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    <link:label id="lab_dei_EntityTaxIdentificationNumber_label_en-US" xlink:label="lab_dei_EntityTaxIdentificationNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Tax Identification Number</link:label>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionRollover_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionRollover" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Increase from Participant Contribution, Rollover</link:label>
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    <link:label id="lab_srt_MaximumMember_label_en-US" xlink:label="lab_srt_MaximumMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maximum [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_MaximumMember" xlink:to="lab_srt_MaximumMember" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_LegalEntityAxis_019eb288-2580-71b0-882e-a724952d880a_terseLabel_en-US" xlink:label="lab_dei_LegalEntityAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Legal Entity [Axis]</link:label>
    <link:label id="lab_dei_LegalEntityAxis_label_en-US" xlink:label="lab_dei_LegalEntityAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Legal Entity [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LegalEntityAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_LegalEntityAxis" xlink:to="lab_dei_LegalEntityAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RangeMember_019eb288-2580-7148-9a9e-a585f27d0ad5_terseLabel_en-US" xlink:label="lab_srt_RangeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Statistical Measurement [Domain]</link:label>
    <link:label id="lab_srt_RangeMember_label_en-US" xlink:label="lab_srt_RangeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statistical Measurement [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RangeMember" xlink:to="lab_srt_RangeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable_019eb288-2580-7f09-b029-a5d98baec8ca_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Description of Plan [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Description of Plan [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MutualFundMember_019eb288-2580-707d-b01f-882fbb497676_terseLabel_en-US" xlink:label="lab_us-gaap_MutualFundMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Mutual funds</link:label>
    <link:label id="lab_us-gaap_MutualFundMember_label_en-US" xlink:label="lab_us-gaap_MutualFundMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Mutual Fund [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MutualFundMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MutualFundMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MutualFundMember" xlink:to="lab_us-gaap_MutualFundMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EbpOtherInvestmentMember_019eb288-2580-7306-8d4f-1e6fb44923b8_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EbpOtherInvestmentMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other investments</link:label>
    <link:label id="lab_us-gaap-ebp_EbpOtherInvestmentMember_label_en-US" xlink:label="lab_us-gaap-ebp_EbpOtherInvestmentMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Other Investment [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EbpOtherInvestmentMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EbpOtherInvestmentMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EbpOtherInvestmentMember" xlink:to="lab_us-gaap-ebp_EbpOtherInvestmentMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable_019eb288-2580-74b0-bdba-fe0b21e0ef1e_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Related Party and Party-in-Interest Transactions [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Related Party and Party-in-Interest Transactions [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable_019eb288-2580-7bc1-be3d-996a49a41942_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Accounting Standard Update and Change in Accounting Principle [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable_label_en-US" xlink:label="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Accounting Standard Update and Change in Accounting Principle [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable" xlink:to="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease_019eb288-2580-70cd-b7cb-1f5985659de7_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total expenses per the financial statements</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Decrease</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecrease" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember_019eb288-2580-7d29-b82c-7dcb041e9f5f_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Self-directed brokerage accounts</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Self-Directed Brokerage Account [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanSelfDirectedBrokerageAccountMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount_019eb288-2580-77eb-8194-3f37b0f1e8b9_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum borrowing amount</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable from Participant, Account, Maximum Borrowing, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock_019eb288-2580-7c14-99cb-17b0d2109ac9_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Measurements</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm_019eb288-2580-79e2-ba6c-54cecf8a487c_terseLabel_en-US" xlink:label="lab_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">General loan, borrowing term</link:label>
    <link:label id="lab_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm_label_en-US" xlink:label="lab_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable From Participant, General Loan, Maximum Borrowing Term</link:label>
    <link:label id="lab_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm_documentation_en-US" xlink:label="lab_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable From Participant, General Loan, Maximum Borrowing Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm" xlink:href="amgn-20260611.xsd#amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm" xlink:to="lab_amgn_EBPNoteReceivableFromParticipantGeneralLoanMaximumBorrowingTerm" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue_019eb288-2580-763f-8a3f-5388a45f4961_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investments at fair value</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue_019eb288-2580-76d5-a99e-672536369d87_verboseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Total investments at fair value</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Excluding Plan Interest in Master Trust, Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock_019eb288-2580-7163-8cac-63b6c625b9e0_terseLabel_en-US" xlink:label="lab_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum contribution to Amgen stock, percentage</link:label>
    <link:label id="lab_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock_label_en-US" xlink:label="lab_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Participant Contribution, Maximum Contribution Percentage to Employer Stock</link:label>
    <link:label id="lab_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock_documentation_en-US" xlink:label="lab_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Participant Contribution, Maximum Contribution Percentage to Employer Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock" xlink:href="amgn-20260611.xsd#amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock" xlink:to="lab_amgn_EBPParticipantContributionMaximumContributionPercentageToEmployerStock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel1Member_019eb288-2580-772a-8aca-f5a0c4ba6ed4_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Quoted prices in active markets for identical assets (Level 1)</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel1Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 1 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel1Member" xlink:to="lab_us-gaap_FairValueInputsLevel1Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock_019eb288-2580-73fc-8765-5b327af02a36_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500 [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAsset_019eb288-2580-7e44-9cae-936bc39b8634_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAsset" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total assets</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAsset_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAsset" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Asset</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanAsset" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAsset"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanAsset" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanAsset" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetAbstract_019eb288-2580-7f48-8e01-cdd1b34cbdc8_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Asset [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanAssetAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RangeAxis_019eb288-2580-7f42-ae1f-6fb403841d3b_terseLabel_en-US" xlink:label="lab_srt_RangeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Statistical Measurement [Axis]</link:label>
    <link:label id="lab_srt_RangeAxis_label_en-US" xlink:label="lab_srt_RangeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statistical Measurement [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RangeAxis" xlink:to="lab_srt_RangeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract_019eb288-2580-7296-8d15-2966b02a27f5_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Additions to (deductions from) net assets:</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Increase [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable_019eb288-2580-742d-9cf9-0e960c01672a_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Statement of Change in Net Asset Available for Benefit [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Statement of Change in Net Asset Available for Benefit [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense_019eb288-2580-7621-a945-0fe14e816300_negatedLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Total expenses per the Form 5500</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Form 5500 Caption, Total Expenses</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionTotalExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanLiability_019eb288-2580-77f5-9807-bdf0d9b1dbcb_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanLiability" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total liabilities</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanLiability_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanLiability" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Liability</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanLiability" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanLiability"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanLiability" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanLiability" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_AmendmentFlag_019eb288-2580-7ca6-ac74-cc2be765233b_terseLabel_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amendment Flag</link:label>
    <link:label id="lab_dei_AmendmentFlag_label_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amendment Flag</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AmendmentFlag" xlink:to="lab_dei_AmendmentFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution_019eb288-2580-7f57-bc22-ffeb83ae8eb9_negatedTerseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Deemed loans</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Net Asset Available for Benefit, Deemed Distribution</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitDeemedDistribution" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock_019eb288-2580-78f6-b3c9-97cd2eb00663_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Basis of Accounting</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Basis of Accounting [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanBasisOfAccountingPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable_019eb288-2580-7dd6-9fe0-c312f17e189e_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Schedule of Asset Held for Investment [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Schedule of Asset Held for Investment [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale_019eb288-2580-730d-8ca1-64ad5c73a662_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other &#8211; principally due from broker</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment Sale, Receivable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReceivableInvestmentSale" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPEmployerContributionMaximumVestingAge_019eb288-2580-79bf-83a7-082490b55210_terseLabel_en-US" xlink:label="lab_amgn_EBPEmployerContributionMaximumVestingAge" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum vesting age</link:label>
    <link:label id="lab_amgn_EBPEmployerContributionMaximumVestingAge_label_en-US" xlink:label="lab_amgn_EBPEmployerContributionMaximumVestingAge" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Employer Contribution Maximum Vesting Age</link:label>
    <link:label id="lab_amgn_EBPEmployerContributionMaximumVestingAge_documentation_en-US" xlink:label="lab_amgn_EBPEmployerContributionMaximumVestingAge" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Maximum Vesting age of participant for company contribution and/ or investment earning in Company Matching Contributions, Fixed Rate Contributions, Discretionary Profit-Sharing Contributions, Qualified Non-Elective Contributions, and Disability Contributions.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPEmployerContributionMaximumVestingAge" xlink:href="amgn-20260611.xsd#amgn_EBPEmployerContributionMaximumVestingAge"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPEmployerContributionMaximumVestingAge" xlink:to="lab_amgn_EBPEmployerContributionMaximumVestingAge" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_CapitalPreservationAssetMember_019eb288-2580-7542-827f-60661499d9f0_terseLabel_en-US" xlink:label="lab_amgn_CapitalPreservationAssetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Capital Preservation Asset Class:</link:label>
    <link:label id="lab_amgn_CapitalPreservationAssetMember_label_en-US" xlink:label="lab_amgn_CapitalPreservationAssetMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Capital Preservation Asset [Member]</link:label>
    <link:label id="lab_amgn_CapitalPreservationAssetMember_documentation_en-US" xlink:label="lab_amgn_CapitalPreservationAssetMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Capital Preservation Asset Class:</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_CapitalPreservationAssetMember" xlink:href="amgn-20260611.xsd#amgn_CapitalPreservationAssetMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_CapitalPreservationAssetMember" xlink:to="lab_amgn_CapitalPreservationAssetMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate_019eb288-2580-773e-80ce-cdca70b55e47_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Interest Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentInterestRate" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_InternationalEquityActiveAssetClassMember_019eb288-2580-7d9e-ae02-0b1aaba319c9_terseLabel_en-US" xlink:label="lab_amgn_InternationalEquityActiveAssetClassMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">International Equity Active Asset Class</link:label>
    <link:label id="lab_amgn_InternationalEquityActiveAssetClassMember_label_en-US" xlink:label="lab_amgn_InternationalEquityActiveAssetClassMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">International Equity Active Asset Class [Member]</link:label>
    <link:label id="lab_amgn_InternationalEquityActiveAssetClassMember_documentation_en-US" xlink:label="lab_amgn_InternationalEquityActiveAssetClassMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">International Equity Active Asset Class</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_InternationalEquityActiveAssetClassMember" xlink:href="amgn-20260611.xsd#amgn_InternationalEquityActiveAssetClassMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_InternationalEquityActiveAssetClassMember" xlink:to="lab_amgn_InternationalEquityActiveAssetClassMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Description of Plan and Accounting Change [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock_019eb288-2580-74fa-96dc-25c5eeec3e4d_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_019eb288-2580-7558-8d1a-799e1d84b1a6_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investments [Domain]</link:label>
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investments [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember" xlink:to="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock_019eb288-2580-7ae8-81d1-09c17524144b_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Use of Estimates</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Use of Estimate [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanUseOfEstimatePolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_U.S.EquityIndexAssetMember_019eb288-2580-7828-a2ac-8df15e4d40d6_terseLabel_en-US" xlink:label="lab_amgn_U.S.EquityIndexAssetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">U.S. Equity Index Asset</link:label>
    <link:label id="lab_amgn_U.S.EquityIndexAssetMember_label_en-US" xlink:label="lab_amgn_U.S.EquityIndexAssetMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">U.S. Equity Index Asset [Member]</link:label>
    <link:label id="lab_amgn_U.S.EquityIndexAssetMember_documentation_en-US" xlink:label="lab_amgn_U.S.EquityIndexAssetMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">U.S. Equity Index Asset</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_U.S.EquityIndexAssetMember" xlink:href="amgn-20260611.xsd#amgn_U.S.EquityIndexAssetMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_U.S.EquityIndexAssetMember" xlink:to="lab_amgn_U.S.EquityIndexAssetMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock_019eb288-2580-7827-b076-1b4dcdf3f518_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Schedule H, line 4i &#8211; Schedule of Assets (Held at End of Year)</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Schedule of Asset Held for Investment [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_CoverAbstract_label_en-US" xlink:label="lab_dei_CoverAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cover [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CoverAbstract" xlink:to="lab_dei_CoverAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid_019eb288-2580-7f77-836b-14b97a94ba57_negatedTerseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Amounts allocated to withdrawing participants</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Net Asset Available for Benefit, Allocation to Withdrawing Participant, Not yet Paid</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500NetAssetAvailableForBenefitAllocationToWithdrawingParticipantNotYetPaid" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash_019eb288-2580-7d3c-98a4-2f6c1636f0b6_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Employer contributions</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Increase from Employer Contribution, Cash</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForEmployerContributionCash" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid_019eb288-2580-7307-af87-129b668a43cd_negatedLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Amounts allocated to withdrawing participants at December&#160;31, 2025</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Payment to Participant, Decrease from Allocation to Withdrawing Participant, Paid</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantDecreaseForAllocationToWithdrawingParticipantPaid" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember_019eb288-2580-7996-bde8-3f1f42e3cb75_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Synthetic investment contracts</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Synthetic Investment Contract [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanSyntheticInvestmentContractMember" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_MinimumMember_019eb288-2580-75c4-bf94-5c1bb097b94a_terseLabel_en-US" xlink:label="lab_srt_MinimumMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Minimum</link:label>
    <link:label id="lab_srt_MinimumMember_label_en-US" xlink:label="lab_srt_MinimumMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Minimum [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_MinimumMember" xlink:to="lab_srt_MinimumMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentTypeAxis_019eb288-2580-7714-8b21-e2601f2e5816_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Type [Axis]</link:label>
    <link:label id="lab_us-gaap_InvestmentTypeAxis_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentTypeAxis" xlink:to="lab_us-gaap_InvestmentTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant_019eb288-2580-73bd-835c-b5612ab4ccb7_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest income on notes receivable from participants</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Increase from Interest Income on Note Receivable from Participant</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestIncomeOnNoteReceivableFromParticipant" xlink:type="arc" order="1"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionExcludingRollover_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForParticipantContributionExcludingRollover" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Increase from Participant Contribution, Excluding Rollover</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestAndDividendIncomeOnInvestment" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseForInterestAndDividendIncomeOnInvestment"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Description of Plan [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanLineItems"/>
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    <link:label id="lab_amgn_EBPNumberOfAssetClasses_019eb288-2580-74d2-a333-adce707277aa_terseLabel_en-US" xlink:label="lab_amgn_EBPNumberOfAssetClasses" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of asset classes</link:label>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanPlanNumber_019eb288-2580-7a66-9c12-97a868cc10d9_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanPlanNumber" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Plan number</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanPlanNumber_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanPlanNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Plan Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanPlanNumber" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanPlanNumber"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavLineItems_019eb288-2580-76df-a014-8550ebe1453f_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV [Line Items]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavLineItems"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock_019eb288-2580-72ce-9137-eac82350113f_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Description of Plan</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Description of Plan [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanDescriptionOfPlanTextBlock"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Statement of Change in Net Asset Available for Benefit [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitLineItems"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable_019eb288-2580-71d9-a091-4c99fdc62a82_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Statement of Net Asset Available for Benefit [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Statement of Net Asset Available for Benefit [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitTable"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems_019eb288-2580-7f03-8976-2191c9b50354_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Schedule of Asset Held for Investment [Line Items]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanScheduleOfAssetHeldForInvestmentLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Schedule of Asset Held for Investment [Line Items]</link:label>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanEmployerCommonStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Employer, Common Stock [Member]</link:label>
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    <link:label id="lab_us-gaap_InvestmentIdentifierAxis_label_en-US" xlink:label="lab_us-gaap_InvestmentIdentifierAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment, Identifier [Axis]</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentIdentifierAxis" xlink:to="lab_us-gaap_InvestmentIdentifierAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense_019eb288-2580-752c-a658-d5a3accc24e0_negatedTerseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Investment and administrative fees</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Decrease from Administrative Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForAdministrativeExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment_019eb288-2580-70e8-9ce2-8212ca73f968_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Grand Total</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Asset Held for Investment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestment" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue_019eb288-2580-78e7-bee8-c8630041e656_terseLabel_en-US" xlink:label="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Current-year adjustment</link:label>
    <link:label id="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue_label_en-US" xlink:label="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Change in Net Asset Available for Benefit, Current Period Increase (Decrease) from Contract Value to Current Value</link:label>
    <link:label id="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue_documentation_en-US" xlink:label="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Change in Net Asset Available for Benefit, Current Period Increase (Decrease) from Contract Value to Current Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:href="amgn-20260611.xsd#amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:to="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitCurrentPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue_019eb288-2580-7d8e-9b0d-c4739415800c_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total fully benefit-responsive investment contracts</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Contract Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentContractValue" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPEmployerContributionVestingServicePeriod_019eb288-2580-7bc0-a8ea-8a97444e8918_terseLabel_en-US" xlink:label="lab_amgn_EBPEmployerContributionVestingServicePeriod" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Vesting period</link:label>
    <link:label id="lab_amgn_EBPEmployerContributionVestingServicePeriod_label_en-US" xlink:label="lab_amgn_EBPEmployerContributionVestingServicePeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Employer Contribution Vesting Service Period</link:label>
    <link:label id="lab_amgn_EBPEmployerContributionVestingServicePeriod_documentation_en-US" xlink:label="lab_amgn_EBPEmployerContributionVestingServicePeriod" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Minimum Vesting service period for company contribution and/ or investment earning to the participant in Company Matching Contributions, Fixed Rate Contributions, Discretionary Profit-Sharing Contributions, Qualified Non-Elective Contributions, and Disability Contributions.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPEmployerContributionVestingServicePeriod" xlink:href="amgn-20260611.xsd#amgn_EBPEmployerContributionVestingServicePeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPEmployerContributionVestingServicePeriod" xlink:to="lab_amgn_EBPEmployerContributionVestingServicePeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock_019eb288-2580-7a0c-865d-88f4fc9943de_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Risks and Uncertainties</link:label>
    <link:label id="lab_us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Risk and Uncertainty [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock" xlink:to="lab_us-gaap-ebp_EbpRiskAndUncertaintyPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentInformationLineItems_019eb288-2580-7055-ba7e-11888f1fed3a_terseLabel_en-US" xlink:label="lab_dei_DocumentInformationLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Document Information [Line Items]</link:label>
    <link:label id="lab_dei_DocumentInformationLineItems_label_en-US" xlink:label="lab_dei_DocumentInformationLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Information [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentInformationLineItems" xlink:to="lab_dei_DocumentInformationLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_InternationalEquityIndexAssetClassMember_019eb288-2580-79a9-a5ac-7b5a98665d05_terseLabel_en-US" xlink:label="lab_amgn_InternationalEquityIndexAssetClassMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">International Equity Index Asset Class</link:label>
    <link:label id="lab_amgn_InternationalEquityIndexAssetClassMember_label_en-US" xlink:label="lab_amgn_InternationalEquityIndexAssetClassMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">International Equity Index Asset Class [Member]</link:label>
    <link:label id="lab_amgn_InternationalEquityIndexAssetClassMember_documentation_en-US" xlink:label="lab_amgn_InternationalEquityIndexAssetClassMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">International Equity Index Asset Class</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_InternationalEquityIndexAssetClassMember" xlink:href="amgn-20260611.xsd#amgn_InternationalEquityIndexAssetClassMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_InternationalEquityIndexAssetClassMember" xlink:to="lab_amgn_InternationalEquityIndexAssetClassMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage_019eb288-2580-7d27-b8ec-bf69bd9a8d0a_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Participant compensation matched, percentage</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Employer Contribution, Participant Compensation Matched, Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanEmployerContributionParticipantCompensationMatchedPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Statement of Change in Net Asset Available for Benefit [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfChangeInNetAssetAvailableForBenefitAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_019eb288-2580-7236-ab9d-70cfbaee06fe_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Significant other observable inputs (Level 2)</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 2 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member" xlink:to="lab_us-gaap_FairValueInputsLevel2Member" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPInvoluntaryCashOutLimit_019eb288-2580-7e62-bcb6-dd2eb36e32c3_terseLabel_en-US" xlink:label="lab_amgn_EBPInvoluntaryCashOutLimit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Involuntary cash-out limit</link:label>
    <link:label id="lab_amgn_EBPInvoluntaryCashOutLimit_label_en-US" xlink:label="lab_amgn_EBPInvoluntaryCashOutLimit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Involuntary Cash-out Limit</link:label>
    <link:label id="lab_amgn_EBPInvoluntaryCashOutLimit_documentation_en-US" xlink:label="lab_amgn_EBPInvoluntaryCashOutLimit" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Involuntary Cash-out Limit</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPInvoluntaryCashOutLimit" xlink:href="amgn-20260611.xsd#amgn_EBPInvoluntaryCashOutLimit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPInvoluntaryCashOutLimit" xlink:to="lab_amgn_EBPInvoluntaryCashOutLimit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquitySecuritiesMember_019eb288-2580-7c66-a373-e20b04f520d0_terseLabel_en-US" xlink:label="lab_us-gaap_EquitySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common and preferred stocks</link:label>
    <link:label id="lab_us-gaap_EquitySecuritiesMember_label_en-US" xlink:label="lab_us-gaap_EquitySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquitySecuritiesMember" xlink:to="lab_us-gaap_EquitySecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPNumberOfLoansOutstandingMaximum_019eb288-2580-7b42-958a-264ce0d88a03_terseLabel_en-US" xlink:label="lab_amgn_EBPNumberOfLoansOutstandingMaximum" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum number of loans outstanding</link:label>
    <link:label id="lab_amgn_EBPNumberOfLoansOutstandingMaximum_label_en-US" xlink:label="lab_amgn_EBPNumberOfLoansOutstandingMaximum" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Number of Loans Outstanding, Maximum</link:label>
    <link:label id="lab_amgn_EBPNumberOfLoansOutstandingMaximum_documentation_en-US" xlink:label="lab_amgn_EBPNumberOfLoansOutstandingMaximum" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Number of Loans Outstanding, Maximum</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPNumberOfLoansOutstandingMaximum" xlink:href="amgn-20260611.xsd#amgn_EBPNumberOfLoansOutstandingMaximum"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPNumberOfLoansOutstandingMaximum" xlink:to="lab_amgn_EBPNumberOfLoansOutstandingMaximum" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod_019eb288-2580-7df3-8eac-b3685b5a9984_negatedLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Deemed loans at December&#160;31, 2025</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Change in Net Asset Available for Benefit, Current Period, Decrease from Deemed Distribution</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500ChangeInNetAssetAvailableForBenefitDecreaseForDeemedDistributionCurrentPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss_019eb288-2580-7d1d-9e99-c4fca008d027_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net income per the Form 5500</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Form 5500 Caption, Net Income (Loss)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetIncomeLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate_019eb288-2580-765d-ae9d-cbee5be7c298_terseLabel_en-US" xlink:label="lab_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Automatic deferral rate, annual increase</link:label>
    <link:label id="lab_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate_label_en-US" xlink:label="lab_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Participant Contribution, Automatic, Annual Increase Deferral Rate</link:label>
    <link:label id="lab_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate_documentation_en-US" xlink:label="lab_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Annual increase in percentage of eligible compensation contributed for participant automatically enrolled in employee stock purchase, saving, or similar plan (employee benefit plan (EBP)) until the contribution reaches maximum threshold.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate" xlink:href="amgn-20260611.xsd#amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate" xlink:to="lab_amgn_EBPParticipantContributionAutomaticAnnualIncreaseDeferralRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable_019eb288-2580-7fc1-bcb0-e5285cf3bd36_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Tax Status [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Tax Status [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease_019eb288-2580-7c6a-ba25-d6a4328866cb_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net increase</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Increase (Decrease)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecrease" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock_019eb288-2580-7ea9-9f9e-d8d5f39b5a6d_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Party-in-Interest Transactions</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Related Party and Party-in-Interest Transactions [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Related Party and Party-in-Interest Transactions [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Accounting Policy, Accounting Standard Update, and Change in Accounting Principle [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanAccountingPolicyAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate_019eb288-2580-733e-b7c7-d881a422effa_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Automatic deferral rate</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Participant Contribution, Automatic, Deferral Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantContributionAutomaticDeferralRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant_019eb288-2580-738c-ace5-ef09cab6f732_negatedTerseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Benefits paid</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Decrease from Payment to Participant</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitDecreaseForPaymentToParticipant" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue_019eb288-2580-7ba2-b4f5-3dc8b7c7f383_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Asset Held for Investment, Investment, Excluding Plan Interest in Master Trust, Current Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentInvestmentExcludingPlanInterestInMasterTrustCurrentValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019eb288-2580-7434-abc9-692109d53dfb_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy and NAV [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy and NAV [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm_019eb288-2580-7b9d-9b1e-689f65d52f43_terseLabel_en-US" xlink:label="lab_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Primary residence, borrowing term</link:label>
    <link:label id="lab_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm_label_en-US" xlink:label="lab_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable From Participant, Account, Primary Residence, Maximum Borrowing Term</link:label>
    <link:label id="lab_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm_documentation_en-US" xlink:label="lab_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable From Participant, Account, Primary Residence, Maximum Borrowing Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm" xlink:href="amgn-20260611.xsd#amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm" xlink:to="lab_amgn_EBPNoteReceivableFromParticipantAccountPrimaryResidenceMaximumBorrowingTerm" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Statement of Net Asset Available for Benefit [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase_019eb288-2580-7e59-a526-0a7fce8bff6b_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other &#8211; principally due to broker</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Liability for Investment Purchase</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityInvestmentPurchase" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Tax Status [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table_019eb288-2580-722b-a03a-216bfc6602dc_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500 [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500 [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Table" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBP001Member_019eb288-2580-7f2b-93e5-2410d63e2212_terseLabel_en-US" xlink:label="lab_amgn_EBP001Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP 001</link:label>
    <link:label id="lab_amgn_EBP001Member_label_en-US" xlink:label="lab_amgn_EBP001Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP 001 [Member]</link:label>
    <link:label id="lab_amgn_EBP001Member_documentation_en-US" xlink:label="lab_amgn_EBP001Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP 001</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBP001Member" xlink:href="amgn-20260611.xsd#amgn_EBP001Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBP001Member" xlink:to="lab_amgn_EBP001Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock_019eb288-2580-7cf7-8bbc-b70ea27464ef_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fully Benefit-Responsive Investment Contract</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Fully Benefit-Responsive Investment Contract [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanFullyBenefitResponsiveInvestmentContractTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPCashInstallmentPeriod_019eb288-2580-7718-80a7-09fd6aaa0c0e_terseLabel_en-US" xlink:label="lab_amgn_EBPCashInstallmentPeriod" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash installment period</link:label>
    <link:label id="lab_amgn_EBPCashInstallmentPeriod_label_en-US" xlink:label="lab_amgn_EBPCashInstallmentPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Cash Installment Period</link:label>
    <link:label id="lab_amgn_EBPCashInstallmentPeriod_documentation_en-US" xlink:label="lab_amgn_EBPCashInstallmentPeriod" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Cash Installment Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPCashInstallmentPeriod" xlink:href="amgn-20260611.xsd#amgn_EBPCashInstallmentPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPCashInstallmentPeriod" xlink:to="lab_amgn_EBPCashInstallmentPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems_019eb288-2580-7555-a3a7-1fe7f904bc06_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500 [Line Items]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500 [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500LineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock_019eb288-2580-768d-a26e-3afff258334e_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Reconciliation of Financial Statements to Form 5500</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500 [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500TextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution_019eb288-2580-72dc-9e72-8bcbe40010bb_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notes Receivable from Participants*</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Asset Held for Investment, Participant Loan, after Deemed Distribution</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanAssetHeldForInvestmentParticipantLoanAfterDeemedDistribution" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock_019eb288-2580-74c3-aba7-38faf9425287_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Measurement, Investment Income and Losses, Fully Benefit-Responsive Investment Contracts, and Due from/to Brokers</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel12And3Member_019eb288-2580-73cb-9b44-545d3cab0ef5_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel12And3Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel12And3Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel12And3Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 1, Level 2, and Level 3 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel12And3Member" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel12And3Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel12And3Member" xlink:to="lab_us-gaap_FairValueInputsLevel12And3Member" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPNumberOfAmendmentsMadeToPlan_019eb288-2580-7ccd-90ce-1f16eb2968bd_terseLabel_en-US" xlink:label="lab_amgn_EBPNumberOfAmendmentsMadeToPlan" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of amendments</link:label>
    <link:label id="lab_amgn_EBPNumberOfAmendmentsMadeToPlan_label_en-US" xlink:label="lab_amgn_EBPNumberOfAmendmentsMadeToPlan" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Number Of Amendments Made To Plan</link:label>
    <link:label id="lab_amgn_EBPNumberOfAmendmentsMadeToPlan_documentation_en-US" xlink:label="lab_amgn_EBPNumberOfAmendmentsMadeToPlan" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Number Of Amendments Made To Plan</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPNumberOfAmendmentsMadeToPlan" xlink:href="amgn-20260611.xsd#amgn_EBPNumberOfAmendmentsMadeToPlan"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPNumberOfAmendmentsMadeToPlan" xlink:to="lab_amgn_EBPNumberOfAmendmentsMadeToPlan" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems_019eb288-2580-7543-8fa9-95cc7c522dd0_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Accounting Standard Update and Change in Accounting Principle [Line Items]</link:label>
    <link:label id="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Accounting Standard Update and Change in Accounting Principle [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems" xlink:to="lab_us-gaap-ebp_EbpAccountingStandardUpdateAndChangeInAccountingPrincipleLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentType_019eb288-2580-7a70-9fa3-e5b135211749_terseLabel_en-US" xlink:label="lab_dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Document Type</link:label>
    <link:label id="lab_dei_DocumentType_label_en-US" xlink:label="lab_dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Type</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentType" xlink:to="lab_dei_DocumentType" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityCentralIndexKey_019eb288-2580-77cc-af7b-7fadde68de4d_terseLabel_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:label id="lab_dei_EntityCentralIndexKey_label_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCentralIndexKey" xlink:to="lab_dei_EntityCentralIndexKey" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue_019eb288-2580-7d5b-8e77-a94825b77169_terseLabel_en-US" xlink:label="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Prior-year adjustment</link:label>
    <link:label id="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue_label_en-US" xlink:label="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Change in Net Asset Available for Benefit, Prior Period Increase (Decrease) from Contract Value to Current Value</link:label>
    <link:label id="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue_documentation_en-US" xlink:label="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Change in Net Asset Available for Benefit, Prior Period Increase (Decrease) from Contract Value to Current Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:href="amgn-20260611.xsd#amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:to="lab_amgn_EBPReconciliationToForm5500ChangeInNetAssetAvailableForBenefitPriorPeriodIncreaseDecreaseFromContractValueToCurrentValue" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPEmployerContributionVestingServicePeriodBreakInService_019eb288-2580-772b-84c6-61d40b962879_terseLabel_en-US" xlink:label="lab_amgn_EBPEmployerContributionVestingServicePeriodBreakInService" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Break in service period</link:label>
    <link:label id="lab_amgn_EBPEmployerContributionVestingServicePeriodBreakInService_label_en-US" xlink:label="lab_amgn_EBPEmployerContributionVestingServicePeriodBreakInService" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Employer Contribution Vesting Service Period, Break in Service</link:label>
    <link:label id="lab_amgn_EBPEmployerContributionVestingServicePeriodBreakInService_documentation_en-US" xlink:label="lab_amgn_EBPEmployerContributionVestingServicePeriodBreakInService" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Employer Contribution Vesting Service Period, Break in Service</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPEmployerContributionVestingServicePeriodBreakInService" xlink:href="amgn-20260611.xsd#amgn_EBPEmployerContributionVestingServicePeriodBreakInService"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPEmployerContributionVestingServicePeriodBreakInService" xlink:to="lab_amgn_EBPEmployerContributionVestingServicePeriodBreakInService" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate_019eb288-2580-7626-b819-cf7641185223_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Asset Held for Investment, Participant Loan, Interest Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanParticipantLoanInterestRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Abstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Abstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation of Financial Statement to Form 5500 [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Abstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Abstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Abstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500Abstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember_019eb288-2580-7838-8285-348484897082_terseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Collective trust funds</link:label>
    <link:label id="lab_us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember_label_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Collective Trust [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" xlink:to="lab_us-gaap_DefinedBenefitPlanCommonCollectiveTrustMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems_019eb288-2580-7aff-9185-20f94d6f7e89_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Tax Status [Line Items]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Tax Status [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsMember_019eb288-2580-76c4-9087-e208c3348f86_terseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash and cash equivalents</link:label>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsMember_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash and Cash Equivalents [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsMember" xlink:to="lab_us-gaap_CashAndCashEquivalentsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant_019eb288-2580-7094-aad6-21ca0ca285fe_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notes receivable from participants</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable from Participant</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipant" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_FixedIncomeIndexAssetMember_019eb288-2580-7875-8b25-ffb2569e4c07_terseLabel_en-US" xlink:label="lab_amgn_FixedIncomeIndexAssetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fixed Income Index Asset</link:label>
    <link:label id="lab_amgn_FixedIncomeIndexAssetMember_label_en-US" xlink:label="lab_amgn_FixedIncomeIndexAssetMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fixed Income Index Asset [Member]</link:label>
    <link:label id="lab_amgn_FixedIncomeIndexAssetMember_documentation_en-US" xlink:label="lab_amgn_FixedIncomeIndexAssetMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Fixed Income Index Asset</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_FixedIncomeIndexAssetMember" xlink:href="amgn-20260611.xsd#amgn_FixedIncomeIndexAssetMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_FixedIncomeIndexAssetMember" xlink:to="lab_amgn_FixedIncomeIndexAssetMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_019eb288-2580-752d-945a-b66312e4e109_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy and NAV [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_label_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy and NAV [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock_019eb288-2580-7592-8d18-754f5681602a_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Summary of Significant Accounting Policies</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Summary of Accounting Policy [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanSummaryOfAccountingPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityRegistrantName_019eb288-2580-7736-a4c9-674e35ecf76d_terseLabel_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:label id="lab_dei_EntityRegistrantName_label_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityRegistrantName" xlink:to="lab_dei_EntityRegistrantName" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract_019eb288-2580-7cf6-8c14-3abc694f1cea_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Liabilities</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Liability [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanLiabilityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock_019eb288-2580-718c-92e4-66df8759603e_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Income Tax Status</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Tax Status [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanTaxStatusTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage_019eb288-2580-7db6-9312-d10e82167d2a_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum borrowing, to total account, percentage</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable from Participant, Account, Maximum Borrowing, to Total Account, Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantAccountMaximumBorrowingToTotalAccountPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage_019eb288-2580-7718-9d18-d493b818998a_terseLabel_en-US" xlink:label="lab_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Maximum annual compensation to total compensation, percentage</link:label>
    <link:label id="lab_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage_label_en-US" xlink:label="lab_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Participant Contribution, Maximum Contribution to Eligible Compensation, Percentage</link:label>
    <link:label id="lab_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage_documentation_en-US" xlink:label="lab_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Participant Contribution, Maximum Contribution to Eligible Compensation, Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage" xlink:href="amgn-20260611.xsd#amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage" xlink:to="lab_amgn_EBPParticipantContributionMaximumContributionToEligibleCompensationPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentInformationTable_019eb288-2580-7a16-9a27-f26ae6b12625_terseLabel_en-US" xlink:label="lab_dei_DocumentInformationTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Document Information [Table]</link:label>
    <link:label id="lab_dei_DocumentInformationTable_label_en-US" xlink:label="lab_dei_DocumentInformationTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Information [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentInformationTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentInformationTable" xlink:to="lab_dei_DocumentInformationTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock_019eb288-2580-7ad2-9bfa-6c9eb6cfe653_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notes Receivable from Participants</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Note Receivable from Participant [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanNoteReceivableFromParticipantPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment_019eb288-2580-799f-9c1b-f700f8e8e884_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net increase in net assets available for benefits per the financial statements</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Change in Net Asset Available for Benefit, Increase (Decrease) from Income (Loss) on Investment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanChangeInNetAssetAvailableForBenefitIncreaseDecreaseForIncomeLossOnInvestment" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid_019eb288-2580-7ac7-9d07-31a0e9ca50bf_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amounts allocated to withdrawing participants at December&#160;31, 2024</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Reconciliation to Form 5500, Payment to Participant, Increase from Allocation to Withdrawing Participant, Not yet Paid</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanReconciliationToForm5500PaymentToParticipantIncreaseForAllocationToWithdrawingParticipantNotYetPaid" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems_019eb288-2580-76cb-877d-873767d33f4b_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Related Party and Party-in-Interest Transactions [Line Items]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Related Party and Party-in-Interest Transactions [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanRelatedPartyAndPartyInInterestTransactionsLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_U.S.EquityActiveAssetMember_019eb288-2580-72e7-948c-bfd1358882b6_terseLabel_en-US" xlink:label="lab_amgn_U.S.EquityActiveAssetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">U.S. Equity Active Asset</link:label>
    <link:label id="lab_amgn_U.S.EquityActiveAssetMember_label_en-US" xlink:label="lab_amgn_U.S.EquityActiveAssetMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">U.S. Equity Active Asset [Member]</link:label>
    <link:label id="lab_amgn_U.S.EquityActiveAssetMember_documentation_en-US" xlink:label="lab_amgn_U.S.EquityActiveAssetMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">U.S. Equity Active Asset</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_U.S.EquityActiveAssetMember" xlink:href="amgn-20260611.xsd#amgn_U.S.EquityActiveAssetMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_U.S.EquityActiveAssetMember" xlink:to="lab_amgn_U.S.EquityActiveAssetMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel3Member_019eb288-2580-7ecf-a279-b635b15d3828_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Significant unobservable inputs (Level 3)</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel3Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 3 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel3Member" xlink:to="lab_us-gaap_FairValueInputsLevel3Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit_019eb288-2580-743c-b5e6-adb3b2f6822b_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net assets available for benefits</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit_019eb288-2580-7278-82a4-e03d5fc95829_periodStartLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Net assets available for benefits at beginning of year</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit_019eb288-2580-7638-8de7-2420a1e71a37_periodEndLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Net assets available for benefits at end of year</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit_019eb288-2580-78fe-8e45-18d9371c38e7_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net assets available for benefits per the financial statements</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Net Asset Available for Benefit</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanNetAssetAvailableForBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityDomain_019eb288-2580-7768-b981-cb10bbfcddf8_terseLabel_en-US" xlink:label="lab_dei_EntityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Entity [Domain]</link:label>
    <link:label id="lab_dei_EntityDomain_label_en-US" xlink:label="lab_dei_EntityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity [Domain]</link:label>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue_019eb288-2580-7455-b682-1872e32b2057_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investments in fully benefit-responsive investment contracts at contract value</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Excluding Plan Interest in Master Trust, Contract Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentExcludingPlanInterestInMasterTrustContractValue" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_FixedIncomeActiveAssetMember_019eb288-2580-7c85-9a75-4f7251ff99bd_terseLabel_en-US" xlink:label="lab_amgn_FixedIncomeActiveAssetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fixed Income Active Asset</link:label>
    <link:label id="lab_amgn_FixedIncomeActiveAssetMember_label_en-US" xlink:label="lab_amgn_FixedIncomeActiveAssetMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fixed Income Active Asset [Member]</link:label>
    <link:label id="lab_amgn_FixedIncomeActiveAssetMember_documentation_en-US" xlink:label="lab_amgn_FixedIncomeActiveAssetMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Fixed Income Active Asset</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_FixedIncomeActiveAssetMember" xlink:to="lab_amgn_FixedIncomeActiveAssetMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesMember_019eb288-2580-79d7-a3d5-30024cad873d_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt securities</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesMember_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesMember" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesMember" xlink:to="lab_us-gaap_DebtSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_ParticipantSelfDirectedAccountsMember_019eb288-2580-795b-ba47-5e0e79038b83_terseLabel_en-US" xlink:label="lab_amgn_ParticipantSelfDirectedAccountsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Participant Self-Directed Accounts</link:label>
    <link:label id="lab_amgn_ParticipantSelfDirectedAccountsMember_label_en-US" xlink:label="lab_amgn_ParticipantSelfDirectedAccountsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Participant Self-Directed Accounts [Member]</link:label>
    <link:label id="lab_amgn_ParticipantSelfDirectedAccountsMember_documentation_en-US" xlink:label="lab_amgn_ParticipantSelfDirectedAccountsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Participant Self-Directed Accounts</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_ParticipantSelfDirectedAccountsMember" xlink:href="amgn-20260611.xsd#amgn_ParticipantSelfDirectedAccountsMember"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit_019eb288-2580-73a6-8138-4338fa79bf7f_totalLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net assets per the Form 5500</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Form 5500 Caption, Net Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit" xlink:to="lab_us-gaap-ebp_EmployeeBenefitPlanForm5500CaptionNetAssetAvailableForBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_amgn_EBPParticipantLoanBasisSpreadOnVariableRate_019eb288-2580-75a8-9fe2-1b9c26c6ba5a_terseLabel_en-US" xlink:label="lab_amgn_EBPParticipantLoanBasisSpreadOnVariableRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Basis spread on variable rate</link:label>
    <link:label id="lab_amgn_EBPParticipantLoanBasisSpreadOnVariableRate_label_en-US" xlink:label="lab_amgn_EBPParticipantLoanBasisSpreadOnVariableRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Participant Loan, Basis Spread On Variable Rate</link:label>
    <link:label id="lab_amgn_EBPParticipantLoanBasisSpreadOnVariableRate_documentation_en-US" xlink:label="lab_amgn_EBPParticipantLoanBasisSpreadOnVariableRate" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">EBP, Participant Loan, Basis Spread On Variable Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_amgn_EBPParticipantLoanBasisSpreadOnVariableRate" xlink:href="amgn-20260611.xsd#amgn_EBPParticipantLoanBasisSpreadOnVariableRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_amgn_EBPParticipantLoanBasisSpreadOnVariableRate" xlink:to="lab_amgn_EBPParticipantLoanBasisSpreadOnVariableRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTable_019eb288-2580-7c19-8234-fcf8131f1754_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV [Table]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTable_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Investment, Fair Value and NAV [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTable" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanInvestmentFairValueAndNavTable"/>
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    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems_019eb288-2580-756b-a0ba-7ad945ff9ef9_terseLabel_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">EBP, Statement of Net Asset Available for Benefit [Line Items]</link:label>
    <link:label id="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems_label_en-US" xlink:label="lab_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EBP, Statement of Net Asset Available for Benefit [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2026/ebp/elts/us-gaap-ebp-2026.xsd#us-gaap-ebp_EmployeeBenefitPlanStatementOfNetAssetAvailableForBenefitLineItems"/>
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