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          <link:definition>999064 - Disclosure - Joint Venture (Details Narrative)</link:definition>
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    <element id="opgn_AdditionalFunds" name="AdditionalFunds" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_AgreementAxis" name="AgreementAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="opgn_AgreementDomain" name="AgreementDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_AdditionalAggregateValue" name="AdditionalAggregateValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_NetIncomeLossBasic" name="NetIncomeLossBasic" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_NetIncomeLossDiluted" name="NetIncomeLossDiluted" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_NetLossIncomeAllocatedToPreferredStockholdersDiluted" name="NetLossIncomeAllocatedToPreferredStockholdersDiluted" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_BasicWeightedAverageSharesOutstandingDiluted" name="BasicWeightedAverageSharesOutstandingDiluted" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IncrementalLoss" name="IncrementalLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_AccountsReceivablePeriodDue" name="AccountsReceivablePeriodDue" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_ConcentrationRiskPercentage" name="ConcentrationRiskPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_CashConsideration" name="CashConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_ShareSaleAgreementDescription" name="ShareSaleAgreementDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_ChangeInFairValue" name="ChangeInFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_LeaseholdImprovementPropertyAndEquipment" name="LeaseholdImprovementPropertyAndEquipment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_OperatingLeaseRightOfUseAssets" name="OperatingLeaseRightOfUseAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_AccruedServiceFees" name="AccruedServiceFees" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_AccruedFranchiseTaxes" name="AccruedFranchiseTaxes" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_StockWarrantsExpirationDate" name="StockWarrantsExpirationDate" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IncomeStatementLocationsAxis" name="IncomeStatementLocationsAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="opgn_IncomeStatementLocationsDomain" name="IncomeStatementLocationsDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_StatedValuePerShareOfSeriesDPreferredStock" name="StatedValuePerShareOfSeriesDPreferredStock" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_PreferredStockParValue" name="PreferredStockParValue" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_ConsiderationPaid" name="ConsiderationPaid" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_PurchasePriceUnpaid" name="PurchasePriceUnpaid" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_PreferredStockConvertedShares" name="PreferredStockConvertedShares" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_BeneficialOwnershipLimitation" name="BeneficialOwnershipLimitation" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IissuanceUnder2026PlanOverNext" name="IissuanceUnder2026PlanOverNext" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_DeferredTaxAssetsOperatingLeaseLiability" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_ValuationAllowance" name="ValuationAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_DeferredTaxAssetsOperatingLeaseRightOfUseAsset" name="DeferredTaxAssetsOperatingLeaseRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IncomeTaxReconciliationStatutoryTaxRateDifferenceAmount" name="IncomeTaxReconciliationStatutoryTaxRateDifferenceAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_EffectiveIncomeTaxRateReconciliationStatutoryTaxRateDifferenceRate" name="EffectiveIncomeTaxRateReconciliationStatutoryTaxRateDifferenceRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IncomeTaxReconciliationReturnToProvisionTrueupsAmount" name="IncomeTaxReconciliationReturnToProvisionTrueupsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_EffectiveIncomeTaxRateReconciliationReturnToProvisionTrueupsRate" name="EffectiveIncomeTaxRateReconciliationReturnToProvisionTrueupsRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IncomeTaxReconciliationStateTaxRateChangesAmount" name="IncomeTaxReconciliationStateTaxRateChangesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_EffectiveIncomeTaxRateReconciliationStateTaxRateChangesRate" name="EffectiveIncomeTaxRateReconciliationStateTaxRateChangesRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IncomeTaxReconciliationLossOfExpiredNetOperatingLossesAmount" name="IncomeTaxReconciliationLossOfExpiredNetOperatingLossesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_EffectiveIncomeTaxRateReconciliationLossOfExpiredNetOperatingLossesRate" name="EffectiveIncomeTaxRateReconciliationLossOfExpiredNetOperatingLossesRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_IncomeTaxReconciliationAdjustmentOnDeferredForeignIntangibleAmount" name="IncomeTaxReconciliationAdjustmentOnDeferredForeignIntangibleAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_EffectiveIncomeTaxRateReconciliationAdjustmentOnDeferredForeignIntangibleRate" name="EffectiveIncomeTaxRateReconciliationAdjustmentOnDeferredForeignIntangibleRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_ChangeChargedToIncomeTaxExpense" name="ChangeChargedToIncomeTaxExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_PerformedOutside" name="PerformedOutside" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_RouAssetsAbstract" name="RouAssetsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_LeaseRightOfUseAsset" name="LeaseRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_CurrentAbstract" name="CurrentAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_NoncurrentAbstract" name="NoncurrentAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_LeaseLiability" name="LeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" name="CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_CashUsedInOperatingActivitiesAbstract" name="CashUsedInOperatingActivitiesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_CashUsedInFinancingActivitiesAbstract" name="CashUsedInFinancingActivitiesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_RouAssetsObtainedInExchangeForLeaseObligationsAbstract" name="RouAssetsObtainedInExchangeForLeaseObligationsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_OperatingLeases" name="OperatingLeases" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="opgn_ContractualPurchasePrice" name="ContractualPurchasePrice" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
