Exhibit 21.1

SUBSIDIARIES OF CANOPY GROWTH CORPORATION

As of March 31, 2026

Entity Name

Jurisdiction of Incorporation or Organization

10663824 Canada Inc.

Canada

11065220 Canada Inc.

Canada

Abba Medix Corp.

Ontario

Apollo Applied Research Inc.

Canada

Canada House Clinics Inc.

New Brunswick

Canopy Growth Australia PTY Ltd.

Australia

Canopy Growth Germany GmbH

Germany

Canopy Growth Holdings B.V.

Netherlands

Canopy Growth LATAM Holdings Corporation

Canada

Canopy Growth Polska Sp. Z. o. o.

Poland

Canopy Growth USA, LLC

Delaware

EB Transaction Corp.

Delaware

EB Transaction Sub I LLC

Delaware

IsoCanMed Inc.

Canada

Montréal Cannabis Medical Inc.

Canada

MTL Cannabis Corp.

Canada

Storz & Bickel America, Inc.

California

Storz & Bickel GmbH

Germany

The Supreme Cannabis Company, Inc.

Canada

Tweed Inc.

Ontario

Tweed Leasing Corp.

Canada