<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e4c92-d739-7300-afc6-d8634b746533,g:66a15168-401a-4b51-b069-bd01b5ce0b5b-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.dexcom.com/role/CoverPage" xlink:type="simple" xlink:href="dxcm-20260527.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.dexcom.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019e4c92-d73a-7c21-8ec5-e6cbc9a58362" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_DocumentType_019e4c92-d73a-7c21-8ec5-e6cbc9a58362" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019e4c92-d73a-78f8-9826-88f172c8eb3e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_DocumentPeriodEndDate_019e4c92-d73a-78f8-9826-88f172c8eb3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019e4c92-d73a-77d0-aec1-aa95158c4105" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_AmendmentFlag_019e4c92-d73a-77d0-aec1-aa95158c4105" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019e4c92-d73a-7a80-904e-e18fdb191957" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityCentralIndexKey_019e4c92-d73a-7a80-904e-e18fdb191957" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019e4c92-d73a-7191-a0e1-adf7353c5dbf" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019e4c92-d73a-7cf1-a0fd-a9b21ee5a09e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityRegistrantName_019e4c92-d73a-7cf1-a0fd-a9b21ee5a09e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019e4c92-d73a-7881-a365-a1b6dc944de4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019e4c92-d73a-7881-a365-a1b6dc944de4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019e4c92-d73a-73ef-8f1c-5ca143a36b11" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityFileNumber_019e4c92-d73a-73ef-8f1c-5ca143a36b11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019e4c92-d73a-7e23-a15b-ed3ced1e068d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityTaxIdentificationNumber_019e4c92-d73a-7e23-a15b-ed3ced1e068d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019e4c92-d73a-708f-a339-b05fc9d0e8fe" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityAddressAddressLine1_019e4c92-d73a-708f-a339-b05fc9d0e8fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019e4c92-d73a-7ab3-a2ca-3c733219408c" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityAddressCityOrTown_019e4c92-d73a-7ab3-a2ca-3c733219408c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019e4c92-d73a-75e1-87ea-2be8f4269026" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityAddressStateOrProvince_019e4c92-d73a-75e1-87ea-2be8f4269026" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019e4c92-d73a-700e-93d5-7c01de5dddc4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityAddressPostalZipCode_019e4c92-d73a-700e-93d5-7c01de5dddc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019e4c92-d73a-7e83-9e01-0d8191b78ffd" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_CityAreaCode_019e4c92-d73a-7e83-9e01-0d8191b78ffd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019e4c92-d73a-7163-86f0-ae0912fb94d7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_LocalPhoneNumber_019e4c92-d73a-7163-86f0-ae0912fb94d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019e4c92-d73a-7da3-a08a-7a2564337b6d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_WrittenCommunications_019e4c92-d73a-7da3-a08a-7a2564337b6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019e4c92-d73a-7a36-af46-ac62b0dd5fa0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_SolicitingMaterial_019e4c92-d73a-7a36-af46-ac62b0dd5fa0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019e4c92-d73a-73e5-a391-e9b227cf7a32" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_PreCommencementTenderOffer_019e4c92-d73a-73e5-a391-e9b227cf7a32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019e4c92-d73a-73eb-a99e-89b24eaaa9f6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019e4c92-d73a-73eb-a99e-89b24eaaa9f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019e4c92-d73a-753f-8fc4-fae5b2c94132" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_Security12bTitle_019e4c92-d73a-753f-8fc4-fae5b2c94132" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019e4c92-d73a-72db-a0dd-a1ab2c23fae4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_TradingSymbol_019e4c92-d73a-72db-a0dd-a1ab2c23fae4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019e4c92-d73a-72cd-ba68-2d5b7fdfad86" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_SecurityExchangeName_019e4c92-d73a-72cd-ba68-2d5b7fdfad86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019e4c92-d73a-75a0-a60b-f7d285c1070f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e4c92-d73a-7138-9efa-1ac1804b2e64" xlink:to="loc_dei_EntityEmergingGrowthCompany_019e4c92-d73a-75a0-a60b-f7d285c1070f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
