Exhibit 1.01

Conflict Minerals Report of Outset Medical, Inc.

for the reporting period from January 1, 2025 to December 31, 2025

Introduction

This Conflict Minerals Report (the “Report”) of Outset Medical, Inc. (“Outset”) has been prepared pursuant to Rule 13p-1 (the “Rule”) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), for calendar year 2025 (the “Reporting Period”).

The Rule requires disclosure of certain information when a company manufactures or contracts to manufacture products and the minerals specified in the Rule are necessary to the functionality or production of those products. The specified minerals, which are collectively referred to in this Report as “Conflict Minerals,” are gold, columbite-tantalite (coltan), cassiterite and wolframite, including their derivatives, which are limited to tantalum, tin and tungsten. The “Covered Countries,” for the purposes of the Rule and this Report, are the Democratic Republic of the Congo (“DRC”) and each adjoining country. Certain other terms in this Report are defined in the Rule, Form SD or SEC Release No. 34-67716 issued by the U.S. Securities and Exchange Commission (“SEC”) on August 22, 2012, and the reader is referred to those sources for such definitions.

Company and Product Overview

Outset is headquartered in the United States and operates a manufacturing facility in Mexico. Outset is a medical technology company pioneering a first-of-its-kind technology to improve clinical outcomes in dialysis with less cost and complexity. We believe the Tablo® Hemodialysis System, cleared by the U.S. Food and Drug Administration for use from the hospital to the home, represents a significant technological advancement that transforms the dialysis experience for patients and operationally simplifies it for providers. Tablo serves as a single enterprise solution designed to be utilized across the continuum of care, allowing dialysis to be delivered anytime, anywhere and by virtually anyone.

The Tablo Hemodialysis System includes: (i) the Tablo console, a compact, mobile machine consisting of an integrated water purification, on-demand dialysate production system and touchscreen interface and (ii) the Tablo cartridge, a disposable single use pre-strung cartridge that clicks into place and consists of pre-configured blood, saline, and infusion tubing. In addition, TabloCart is an accessory for the Tablo system that provides added maneuverability and optional prefiltration or storage.

This Report relates to products: (i) for which Conflict Minerals are necessary to their functionality or production; (ii) that were manufactured, or contracted to be manufactured, by Outset; and (iii) for which the manufacture was completed during the Reporting Period. These products, which are referred to in this Report collectively as the “Covered Products,” include the Tablo console and TabloCart. Based on our assessment of the underlying components, which contain only plastics, we determined that Tablo cartridges manufactured or contracted to be manufactured by us in 2025 did not contain Conflict Minerals. As a result, Tablo cartridges are not Covered Products for this Reporting Period.

Supply Chain Overview

As a “downstream” purchaser of products or components that contain Conflict Minerals, we are at the end of a very long supply chain where we manufacture or contract to manufacture products and do not directly source Conflict Minerals from mines, smelters or refiners nor specifically design Conflict Minerals into our products.

Reasonable Country-of-Origin Inquiry

We conducted a good faith, reasonable country-of-origin inquiry (“RCOI”) regarding the Conflict Minerals that were necessary to the functionality or production of the Covered Products (the “necessary Conflict Minerals”). This RCOI was reasonably designed to determine whether any of the necessary Conflict Minerals originated in the Covered Countries and whether any of the necessary Conflict Minerals may have been from recycled or scrap sources.

We compiled a list of Tier 1 (i.e., direct) suppliers in the bill of materials for the Covered Products for which the manufacture was completed during the Reporting Period, and considered these 92 suppliers to fall within the scope of our RCOI. In this Report, we refer to these suppliers as “in-scope suppliers”.

We engaged a third-party service provider, Source Intelligence, to assist us with certain elements of our RCOI and due diligence efforts as described below. Following an introductory email from Outset outlining our Conflict Minerals program requirements and identifying Source Intelligence as a partner, in-scope suppliers were contacted by Source Intelligence as part of the RCOI process. These suppliers were first asked a short set of questions including whether the products they supplied to Outset contain Conflict Minerals. Suppliers that indicated that the products they supplied to Outset do not contain Conflict Minerals were deemed responsive to the inquiry and were not asked to provide additional information, while suppliers that indicated that the products they supplied to Outset do contain Conflict Minerals were asked to complete and submit a Conflict Minerals Reporting Template (“CMRT”) developed by the Responsible Minerals Initiative (“RMI”). The CMRT provided a standardized method for collecting representations, statements and data from these suppliers related to the presence, use, source and chain of custody of the Conflict Minerals in supplier components that are incorporated in the Covered Products. Following multiple reminder emails from Source Intelligence, Outset directly contacted suppliers that were unresponsive to Source Intelligence’s communications and requested that they complete and submit a CMRT.

Source Intelligence maintained an online platform for submission, validation and management of supplier responses. Suppliers generally uploaded their completed CMRTs to the online platform or completed an online version of the CMRT. Of the 92 in-scope suppliers contacted, approximately 83% (76 suppliers) responded to Outset’s request by providing a completed CMRT or otherwise confirming that the products they supplied to Outset do not contain Conflict Minerals.

Design of Due Diligence

We designed our due diligence measures to conform, in all material respects, to the internationally recognized due diligence framework in The Organisation for Economic Co-operation and Development (“OECD”) Due Diligence Guidance for Responsible Supply Chain of Minerals from Conflict-Affected and High Risk Areas: Third Edition, including the related supplements on gold, tin, tantalum and tungsten (the “OECD Guidance”), consistent with our position in the minerals supply chain as a downstream purchaser. The scope of our due diligence remained on Conflict Minerals - namely gold, tantalum, tin and tungsten, or 3TG.

Description of Due Diligence Measures

Our due diligence measures performed with respect to Covered Products for the Reporting Period included the following:

To identify risk in our supply chain, we relied on our suppliers to provide information on the presence, use, source and chain of custody of the Conflict Minerals contained in supplier products or components included in the Covered Products. Following an initial inquiry, completed CMRTs were requested from in scope suppliers as appropriate. Source Intelligence assisted with reviewing suppliers’ completed CMRTs, evaluated supplier responses for plausibility, consistency and gaps in information, and followed up with suppliers to request clarification or additional information or otherwise address quality control flags.

Source Intelligence maintains a smelter and refiner database to document (i) which facilities are known metal processors (i.e., verified) based on lists published by the RMI as well as its own research and direct supplier outreach, (ii) which companies are exclusive recyclers, (iii) mine country of origin information and (iv) conflict-free certification status. To verify smelters and refiners listed by suppliers in completed CMRTs, Source Intelligence compared the identified facilities against its list of known metal processors. Supplier responses listing entities that are not verified smelters or refiners were flagged during the quality control process and suppliers were asked for further clarification.

To determine conflict-free certification status, Source Intelligence compared the verified smelters and refiners against lists of facilities that have been certified as conflict-free by independent third-party audit programs, specifically the Responsible Minerals Assurance Process (“RMAP”), developed by the RMI, the London Bullion Market Association (LBMA) Good Delivery Program and the Responsible Jewellery Council (RJC) Chain-of-Custody Certification.

Through its platform, Source Intelligence assigned a risk classification to each submitted CMRT to indicate the level of risk associated with the data provided in such CMRT and provide us with certain risk indicators designed to inform our internal risk mitigation policies and procedures. These CMRT risk classifications are based on the smelter and refiner data provided in a given CMRT (including mine country of origin information, the associated country risk level, and conflict-free certification status), as well as any flags that are raised and remain unresolved through the quality control process, such as incomplete or inconsistent responses.

We determine on a case-by-case basis the appropriate risk mitigation strategy for supply chain risks identified in the course of our due diligence efforts, including where suppliers do not cooperate with our information requests or ultimately, notwithstanding encouragement from Outset, do not meet our expectations with respect to responsible conflict-free sourcing. Potential outcomes include providing access to additional education and training, cautioning the supplier, requiring additional information or corrective actions from the supplier to address our concerns, continuing to work with the supplier while risks are addressed and escalating issues to senior management as appropriate. For any supplier that is ultimately unable to source Outset’s materials from smelters or refiners that have been certified as conflict-free by an independent third-party audit program, we plan to assess the risks on a case-by-case basis and determine proper strategies, taking into consideration various factors including supplier size and capabilities, and whether products and technologies provided by the supplier can be dual-sourced, developed, or ultimately, replaced.

As a downstream purchaser, we do not have a direct relationship with the smelters and refiners in our supply chain, and we do not perform or direct audits of these entities. Instead, we rely on audits performed by independent third party audit programs, specifically the RMAP, LMBA Good Delivery Program and the RJC Chain-of-Custody Certification. These audit programs evaluate smelter and refiner activities and determine whether the smelter or refiner demonstrates that it has systems and controls in place to ensure that all materials it processes originate from conflict-free sources.

In addition, Source Intelligence attempts to directly contact smelters and refiners that are not currently certified as conflict-free to gain more information about their sourcing practices, including countries of origin and transfer, whether there are internal due diligence procedures in place or other processes the entity takes to track the chain-of-custody on the source of its mineral ores. Source Intelligence also performs internet research to determine whether there are any outside sources of information regarding the facility’s sourcing practices.

We expect to report annually, to the extent required by the Rule, and have posted our Form SD containing this Report on our website at: https://investors.outsetmedical.com/financial-information/sec-filings.

Results of Due Diligence Performed

The due diligence measures described above revealed the following:

With respect to those responsive suppliers that listed in their CMRTs one or more smelters or refiners which, based on Source Intelligence’s smelter database, are believed to source from at least one Covered Country but have not been independently certified as conflict-free, a substantial majority provided a company-level CMRT, rather than a product-level response specific to the components supplied to Outset and incorporated in the Covered Products. In addition, Source Intelligence’s smelter database identifies all countries from which a particular metal processor is believed to source materials on an enterprise-wide basis. As a result, we are unable to trace the Conflict Minerals sourced from specific smelters or refiners to particular products, and are thus unable to confirm whether such Conflict Minerals were contained in components supplied to us. Consequently, we believe our data may contain a number of “false positives” in relation to the risk that necessary Conflict Minerals actually supplied to us and used in the Covered Products were sourced from a smelter or refiner that in turn sourced them from a Covered Country and is not certified-as conflict free.

Identified Smelters and Refiners

We have listed on Appendix 1 the verified smelters and refiners (by metal) identified by our in-scope suppliers in completed CMRTs as a result of our RCOI and due diligence, as well as, based on information from the Source Intelligence smelter database, the RMI identification, location and conflict-free certification status of each smelter and refiner.

Out of the 34 suppliers that reported having Conflict Minerals in their products, 28 provided company-level responses (i.e., information regarding all Conflict Minerals used in every component and product they manufacture ), 4 provided product-level responses (i.e., information for the particular types of products and components they supplied to Outset), and 2 provided

responses at a different level defined by the supplier within the CMRT. As a result, some of the smelters and refiners reported to Outset and identified on Appendix 1 may not actually have been used to process the necessary Conflict Minerals in the Covered Products.

Identified Countries of Origin

We do not have sufficient information to reliably determine the countries of origin of all the necessary Conflict Minerals in the Covered Products given that certain suppliers provided inconsistent or incomplete responses or provided information at the company-level. However, based on the smelters and refiners listed by in-scope suppliers in completed CMRTs, combined with associated mine country of origin information from Source Intelligence’s smelter database, the countries of origin may include the countries listed on Appendix 2. As discussed above, because the majority of responsive suppliers provided information at the company-level, and because Source Intelligence’s smelter database tracks mine country of origin information for metal processors on an enterprise-wide basis, we believe there are likely countries of origin in Appendix 2 that are not countries of origin of the necessary Conflict Minerals included in the Covered Products. As a result, we are unable to reliably determine whether any of the necessary Conflict Minerals in the Covered Products originated in the Covered Countries or whether such Conflict Minerals were entirely from recycled or scrap sources or were from other conflict-free sources.

Efforts to Determine Mine or Location of Origin

Our efforts to determine the mines or locations of origin included the use of the due diligence measures described above.

Future Due Diligence and Risk Mitigation Measures

As we continue our Conflict Minerals program, we intend to take the following steps to further enhance our due diligence measures and to mitigate the risk that, with respect to any of the Covered Products, necessary Conflict Minerals were used, directly or indirectly, to finance or benefit armed groups in the Covered Countries:

Inherent Limitations on Due Diligence Measures

Our supply chain with respect to the Covered Products is complex, and our procurement and manufacturing process is significantly removed from the sourcing, mining, smelting and refining of Conflict Minerals. As a result, we do not have direct contractual relationships with smelters, refiners or mines, and there are many third parties in the supply chain between the ultimate manufacture of the Covered Products and the original sources of Conflict Minerals. Moreover, we believe that the smelters and refiners of the Conflict Minerals are best situated to identify the sources of Conflict Minerals and, therefore, have taken steps to identify the applicable smelters and refiners of necessary Conflict Minerals in our supply chain using the CMRT. However, tracing these minerals to their sources is a challenge that requires us to rely on our direct suppliers in our efforts to achieve supply chain transparency, including obtaining information regarding the origin of the necessary Conflict Minerals. The information provided by suppliers or third-party service providers may be inaccurate or incomplete or subject to other irregularities. In addition, because of our relative location within the supply chain in relation to the actual extraction and transport of Conflict Minerals, our ability to verify the accuracy of information reported by suppliers is limited.

Cautionary Note on Forward-Looking Statements

Forward-looking statements in this Report are made pursuant to the safe harbor provisions of Section 21E of the Exchange Act, and other federal securities laws. Investors are cautioned that statements in this Report that are not strictly historical statements, including without limitation, our intentions and expectations regarding future supplier engagement, due diligence and risk mitigation efforts, strategy and future reporting, constitute forward-looking statements that involve risks and uncertainties. Words such as “expect,” “anticipate,” “target,” “goal,” “project,” “intend,” “plan,” “believe,” “seek,” “estimate,” “evaluate,” “may,” “will,” “should,” “would,” “could,” “potential,” “forecast,” “guidance,” “outlook,” “predicts,” variations of these words, and similar expressions are intended to identify such forward-looking statements. Actual results could differ materially from the forward-looking statements. Forward-looking statements are subject to the occurrence of many events outside our control. Risks and uncertainties that could cause actual results to differ include, without limitation, the possibility of future regulatory changes and other developments relating to Conflict Minerals disclosures, changes in or developments related to our products or supply chain, changes to our supplier base, risks and uncertainties associated with the progress of industry and other supply chain transparency and smelter or refiner validation programs for Conflict Minerals (including the possibility of inaccurate information, fraud and other irregularities), inadequate supplier education and knowledge, limitations on the ability or willingness of suppliers to provide more accurate, complete and detailed information and limitations on our ability to verify the accuracy or completeness of any supply chain information provided by suppliers or others, as well as the other risks and uncertainties further described in the “Risk Factors” section of our most recent Annual Report and Quarterly Report, as well as in our other reports filed with or furnished to the SEC. Forward-looking statements should be considered in light of these risks and uncertainties. Investors and others are cautioned not to place undue reliance on forward-looking statements.

We have provided information as of the date of this Report and undertake no obligation to revise or update any forward-looking statements for any reason. Subsequent events, such as the inability or unwillingness of any of our suppliers, smelters or refiners to comply with Outset’s Conflict Minerals policy, may affect our future disclosures and determinations under the Rule. In addition, our due diligence and reporting obligations under the Rule may change in the future and our ability to implement certain processes or obtain information from our suppliers may differ materially from those anticipated or implied in this Report.

APPENDIX 1

Smelters and Refiners by Metal

Based on the information that was provided by our in-scope suppliers in completed CMRTs, we believe that, to the extent reasonably determinable by Outset, the facilities that may have been used to process the necessary Conflict Minerals contained in the Covered Products included the verified smelters and refiners identified below. However, as noted above, where our suppliers provided information on a division- or company-wide basis regarding all Conflict Minerals used in every component and product they manufacture rather than responses specific to the types of products and components supplied to Outset for use in the Covered Products, the smelters and refiners reported to us by those suppliers may not actually have been used to process the necessary Conflict Minerals in the Covered Products. The below smelter information is based on data available in Source Intelligence’s smelter database as of April 2026. Any changes to the database that took place after April 2026 are not reflected.

* For purposes of the “Conflict Free Certification” status column in the table below:

APPENDIX 2

Potential Countries of Origin of Conflict Minerals