NAV (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedPartyandPartyinInterestTransactionsDetails" roleURI="http://gsk.com/role/RelatedPartyandPartyinInterestTransactionsDetails">
        <link:definition>0000022 - Disclosure - Related Party and Party in Interest Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ReconciliationtoForm5500Details" roleURI="http://gsk.com/role/ReconciliationtoForm5500Details">
        <link:definition>0000023 - Disclosure - Reconciliation to Form 5500 (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RisksandUncertaintiesNarrativeDetails" roleURI="http://gsk.com/role/RisksandUncertaintiesNarrativeDetails">
        <link:definition>0000024 - Disclosure - Risks and Uncertainties - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RisksandUncertaintiesNarrativeDetails_1" roleURI="http://gsk.com/role/RisksandUncertaintiesNarrativeDetails_1">
        <link:definition>0000024 - Disclosure - Risks and Uncertainties - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RisksandUncertaintiesScheduleofinvestmentsDetails" roleURI="http://gsk.com/role/RisksandUncertaintiesScheduleofinvestmentsDetails">
        <link:definition>0000025 - Disclosure - Risks and Uncertainties - Schedule of investments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RisksandUncertaintiesScheduleofinvestmentsDetails_1" roleURI="http://gsk.com/role/RisksandUncertaintiesScheduleofinvestmentsDetails_1">
        <link:definition>0000025 - Disclosure - Risks and Uncertainties - Schedule of investments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ScheduleHLine4iScheduleofAssetsHeldatEndofYearDetails" roleURI="http://gsk.com/role/ScheduleHLine4iScheduleofAssetsHeldatEndofYearDetails">
        <link:definition>0000026 - Disclosure - Schedule H, Line 4i - Schedule of Assets (Held at End of Year) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ScheduleHLine4iScheduleofAssetsHeldatEndofYearDetails_1" roleURI="http://gsk.com/role/ScheduleHLine4iScheduleofAssetsHeldatEndofYearDetails_1">
        <link:definition>0000026 - Disclosure - Schedule H, Line 4i - Schedule of Assets (Held at End of Year) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="gskpr_EBP002Member" abstract="true" name="EBP002Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="gskpr_EBPCashPolicyTextBlock" abstract="false" name="EBPCashPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="gskpr_VanguardRetirementSavingsTrustIVMember" abstract="true" name="VanguardRetirementSavingsTrustIVMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="gskpr_BancoPopularDePuertoRicoMember" abstract="true" name="BancoPopularDePuertoRicoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="gskpr_StateStreetBankAndTrustCompanyMember" abstract="true" name="StateStreetBankAndTrustCompanyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="gskpr_EBPParticipantContributionAfterTaxMaximumAnnualCompensationToTotalCompensationPercentage" abstract="false" name="EBPParticipantContributionAfterTaxMaximumAnnualCompensationToTotalCompensationPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="gskpr_EBPEmployeeContributionCatchUpContributionsEligibilityAge" abstract="false" name="EBPEmployeeContributionCatchUpContributionsEligibilityAge" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="gskpr_EBPEmployerContributionNumberOfHoursOfCreditedService" abstract="false" name="EBPEmployerContributionNumberOfHoursOfCreditedService" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="gskpr_EBPEmployerCoreContributionPercentage" abstract="false" name="EBPEmployerCoreContributionPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="gskpr_EBPDefaultInvestmentTargetRetirementAge" abstract="false" name="EBPDefaultInvestmentTargetRetirementAge" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="gskpr_EBPPreTaxAndRothContributionsMinimumWithdrawingAge" abstract="false" name="EBPPreTaxAndRothContributionsMinimumWithdrawingAge" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="gskpr_EBPPaymentOfBenefitsThreshold" abstract="false" name="EBPPaymentOfBenefitsThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="gskpr_EBPMaximumNumberOfAnnualPartialDistributions" abstract="false" name="EBPMaximumNumberOfAnnualPartialDistributions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="gskpr_EBPMaximumPeriodOfAnnualDistributions" abstract="false" name="EBPMaximumPeriodOfAnnualDistributions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="gskpr_EBPAdministrativeExpensePaid" abstract="false" name="EBPAdministrativeExpensePaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="gskpr_StateStreetInvestmentManagementFundsMember" abstract="true" name="StateStreetInvestmentManagementFundsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="gskpr_BlackRockGovernmentShortTermInvestmentFundMember" abstract="true" name="BlackRockGovernmentShortTermInvestmentFundMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="gskpr_EBPNumberOfFunds" abstract="false" name="EBPNumberOfFunds" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="gskpr_EBPEmployerADRsMember" abstract="true" name="EBPEmployerADRsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
