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  <xs:element id="iclr_PRAHealthSciencesIncMember" abstract="true" name="PRAHealthSciencesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_GoodwillAndIntangibleAssetsHeldAtFairValueMember" abstract="true" name="GoodwillAndIntangibleAssetsHeldAtFairValueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_VehiclesGross" abstract="false" name="VehiclesGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="iclr_SeniorSecuredRevolvingLoanFacilityMember" abstract="true" name="SeniorSecuredRevolvingLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_SeniorSecuredCreditFacilityAndSeniorSecuredNotesMember" abstract="true" name="SeniorSecuredCreditFacilityAndSeniorSecuredNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_VariableRateComponentTwoMember" abstract="true" name="VariableRateComponentTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_InterestExpenseCreditOther" abstract="false" name="InterestExpenseCreditOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_LongTermDebtMaturityYearFiveAndThereafter" abstract="false" name="LongTermDebtMaturityYearFiveAndThereafter" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="iclr_ShareRepurchaseProgramAuthorizedAdditionalAmount" abstract="false" name="ShareRepurchaseProgramAuthorizedAdditionalAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_PersonnelRelatedLiabilitiesMember" abstract="true" name="PersonnelRelatedLiabilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_FacilitiesRelatedLiabilityMember" abstract="true" name="FacilitiesRelatedLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_ScheduleOfComponentsOfIncomeBeforeIncomeTaxExpenseBenefitLineItems" abstract="true" name="ScheduleOfComponentsOfIncomeBeforeIncomeTaxExpenseBenefitLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iclr_ReconciliationOfProvisionOfIncomeTaxesTable" abstract="true" name="ReconciliationOfProvisionOfIncomeTaxesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="iclr_ReconciliationOfProvisionOfIncomeTaxesLineItems" abstract="true" name="ReconciliationOfProvisionOfIncomeTaxesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="iclr_ForeignTaxJurisdictionOtherExcludingTheUnitedKingdomAndGermanyMember" abstract="true" name="ForeignTaxJurisdictionOtherExcludingTheUnitedKingdomAndGermanyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_EffectiveIncomeTaxRateReconciliationInvestorTaxExpenseBenefitOnForeignSubsidiaryEarningsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationInvestorTaxExpenseBenefitOnForeignSubsidiaryEarningsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_EffectiveIncomeTaxRateReconciliationForeignTaxEffectsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationForeignTaxEffectsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_EffectiveIncomeTaxRateReconciliationInvestorTaxBenefitOnForeignSubsidiaryEarningsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationInvestorTaxBenefitOnForeignSubsidiaryEarningsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iclr_EffectiveIncomeTaxRateReconciliationForeignTaxEffectsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationForeignTaxEffectsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iclr_EffectiveIncomeTaxRateReconciliationChangeInUnrecognizedTaxBenefitsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationChangeInUnrecognizedTaxBenefitsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_DeferredTaxAssetsOperatingLossAndTaxCreditsCarryforwards" abstract="false" name="DeferredTaxAssetsOperatingLossAndTaxCreditsCarryforwards" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_DeferredTaxAssetsOperatingLeaseLiability" abstract="false" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_DeferredTaxAssetsTaxDeferredExpenseOtherLiabilities" abstract="false" name="DeferredTaxAssetsTaxDeferredExpenseOtherLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iclr_DeferredTaxAssetContractWithCustomerLiability" abstract="false" name="DeferredTaxAssetContractWithCustomerLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="iclr_UnitedStatesStateJurisdictionMember" abstract="true" name="UnitedStatesStateJurisdictionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_IncomeTaxExpenseMember" abstract="true" name="IncomeTaxExpenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_TaxOfBusinessAcquiredMember" abstract="true" name="TaxOfBusinessAcquiredMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_TaxYear2026To2045Member" abstract="true" name="TaxYear2026To2045Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_DeferredTaxAssetsAdditionalTaxCreditCarryforwardsNotSubjectToExpiration" abstract="false" name="DeferredTaxAssetsAdditionalTaxCreditCarryforwardsNotSubjectToExpiration" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="iclr_TaxYear2026To2039Member" abstract="true" name="TaxYear2026To2039Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_TaxYear20402045Member" abstract="true" name="TaxYear20402045Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_CompensationRelatedCostsShareBasedPaymentsDisclosureTable" abstract="true" name="CompensationRelatedCostsShareBasedPaymentsDisclosureTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
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  <xs:element id="iclr_EmployeeStockPlanTwentyZeroEightPlanMember" abstract="true" name="EmployeeStockPlanTwentyZeroEightPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_OptionPlans2008Member" abstract="true" name="OptionPlans2008Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_RestrictedStockUnitsTwentyThirteenMember" abstract="true" name="RestrictedStockUnitsTwentyThirteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_ConsultantsRestrictedStockUnitsTwentyNineteenMember" abstract="true" name="ConsultantsRestrictedStockUnitsTwentyNineteenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_PerformanceBasedGrantsMember" abstract="true" name="PerformanceBasedGrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_AwardDate2018Member" abstract="true" name="AwardDate2018Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_The2020LegacyPRAPlanMember" abstract="true" name="The2020LegacyPRAPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="iclr_OutsideDirectorMember" abstract="true" name="OutsideDirectorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_WithinNextTwelveMonthsMember" abstract="true" name="WithinNextTwelveMonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_CompensationRelatedCostsShareBasedPaymentsDisclosureLineItems" abstract="true" name="CompensationRelatedCostsShareBasedPaymentsDisclosureLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iclr_LimitOfSharesIssuedOrToBeIssuedPursuantToOptionsGranted" abstract="false" name="LimitOfSharesIssuedOrToBeIssuedPursuantToOptionsGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodFairValuePerShare" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodFairValuePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
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  <xs:element id="iclr_StockOptionAndAwardPlansMember" abstract="true" name="StockOptionAndAwardPlansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndSettledInCashInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndSettledInCashInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="iclr_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndSettledInCashInPeriodWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndSettledInCashInPeriodWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="iclr_RestOfEuropeMember" abstract="true" name="RestOfEuropeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_RestOfWorldMember" abstract="true" name="RestOfWorldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_EarningsPerShareBasicAndDilutedEPSAbstract" abstract="true" name="EarningsPerShareBasicAndDilutedEPSAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iclr_AccumulatedOtherComprehensiveLossCashFlowHedgeGainLossReclassificationAfterTax" abstract="false" name="AccumulatedOtherComprehensiveLossCashFlowHedgeGainLossReclassificationAfterTax" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="iclr_AfimmuneLimitedMember" abstract="true" name="AfimmuneLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_BridgeSecuredCreditFacilityMember" abstract="true" name="BridgeSecuredCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iclr_HealthVerityInc.Member" abstract="true" name="HealthVerityInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
