Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement on Form S-3 of Silexion Therapeutics Corp of our report dated March 17, 2026, relating to the financial statements,
which appears in Silexion Therapeutics Corp’s Annual Report on Form 10-K for the year ended December 31, 2025. We also consent to the reference to us under the heading “Experts” in such Registration Statement.
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/s/ Kesselman & Kesselman
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Certified Public Accountants (Isr.)
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A member firm of PricewaterhouseCoopers International Limited
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Tel-Aviv, Israel
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June 12, 2026
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