v3.26.1
Pay vs Performance Disclosure - USD ($)
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
Pay Versus Performance
In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer (PEO) and our other named executive officers (our
Non-PEO
NEOs) and Company performance for the fiscal years listed below. The talent and compensation committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown.
 
Year
  
Summary
Compensation
Table Total for
PEO ($)
(1)
    
Compensation
Actually Paid to
PEO ($)
(1)(2)(3)
   
Average
Summary
Compensation
Table Total for
Non-PEO NEOs

($)
(1)
    
Average
Compensation
Actually Paid to
Non-PEO NEOs

($)
(1)(2)(3)
   
Value of Initial
Fixed $100
Investment based
on
TSR ($)
(4)
    
Net Income
($ Thousands)
 
2025
     1,205,710        105,003       744,805        456,589       31.55        (73,600
2024
     3,549,950        4,581,646       1,118,658        790,704       39.83        (86,599
2023
     5,197,331        (136,662     1,407,506        (320,892     33.45        (86,277
 
(1)
Omid Farokhzad, M.D. was our PEO for each year presented. The individuals comprising the
Non-PEO
NEOs for each year presented are listed below:
 
2025
  
2023 - 2024
David Horn
   David Horn
   Elona Kogan
 
(2)
 
The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation
S-K
and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
(3)
 
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table.
 
Year
 
Summary Compensation
Table Total for PEO ($)
   
Exclusion of Stock Awards
and Option Awards for
PEO ($)
   
Inclusion of Equity Values
for PEO ($)
   
Compensation Actually
Paid to PEO ($)
 
2025
    1,205,710       —         (1,100,707     105,003  
2024
    3,549,950       (2,360,377     3,392,073       4,581,646  
2023
    5,197,331       (4,015,530     (1,318,463     (136,662
 
Year
 
Average Summary
Compensation Table Total
for
Non-PEO
NEOs ($)
   
Average Exclusion of
Stock Awards and Option
Awards for
Non-PEO

NEOs ($)
   
Average Inclusion of
Equity Values for
Non-PEO
NEOs ($)
   
Average Compensation
Actually Paid to Non-PEO

NEOs ($)
 
2025
    744,805       —         (288,216     456,589  
2024
    1,118,658       (601,024     273,070       790,704  
2023
    1,407,506       (788,760     (939,638     (320,892
 
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables (the Company has not paid dividends historically as a public company and does not sponsor any pension arrangements; thus no adjustments are made for these items):
 
Year
 
Year-End Fair

Value of Equity
Awards Granted
During Year That
Remained
Outstanding and
Unvested as of
Last Day of Year
for PEO ($)
   
Change in Fair
Value from Last
Day of Prior Year
to Last Day of
Year of
Outstanding and
Unvested Equity
Awards for PEO
($)
   
Vesting-Date Fair

Value of Equity
Awards Granted
During Year that
Vested During
Year for PEO ($)
   
Change in Fair
Value from Last
Day of Prior Year
to Vesting Date of
Unvested Equity
Awards Granted
in Prior Year that
Vested During
Year for PEO ($)
   
Fair Value at Last
Day of Prior Year
of Equity Awards
Granted in Prior
Year that
Forfeited During
Year for PEO ($)
   
Total - Inclusion of

Equity Values for
PEO ($)
 
2025
    —         (1,107,996     —         7,289       —         (1,100,707
2024
    2,996,803       451,882       —         (56,612     —         3,392,073  
2023
    1,542,178       (1,645,982     —         (1,214,659     —         (1,318,463
 
Year
 
Average Year-End

Fair Value of
Equity Awards
Granted During
Year That
Remained
Outstanding and
Unvested as of
Last Day of Year
for
Non-PEO

NEOs ($)
   
Average Change in
Fair Value from
Last Day of Prior
Year to Last Day
of Year of
Outstanding and
Unvested Equity
Awards for Non-
PEO NEOs ($)
   
Average Vesting-
Date Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
Non-PEO
NEOs
($)
   
Average Change in
Fair Value from
Last Day of Prior
Year to Vesting
Date of Unvested
Equity Awards
Granted in Prior
Year that Vested
During Year for
Non-PEO
NEOs
($)
   
Average Fair
Value at Last Day
of Prior Year of
Equity Awards
Granted in Prior
Year that
Forfeited During
Year for
Non-PEO
NEOs
($)
   
Total - Average

Inclusion of Equity
Values for Non-
PEO NEOs ($)
 
2025
    —         (260,227     —         (27,989     —         (288,216
2024
    427,600       64,266       —         (18,866     (199,930     273,070  
2023
    299,987       (733,276     —         (506,349     —         (939,638
 
(4)
 
Assumes $100 was invested in the Company for the period starting December 31, 2022, through the end of the listed year. Historical stock performance is not necessarily indicative of future stock performance.
   
Named Executive Officers, Footnote
(1)
Omid Farokhzad, M.D. was our PEO for each year presented. The individuals comprising the
Non-PEO
NEOs for each year presented are listed below:
 
2025
  
2023 - 2024
David Horn
   David Horn
   Elona Kogan
   
PEO Total Compensation Amount $ 1,205,710 $ 3,549,950 $ 5,197,331
PEO Actually Paid Compensation Amount $ 105,003 4,581,646 (136,662)
Adjustment To PEO Compensation, Footnote
(3)
 
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table.
 
Year
 
Summary Compensation
Table Total for PEO ($)
   
Exclusion of Stock Awards
and Option Awards for
PEO ($)
   
Inclusion of Equity Values
for PEO ($)
   
Compensation Actually
Paid to PEO ($)
 
2025
    1,205,710       —         (1,100,707     105,003  
2024
    3,549,950       (2,360,377     3,392,073       4,581,646  
2023
    5,197,331       (4,015,530     (1,318,463     (136,662
 
Year
 
Average Summary
Compensation Table Total
for
Non-PEO
NEOs ($)
   
Average Exclusion of
Stock Awards and Option
Awards for
Non-PEO

NEOs ($)
   
Average Inclusion of
Equity Values for
Non-PEO
NEOs ($)
   
Average Compensation
Actually Paid to Non-PEO

NEOs ($)
 
2025
    744,805       —         (288,216     456,589  
2024
    1,118,658       (601,024     273,070       790,704  
2023
    1,407,506       (788,760     (939,638     (320,892
 
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables (the Company has not paid dividends historically as a public company and does not sponsor any pension arrangements; thus no adjustments are made for these items):
 
Year
 
Year-End Fair

Value of Equity
Awards Granted
During Year That
Remained
Outstanding and
Unvested as of
Last Day of Year
for PEO ($)
   
Change in Fair
Value from Last
Day of Prior Year
to Last Day of
Year of
Outstanding and
Unvested Equity
Awards for PEO
($)
   
Vesting-Date Fair

Value of Equity
Awards Granted
During Year that
Vested During
Year for PEO ($)
   
Change in Fair
Value from Last
Day of Prior Year
to Vesting Date of
Unvested Equity
Awards Granted
in Prior Year that
Vested During
Year for PEO ($)
   
Fair Value at Last
Day of Prior Year
of Equity Awards
Granted in Prior
Year that
Forfeited During
Year for PEO ($)
   
Total - Inclusion of

Equity Values for
PEO ($)
 
2025
    —         (1,107,996     —         7,289       —         (1,100,707
2024
    2,996,803       451,882       —         (56,612     —         3,392,073  
2023
    1,542,178       (1,645,982     —         (1,214,659     —         (1,318,463
 
Year
 
Average Year-End

Fair Value of
Equity Awards
Granted During
Year That
Remained
Outstanding and
Unvested as of
Last Day of Year
for
Non-PEO

NEOs ($)
   
Average Change in
Fair Value from
Last Day of Prior
Year to Last Day
of Year of
Outstanding and
Unvested Equity
Awards for Non-
PEO NEOs ($)
   
Average Vesting-
Date Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
Non-PEO
NEOs
($)
   
Average Change in
Fair Value from
Last Day of Prior
Year to Vesting
Date of Unvested
Equity Awards
Granted in Prior
Year that Vested
During Year for
Non-PEO
NEOs
($)
   
Average Fair
Value at Last Day
of Prior Year of
Equity Awards
Granted in Prior
Year that
Forfeited During
Year for
Non-PEO
NEOs
($)
   
Total - Average

Inclusion of Equity
Values for Non-
PEO NEOs ($)
 
2025
    —         (260,227     —         (27,989     —         (288,216
2024
    427,600       64,266       —         (18,866     (199,930     273,070  
2023
    299,987       (733,276     —         (506,349     —         (939,638
   
Non-PEO NEO Average Total Compensation Amount $ 744,805 1,118,658 1,407,506
Non-PEO NEO Average Compensation Actually Paid Amount $ 456,589 790,704 (320,892)
Adjustment to Non-PEO NEO Compensation Footnote
(3)
 
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table.
 
Year
 
Summary Compensation
Table Total for PEO ($)
   
Exclusion of Stock Awards
and Option Awards for
PEO ($)
   
Inclusion of Equity Values
for PEO ($)
   
Compensation Actually
Paid to PEO ($)
 
2025
    1,205,710       —         (1,100,707     105,003  
2024
    3,549,950       (2,360,377     3,392,073       4,581,646  
2023
    5,197,331       (4,015,530     (1,318,463     (136,662
 
Year
 
Average Summary
Compensation Table Total
for
Non-PEO
NEOs ($)
   
Average Exclusion of
Stock Awards and Option
Awards for
Non-PEO

NEOs ($)
   
Average Inclusion of
Equity Values for
Non-PEO
NEOs ($)
   
Average Compensation
Actually Paid to Non-PEO

NEOs ($)
 
2025
    744,805       —         (288,216     456,589  
2024
    1,118,658       (601,024     273,070       790,704  
2023
    1,407,506       (788,760     (939,638     (320,892
 
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables (the Company has not paid dividends historically as a public company and does not sponsor any pension arrangements; thus no adjustments are made for these items):
 
Year
 
Year-End Fair

Value of Equity
Awards Granted
During Year That
Remained
Outstanding and
Unvested as of
Last Day of Year
for PEO ($)
   
Change in Fair
Value from Last
Day of Prior Year
to Last Day of
Year of
Outstanding and
Unvested Equity
Awards for PEO
($)
   
Vesting-Date Fair

Value of Equity
Awards Granted
During Year that
Vested During
Year for PEO ($)
   
Change in Fair
Value from Last
Day of Prior Year
to Vesting Date of
Unvested Equity
Awards Granted
in Prior Year that
Vested During
Year for PEO ($)
   
Fair Value at Last
Day of Prior Year
of Equity Awards
Granted in Prior
Year that
Forfeited During
Year for PEO ($)
   
Total - Inclusion of

Equity Values for
PEO ($)
 
2025
    —         (1,107,996     —         7,289       —         (1,100,707
2024
    2,996,803       451,882       —         (56,612     —         3,392,073  
2023
    1,542,178       (1,645,982     —         (1,214,659     —         (1,318,463
 
Year
 
Average Year-End

Fair Value of
Equity Awards
Granted During
Year That
Remained
Outstanding and
Unvested as of
Last Day of Year
for
Non-PEO

NEOs ($)
   
Average Change in
Fair Value from
Last Day of Prior
Year to Last Day
of Year of
Outstanding and
Unvested Equity
Awards for Non-
PEO NEOs ($)
   
Average Vesting-
Date Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
Non-PEO
NEOs
($)
   
Average Change in
Fair Value from
Last Day of Prior
Year to Vesting
Date of Unvested
Equity Awards
Granted in Prior
Year that Vested
During Year for
Non-PEO
NEOs
($)
   
Average Fair
Value at Last Day
of Prior Year of
Equity Awards
Granted in Prior
Year that
Forfeited During
Year for
Non-PEO
NEOs
($)
   
Total - Average

Inclusion of Equity
Values for Non-
PEO NEOs ($)
 
2025
    —         (260,227     —         (27,989     —         (288,216
2024
    427,600       64,266       —         (18,866     (199,930     273,070  
2023
    299,987       (733,276     —         (506,349     —         (939,638
   
Compensation Actually Paid vs. Total Shareholder Return
Relationship Between PEO and
Non-PEO
NEO Compensation Actually Paid and Company Total Shareholder Return (TSR)
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our
Non-PEO
NEOs, and the Company’s cumulative TSR over the three most recently completed fiscal years.
 
 
LOGO
 
   
Compensation Actually Paid vs. Net Income
Relationship Between PEO and
Non-PEO
NEO Compensation Actually Paid and Net Income
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our
Non-PEO
NEOs, and our Net Income during the three most recently completed fiscal years.
 
 
LOGO
 
   
Total Shareholder Return Amount $ 31.55 39.83 33.45
Net Income (Loss) $ (73,600,000) $ (86,599,000) $ (86,277,000)
PEO Name Omid Farokhzad Omid Farokhzad Omid Farokhzad
Additional 402(v) Disclosure The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation
S-K
and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
   
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 0 $ (2,360,377) $ (4,015,530)
PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (1,100,707) 3,392,073 (1,318,463)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 2,996,803 1,542,178
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (1,107,996) 451,882 (1,645,982)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 0 0
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 7,289 (56,612) (1,214,659)
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 0 0
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 (601,024) (788,760)
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (288,216) 273,070 (939,638)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 427,600 299,987
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (260,227) 64,266 (733,276)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0 0 0
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (27,989) (18,866) (506,349)
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 0 $ (199,930) $ 0