The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIVAX SA SPONSORED ADS 00370M103 36,621,233 328,884 SH SOLE 328,884 0 0
ADAGIO MED HLDGS INC COM 00534B100 11,012,382 9,876,576 SH SOLE 9,876,576 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 2,116,700 152,500 SH SOLE 152,500 0 0
ADMA BIOLOGICS INC COM 000899104 4,209,769 467,233 SH SOLE 467,233 0 0
AGOMAB THERAPEUTICS NV SPONSORED ADS 00860C102 6,294,000 600,000 SH SOLE 600,000 0 0
ALTO NEUROSCIENCE INC COM SHS 02157Q109 45,182,395 2,009,893 SH SOLE 2,009,893 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 115,159,860 8,284,882 SH SOLE 8,284,882 0 0
ANTERIS TECHNOLOGIES GLOBAL COM 03675P102 19,011,392 3,425,476 SH SOLE 3,425,476 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 3,256,860 80,956 SH SOLE 80,956 0 0
APOGEE THERAPEUTICS INC COM 03770N101 129,654,121 1,540,384 SH SOLE 1,540,384 0 0
ARTIVION INC COM 228903100 59,957,560 1,637,290 SH SOLE 1,637,290 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 350,281,925 1,531,421 SH SOLE 1,531,421 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306 2,085,228 139,667 SH SOLE 139,667 0 0
AXOGEN INC COM 05463X106 23,101,947 697,312 SH SOLE 697,312 0 0
AXSOME THERAPEUTICS INC. COM 05464T104 25,344,549 149,950 SH SOLE 149,950 0 0
BELITE BIO INC SPONSORED ADS 07782B104 24,231,532 151,979 SH SOLE 151,979 0 0
BETA BIONICS INC COM 08659B102 8,446,299 842,944 SH SOLE 842,944 0 0
BILLIONTOONE INC CL A 090168105 7,247,639 91,812 SH SOLE 91,812 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 70,771,994 7,434,033 SH SOLE 7,434,033 0 0
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405 27,549,386 377,544 SH SOLE 377,544 0 0
CELCUITY INC COM 15102K100 356,938,608 3,127,200 SH SOLE 3,127,200 0 0
CELCUITY INC NOTE 2.750% 8/0 15102KAA8 15,875,774 6,500,000 PRN SOLE 6,500,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 208,883,627 5,258,903 SH SOLE 5,258,903 0 0
COGENT BIOSCIENCES INC COM 19240Q201 4,660,446 121,082 SH SOLE 121,082 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101 2,076,864 792,696 SH SOLE 792,696 0 0
CONTINEUM THERAPEUTICS INC CL A 21217B100 16,398,032 1,255,592 SH SOLE 1,255,592 0 0
CORCEPT THERAPEUTICS INC COM 218352102 2,015,500 50,000 SH SOLE 50,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 33,538,412 2,292,441 SH SOLE 2,292,441 0 0
CRESCENT BIOPHARMA INC. COM G2545C104 3,801,525 206,942 SH SOLE 206,942 0 0
CUMBERLAND PHARMACEUTICALS I COM 230770109 640,179 196,978 SH SOLE 196,978 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105 47,464,473 10,098,824 SH SOLE 10,098,824 0 0
DAMORA THERAPEUTICS INC COM NEW 36322Q206 31,675,700 1,223,000 SH SOLE 1,223,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 37,644,331 1,755,799 SH SOLE 1,755,799 0 0
DBV TECHNOLOGIES S A SPONSORED ADS 23306J309 20,146,128 964,391 SH SOLE 964,391 0 0
DYNE THERAPEUTICS INC COM 26818M108 84,646,051 4,668,839 SH SOLE 4,668,839 0 0
EDESA BIOTECH INC COM NEW 27966L306 2,945,740 563,239 SH SOLE 563,239 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 139,355,181 4,423,974 SH SOLE 4,423,974 0 0
ENGENE HOLDINGS INC COM 29286M105 39,685,316 5,827,506 SH SOLE 5,827,506 0 0
ENSYSCE BIOSCIENCES INC COM NEW 293602504 46,670 86,666 SH SOLE 86,666 0 0
EVOLUS INC COM 30052C107 5,289,003 1,286,862 SH SOLE 1,286,862 0 0
EVOMMUNE INC COM SHS 30054Y107 10,307,567 448,350 SH SOLE 448,350 0 0
EXAGEN INC COM 30068X103 344,679 114,893 SH SOLE 114,893 0 0
GUARDANT HEALTH INC COM 40131M109 27,711,000 300,000 SH SOLE 300,000 0 0
IMMATICS N.V SHS N44445109 102,173,207 10,383,456 SH SOLE 10,383,456 0 0
IMMUNOVANT INC COM 45258J102 39,678,994 1,597,383 SH SOLE 1,597,383 0 0
INHIBIKASE THERAPEUTICS INC COM NEW 45719W205 3,889,200 2,315,000 SH SOLE 2,315,000 0 0
INHIBRX BIOSCIENCES INC COM 45720N103 96,993,192 1,442,707 SH SOLE 1,442,707 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 39,377,305 85,419 SH SOLE 85,419 0 0
INVIVYD INC COM 00534A102 27,117,094 20,859,303 SH SOLE 20,859,303 0 0
IONIS PHARMACEUTICALS INC COM 462222100 37,845,360 504,000 SH SOLE 504,000 0 0
IRHYTHM HOLDINGS INC COM 450056106 12,395,169 105,026 SH SOLE 105,026 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 32,138,500 170,000 SH SOLE 170,000 0 0
LEONABIO INC COM 04746L203 19,113,830 1,859,322 SH SOLE 1,859,322 0 0
MEDLINE INC COM CL A 58507V107 1,246,000 28,000 SH SOLE 28,000 0 0
MEIRAGTX HLDGS PLC COM G59665102 89,312,864 10,326,103 SH SOLE 10,326,103 0 0
MODERNA INC COM 60770K107 50,800,000 1,000,000 SH Put SOLE 1,000,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 48,865,538 12,594,211 SH SOLE 12,594,211 0 0
NEUMORA THERAPEUTICS INC. COM 640979100 9,952,989 5,104,097 SH SOLE 5,104,097 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,569,687 65,050 SH SOLE 65,050 0 0
NURIX THERAPEUTICS INC COM 67080M103 57,518,594 3,710,877 SH SOLE 3,710,877 0 0
NUVALENT INC COM 670703107 161,922,737 1,580,505 SH SOLE 1,580,505 0 0
OCULAR THERAPEUTIX INC COM 67576A100 4,235,000 500,000 SH Call SOLE 500,000 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102 13,130,860 493,827 SH SOLE 493,827 0 0
OMADA HEALTH INC COM 68170A108 9,884,168 786,330 SH SOLE 786,330 0 0
OPUS GENETICS INC COM 67577R102 8,353,081 1,835,842 SH SOLE 1,835,842 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106 21,411,101 5,037,906 SH SOLE 5,037,906 0 0
ORUKA THERAPEUTICS INC COM 687604108 68,449,324 1,395,501 SH SOLE 1,395,501 0 0
OUTSET MED INC COM NEW 690145206 3,199,998 833,333 SH SOLE 833,333 0 0
PALATIN TECHNOLOGIES INC COM NEW 696077601 1,079,082 61,945 SH SOLE 61,945 0 0
PALISADE BIO INC COM 696389402 15,624,261 8,928,149 SH SOLE 8,928,149 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 10,276,750 925,000 SH SOLE 925,000 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 655,974,329 2,035,986 SH SOLE 2,035,986 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 129,734,647 1,230,879 SH SOLE 1,230,879 0 0
RAPPORT THERAPEUTICS INC COM 75383L102 21,087,051 673,923 SH SOLE 673,923 0 0
RELAY THERAPEUTICS INC COM 75943R102 97,023,853 9,751,141 SH SOLE 9,751,141 0 0
REPLIGEN CORP COM 759916109 33,053,341 280,541 SH SOLE 280,541 0 0
REVOLUTION MEDICINES INC COM 76155X100 25,148,850 258,600 SH SOLE 258,600 0 0
REVOLUTION MEDICINES INC *W EXP 12/17/202 76155X118 447,500 250,000 SH SOLE 250,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 206,448,951 2,373,795 SH SOLE 2,373,795 0 0
ROIVANT SCIENCES LTD SHS G76279101 229,507,270 8,285,461 SH SOLE 8,285,461 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202 24,633,576 6,431,743 SH SOLE 6,431,743 0 0
SIONNA THERAPEUTICS INC COM 829401108 26,396,820 658,439 SH SOLE 658,439 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204 85,727,851 11,906,646 SH SOLE 11,906,646 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202 190,825,869 3,783,225 SH SOLE 3,783,225 0 0
SURROZEN INC COM NEW 86889P208 6,682,218 229,393 SH SOLE 229,393 0 0
SURROZEN INC *W EXP 08/01/203 86889P117 2,667 166,666 SH SOLE 166,666 0 0
SUTRO BIOPHARMA INC COM SHS 869367201 17,818,297 715,307 SH SOLE 715,307 0 0
TANGO THERAPEUTICS INC COM 87583X109 16,906,561 808,153 SH SOLE 808,153 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 23,150,034 1,447,782 SH SOLE 1,447,782 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 123,075,190 4,142,551 SH SOLE 4,142,551 0 0
TWIST BIOSCIENCE CORP COM 90184D100 7,128,000 150,000 SH SOLE 150,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 22,901,415 1,170,829 SH SOLE 1,170,829 0 0
X4 PHARMACEUTICALS INC COM NEW 98420X202 27,826,486 6,737,648 SH SOLE 6,737,648 0 0
ZYMEWORKS INC COM 98985Y108 87,892,353 3,510,078 SH SOLE 3,510,078 0 0