<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e75e2-1db4-7b7e-acec-d10f6b4c0951,g:ff4087cb-dd03-418e-9ee9-ebe86101df20-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.biomarin.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="bmrn-20260602.xsd#DocumentandEntityInformationDocument"/>
  <link:presentationLink xlink:role="http://www.biomarin.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019e75e2-1db4-7bc9-aa1d-72f6beb075c7" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_DocumentType_019e75e2-1db4-7bc9-aa1d-72f6beb075c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019e75e2-1db4-7b3f-9c5a-58dcf5e2e5b1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_DocumentPeriodEndDate_019e75e2-1db4-7b3f-9c5a-58dcf5e2e5b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019e75e2-1db4-7603-9acb-41c428faa370" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityRegistrantName_019e75e2-1db4-7603-9acb-41c428faa370" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019e75e2-1db4-7c82-841e-495101114333" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019e75e2-1db4-7c82-841e-495101114333" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019e75e2-1db4-7fa4-9b0d-0669884e77e9" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityFileNumber_019e75e2-1db4-7fa4-9b0d-0669884e77e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019e75e2-1db4-7ec4-8cc3-1f96032d9fab" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityTaxIdentificationNumber_019e75e2-1db4-7ec4-8cc3-1f96032d9fab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019e75e2-1db4-7e6f-bb6d-7f46f4f64703" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityAddressAddressLine1_019e75e2-1db4-7e6f-bb6d-7f46f4f64703" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019e75e2-1db4-7896-a173-17d373d044f2" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityAddressCityOrTown_019e75e2-1db4-7896-a173-17d373d044f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019e75e2-1db4-7dd7-9b8c-55b3b3cfaa8e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityAddressStateOrProvince_019e75e2-1db4-7dd7-9b8c-55b3b3cfaa8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019e75e2-1db4-7af2-bb14-df8643fd09f1" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityAddressPostalZipCode_019e75e2-1db4-7af2-bb14-df8643fd09f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019e75e2-1db4-7926-bed7-8bc4c47883d8" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_CityAreaCode_019e75e2-1db4-7926-bed7-8bc4c47883d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019e75e2-1db4-7c6f-913a-55dfb87cd820" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_LocalPhoneNumber_019e75e2-1db4-7c6f-913a-55dfb87cd820" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019e75e2-1db4-7e76-b540-cdd3b5c9f6c7" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_WrittenCommunications_019e75e2-1db4-7e76-b540-cdd3b5c9f6c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019e75e2-1db4-7296-938f-05df514fc884" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_SolicitingMaterial_019e75e2-1db4-7296-938f-05df514fc884" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019e75e2-1db4-74f2-8566-7c4865ced60a" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_PreCommencementTenderOffer_019e75e2-1db4-74f2-8566-7c4865ced60a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019e75e2-1db4-776d-837d-39bc7962a70e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019e75e2-1db4-776d-837d-39bc7962a70e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019e75e2-1db4-7a65-bb39-d3c420732d37" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_Security12bTitle_019e75e2-1db4-7a65-bb39-d3c420732d37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019e75e2-1db4-722a-be92-742c627507ab" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_TradingSymbol_019e75e2-1db4-722a-be92-742c627507ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019e75e2-1db4-73df-880b-5a3456d81732" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_SecurityExchangeName_019e75e2-1db4-73df-880b-5a3456d81732" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019e75e2-1db4-77a4-aae7-a820bd953207" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityEmergingGrowthCompany_019e75e2-1db4-77a4-aae7-a820bd953207" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019e75e2-1db4-72a5-b8d3-9b0d59718662" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_AmendmentFlag_019e75e2-1db4-72a5-b8d3-9b0d59718662" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019e75e2-1db4-7ec0-ab0d-fb23a781cde3" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e75e2-1db4-71f6-bf8b-4778249eb845" xlink:to="loc_dei_EntityCentralIndexKey_019e75e2-1db4-7ec0-ab0d-fb23a781cde3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
