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License Agreement, Advances From Collaboration Partners, Legal, and Other Contingencies (Detail) - USD ($)		1 Months Ended					3 Months Ended		6 Months Ended	12 Months Ended
	Mar. 11, 2024	Oct. 31, 2025	Oct. 30, 2025	Jun. 30, 2023	Mar. 31, 2022	May 31, 2021	Mar. 31, 2026	Mar. 31, 2025	Jun. 30, 2023	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2019	Jan. 03, 2025	Jul. 10, 2024
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Aggregate milestone payment							$ 470,000,000			$ 470,000,000
Gain (loss) on fair value recognized										100,000		$ (100,000)
Clinical and regulatory milestone payments received							3,600,000			3,600,000
Patent Expenses Due To Harvard							100,000	$ 100,000		100,000	$ 100,000	100,000
Debt Instrument, Unamortized Discount										0
Long term debt										1,000,000
2019 CFF Award [Member]
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2022 CFF Award [Member]
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2021 CFF Award [Member]
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Hercules Term Loan Agreement
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Royalty payment as percentage of net sales			1.00%
Royalties			$ 300,000
Elox - CFF [Member] \| 2022 CFF Award [Member]
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Aggregate milestone payment											400,000	200,000
Percentage Of Consideration Received For Disposition Event			10.00%
Elox - CFF [Member] \| 2025 CFF Award [Member]
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Value of the embedded derivative										0
Elox - CFF [Member] \| Elox - Phase Two Clinical Development [Member] \| 2022 CFF Award [Member]
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Aggregate milestone payment				$ 200,000
Remaining amount of award payable upon achievement certain clinical development milestones									$ 7,400,000
Almirall License Agreement
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Upfront payment received	$ 3,000,000
Aggregate milestone payment	$ 470,000,000
Total transaction price										3,100,000
Regulatory Milestone											3,000,000
Almirall License Agreement \| License and Service [Member]
Legal And Other Contingencies [Line Items]
Revenue											6,400,000
Cystic Fibrosis Foundation [Member]
Legal And Other Contingencies [Line Items]
Funding award amount received							0	0
Royalty payment as percentage of net sales		1.00%
Royalties		$ 300,000
Debt Instrument, Unamortized Discount										300,000
Cystic Fibrosis Foundation [Member] \| 2025 CFF Award [Member]
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Value of the embedded derivative
Maximum [Member]
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Related party transaction percentage of expenses										5.00%
Maximum [Member] \| 2019 CFF Award [Member]
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Funding award amount received													$ 3,600,000
Maximum [Member] \| 2021 CFF Award [Member]
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Funding award amount received						$ 2,600,000
Maximum [Member] \| Elox - CFF [Member] \| Elox - Phase Two Clinical Development [Member] \| 2022 CFF Award [Member]
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Award to fund development milestones					$ 15,900,000
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Legal And Other Contingencies [Line Items]
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Research and Development Agreements [Member]
Legal And Other Contingencies [Line Items]
Research and development grants received							$ 0	0		$ 0	$ 0	0
Repayment percentage of grants received							100.00%				100.00%
Royalty received including accrued LIBOR interest							$ 2,800,000			2,800,000
Research and Development Agreements [Member] \| Israel Innovation Authority [Member]
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Research and development grants received							$ 2,600,000			2,600,000
Technion Research and Development Foundation Ltd [Member]
Legal And Other Contingencies [Line Items]
Award to fund development milestones								$ 6,500,000		6,500,000
Research and development expense										$ 100,000	$ 100,000	$ 100,000