Exhibit 1.01

CONFLICT MINERALS REPORT for the year ending December 31, 2025

Introduction

Smith & Nephew plc, also referred to as “Smith & Nephew”, the “company”, “we”, “our”, and “us” is a global medical technology business. We have products in the following fields: Orthopaedic Reconstruction, Advanced Wound Management, Sports Medicine and Trauma & Extremities.

This Conflict Minerals Report (CMR) for the year ended December 31, 2025, is presented to comply with Rule 13p-1 under the Securities Exchange Act of 1934 (the Rule) and Form SD. The Rule imposes certain reporting obligations on U.S. Securities and Exchange Commission (SEC) issuers whose manufactured products contain certain minerals which are “necessary to the functionality or production” of their products. These minerals are cassiterite, columbite, tantalite (coltan), gold, wolframite, and their derivatives, which are limited to tin, tantalum and tungsten (collectively, 3TG or Conflict Minerals). The Rule focuses on 3TG emanating from the Democratic Republic of the Congo (DRC) region and nine adjoining countries (collectively the Covered Countries). If an issuer has reason to believe that any of the Conflict Minerals in their supply chain may have originated in the Covered Countries, or if they are unable to determine the country of origin of those Conflict Minerals, then the issuer must exercise due diligence on the Conflict Minerals’ source and chain of custody and submit a CMR to the SEC that includes a description of those due diligence measures.

This CMR relates to the process undertaken for Smith & Nephew products that were manufactured, or contracted to be manufactured, during calendar year 2025 and that contain 3TGs. Third party products that Smith & Nephew sells but does not manufacture or contract to manufacture are outside the scope of this CMR.

Executive Summary

Whilst Smith & Nephew’s products may contain components or materials that utilize 3TG, Smith & Nephew does not purchase 3TG directly from mines, smelters, or refiners. The majority of Smith & Nephew’s suppliers and their upstream suppliers are not directly subject to the Rule issued pursuant to Section 1502 of the Dodd-Frank Wall Street Reform and Consumer Protection Act. Smith & Nephew is reliant on the provision of information by its suppliers to determine whether any 3TG in its products originated in the Covered Countries.

Smith & Nephew performed a Reasonable Country of Origin Inquiry (RCOI) on suppliers believed to provide Smith & Nephew with materials or components containing 3TGs necessary to the functionality or production of Smith & Nephew’s products. Smith & Nephew’s suppliers identified 332 valid smelters and refineries (smelters) in their supply chains. Of these 332 smelters, Smith & Nephew identified 48 as sourcing (or there was a reason to believe they may be sourcing) from the Covered Countries. Smith & Nephew’s due diligence review indicated that 32 of these smelters have been audited and recognized as conflict free by the Responsible Minerals Assurance Process (RMAP). Risk mitigation was conducted on the remaining 16 smelters.

Company Management Systems

Smith & Nephew established robust management systems according to Step 1 of the OECD Due Diligence Guidance. Smith & Nephew’s systems included:

RCOI

Smith & Nephew designed its RCOI process in accordance with Step 2A and 2B of the OECD Due Diligence Guidance. Smith & Nephew’s RCOI process involved two stages:

Supplier RCOI

Smith & Nephew designed its supplier RCOI process to identify, to the best of Smith & Nephew’s efforts, the smelters in Smith & Nephew’s supply chain in accordance with Step 2A of the OECD Due Diligence Guidance. Smith & Nephew’s supplier RCOI process for the 2025 reporting period included the following:

For the 2025 reporting period, Smith & Nephew’s RCOI process was executed by Claigan Environmental Inc., a third-party contractor. Smith & Nephew’s suppliers identified 332 smelters in their supply chains. The specific list of smelters is included in the “Smelter and Refineries” section at the end of this CMR.

Smelter RCOI

Due to the overlap between smelter RCOI and smelter due diligence, the smelter RCOI process is summarized in the due diligence section of this CMR.

Due Diligence

Smith & Nephew’s Due Diligence Process was designed in accordance with the applicable sections of Steps 2, 3, and 4 of the OECD Due Diligence Guidance.

Smelter RCOI and Due Diligence

Smith & Nephew’s smelter RCOI and due diligence process were designed to:

Smith & Nephew’s smelter RCOI and Due Diligence Process included the following:

Smith & Nephew’s suppliers identified 332 valid smelters and refineries (smelters) in their supply chains. Of these 332 smelters, Smith & Nephew identified 48 as sourcing (or there was a reason to believe they may be sourcing) from the Covered Countries. Smith & Nephew’s due diligence review indicated that 32 of these smelters have been audited and recognized as conflict free by the Responsible Minerals Assurance Process (RMAP). Risk mitigation was conducted on the remaining 16 smelters.

Risk Mitigation

Smith & Nephew conducted risk mitigation on 16 smelters that were not recognized as conformant to the RMAP. Smith & Nephew’s risk mitigation was designed in accordance with Step 3B of the OECD Due Diligence Guidance and was reported to Smith & Nephew’s Sr. Director, ESG Regulations and Reporting, in accordance with Step 3A of the OECD Due Diligence Guidance.

As part of Smith & Nephew’s risk mitigation process, additional due diligence was performed to determine if there was any reason to believe the relevant smelters directly or indirectly financed or benefited armed groups in the DRC or adjoining countries. Notifications were issued to relevant suppliers regarding engaging smelters, either directly or through any necessary upstream suppliers, to promote participation in the RMAP. Suppliers were requested to consider removal of non RMAP conformant smelters from their supply chains, if smelters are unwilling or unable to participate in the RMAP.

Smith & Nephew will continue to engage with its suppliers on an ongoing basis with regards to these efforts and to ensure appropriate risk mitigation.

Improvement Plan

Smith & Nephew has a global, multi-tier, significantly complex and highly regulated supply chain. Supply chain changes carry long lead times and the necessity for extensive quality and safety related due diligence checks, as well as in certain instances, the obtaining of approvals from regulators. Smith & Nephew therefore works collaboratively with suppliers to educate and manage change on an ongoing basis and to ensure conformance with Smith & Nephew’s Conflict Minerals Policy.

Smith & Nephew is taking and will continue to take the following steps to improve the due diligence conducted to further mitigate risk that the necessary Conflict Minerals in Smith & Nephew’s products could directly or indirectly benefit or finance armed groups in the Covered Countries:

Smelters and Refineries

Below are the smelters reported to Smith & Nephew as likely in Smith & Nephew’s supply chain in the 2025 reporting period.

Forty-eight of the smelters above declared to be sourcing, or there was reason to believe are sourcing, from the Covered Countries. Under the SEC Final Rule, the requirement is to identify whether or not a smelter is sourcing from the Covered Countries; there is no requirement to identify the specific covered country by the smelter. Given the limitation on the specificity of the smelters’ disclosures, the identified Covered Countries are the Democratic Republic of the Congo, Rwanda, Burundi, Uganda, Tanzania, South Sudan, Zambia, Central African Republic and Angola.