<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c6cf4-e69d-7c64-afb0-299c87f310c2,g:83cd2719-5be3-4fff-8b63-4f6508bf8b7b-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://prophaselabs.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="prph-20251231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-7258-adcd-2511260696ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-7258-adcd-2511260696ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019c70a5-4a9b-7a6f-8391-a12683fc1c0c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019c70a5-4a9b-7a6f-8391-a12683fc1c0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_019c70a5-4a9b-775d-bc6f-51b5b3da0a1c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_EquityMethodInvestments_019c70a5-4a9b-775d-bc6f-51b5b3da0a1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseNoncurrent_019c70a5-4a9b-79d3-a63b-5ef574b45bce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_PrepaidExpenseNoncurrent_019c70a5-4a9b-79d3-a63b-5ef574b45bce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c70a5-4a9b-7d12-84e9-b149cd92e29a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c70a5-4a9b-7d12-84e9-b149cd92e29a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c70a5-4a9b-7812-9984-d6e58f031058" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c70a5-4a9b-7812-9984-d6e58f031058" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019c70a5-4a9b-731e-b9ac-311281f3a856" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_Goodwill_019c70a5-4a9b-731e-b9ac-311281f3a856" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019c70a5-4a9b-7ba2-bdb5-1bc9679a8fdb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019c70a5-4a9b-7ba2-bdb5-1bc9679a8fdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_019c70a5-4a9b-7528-b5ba-021902891a8e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c70a5-4a9b-7a0d-9bbc-454705d1b341" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_019c70a5-4a9b-7528-b5ba-021902891a8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-73f9-b5b7-767e452051b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c70a5-4a9b-7629-ad3b-413d1f0fde0c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-73f9-b5b7-767e452051b2" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c70a5-4a9b-7629-ad3b-413d1f0fde0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019c70a5-4a9b-70d5-b319-bb617034a78f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-73f9-b5b7-767e452051b2" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019c70a5-4a9b-70d5-b319-bb617034a78f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019c70a5-4a9b-75d3-b074-be3ed22d5f8d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-73f9-b5b7-767e452051b2" xlink:to="loc_us-gaap_InventoryNet_019c70a5-4a9b-75d3-b074-be3ed22d5f8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c70a5-4a9b-7fda-b651-4f05cf847c36" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-73f9-b5b7-767e452051b2" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c70a5-4a9b-7fda-b651-4f05cf847c36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c70a5-4a9b-7eb0-b613-78972cc06790" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c70a5-4a9b-73f9-b5b7-767e452051b2" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c70a5-4a9b-7eb0-b613-78972cc06790" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7a73-bf00-c1c491611ff5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnsecuredLongTermDebt_019c70a5-4a9b-7de8-849d-151512391640" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnsecuredLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7a73-bf00-c1c491611ff5" xlink:to="loc_us-gaap_UnsecuredLongTermDebt_019c70a5-4a9b-7de8-849d-151512391640" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionContingentConsiderationLiabilityNoncurrent_019c70a5-4a9b-7c00-980d-5e3cc382c17c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7a73-bf00-c1c491611ff5" xlink:to="loc_us-gaap_AssetAcquisitionContingentConsiderationLiabilityNoncurrent_019c70a5-4a9b-7c00-980d-5e3cc382c17c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019c70a5-4a9b-751d-94c5-d11e021292d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7a73-bf00-c1c491611ff5" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019c70a5-4a9b-751d-94c5-d11e021292d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019c70a5-4a9b-77e4-91d4-cb4d0415a33c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7a73-bf00-c1c491611ff5" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019c70a5-4a9b-77e4-91d4-cb4d0415a33c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019c70a5-4a9b-7a22-bb0e-74e2d3844734" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7a73-bf00-c1c491611ff5" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019c70a5-4a9b-7a22-bb0e-74e2d3844734" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_019c70a5-4a9b-7a9e-b218-e70d55aa9d19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7a73-bf00-c1c491611ff5" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_019c70a5-4a9b-7a9e-b218-e70d55aa9d19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019c70a5-4a9b-7908-85d7-b9c78706435a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-7ead-819d-1a911bd60804" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c70a5-4a9b-7908-85d7-b9c78706435a" xlink:to="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-7ead-819d-1a911bd60804" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7130-aece-f93363bdd3a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019c70a5-4a9b-7908-85d7-b9c78706435a" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_019c70a5-4a9b-7130-aece-f93363bdd3a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-7487-a96e-440263e14e93" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019c70a5-4a9b-711d-8660-581b4ecd5e24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-7487-a96e-440263e14e93" xlink:to="loc_us-gaap_PreferredStockValue_019c70a5-4a9b-711d-8660-581b4ecd5e24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019c70a5-4a9b-76dc-9564-7192426f90ba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-7487-a96e-440263e14e93" xlink:to="loc_us-gaap_CommonStockValue_019c70a5-4a9b-76dc-9564-7192426f90ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019c70a5-4a9b-7592-b90c-0a8271f0afaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-7487-a96e-440263e14e93" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019c70a5-4a9b-7592-b90c-0a8271f0afaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_019c70a5-4a9b-7316-b64f-17b0dd48a514" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-7487-a96e-440263e14e93" xlink:to="loc_us-gaap_TreasuryStockCommonValue_019c70a5-4a9b-7316-b64f-17b0dd48a514" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c70a5-4a9b-7d50-aac0-985917c7ff99" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-7487-a96e-440263e14e93" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c70a5-4a9b-7d50-aac0-985917c7ff99" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ce5b6-a4f6-7892-80db-6c06defa3df0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-7487-a96e-440263e14e93" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ce5b6-a4f6-7892-80db-6c06defa3df0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c70a5-4a9b-7c68-8c71-403695aa66a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019c70a5-4a9b-7221-b358-736c963e6dec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c70a5-4a9b-7c68-8c71-403695aa66a6" xlink:to="loc_us-gaap_Liabilities_019c70a5-4a9b-7221-b358-736c963e6dec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019c70a5-4a9b-71f9-9b2f-24cbc45b9e96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c70a5-4a9b-7c68-8c71-403695aa66a6" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019c70a5-4a9b-71f9-9b2f-24cbc45b9e96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-75b7-83a5-049fbd2b395a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c70a5-4a9b-7c68-8c71-403695aa66a6" xlink:to="loc_us-gaap_StockholdersEquity_019c70a5-4a9b-75b7-83a5-049fbd2b395a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019c70a5-4a9b-7980-9256-aa0fc74e0eb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_AccountsPayableCurrent_019c70a5-4a9b-7980-9256-aa0fc74e0eb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_019c70a5-4a9b-713e-9b24-92225ea2eacf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_019c70a5-4a9b-713e-9b24-92225ea2eacf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedMarketingCostsCurrent_019c70a5-4a9b-7435-b935-1fdd50a75942" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedMarketingCostsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_AccruedMarketingCostsCurrent_019c70a5-4a9b-7435-b935-1fdd50a75942" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_019c70a5-4a9b-70ba-a25a-9a384ed199f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_019c70a5-4a9b-70ba-a25a-9a384ed199f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019c70a5-4a9b-7bde-975f-fcd6798c728b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019c70a5-4a9b-7bde-975f-fcd6798c728b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019c70a5-4a9b-712c-a307-1ac4bd363513" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_ShortTermBorrowings_019c70a5-4a9b-712c-a307-1ac4bd363513" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_019c70a5-4a9b-79f0-9630-e5ce932e88d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertibleDebtCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_019c70a5-4a9b-79f0-9630-e5ce932e88d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_019c70a5-4a9b-7894-9042-c67279ffa4ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_019c70a5-4a9b-7894-9042-c67279ffa4ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019c70a5-4a9b-7a1b-8b92-cac6012280db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019c70a5-4a9b-7a1b-8b92-cac6012280db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_019c70a5-4a9b-7d02-ace6-eb8f545b7877" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_TaxesPayableCurrent_019c70a5-4a9b-7d02-ace6-eb8f545b7877" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019c70a5-4a9b-7476-8a03-74415a91647d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019c70a5-4a9b-7476-8a03-74415a91647d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c70a5-4a9b-7aa3-9a4c-fbbf6ec082d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c70a5-4a9b-76cb-af80-835bb7b54c6a" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c70a5-4a9b-7aa3-9a4c-fbbf6ec082d8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSANDOTHERCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="prph-20251231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONSANDOTHERCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSANDOTHERCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c6cf4-e834-7c18-9357-0faf62b483ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019c6cf4-e834-7c3f-a613-b17c261a0014" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019c6cf4-e834-7c18-9357-0faf62b483ff" xlink:to="loc_us-gaap_GrossProfit_019c6cf4-e834-7c3f-a613-b17c261a0014" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019c6cf4-e834-7d95-ae27-02bff65b2c11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019c6cf4-e834-7c18-9357-0faf62b483ff" xlink:to="loc_us-gaap_OperatingExpenses_019c6cf4-e834-7d95-ae27-02bff65b2c11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c6cf4-e834-7153-b5ff-df36ee9c68ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c6cf4-e834-7e9d-afe7-4cd20f4a6276" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c6cf4-e834-7153-b5ff-df36ee9c68ce" xlink:to="loc_us-gaap_NetIncomeLoss_019c6cf4-e834-7e9d-afe7-4cd20f4a6276" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019c6cf4-e834-75e3-afa4-f786ed35876e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c6cf4-e834-7153-b5ff-df36ee9c68ce" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019c6cf4-e834-75e3-afa4-f786ed35876e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019ce542-1950-75d8-bd84-efaa91dde5ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_019ce542-1950-78a2-9187-73145f2470b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019ce542-1950-75d8-bd84-efaa91dde5ce" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_019ce542-1950-78a2-9187-73145f2470b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_019ce542-1950-7b79-ae93-32291538f4e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019ce542-1950-75d8-bd84-efaa91dde5ce" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_019ce542-1950-7b79-ae93-32291538f4e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019c6cf4-e834-79ab-882e-8322d3eb985b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c6cf4-e834-74e2-8223-f9c46122cebe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019c6cf4-e834-79ab-882e-8322d3eb985b" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c6cf4-e834-74e2-8223-f9c46122cebe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019c6cf4-e834-7853-99ae-b6ed12f4de66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019c6cf4-e834-79ab-882e-8322d3eb985b" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019c6cf4-e834-7853-99ae-b6ed12f4de66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c6cf4-e834-7931-a3b8-a1b354b02d2c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_019c6cf4-e834-729a-aa23-467199ce296d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c6cf4-e834-7931-a3b8-a1b354b02d2c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_019c6cf4-e834-729a-aa23-467199ce296d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019c6cf4-e834-7135-8749-bd91c614f6a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c6cf4-e834-7931-a3b8-a1b354b02d2c" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019c6cf4-e834-7135-8749-bd91c614f6a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019c6cf4-e834-78a5-95c5-ae0af714f4bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019c6cf4-e834-78ea-8db9-271f9bc9db58" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c6cf4-e834-78a5-95c5-ae0af714f4bd" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019c6cf4-e834-78ea-8db9-271f9bc9db58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019c6cf4-e834-729c-ab27-a5fade503472" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c6cf4-e834-78a5-95c5-ae0af714f4bd" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019c6cf4-e834-729c-ab27-a5fade503472" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019c6cf4-e834-7760-99ac-391fe46d6e8c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_019c6cf4-e834-77f0-95d8-470294ec4368" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_019c6cf4-e834-7760-99ac-391fe46d6e8c" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_019c6cf4-e834-77f0-95d8-470294ec4368" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019c6cf4-e834-7ee2-9ad8-01cbbc70fbaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_019c6cf4-e834-7760-99ac-391fe46d6e8c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_019c6cf4-e834-7ee2-9ad8-01cbbc70fbaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c6cf4-e834-744d-a684-fb04e51f662e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_us-gaap_OperatingIncomeLoss_019c6cf4-e834-744d-a684-fb04e51f662e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019c6cf4-e834-7a18-8b19-ab0e8524b8ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019c6cf4-e834-7a18-8b19-ab0e8524b8ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019c6cf4-e834-7459-8691-c10220981765" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019c6cf4-e834-7459-8691-c10220981765" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019c6cf4-e834-75ee-921a-618a1c5c336e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019c6cf4-e834-75ee-921a-618a1c5c336e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019c70ed-459d-7c2f-af2c-6b91d9974413" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019c70ed-459d-7c2f-af2c-6b91d9974413" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019c70ed-459d-70f3-b25e-68945b364a0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019c70ed-459d-70f3-b25e-68945b364a0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_GainLossOnIssuanceOfDebt_019c70ed-459d-7440-be39-1408a4670410" xlink:href="prph-20251231.xsd#prph_GainLossOnIssuanceOfDebt"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_prph_GainLossOnIssuanceOfDebt_019c70ed-459d-7440-be39-1408a4670410" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_GainLossOnDispositionOfPropertyPlantEquipmentLessAmountsClassifiedToGeneralAndAdministrativeExpense_019c70ed-459d-71b0-8ab2-5acbf901d9a7" xlink:href="prph-20251231.xsd#prph_GainLossOnDispositionOfPropertyPlantEquipmentLessAmountsClassifiedToGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_prph_GainLossOnDispositionOfPropertyPlantEquipmentLessAmountsClassifiedToGeneralAndAdministrativeExpense_019c70ed-459d-71b0-8ab2-5acbf901d9a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_EmployeeRetentionTaxCreditIncome_019c70ed-459d-7836-b0db-3f54bef7378d" xlink:href="prph-20251231.xsd#prph_EmployeeRetentionTaxCreditIncome"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_prph_EmployeeRetentionTaxCreditIncome_019c70ed-459d-7836-b0db-3f54bef7378d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019d906b-a776-7a56-b78d-0413a2b6f9ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7c69-b1bc-f212a7e4fca1" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019d906b-a776-7a56-b78d-0413a2b6f9ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_019c6cf4-e834-72df-a5c4-cbc2ca199baa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7f50-94a1-effd4a4647c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_019c6cf4-e834-72df-a5c4-cbc2ca199baa" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c6cf4-e834-7f50-94a1-effd4a4647c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e834-7c00-b4c0-e73f3d927135" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_019c6cf4-e834-72df-a5c4-cbc2ca199baa" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e834-7c00-b4c0-e73f3d927135" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019c6cf4-e834-7e4d-805d-871749389437" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_019c6cf4-e834-747b-960b-b7f6708e21b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_019c6cf4-e834-7e4d-805d-871749389437" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_019c6cf4-e834-747b-960b-b7f6708e21b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019c6cf4-e834-72aa-98d9-fbfa374dc0c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_019c6cf4-e834-7e4d-805d-871749389437" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_019c6cf4-e834-72aa-98d9-fbfa374dc0c0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="prph-20251231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c6cf4-e834-7627-af3d-5f23c6a1b956" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c6cf4-e834-7132-9134-cc9f820bd463" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c6cf4-e834-7627-af3d-5f23c6a1b956" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c6cf4-e834-7132-9134-cc9f820bd463" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c6cf4-e834-7681-a2e9-96913a15ee06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c6cf4-e834-7627-af3d-5f23c6a1b956" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c6cf4-e834-7681-a2e9-96913a15ee06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c6cf4-e834-7643-b34f-7e2913664b31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c6cf4-e834-7627-af3d-5f23c6a1b956" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c6cf4-e834-7643-b34f-7e2913664b31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c6cf4-e834-74b7-9c15-7b04150df8a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019c6cf4-e834-76cb-91bb-4c192bbcdd4b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c6cf4-e834-74b7-9c15-7b04150df8a6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019c6cf4-e834-76cb-91bb-4c192bbcdd4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_019c6cf4-e834-7874-bee2-3cdefdb853de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c6cf4-e834-74b7-9c15-7b04150df8a6" xlink:to="loc_us-gaap_CashProvidedByUsedInInvestingActivitiesDiscontinuedOperations_019c6cf4-e834-7874-bee2-3cdefdb853de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019c6cf4-e834-7518-8b80-7964d4ddede9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019c6cf4-e834-73b4-99c7-8ab52a02d795" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019c6cf4-e834-7518-8b80-7964d4ddede9" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019c6cf4-e834-73b4-99c7-8ab52a02d795" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019c6cf4-e834-7633-bc91-8700e6ebbaf3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019c6cf4-e834-7518-8b80-7964d4ddede9" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_019c6cf4-e834-7633-bc91-8700e6ebbaf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_019c6cf4-e834-7bf9-8cab-cd7cf84d9d90" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_019c6cf4-e834-7518-8b80-7964d4ddede9" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_019c6cf4-e834-7bf9-8cab-cd7cf84d9d90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_ProceedsFromIssuanceOfPublicOffering_019c6cf4-e834-7dd3-86d4-7259453d22f0" xlink:href="prph-20251231.xsd#prph_ProceedsFromIssuanceOfPublicOffering"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:to="loc_prph_ProceedsFromIssuanceOfPublicOffering_019c6cf4-e834-7dd3-86d4-7259453d22f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromNotesPayable_019c6cf4-e834-780a-97b0-c8b751904a78" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromNotesPayable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:to="loc_us-gaap_ProceedsFromNotesPayable_019c6cf4-e834-780a-97b0-c8b751904a78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRelatedPartyDebt_019c6cf4-e834-7837-aabf-8d9a5ca398bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromRelatedPartyDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:to="loc_us-gaap_ProceedsFromRelatedPartyDebt_019c6cf4-e834-7837-aabf-8d9a5ca398bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_019c6cf4-e834-72b2-b627-aa22490e6aaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_019c6cf4-e834-72b2-b627-aa22490e6aaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019c6cf4-e834-7a57-8d74-48faf8a94a47" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019c6cf4-e834-7a57-8d74-48faf8a94a47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfNotesPayable_019c6cf4-e834-77eb-bebb-70ce4bd0f4fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfNotesPayable"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:to="loc_us-gaap_RepaymentsOfNotesPayable_019c6cf4-e834-77eb-bebb-70ce4bd0f4fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_019c7167-bdda-7f22-a90b-53c0df03a8fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfConvertibleDebt"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-757d-9c61-3ad4bf824fce" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_019c7167-bdda-7f22-a90b-53c0df03a8fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c6cf4-e834-7432-86e3-23f98771ab24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-7034-834c-3e4c39de5854" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c6cf4-e834-7432-86e3-23f98771ab24" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_019c6cf4-e834-7034-834c-3e4c39de5854" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations_019c6cf4-e834-73c0-8fed-06b267e5dc9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c6cf4-e834-7432-86e3-23f98771ab24" xlink:to="loc_us-gaap_CashProvidedByUsedInFinancingActivitiesDiscontinuedOperations_019c6cf4-e834-73c0-8fed-06b267e5dc9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_019c6cf4-e834-7c3e-b482-596880ded66b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_019c6cf4-e834-7c3e-b482-596880ded66b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_019c6cf4-e834-723f-bafb-df77fcc5f4f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_019c6cf4-e834-723f-bafb-df77fcc5f4f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019c6cf4-e834-7148-9782-f5475a4bf3ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019c6cf4-e834-7148-9782-f5475a4bf3ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019d91fc-6383-7e15-acaa-2dd5647c9d01" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019d91fc-6383-7e15-acaa-2dd5647c9d01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_019c6cf4-e834-78b4-bc18-43de461f0e1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_019c6cf4-e834-78b4-bc18-43de461f0e1d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019c6cf4-e834-71ac-9681-0e532ba97ac7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_AssetImpairmentCharges_019c6cf4-e834-71ac-9681-0e532ba97ac7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019c6cf4-e834-77a0-93b1-50a6993a4b35" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019c6cf4-e834-77a0-93b1-50a6993a4b35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_GainLossOnIssuanceOfDebt_019c6cf4-e834-7f88-ae16-4daedff7e554" xlink:href="prph-20251231.xsd#prph_GainLossOnIssuanceOfDebt"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_prph_GainLossOnIssuanceOfDebt_019c6cf4-e834-7f88-ae16-4daedff7e554" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnTerminationOfLease_019c6cf4-e834-7139-9ab2-a1c272a20545" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnTerminationOfLease"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_GainLossOnTerminationOfLease_019c6cf4-e834-7139-9ab2-a1c272a20545" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019c6cf4-e834-71b1-849c-6ba8311f6752" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_019c6cf4-e834-71b1-849c-6ba8311f6752" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_NoncashEmployeeRetentionTaxCreditIncome_019c6cf4-e834-75bb-aa4b-c011ee5b65ed" xlink:href="prph-20251231.xsd#prph_NoncashEmployeeRetentionTaxCreditIncome"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_prph_NoncashEmployeeRetentionTaxCreditIncome_019c6cf4-e834-75bb-aa4b-c011ee5b65ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019c6cf4-e834-7408-8af0-af16b60207c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_ShareBasedCompensation_019c6cf4-e834-7408-8af0-af16b60207c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_019c6cf4-e834-7342-8fba-d4b3e458c971" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_019c6cf4-e834-7342-8fba-d4b3e458c971" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_InventoryValuationReserve_019c6cf4-e834-7237-a8d1-8d72781063de" xlink:href="prph-20251231.xsd#prph_InventoryValuationReserve"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_prph_InventoryValuationReserve_019c6cf4-e834-7237-a8d1-8d72781063de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019c6cf4-e834-74ab-abd8-3a1fd9902792" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_InventoryWriteDown_019c6cf4-e834-74ab-abd8-3a1fd9902792" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019c6cf4-e834-7823-a865-bb80d921d008" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019c6cf4-e834-7823-a865-bb80d921d008" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019c6cf4-e834-7045-a086-402fa603ded0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_019c6cf4-e834-7045-a086-402fa603ded0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019c6cf4-e834-7d75-bc01-f072f6b0556b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="18" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_019c6cf4-e834-7d75-bc01-f072f6b0556b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019c6cf4-e834-7b02-8618-33e8fe25fa8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="19" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019c6cf4-e834-7b02-8618-33e8fe25fa8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019c6cf4-e834-71d7-afcb-bc3dfe6eb4da" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="20" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019c6cf4-e834-71d7-afcb-bc3dfe6eb4da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019c6cf4-e834-7bed-90f8-57f8a2d6cfe9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="21" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019c6cf4-e834-7bed-90f8-57f8a2d6cfe9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019c6cf4-e834-7932-b93d-8427cc3b7b42" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="22" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_019c6cf4-e834-7932-b93d-8427cc3b7b42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019c6cf4-e834-7f5c-aba9-db49d20da412" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="23" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_019c6cf4-e834-7f5c-aba9-db49d20da412" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019c6cf4-e834-779d-8835-12fd7c14aec1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="24" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_019c6cf4-e834-779d-8835-12fd7c14aec1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_IncreaseDecreaseInAccruedDiagnosticServices_019c7166-c7a2-72b4-8240-8c5692ca3b7f" xlink:href="prph-20251231.xsd#prph_IncreaseDecreaseInAccruedDiagnosticServices"/>
    <link:calculationArc order="25" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_prph_IncreaseDecreaseInAccruedDiagnosticServices_019c7166-c7a2-72b4-8240-8c5692ca3b7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_IncreaseDecreaseInAccruedAdvertisingAndOtherAllowances_019c7166-c7a2-74ce-8ad6-40c667f621bf" xlink:href="prph-20251231.xsd#prph_IncreaseDecreaseInAccruedAdvertisingAndOtherAllowances"/>
    <link:calculationArc order="26" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_prph_IncreaseDecreaseInAccruedAdvertisingAndOtherAllowances_019c7166-c7a2-74ce-8ad6-40c667f621bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_019c7166-c7a2-70ea-be9f-ce1cb21723c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue"/>
    <link:calculationArc order="27" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_019c7166-c7a2-70ea-be9f-ce1cb21723c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_IncreaseDecreaseInDeferredIncomeTaxLiabilities_019c7166-c7a2-7467-8f75-f11be13fbf64" xlink:href="prph-20251231.xsd#prph_IncreaseDecreaseInDeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="28" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_prph_IncreaseDecreaseInDeferredIncomeTaxLiabilities_019c7166-c7a2-7467-8f75-f11be13fbf64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019c7166-c7a2-715d-8980-78c9a443017f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="29" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019c7166-c7a2-715d-8980-78c9a443017f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019c7166-c7a2-7494-988d-a18d12b48869" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="30" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019c7166-c7a2-7494-988d-a18d12b48869" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019cade9-7f62-7345-a332-8dcdcb775292" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="31" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7b30-b8a4-f727bf45ff2a" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_019cade9-7f62-7345-a332-8dcdcb775292" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c6cf4-e834-7308-b419-95931da3986c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7588-90a9-3c43ca9c7148" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c6cf4-e834-7308-b419-95931da3986c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019c6cf4-e834-7588-90a9-3c43ca9c7148" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_019c6cf4-e834-7dcf-b4d6-f34b00549ec9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c6cf4-e834-7308-b419-95931da3986c" xlink:to="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_019c6cf4-e834-7dcf-b4d6-f34b00549ec9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/SummaryofSignificantAccountingPoliciesScheduleofAccountsReceivableNetDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#SummaryofSignificantAccountingPoliciesScheduleofAccountsReceivableNetDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/SummaryofSignificantAccountingPoliciesScheduleofAccountsReceivableNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNet_019ce59c-e0b3-768c-94d1-e5930dabd91c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGross_019ce59c-e0b3-7175-bb0c-b7ce45b23f43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNet_019ce59c-e0b3-768c-94d1-e5930dabd91c" xlink:to="loc_us-gaap_AccountsReceivableGross_019ce59c-e0b3-7175-bb0c-b7ce45b23f43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_019ce59c-e0b3-7eb6-9d6a-7a7df8cfb5cc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNet_019ce59c-e0b3-768c-94d1-e5930dabd91c" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_019ce59c-e0b3-7eb6-9d6a-7a7df8cfb5cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGross_019ce59c-5bba-7f3b-bead-97fd077d04bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_AccountsReceivableTrade_019ce59c-5bba-7ccb-b8ef-db37943852d1" xlink:href="prph-20251231.xsd#prph_AccountsReceivableTrade"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableGross_019ce59c-5bba-7f3b-bead-97fd077d04bb" xlink:to="loc_prph_AccountsReceivableTrade_019ce59c-5bba-7ccb-b8ef-db37943852d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnbilledContractsReceivable_019ce59c-5bba-7ba8-85fa-2454405706a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnbilledContractsReceivable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableGross_019ce59c-5bba-7f3b-bead-97fd077d04bb" xlink:to="loc_us-gaap_UnbilledContractsReceivable_019ce59c-5bba-7ba8-85fa-2454405706a1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/SummaryofSignificantAccountingPoliciesScheduleofComponentsofInventoryDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#SummaryofSignificantAccountingPoliciesScheduleofComponentsofInventoryDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/SummaryofSignificantAccountingPoliciesScheduleofComponentsofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019c6cf4-e834-7366-982b-13a4deb3afd5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_019c6cf4-e834-79db-9808-60b82adabc66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c6cf4-e834-7366-982b-13a4deb3afd5" xlink:to="loc_us-gaap_InventoryGross_019c6cf4-e834-79db-9808-60b82adabc66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_019c6cf4-e834-77be-8dd6-3d8dddcaf15b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryValuationReserves"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c6cf4-e834-7366-982b-13a4deb3afd5" xlink:to="loc_us-gaap_InventoryValuationReserves_019c6cf4-e834-77be-8dd6-3d8dddcaf15b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_019c6cf4-e834-7c88-9c89-2a41b3f8d52a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_InventoryLabMaterial_019c6cf4-e834-7bc1-ace2-f87257a6e2df" xlink:href="prph-20251231.xsd#prph_InventoryLabMaterial"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019c6cf4-e834-7c88-9c89-2a41b3f8d52a" xlink:to="loc_prph_InventoryLabMaterial_019c6cf4-e834-7bc1-ace2-f87257a6e2df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_019c6cf4-e834-7073-b4f8-11139d3c9ea1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019c6cf4-e834-7c88-9c89-2a41b3f8d52a" xlink:to="loc_us-gaap_InventoryRawMaterials_019c6cf4-e834-7073-b4f8-11139d3c9ea1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_019c6cf4-e834-71dd-82a1-f27762b0bc6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019c6cf4-e834-7c88-9c89-2a41b3f8d52a" xlink:to="loc_us-gaap_InventoryWorkInProcess_019c6cf4-e834-71dd-82a1-f27762b0bc6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_019c6cf4-e834-73f8-8c77-da9dee04ba3f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryGross_019c6cf4-e834-7c88-9c89-2a41b3f8d52a" xlink:to="loc_us-gaap_InventoryFinishedGoods_019c6cf4-e834-73f8-8c77-da9dee04ba3f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#IntangibleAssetsNetScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-717e-8210-be6ced5c8760" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019c6cf4-e8fb-76bb-8d11-e23b6c273ae0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-717e-8210-be6ced5c8760" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019c6cf4-e8fb-76bb-8d11-e23b6c273ae0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019c6cf4-e8fb-7ba4-9c21-0b75227e79f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-717e-8210-be6ced5c8760" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019c6cf4-e8fb-7ba4-9c21-0b75227e79f2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/IntangibleAssetsNetScheduleEstimatedFutureAmortizationExpenseofAcquiredIntangibleAssetsDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#IntangibleAssetsNetScheduleEstimatedFutureAmortizationExpenseofAcquiredIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/IntangibleAssetsNetScheduleEstimatedFutureAmortizationExpenseofAcquiredIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-7396-ad07-8475cae8192b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019c6cf4-e8fb-76b2-b8ae-1d77353d57b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-7396-ad07-8475cae8192b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019c6cf4-e8fb-76b2-b8ae-1d77353d57b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019c6cf4-e8fb-781a-93f6-b7b85b485f8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-7396-ad07-8475cae8192b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019c6cf4-e8fb-781a-93f6-b7b85b485f8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019c6cf4-e8fb-7196-ba63-2a0072ebde4b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-7396-ad07-8475cae8192b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019c6cf4-e8fb-7196-ba63-2a0072ebde4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019c6cf4-e8fb-7949-a5de-dfa2f41c2323" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-7396-ad07-8475cae8192b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019c6cf4-e8fb-7949-a5de-dfa2f41c2323" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_019c6cf4-e8fb-70fa-9469-653eb9f2a43a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-7396-ad07-8475cae8192b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_019c6cf4-e8fb-70fa-9469-653eb9f2a43a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_019c6cf4-e8fb-7f63-b920-c1f926b2b401" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c6cf4-e8fb-7396-ad07-8475cae8192b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_019c6cf4-e8fb-7f63-b920-c1f926b2b401" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019c6cf4-e8fb-71e7-b377-015f9a7eedc2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_019c6cf4-e8fb-7102-8e2c-44feded13a27" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019c6cf4-e8fb-71e7-b377-015f9a7eedc2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_019c6cf4-e8fb-7102-8e2c-44feded13a27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_019c6cf4-e8fb-74aa-aca7-65bbba6e29be" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_019c6cf4-e8fb-71e7-b377-015f9a7eedc2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_019c6cf4-e8fb-74aa-aca7-65bbba6e29be" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#IncomeTaxesScheduleofComponentsofIncomeTaxExpenseBenefitDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_019c6cf4-e8fb-79c2-a476-f1d9d8c85657" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_019c6cf4-e8fb-7b5b-9e3f-0a06bebd49a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_019c6cf4-e8fb-79c2-a476-f1d9d8c85657" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_019c6cf4-e8fb-7b5b-9e3f-0a06bebd49a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_019c6cf4-e8fb-74e2-8ad8-c5998e7fb293" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_019c6cf4-e8fb-79c2-a476-f1d9d8c85657" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_019c6cf4-e8fb-74e2-8ad8-c5998e7fb293" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019c6cf4-e8fb-77ad-94a0-5e190f231ad5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_019c6cf4-e8fb-7c05-a09b-ee211cbad746" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019c6cf4-e8fb-77ad-94a0-5e190f231ad5" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_019c6cf4-e8fb-7c05-a09b-ee211cbad746" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_019c6cf4-e8fb-7a18-a0c0-03cfb689f65a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019c6cf4-e8fb-77ad-94a0-5e190f231ad5" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_019c6cf4-e8fb-7a18-a0c0-03cfb689f65a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-7fc0-bd80-632e082700f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_019c6cf4-e8fb-7ec9-8a15-a61763b78a32" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-7fc0-bd80-632e082700f3" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_019c6cf4-e8fb-7ec9-8a15-a61763b78a32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019c6cf4-e8fb-73de-b5fe-3c4365cbd50b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-7fc0-bd80-632e082700f3" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019c6cf4-e8fb-73de-b5fe-3c4365cbd50b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/IncomeTaxesScheduleofEffectiveIncomeTaxRateReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-799f-8b1d-9e30d6769407" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_019c6cf4-e8fb-7d80-8bd2-35c03b7cf165" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-799f-8b1d-9e30d6769407" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_019c6cf4-e8fb-7d80-8bd2-35c03b7cf165" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_019c6cf4-e8fb-725c-b185-89f0c8cb8e3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-799f-8b1d-9e30d6769407" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpense_019c6cf4-e8fb-725c-b185-89f0c8cb8e3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_019d9081-4cae-7be3-b235-884d0c9e691b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-799f-8b1d-9e30d6769407" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_019d9081-4cae-7be3-b235-884d0c9e691b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_019d9081-4cae-72f2-a63e-c9f5d4e86a38" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-799f-8b1d-9e30d6769407" xlink:to="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_019d9081-4cae-72f2-a63e-c9f5d4e86a38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_019d9081-4cae-7ffb-b876-3f9100f45892" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_019c6cf4-e8fb-799f-8b1d-9e30d6769407" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_019d9081-4cae-7ffb-b876-3f9100f45892" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019d9081-66fe-7bba-a100-a8f3ce6d10ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019d9081-66fe-79e0-b7fb-0b55ba2f0544" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019d9081-66fe-7bba-a100-a8f3ce6d10ae" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_019d9081-66fe-79e0-b7fb-0b55ba2f0544" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense_019d9081-66fe-7e75-8c70-65b6a80fb69c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019d9081-66fe-7bba-a100-a8f3ce6d10ae" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense_019d9081-66fe-7e75-8c70-65b6a80fb69c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019d9081-66fe-74af-ba0f-187d331ff952" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019d9081-66fe-7bba-a100-a8f3ce6d10ae" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_019d9081-66fe-74af-ba0f-187d331ff952" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019d9081-66fe-7d67-aab5-31179a0a5991" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019d9081-66fe-7bba-a100-a8f3ce6d10ae" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_019d9081-66fe-7d67-aab5-31179a0a5991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_019d9081-66fe-775f-be00-009fb2583824" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_019d9081-66fe-7bba-a100-a8f3ce6d10ae" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_019d9081-66fe-775f-be00-009fb2583824" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/IncomeTaxesScheduleofIncomeTaxesPaidDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#IncomeTaxesScheduleofIncomeTaxesPaidDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/IncomeTaxesScheduleofIncomeTaxesPaidDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_019d9257-abce-7e43-9024-cf2e0b07f3af" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxesPaidNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidFederalAfterRefundReceived_019d9257-abce-71bb-bee9-f9bc0065b467" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidFederalAfterRefundReceived"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_019d9257-abce-7e43-9024-cf2e0b07f3af" xlink:to="loc_us-gaap_IncomeTaxPaidFederalAfterRefundReceived_019d9257-abce-71bb-bee9-f9bc0065b467" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived_019d9257-abce-7530-9e6e-36fab442c2c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_019d9257-abce-7e43-9024-cf2e0b07f3af" xlink:to="loc_us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived_019d9257-abce-7530-9e6e-36fab442c2c5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_DeferredTaxAssetsOperatingLossCarryforwardsAndCapitalLossCarryforwards_019c6cf4-e8fb-7605-b7b2-92d838ff88df" xlink:href="prph-20251231.xsd#prph_DeferredTaxAssetsOperatingLossCarryforwardsAndCapitalLossCarryforwards"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_prph_DeferredTaxAssetsOperatingLossCarryforwardsAndCapitalLossCarryforwards_019c6cf4-e8fb-7605-b7b2-92d838ff88df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_019c6cf4-e8fb-72cc-97fd-a3d233c4f171" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_019c6cf4-e8fb-72cc-97fd-a3d233c4f171" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_019c6cf4-e8fb-71b8-84af-38f692d5bbfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_019c6cf4-e8fb-71b8-84af-38f692d5bbfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_DeferredTaxAssetsCapitalLeaseObligations_019c6cf4-e8fb-7b23-a8ca-2c1492262505" xlink:href="prph-20251231.xsd#prph_DeferredTaxAssetsCapitalLeaseObligations"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_prph_DeferredTaxAssetsCapitalLeaseObligations_019c6cf4-e8fb-7b23-a8ca-2c1492262505" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_019c6cf4-e8fb-7cea-bc35-d40aa87aba57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_019c6cf4-e8fb-7cea-bc35-d40aa87aba57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_019c6cf4-e8fb-7752-ae9b-010009e19977" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_019c6cf4-e8fb-7752-ae9b-010009e19977" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_019c6cf4-e8fb-79d6-b5ff-fb7084110c59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_019c6cf4-e8fb-79d6-b5ff-fb7084110c59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_019c6cf4-e8fb-7f11-8fa0-68ac6f50cbca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_019c6cf4-e8fb-740e-aa9d-bbd2674dabd4" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_019c6cf4-e8fb-7f11-8fa0-68ac6f50cbca" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/OtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#OtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/OtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019ce32f-4d3d-7f1e-a6a7-13e31d746341" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019ce32f-4d3d-7380-b946-83c5e7a56b72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019ce32f-4d3d-7f1e-a6a7-13e31d746341" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019ce32f-4d3d-7380-b946-83c5e7a56b72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019ce32f-4d3d-7415-a7f3-c3250ff7e3fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019ce32f-4d3d-7f1e-a6a7-13e31d746341" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019ce32f-4d3d-7415-a7f3-c3250ff7e3fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_019ce32f-4d3d-7350-bcc8-172f683da26a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019ce32f-4d3d-7f1e-a6a7-13e31d746341" xlink:to="loc_us-gaap_InterestPayableCurrent_019ce32f-4d3d-7350-bcc8-172f683da26a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_AccruedReturns_019d19ac-68b1-76fa-8eb9-a8ecb4420e8a" xlink:href="prph-20251231.xsd#prph_AccruedReturns"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019ce32f-4d3d-7f1e-a6a7-13e31d746341" xlink:to="loc_prph_AccruedReturns_019d19ac-68b1-76fa-8eb9-a8ecb4420e8a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/LeasesScheduleofQuantitativeInformationaboutOperatingandFinanceLeasesDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#LeasesScheduleofQuantitativeInformationaboutOperatingandFinanceLeasesDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/LeasesScheduleofQuantitativeInformationaboutOperatingandFinanceLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_prph_FinanceLeaseCost_019c6cf4-e8fb-7334-8b7e-d046ef482b5b" xlink:href="prph-20251231.xsd#prph_FinanceLeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_019c6cf4-e8fb-7050-b83d-8966fe37c5bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_prph_FinanceLeaseCost_019c6cf4-e8fb-7334-8b7e-d046ef482b5b" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_019c6cf4-e8fb-7050-b83d-8966fe37c5bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019c6cf4-e8fb-7d5d-841c-94b30c8a903e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_prph_FinanceLeaseCost_019c6cf4-e8fb-7334-8b7e-d046ef482b5b" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019c6cf4-e8fb-7d5d-841c-94b30c8a903e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/LeasesScheduleofMaturityofOperatingandFinanceLeasesDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#LeasesScheduleofMaturityofOperatingandFinanceLeasesDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/LeasesScheduleofMaturityofOperatingandFinanceLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c6cf4-e8fb-7130-a514-29c2615f33b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019c6cf4-e8fb-7375-ba2e-eb27d00a7abe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c6cf4-e8fb-7130-a514-29c2615f33b2" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019c6cf4-e8fb-7375-ba2e-eb27d00a7abe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019c6cf4-e8fb-78ed-944f-ccc9977700ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c6cf4-e8fb-7130-a514-29c2615f33b2" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019c6cf4-e8fb-78ed-944f-ccc9977700ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/LeasesScheduleofMaturityofOperatingandFinanceLeasesDetails_1" xlink:type="simple" xlink:href="prph-20251231.xsd#LeasesScheduleofMaturityofOperatingandFinanceLeasesDetails_1"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/LeasesScheduleofMaturityofOperatingandFinanceLeasesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c8b74-4e99-73e1-ac92-6de9c16988a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019c8b74-4e99-7708-9260-cae4f73682cd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c8b74-4e99-73e1-ac92-6de9c16988a3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019c8b74-4e99-7708-9260-cae4f73682cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019c8b74-4e99-7e4b-8215-777dd7b23a78" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019c8b74-4e99-73e1-ac92-6de9c16988a3" xlink:to="loc_us-gaap_FinanceLeaseLiability_019c8b74-4e99-7e4b-8215-777dd7b23a78" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/DiscontinuedOperationsScheduleofReconciliationofDiscontinuedOperationsDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#DiscontinuedOperationsScheduleofReconciliationofDiscontinuedOperationsDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/DiscontinuedOperationsScheduleofReconciliationofDiscontinuedOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_019c6cf4-e8fc-7ce9-a2b2-bf67856c872e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGrossProfitLoss_019c6cf4-e8fc-771a-b156-5f029368e218" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGrossProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_019c6cf4-e8fc-7ce9-a2b2-bf67856c872e" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGrossProfitLoss_019c6cf4-e8fc-771a-b156-5f029368e218" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_019c6cf4-e8fc-7ebd-ac2e-04402bf8e0eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_019c6cf4-e8fc-7ce9-a2b2-bf67856c872e" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_019c6cf4-e8fc-7ebd-ac2e-04402bf8e0eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_019c6cf4-e8fc-793e-88df-00441ecac0b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense_019c6cf4-e8fc-723d-aa53-99c61182a5cf" xlink:href="prph-20251231.xsd#prph_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_019c6cf4-e8fc-793e-88df-00441ecac0b3" xlink:to="loc_prph_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense_019c6cf4-e8fc-723d-aa53-99c61182a5cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGeneralAndAdministrativeExpense_019c6cf4-e8fc-7bf8-96df-7dfedf20a141" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingExpense_019c6cf4-e8fc-793e-88df-00441ecac0b3" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGeneralAndAdministrativeExpense_019c6cf4-e8fc-7bf8-96df-7dfedf20a141" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGrossProfitLoss_019c6cf4-e8fc-7aba-885e-be07e3be6b1b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGrossProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationCostsOfGoodsSold_019c6cf4-e8fc-7379-ae14-386693540f3b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationCostsOfGoodsSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGrossProfitLoss_019c6cf4-e8fc-7aba-885e-be07e3be6b1b" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationCostsOfGoodsSold_019c6cf4-e8fc-7379-ae14-386693540f3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_019c6cf4-e8fc-757c-93bf-42e2b37a8c26" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGrossProfitLoss_019c6cf4-e8fc-7aba-885e-be07e3be6b1b" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_019c6cf4-e8fc-757c-93bf-42e2b37a8c26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019c6cf4-e8fc-78b5-9856-8f700a40f32f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherIncome_019c6cf4-e8fc-772e-a3fd-c4c5a5001f36" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherIncome"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019c6cf4-e8fc-78b5-9856-8f700a40f32f" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherIncome_019c6cf4-e8fc-772e-a3fd-c4c5a5001f36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInterestExpense_019c6cf4-e8fc-7dc5-a7cb-ba5976b03e23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationInterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019c6cf4-e8fc-78b5-9856-8f700a40f32f" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInterestExpense_019c6cf4-e8fc-7dc5-a7cb-ba5976b03e23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_019c6cf4-e8fc-797b-bb73-81c48d9dfa16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_019c6cf4-e8fc-78b5-9856-8f700a40f32f" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOperatingIncomeLoss_019c6cf4-e8fc-797b-bb73-81c48d9dfa16" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://prophaselabs.com/role/DiscontinuedOperationsScheduleofReconciliationoftheCarryingAmountsofAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="prph-20251231.xsd#DiscontinuedOperationsScheduleofReconciliationoftheCarryingAmountsofAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://prophaselabs.com/role/DiscontinuedOperationsScheduleofReconciliationoftheCarryingAmountsofAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-7248-ba50-228ee0f37b49" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent_019c6cf4-e8fc-72d7-9cbb-b90520d5ed7b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-7248-ba50-228ee0f37b49" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent_019c6cf4-e8fc-72d7-9cbb-b90520d5ed7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_019c6cf4-e8fc-7d85-837b-aca2e6d02975" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-7248-ba50-228ee0f37b49" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_019c6cf4-e8fc-7d85-837b-aca2e6d02975" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_DisposalGroupIncludingDiscontinuedOperationRestrictedCash_019c6cf4-e8fc-764e-8da5-3031f7a0df30" xlink:href="prph-20251231.xsd#prph_DisposalGroupIncludingDiscontinuedOperationRestrictedCash"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-7248-ba50-228ee0f37b49" xlink:to="loc_prph_DisposalGroupIncludingDiscontinuedOperationRestrictedCash_019c6cf4-e8fc-764e-8da5-3031f7a0df30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsNotesAndLoansReceivableNet_019c6cf4-e8fc-7656-9807-b2d58245db4d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsNotesAndLoansReceivableNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-7248-ba50-228ee0f37b49" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsNotesAndLoansReceivableNet_019c6cf4-e8fc-7656-9807-b2d58245db4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_019c6cf4-e9b8-7a66-8750-3e77790a0e5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent_019c6cf4-e9b8-760b-bf87-21f884777c30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_019c6cf4-e9b8-7a66-8750-3e77790a0e5a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent_019c6cf4-e9b8-760b-bf87-21f884777c30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentAssets_019c6cf4-e9b8-7e7a-b6e8-a720eb5cd8dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_019c6cf4-e9b8-7a66-8750-3e77790a0e5a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherNoncurrentAssets_019c6cf4-e9b8-7e7a-b6e8-a720eb5cd8dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_019c6cf4-e8fc-7b87-b3f6-7c6dfc92be57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_DisposalGroupIncludingDiscontinuedOperationLongTermDebtNoncurrent_019c6cf4-e8fc-7b4c-b5bf-11c26f7878d2" xlink:href="prph-20251231.xsd#prph_DisposalGroupIncludingDiscontinuedOperationLongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_019c6cf4-e8fc-7b87-b3f6-7c6dfc92be57" xlink:to="loc_prph_DisposalGroupIncludingDiscontinuedOperationLongTermDebtNoncurrent_019c6cf4-e8fc-7b4c-b5bf-11c26f7878d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation_019c6cf4-e8fc-71d7-ad08-eb540e55cfbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-7ed5-87ab-e8f58f11876e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation_019c6cf4-e8fc-71d7-ad08-eb540e55cfbc" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-7ed5-87ab-e8f58f11876e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_019c6cf4-e8fc-7265-952e-dba55431d382" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation_019c6cf4-e8fc-71d7-ad08-eb540e55cfbc" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_019c6cf4-e8fc-7265-952e-dba55431d382" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation_019c6cf4-e8fc-7a6b-827c-cf9d31275a1a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-72c1-b820-f7f923d1a3cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation_019c6cf4-e8fc-7a6b-827c-cf9d31275a1a" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c6cf4-e8fc-72c1-b820-f7f923d1a3cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_019c6cf4-e8fc-7dc5-b61d-f298ef904609" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation_019c6cf4-e8fc-7a6b-827c-cf9d31275a1a" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationNoncurrent_019c6cf4-e8fc-7dc5-b61d-f298ef904609" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c71aa-2c10-7dc6-9c8a-29ce2070bec7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsPayableCurrent_019c71aa-2c10-7032-bd97-bd13d3d0bf2e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c71aa-2c10-7dc6-9c8a-29ce2070bec7" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsPayableCurrent_019c71aa-2c10-7032-bd97-bd13d3d0bf2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_DisposalGroupIncludingDiscontinuedOperationNotesPayableCurrent_019c71aa-2c10-73a6-b948-c7d7782e763b" xlink:href="prph-20251231.xsd#prph_DisposalGroupIncludingDiscontinuedOperationNotesPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c71aa-2c10-7dc6-9c8a-29ce2070bec7" xlink:to="loc_prph_DisposalGroupIncludingDiscontinuedOperationNotesPayableCurrent_019c71aa-2c10-73a6-b948-c7d7782e763b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_prph_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityCurrent_019c71aa-2c10-7af1-844a-09449a5940b9" xlink:href="prph-20251231.xsd#prph_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c71aa-2c10-7dc6-9c8a-29ce2070bec7" xlink:to="loc_prph_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityCurrent_019c71aa-2c10-7af1-844a-09449a5940b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentLiabilities_019c71aa-2c10-725b-8c41-4344f1717362" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperationCurrent_019c71aa-2c10-7dc6-9c8a-29ce2070bec7" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentLiabilities_019c71aa-2c10-725b-8c41-4344f1717362" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
