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  <xs:element id="prph_SaleOfStockAggregateInitialOfferingPriceMaximum" abstract="false" name="SaleOfStockAggregateInitialOfferingPriceMaximum" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_SaleOfStockCommissionPercentage" abstract="false" name="SaleOfStockCommissionPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="prph_SaleOfStockConsiderationReceivedOnTransactionGross" abstract="false" name="SaleOfStockConsiderationReceivedOnTransactionGross" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_ClassOfWarrantOrRightPurchasesPercentage" abstract="false" name="ClassOfWarrantOrRightPurchasesPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="prph_CommonStockIncreaseDecreaseInCapitalSharesReservedForFutureIssuance" abstract="false" name="CommonStockIncreaseDecreaseInCapitalSharesReservedForFutureIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="prph_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_WarrantsAndRightsOutstandingPeriodFromCommencementOfSalesOfSharesInWhichWarrantsAreNotExercisable" abstract="false" name="WarrantsAndRightsOutstandingPeriodFromCommencementOfSalesOfSharesInWhichWarrantsAreNotExercisable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="prph_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedWeightedAverageRemainingContractualTerm" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedWeightedAverageRemainingContractualTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="prph_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsVestedAndExpectedToVestExercisableNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsVestedAndExpectedToVestExercisableNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="prph_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsOutstandingWeightedAverageExercisePrice1" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsOutstandingWeightedAverageExercisePrice1" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="prph_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsOutstandingGrantedWeightedAverageExercisePrice1" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsOutstandingGrantedWeightedAverageExercisePrice1" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="prph_WeightedAverageExercisePriceWarrantsExercised" abstract="false" name="WeightedAverageExercisePriceWarrantsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="prph_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsVestedAndExercisableWeightedAverageExercisePrice1" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsVestedAndExercisableWeightedAverageExercisePrice1" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="prph_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeGrantedWarrantsWeightedAverageRemainingContractualTerm2" abstract="false" name="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeGrantedWarrantsWeightedAverageRemainingContractualTerm2" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="prph_WeightedAverageRemainingContractualLifeWarrantsVestedAndExercisable" abstract="false" name="WeightedAverageRemainingContractualLifeWarrantsVestedAndExercisable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="prph_NewYorkCityMember" abstract="true" name="NewYorkCityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_DeferredTaxAssetsOperatingLossCarryforwardsAndCapitalLossCarryforwards" abstract="false" name="DeferredTaxAssetsOperatingLossCarryforwardsAndCapitalLossCarryforwards" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DeferredTaxAssetsCapitalLeaseObligations" abstract="false" name="DeferredTaxAssetsCapitalLeaseObligations" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_TaxCreditCarryforwardLimitationAmount" abstract="false" name="TaxCreditCarryforwardLimitationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_AccruedReturns" abstract="false" name="AccruedReturns" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_PhaseThreeMember" abstract="true" name="PhaseThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_NewDrugApplicationMember" abstract="true" name="NewDrugApplicationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_LinebackerLicenseAgreementsMember" abstract="true" name="LinebackerLicenseAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_EquivirLicenseAgreementMember" abstract="true" name="EquivirLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_BESmartLicenseAgreementMember" abstract="true" name="BESmartLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_UpfrontLicenseFee" abstract="false" name="UpfrontLicenseFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_LicenseAgreementTerm" abstract="false" name="LicenseAgreementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="prph_AdditionalPaymentOfFee" abstract="false" name="AdditionalPaymentOfFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_LicenseOrRoyaltyNetRevenuePercentage" abstract="false" name="LicenseOrRoyaltyNetRevenuePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="prph_NumberOfSites" abstract="false" name="NumberOfSites" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="prph_CollaborativeArrangementEstimatedAnnualProcedures" abstract="false" name="CollaborativeArrangementEstimatedAnnualProcedures" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_CollaborativeArrangementEstimatedMarketOpportunityValue" abstract="false" name="CollaborativeArrangementEstimatedMarketOpportunityValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_CPMMember" abstract="false" name="CPMMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_OldBridgeNewJerseyMember" abstract="false" name="OldBridgeNewJerseyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_NewYorkSecondFloorLeaseMember" abstract="true" name="NewYorkSecondFloorLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_NewYorkFirstFloorLeaseMember" abstract="true" name="NewYorkFirstFloorLeaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_LesseeOperatingLeaseMonthlyBaseRent" abstract="false" name="LesseeOperatingLeaseMonthlyBaseRent" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_OperatingLeaseSurrenderSettlementAmountMonthly" abstract="false" name="OperatingLeaseSurrenderSettlementAmountMonthly" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_OperatingLeaseNumberOfSurrenderSettlementInstallments" abstract="false" name="OperatingLeaseNumberOfSurrenderSettlementInstallments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="prph_OperatingLeaseLiabilityDecreaseFromLeaseTermination" abstract="false" name="OperatingLeaseLiabilityDecreaseFromLeaseTermination" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_OperatingLeaseRightOfUseAssetDecreaseFromLeaseTermination" abstract="false" name="OperatingLeaseRightOfUseAssetDecreaseFromLeaseTermination" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_OperatingLeaseNonRefundableSecurityDepositWriteoff" abstract="false" name="OperatingLeaseNonRefundableSecurityDepositWriteoff" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_LesseeFinanceLeaseInterestRate" abstract="false" name="LesseeFinanceLeaseInterestRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="prph_FinanceLeaseCost" abstract="false" name="FinanceLeaseCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseRightOfUseAssetAfterAccumulatedAmortization" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationFinanceLeaseRightOfUseAssetAfterAccumulatedAmortization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseRightOfUseAssetAccumulatedAmortization" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationFinanceLeaseRightOfUseAssetAccumulatedAmortization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DiagnosticServicesMember" abstract="false" name="DiagnosticServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_ConsumerProductsMember" abstract="false" name="ConsumerProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_UnallocatedCorporateMember" abstract="false" name="UnallocatedCorporateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_CommonStockPurchaseWarrantsMember" abstract="false" name="CommonStockPurchaseWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_ConsultingServicesMember" abstract="true" name="ConsultingServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_CapitalLeasesMember" abstract="true" name="CapitalLeasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_CurrentAndAccruedPayablesMember" abstract="true" name="CurrentAndAccruedPayablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_ExistingLoanFromAffiliatesMember" abstract="true" name="ExistingLoanFromAffiliatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_AccruedInterestMember" abstract="true" name="AccruedInterestMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_NoncashOrPartNoncashDivestitureCapitalExpendituresAvoided" abstract="false" name="NoncashOrPartNoncashDivestitureCapitalExpendituresAvoided" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_NoncashOrPartNoncashDivestitureEmployeeAnnualOverheadTransferred" abstract="false" name="NoncashOrPartNoncashDivestitureEmployeeAnnualOverheadTransferred" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationRestrictedCash" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationRestrictedCash" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationNotesPayableCurrent" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationNotesPayableCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityCurrent" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationFinanceLeaseLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationUnamortizedDiscountNoncurrent" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationUnamortizedDiscountNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_DisposalGroupIncludingDiscontinuedOperationLongTermDebtNoncurrent" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationLongTermDebtNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="prph_PDXMember" abstract="true" name="PDXMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_LoanAgreementsMember" abstract="true" name="LoanAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_AugustFutureFinancingAgreementMember" abstract="true" name="AugustFutureFinancingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_NoteMember" abstract="true" name="NoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_JanuaryLabrysNoteMember" abstract="true" name="JanuaryLabrysNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_MarchLabrysNoteMember" abstract="true" name="MarchLabrysNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_FirstMarchFutureReceiptsFinancingAgreementMember" abstract="true" name="FirstMarchFutureReceiptsFinancingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_SecondMarchFutureReceiptsFinancingAgreementMember" abstract="true" name="SecondMarchFutureReceiptsFinancingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_GeneratingELOCMember" abstract="true" name="GeneratingELOCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_JanuaryLabrysSPAMember" abstract="true" name="JanuaryLabrysSPAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_MarchLabrysSPAMember" abstract="true" name="MarchLabrysSPAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_PrefundedCommonStockPurchaseWarrantMember" abstract="true" name="PrefundedCommonStockPurchaseWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="prph_DebtInstrumentConvertibleBeneficialOwnershipLimitationPercentage" abstract="false" name="DebtInstrumentConvertibleBeneficialOwnershipLimitationPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="prph_DebtInstrumentConvertiblePeriodFromIssuanceDate" abstract="false" name="DebtInstrumentConvertiblePeriodFromIssuanceDate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="prph_EquityLineOfCreditFacilityMaximumAmountOfSellableStock" abstract="false" name="EquityLineOfCreditFacilityMaximumAmountOfSellableStock" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
