<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e17b8-9e37-7dcd-b3bf-e6b2e31072c0,g:a4f408b7-4f3a-41e8-8d62-914db5df709c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.zoetis.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="zts-20260520.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.zoetis.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019e17b8-9e37-7f22-9acc-cb51844facab" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_DocumentType_019e17b8-9e37-7f22-9acc-cb51844facab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019e17b8-9e37-7729-b791-0f88b26648ac" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_DocumentPeriodEndDate_019e17b8-9e37-7729-b791-0f88b26648ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019e17b8-9e37-7997-8acc-34c1e54615d4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityRegistrantName_019e17b8-9e37-7997-8acc-34c1e54615d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019e17b8-9e37-780a-b02f-6a1b4318f4b7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityCentralIndexKey_019e17b8-9e37-780a-b02f-6a1b4318f4b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019e17b8-9e37-787b-9c06-cf2956bc538a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_AmendmentFlag_019e17b8-9e37-787b-9c06-cf2956bc538a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019e17b8-9e37-7898-a6a1-5117bc016236" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019e17b8-9e37-7898-a6a1-5117bc016236" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019e17b8-9e37-7ee3-8aad-99118e9d1d57" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityFileNumber_019e17b8-9e37-7ee3-8aad-99118e9d1d57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019e17b8-9e37-7dd3-8942-b258b021ee34" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityTaxIdentificationNumber_019e17b8-9e37-7dd3-8942-b258b021ee34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019e17b8-9e37-759b-9a56-fa281f18920e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityAddressAddressLine1_019e17b8-9e37-759b-9a56-fa281f18920e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019e17b8-9e37-7c91-9b5b-c8d2b8215c9b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityAddressCityOrTown_019e17b8-9e37-7c91-9b5b-c8d2b8215c9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019e17b8-9e37-7261-b4ed-487d62ec8342" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityAddressStateOrProvince_019e17b8-9e37-7261-b4ed-487d62ec8342" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019e17b8-9e37-7244-84ff-4e62f673b26a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityAddressPostalZipCode_019e17b8-9e37-7244-84ff-4e62f673b26a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019e17b8-9e37-783a-ac24-91bab2039b40" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_CityAreaCode_019e17b8-9e37-783a-ac24-91bab2039b40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019e17b8-9e37-7507-93b1-6f236fa775ee" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_LocalPhoneNumber_019e17b8-9e37-7507-93b1-6f236fa775ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019e17b8-9e37-742f-bee5-0a114f3e2405" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_WrittenCommunications_019e17b8-9e37-742f-bee5-0a114f3e2405" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019e17b8-9e37-7c42-9aee-1698638c8c28" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_SolicitingMaterial_019e17b8-9e37-7c42-9aee-1698638c8c28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019e17b8-9e37-7877-8daf-755d5b1b7630" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_PreCommencementTenderOffer_019e17b8-9e37-7877-8daf-755d5b1b7630" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019e17b8-9e37-72da-91b5-6f410cde6554" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019e17b8-9e37-72da-91b5-6f410cde6554" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019e17b8-9e37-7eb0-8d76-d170d987b1d3" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_Security12bTitle_019e17b8-9e37-7eb0-8d76-d170d987b1d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019e17b8-9e37-7104-a2fa-9f4cb60235d4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_TradingSymbol_019e17b8-9e37-7104-a2fa-9f4cb60235d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019e17b8-9e37-7f65-99ff-ae7bfbb7a464" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_SecurityExchangeName_019e17b8-9e37-7f65-99ff-ae7bfbb7a464" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019e17b8-9e37-7720-a62f-a174208b620f" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019e17b8-9e37-7a80-bf7f-326e2c8d3751" xlink:to="loc_dei_EntityEmergingGrowthCompany_019e17b8-9e37-7720-a62f-a174208b620f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
