0001819133 2026-06-10 2026-06-10 0001819133 1 2026-06-10 2026-06-10 0001819133 2 2026-06-10 2026-06-10 iso4217:USD pure shares S-3 424B5 EX-FILING FEES 333-291684 0001819133 Tango Therapeutics, Inc. N/A N/A S-3 Tango Therapeutics, Inc. false Equity Common Stock, par value $0.001 per share true 23000071 30.00 690002130.00 0.0001381 95289.30 false Equity Pre-Funded Warrants to purchase Common Stock true 1833395 30.00 0.0001381 0.00 690002130.00 95289.30 0.00 0.00 95289.30 The amount registered assumes the exercise in full of the underwriters' option to purchase up to 3,000,009 additional shares of common stock and includes 1,833,395 shares of common stock issuable upon the exercise of the pre-funded warrants to purchase common stock. Represents the sum of the offering price of the pre-funded warrant sales price of $29.999 per pre-funded warrant and the exercise price of $0.001 per share issuable pursuant to the pre-funded warrants. The filing fee, calculated in accordance with Rule 457(r) under the Securities Act of 1933, as amended, has been transmitted to the Securities and Exchange Commission in connection with the securities offered by means of this prospectus supplement. This "Calculation of Filing Fee" table shall be deemed to update the "Calculation of Registration Fee" table in the Registrant's Registration Statement on Form S-3 filed with the Securities and Exchange Commission on November 21, 2025 (File No. 333-291684). Pursuant to Rule 416 under the Securities Act, the pre-funded warrants to purchase common stock being registered hereunder include such indeterminate number of additional shares of common stock as may be issued after the date hereof as a result of share splits, share dividends or similar transactions. The registration fee for the pre-funded warrants is being allocated to the shares of common stock issuable upon exercise of the pre-funded warrants. 690002130.00 true