<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e89b8-e60e-76f9-856c-f09e6e530e4a,g:6bf625ce-9819-450b-bf35-ac926899b26d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.orasure.com/role/Cover" xlink:type="simple" xlink:href="osur-20260603.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.orasure.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019e89b8-e60e-7b96-9a53-9484eda4f3d1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_DocumentType_019e89b8-e60e-7b96-9a53-9484eda4f3d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019e89b8-e60e-73a4-a79f-aaca8f7af772" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_DocumentPeriodEndDate_019e89b8-e60e-73a4-a79f-aaca8f7af772" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019e89b8-e60e-78d1-8736-6ac2372c3888" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityRegistrantName_019e89b8-e60e-78d1-8736-6ac2372c3888" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019e89b8-e60e-7c20-883b-4635619a87ba" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019e89b8-e60e-7c20-883b-4635619a87ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019e89b8-e60e-7e93-81e3-ec15e6fd3861" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityFileNumber_019e89b8-e60e-7e93-81e3-ec15e6fd3861" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019e89b8-e60e-721c-853c-e52159da49df" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityTaxIdentificationNumber_019e89b8-e60e-721c-853c-e52159da49df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019e89b8-e60e-7007-9f05-223c89406324" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityAddressAddressLine1_019e89b8-e60e-7007-9f05-223c89406324" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019e89b8-e60e-78d2-867c-db783ee7f7da" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityAddressCityOrTown_019e89b8-e60e-78d2-867c-db783ee7f7da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019e89b8-e60e-75b3-a124-8379bbb78808" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityAddressStateOrProvince_019e89b8-e60e-75b3-a124-8379bbb78808" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019e89b8-e60e-7e1f-99eb-221ccf1158cc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityAddressPostalZipCode_019e89b8-e60e-7e1f-99eb-221ccf1158cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019e89b8-e60e-7f13-937c-6e7dae651830" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_CityAreaCode_019e89b8-e60e-7f13-937c-6e7dae651830" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019e89b8-e60e-73d0-b757-8ceccbc08198" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_LocalPhoneNumber_019e89b8-e60e-73d0-b757-8ceccbc08198" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019e89b8-e60e-7ceb-a6e1-3133610d8067" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_Security12bTitle_019e89b8-e60e-7ceb-a6e1-3133610d8067" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019e89b8-e60e-7c18-8d15-b46e12a53257" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_TradingSymbol_019e89b8-e60e-7c18-8d15-b46e12a53257" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019e89b8-e60e-787c-99a4-13dd4242097e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_SecurityExchangeName_019e89b8-e60e-787c-99a4-13dd4242097e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019e89b8-e60e-70a7-a994-079ee2da7c12" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_WrittenCommunications_019e89b8-e60e-70a7-a994-079ee2da7c12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019e89b8-e60e-76ca-8ae3-aea54c905146" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_SolicitingMaterial_019e89b8-e60e-76ca-8ae3-aea54c905146" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019e89b8-e60e-7dea-83d9-c0239641f897" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_PreCommencementTenderOffer_019e89b8-e60e-7dea-83d9-c0239641f897" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019e89b8-e60e-7eb6-bd1c-dc1bb15b1fef" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019e89b8-e60e-7eb6-bd1c-dc1bb15b1fef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019e89b8-e60e-7685-9008-342af5256097" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityEmergingGrowthCompany_019e89b8-e60e-7685-9008-342af5256097" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019e89b8-e60e-713f-a366-c0370536ed5f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_AmendmentFlag_019e89b8-e60e-713f-a366-c0370536ed5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019e89b8-e60e-772a-9cbb-e410f6505211" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_EntityCentralIndexKey_019e89b8-e60e-772a-9cbb-e410f6505211" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_019e89b8-e60e-7b39-8ef2-835ba06562a5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e89b8-e60e-7ca1-993c-3315f9b6c56f" xlink:to="loc_dei_CurrentFiscalYearEndDate_019e89b8-e60e-7b39-8ef2-835ba06562a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
