0001503802 2026-05-26 2026-05-26 0001503802 1 2026-05-26 2026-05-26 iso4217:USD pure shares S-8 S-8 EX-FILING FEES 0001503802 Karyopharm Therapeutics Inc. N/A false S-8 Karyopharm Therapeutics Inc. Equity Common Stock, par value $0.0001 per share true 3950000 7.98 31521000.00 0.0001381 4353.05 31521000.00 4353.05 0.00 4353.05 (a) Karyopharm Therapeutics Inc., a Delaware corporation (the "Registrant"), is registering an additional 3,950,000 shares of common stock, par value $0.0001 per share (the "Common Stock"), that may be issued under the Karyopharm Therapeutics Inc. 2022 Equity Incentive Plan, as amended (the "Plan"). Pursuant to Rule 416 of the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement also covers such additional and indeterminate number of securities as may become issuable pursuant to the provisions of the Plan relating to adjustments for changes resulting from a stock dividend, stock split or similar change. (b) The offering price per unit and in the aggregate are estimated in accordance with Rule 457(h) under the Securities Act solely for the purpose of calculating the registration fee. The price of $7.98 per share represents the average high and low sales prices of the Common Stock as quoted on the Nasdaq Stock Market on May 21, 2026.