<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Tue May 19 20:49:37 UTC 2026 -->
<xs:schema elementFormDefault="qualified" xmlns:srt-types="http://fasb.org/srt-types/2026" targetNamespace="http://oramed.com/20260331" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:us-types="http://fasb.org/us-types/2026" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:ormp="http://oramed.com/20260331" xmlns:dtr="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:type="simple" xlink:href="ormp-20260331_lab.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="ormp-20260331_pre.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="ormp-20260331_def.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="ormp-20260331_cal.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef"/>
      <link:roleType roleURI="http://oramed.com/role/ConsolidatedBalanceSheet" id="ormp_r_ConsolidatedBalanceSheet">
        <link:definition>995301 - Statement - Interim Condensed Consolidated Balance Sheets (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ConsolidatedBalanceSheet_Parentheticals" id="ormp_r_ConsolidatedBalanceSheet_Parentheticals">
        <link:definition>995302 - Statement - Interim Condensed Consolidated Balance Sheets (Unaudited) (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ConsolidatedIncomeStatement" id="ormp_r_ConsolidatedIncomeStatement">
        <link:definition>995303 - Statement - Interim Condensed Consolidated Statements of Comprehensive Income (loss) (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ShareholdersEquityType2or3" id="ormp_r_ShareholdersEquityType2or3">
        <link:definition>995304 - Statement - Interim Condensed Consolidated Statements of Changes in Stockholders&#8217; Equity (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ConsolidatedCashFlow" id="ormp_r_ConsolidatedCashFlow">
        <link:definition>995305 - Statement - Interim Condensed Consolidated Statements of Cash Flows (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/General" id="ormp_r_General">
        <link:definition>995306 - Disclosure - General</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/SignificantAccountingPolicies" id="ormp_r_SignificantAccountingPolicies">
        <link:definition>995307 - Disclosure - Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/MarketableSecurities" id="ormp_r_MarketableSecurities">
        <link:definition>995308 - Disclosure - Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentsatFairValue" id="ormp_r_InvestmentsatFairValue">
        <link:definition>995309 - Disclosure - Investments, at Fair Value</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentInRealEstate" id="ormp_r_InvestmentInRealEstate">
        <link:definition>995310 - Disclosure - Investment In Real Estate</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/LoantoanEquityMethodInvestee" id="ormp_r_LoantoanEquityMethodInvestee">
        <link:definition>995311 - Disclosure - Loan to an Equity Method Investee</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/LoanAgreementMeasuredinFairValue" id="ormp_r_LoanAgreementMeasuredinFairValue">
        <link:definition>995312 - Disclosure - Loan Agreement Measured in Fair Value</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentinAssociateatFairValue" id="ormp_r_InvestmentinAssociateatFairValue">
        <link:definition>995313 - Disclosure - Investment in Associate at Fair Value</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentinLifeward" id="ormp_r_InvestmentinLifeward">
        <link:definition>995314 - Disclosure - Investment in Lifeward</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/Commitments" id="ormp_r_Commitments">
        <link:definition>995315 - Disclosure - Commitments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/AccountsPayableandAccruedExpenses" id="ormp_r_AccountsPayableandAccruedExpenses">
        <link:definition>995316 - Disclosure - Accounts Payable and Accrued Expenses</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/StockholdersEquity" id="ormp_r_StockholdersEquity">
        <link:definition>995317 - Disclosure - Stockholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/IncomeLossPerShareofCommonStock" id="ormp_r_IncomeLossPerShareofCommonStock">
        <link:definition>995318 - Disclosure - Income (Loss) Per Share of Common Stock</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/FinancialIncomeLossNet" id="ormp_r_FinancialIncomeLossNet">
        <link:definition>995319 - Disclosure - Financial Income (Loss), Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/TaxesonIncome" id="ormp_r_TaxesonIncome">
        <link:definition>995320 - Disclosure - Taxes on Income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/SegmentReporting" id="ormp_r_SegmentReporting">
        <link:definition>995321 - Disclosure - Segment Reporting</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/RelatedPartyTransactions" id="ormp_r_RelatedPartyTransactions">
        <link:definition>995322 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/SubsequentEvents" id="ormp_r_SubsequentEvents">
        <link:definition>995323 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/AccountingPoliciesByPolicy" id="ormp_r_AccountingPoliciesByPolicy">
        <link:definition>996000 - Disclosure - Accounting Policies, by Policy (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/SignificantAccountingPoliciesTables" id="ormp_r_SignificantAccountingPoliciesTables">
        <link:definition>996001 - Disclosure - Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/MarketableSecuritiesTables" id="ormp_r_MarketableSecuritiesTables">
        <link:definition>996002 - Disclosure - Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentsatFairValueTables" id="ormp_r_InvestmentsatFairValueTables">
        <link:definition>996003 - Disclosure - Investments, at Fair Value (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentinAssociateatFairValueTables" id="ormp_r_InvestmentinAssociateatFairValueTables">
        <link:definition>996004 - Disclosure - Investment in Associate at Fair Value (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentinLifewardTables" id="ormp_r_InvestmentinLifewardTables">
        <link:definition>996005 - Disclosure - Investment in Lifeward (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/CommitmentsTables" id="ormp_r_CommitmentsTables">
        <link:definition>996006 - Disclosure - Commitments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/AccountsPayableandAccruedExpensesTables" id="ormp_r_AccountsPayableandAccruedExpensesTables">
        <link:definition>996007 - Disclosure - Accounts Payable and Accrued Expenses (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/StockholdersEquityTables" id="ormp_r_StockholdersEquityTables">
        <link:definition>996008 - Disclosure - Stockholders' Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/IncomeLossPerShareofCommonStockTables" id="ormp_r_IncomeLossPerShareofCommonStockTables">
        <link:definition>996009 - Disclosure - Income (Loss) Per Share of Common Stock (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/FinancialIncomeLossNetTables" id="ormp_r_FinancialIncomeLossNetTables">
        <link:definition>996010 - Disclosure - Financial Income (Loss), Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/TaxesonIncomeTables" id="ormp_r_TaxesonIncomeTables">
        <link:definition>996011 - Disclosure - Taxes on Income (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/GeneralDetails" id="ormp_r_GeneralDetails">
        <link:definition>996012 - Disclosure - General (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/SignificantAccountingPoliciesDetails" id="ormp_r_SignificantAccountingPoliciesDetails">
        <link:definition>996013 - Disclosure - Significant Accounting Policies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofFairValueMeasurementsonaRecurringBasisTable" id="ormp_r_ScheduleofFairValueMeasurementsonaRecurringBasisTable">
        <link:definition>996014 - Disclosure - Significant Accounting Policies - Schedule of Fair Value Measurements on a Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/MarketableSecuritiesDetails" id="ormp_r_MarketableSecuritiesDetails">
        <link:definition>996015 - Disclosure - Marketable Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofMarketableSecuritiesIncludeInvestmentsinEquitySecuritiesTable" id="ormp_r_ScheduleofMarketableSecuritiesIncludeInvestmentsinEquitySecuritiesTable">
        <link:definition>996016 - Disclosure - Marketable Securities - Schedule of Marketable Securities Include Investments in Equity Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentsatFairValueDetails" id="ormp_r_InvestmentsatFairValueDetails">
        <link:definition>996017 - Disclosure - Investments, at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofAssumptionsandEstimatesValuationTable" id="ormp_r_ScheduleofAssumptionsandEstimatesValuationTable">
        <link:definition>996018 - Disclosure - Investments, at Fair Value - Schedule of Assumptions and Estimates Valuation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofFairValueCompositionTable" id="ormp_r_ScheduleofFairValueCompositionTable">
        <link:definition>996019 - Disclosure - Investments, at Fair Value - Schedule of Fair Value Composition (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofRefinancingTransactionTable" id="ormp_r_ScheduleofRefinancingTransactionTable">
        <link:definition>996020 - Disclosure - Investments, at Fair Value - Schedule of Refinancing Transaction (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofFairValueBreakdownTable" id="ormp_r_ScheduleofFairValueBreakdownTable">
        <link:definition>996021 - Disclosure - Investments, at Fair Value - Schedule of Fair Value Breakdown (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentInRealEstateDetails" id="ormp_r_InvestmentInRealEstateDetails">
        <link:definition>996022 - Disclosure - Investment In Real Estate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/LoantoanEquityMethodInvesteeDetails" id="ormp_r_LoantoanEquityMethodInvesteeDetails">
        <link:definition>996023 - Disclosure - Loan to an Equity Method Investee (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/LoanAgreementMeasuredinFairValueDetails" id="ormp_r_LoanAgreementMeasuredinFairValueDetails">
        <link:definition>996024 - Disclosure - Loan Agreement Measured in Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentinAssociateatFairValueDetails" id="ormp_r_InvestmentinAssociateatFairValueDetails">
        <link:definition>996025 - Disclosure - Investment in Associate at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofFinancialInformationTable" id="ormp_r_ScheduleofFinancialInformationTable">
        <link:definition>996026 - Disclosure - Investment in Associate at Fair Value - Schedule of Financial Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofValuationoftheWarrantsTable" id="ormp_r_ScheduleofValuationoftheWarrantsTable">
        <link:definition>996027 - Disclosure - Investment in Associate at Fair Value - Schedule of Valuation of the Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/InvestmentinLifewardDetails" id="ormp_r_InvestmentinLifewardDetails">
        <link:definition>996028 - Disclosure - Investment in Lifeward (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofValuationoftheNotesandWarrantsTable" id="ormp_r_ScheduleofValuationoftheNotesandWarrantsTable">
        <link:definition>996029 - Disclosure - Investment in Lifeward - Schedule of Valuation of the Notes and Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/CommitmentsDetails" id="ormp_r_CommitmentsDetails">
        <link:definition>996030 - Disclosure - Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofOperatingRightofUseAssetsandOperatingLeaseLiabilitiesTable" id="ormp_r_ScheduleofOperatingRightofUseAssetsandOperatingLeaseLiabilitiesTable">
        <link:definition>996031 - Disclosure - Commitments - Schedule of Operating Right-of-Use Assets and Operating Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofRightofUseAssetsOvertheRemainingLeaseTable" id="ormp_r_ScheduleofRightofUseAssetsOvertheRemainingLeaseTable">
        <link:definition>996032 - Disclosure - Commitments - Schedule of Right-of-Use Assets Over the Remaining Lease (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofAccountsPayableandAccruedExpensesTable" id="ormp_r_ScheduleofAccountsPayableandAccruedExpensesTable">
        <link:definition>996033 - Disclosure - Accounts Payable and Accrued Expenses - Schedule of Accounts Payable and Accrued Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/StockholdersEquityDetails" id="ormp_r_StockholdersEquityDetails">
        <link:definition>996034 - Disclosure - Stockholders' Equity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofRSUsGrantedtoEmployeesTable" id="ormp_r_ScheduleofRSUsGrantedtoEmployeesTable">
        <link:definition>996035 - Disclosure - Stockholders' Equity - Schedule of RSUs Granted to Employees (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/IncomeLossPerShareofCommonStockDetails" id="ormp_r_IncomeLossPerShareofCommonStockDetails">
        <link:definition>996036 - Disclosure - Income (Loss) Per Share of Common Stock (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofEarningsPerShareTable" id="ormp_r_ScheduleofEarningsPerShareTable">
        <link:definition>996037 - Disclosure - Income (Loss) Per Share of Common Stock - Schedule of Earnings Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofFinancialIncomeLossNetTable" id="ormp_r_ScheduleofFinancialIncomeLossNetTable">
        <link:definition>996038 - Disclosure - Financial Income (Loss), Net - Schedule of Financial Income (Loss), Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/ScheduleofTaxesonIncomeTable" id="ormp_r_ScheduleofTaxesonIncomeTable">
        <link:definition>996039 - Disclosure - Taxes on Income - Schedule of Taxes on Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/SegmentReportingDetails" id="ormp_r_SegmentReportingDetails">
        <link:definition>996040 - Disclosure - Segment Reporting (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/RelatedPartyTransactionsDetails" id="ormp_r_RelatedPartyTransactionsDetails">
        <link:definition>996041 - Disclosure - Related Party Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/SubsequentEventsDetails" id="ormp_r_SubsequentEventsDetails">
        <link:definition>996042 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://oramed.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
        <link:definition>000 - Document - Document And Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://fasb.org/us-types/2026" schemaLocation="https://xbrl.fasb.org/us-gaap/2026/elts/us-types-2026.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://fasb.org/srt-types/2026" schemaLocation="https://xbrl.fasb.org/srt/2026/elts/srt-types-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/sic/2026" schemaLocation="https://xbrl.sec.gov/sic/2026/sic-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2026" schemaLocation="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2026" schemaLocation="https://xbrl.sec.gov/ecd/2026/ecd-sub-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei-sub/2026" schemaLocation="https://xbrl.sec.gov/dei/2026/dei-sub-2026.xsd"/>
  <xs:element name="Rule10b51ArrangementModifiedFlag" type="xbrli:booleanItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_Rule10b51ArrangementModifiedFlag"/>
  <xs:element name="NonRule10b51ArrangementModifiedFlag" type="xbrli:booleanItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NonRule10b51ArrangementModifiedFlag"/>
  <xs:element name="ScheduleOfFairValueMeasurementsOnARecurringBasisAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfFairValueMeasurementsOnARecurringBasisAbstract"/>
  <xs:element name="ScheduleOfMarketableSecuritiesIncludeInvestmentsInEquitySecuritiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfMarketableSecuritiesIncludeInvestmentsInEquitySecuritiesAbstract"/>
  <xs:element name="ScheduleOfAssumptionsAndEstimatesValuationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfAssumptionsAndEstimatesValuationAbstract"/>
  <xs:element name="ScheduleOfFairValueCompositionAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfFairValueCompositionAbstract"/>
  <xs:element name="ScheduleOfRefinancingTransactionAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfRefinancingTransactionAbstract"/>
  <xs:element name="ScheduleOfFairValueBreakdownAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfFairValueBreakdownAbstract"/>
  <xs:element name="ScheduleOfFinancialInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfFinancialInformationAbstract"/>
  <xs:element name="ScheduleOfValuationOfTheWarrantsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfValuationOfTheWarrantsAbstract"/>
  <xs:element name="ScheduleOfValuationOfTheNotesAndWarrantsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfValuationOfTheNotesAndWarrantsAbstract"/>
  <xs:element name="ScheduleOfRsusGrantedToEmployeesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfRsusGrantedToEmployeesAbstract"/>
  <xs:element name="ScheduleOfEarningsPerShareAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfEarningsPerShareAbstract"/>
  <xs:element name="ScheduleOfFinancialIncomeLossNetAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfFinancialIncomeLossNetAbstract"/>
  <xs:element name="ScheduleOfTaxesOnIncomeAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfTaxesOnIncomeAbstract"/>
  <xs:element name="UnlabeledAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_UnlabeledAbstract"/>
  <xs:element name="ChangesDuringTheThreeMonthsEndedMarch312026Abstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ChangesDuringTheThreeMonthsEndedMarch312026Abstract"/>
  <xs:element name="ChangesDuringTheThreeMonthsEndedMarch312025Abstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ChangesDuringTheThreeMonthsEndedMarch312025Abstract"/>
  <xs:element name="ShortTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ShortTermAbstract"/>
  <xs:element name="LongTermAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LongTermAbstract"/>
  <xs:element name="ConvertibleNoteCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_ConvertibleNoteCurrent"/>
  <xs:element name="InvestmentInLifeward" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInLifeward"/>
  <xs:element name="EmployeeRightsUponRetirementNoncurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_EmployeeRightsUponRetirementNoncurrent"/>
  <xs:element name="AccumulatedDeficitForfeitedDividend" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_AccumulatedDeficitForfeitedDividend"/>
  <xs:element name="GainOnAmountsFundedInRespectOfEmployeeRightsUponRetirement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_GainOnAmountsFundedInRespectOfEmployeeRightsUponRetirement"/>
  <xs:element name="IncreaseDecreaseinDeferredIncome" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_IncreaseDecreaseinDeferredIncome"/>
  <xs:element name="ProceedsFromInvestmentAtFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_ProceedsFromInvestmentAtFairValue"/>
  <xs:element name="InvestmentInEquityMethodInvestee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInEquityMethodInvestee"/>
  <xs:element name="LifewardTransactions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_LifewardTransactions"/>
  <xs:element name="InterestReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_InterestReceived"/>
  <xs:element name="InvestmentInEquityMethod" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInEquityMethod"/>
  <xs:element name="InvestmentInLifewards" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInLifewards"/>
  <xs:element name="ForfeitedDividends" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_ForfeitedDividends"/>
  <xs:element name="TaxWithholdingsRelatedToStockbasedCompensationSettlements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_TaxWithholdingsRelatedToStockbasedCompensationSettlements"/>
  <xs:element name="RecentlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RecentlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock"/>
  <xs:element name="OtherIncomePolicyPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_OtherIncomePolicyPolicyTextBlock"/>
  <xs:element name="InvestmentInAlphaTauPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInAlphaTauPolicyTextBlock"/>
  <xs:element name="InvestmentInLifewardPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInLifewardPolicyTextBlock"/>
  <xs:element name="ScheduleOfAssumptionsAndEstimatesValuationTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfAssumptionsAndEstimatesValuationTableTextBlock"/>
  <xs:element name="ScheduleOfRefinancingTransactionTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfRefinancingTransactionTableTextBlock"/>
  <xs:element name="InformationByCategoryOfDebtSecurityDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InformationByCategoryOfDebtSecurityDomainDomain"/>
  <xs:element name="InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsTable"/>
  <xs:element name="InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentsatFairValueScheduleofAssumptionsandEstimatesValuationDetailsLineItems"/>
  <xs:element name="InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_InvestmentsatFairValueScheduleofFairValueCompositionDetailsTable"/>
  <xs:element name="InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_InvestmentsatFairValueScheduleofRefinancingTransactionDetailsTable"/>
  <xs:element name="IncomeFromTheRoyaltyAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_IncomeFromTheRoyaltyAgreement"/>
  <xs:element name="PrincipalPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_PrincipalPayments"/>
  <xs:element name="ProceedsFromTheSaleOfSubsequentPennyWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_ProceedsFromTheSaleOfSubsequentPennyWarrants"/>
  <xs:element name="InterestPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_InterestPayments"/>
  <xs:element name="AccruedInterest" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_AccruedInterest"/>
  <xs:element name="TaxWithholdingsRelatedToNetSettlements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_TaxWithholdingsRelatedToNetSettlements"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodVestingPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodVestingPeriod"/>
  <xs:element name="FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsTable"/>
  <xs:element name="FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_FinancialIncomeLossNetScheduleofFinancialIncomeLossNetDetailsLineItems"/>
  <xs:element name="FinancialIncomeLossNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_FinancialIncomeLossNet"/>
  <xs:element name="TotalTaxesOnIncome" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_TotalTaxesOnIncome"/>
  <xs:element name="GeneralDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_GeneralDetailsTable"/>
  <xs:element name="GeneralDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_GeneralDetailsLineItems"/>
  <xs:element name="FundsPlannedForClinicalTrialAndRelatedDevelopmentActivities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_FundsPlannedForClinicalTrialAndRelatedDevelopmentActivities"/>
  <xs:element name="OutstandingPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_OutstandingPercentage"/>
  <xs:element name="PercentageOfRevenueSharingPayments" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfRevenueSharingPayments"/>
  <xs:element name="LifewardRevenueShareTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LifewardRevenueShareTerm"/>
  <xs:element name="PercentageOfPreFundedWarrants" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfPreFundedWarrants"/>
  <xs:element name="IncreaseInExercisePriceOfWarrantPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_IncreaseInExercisePriceOfWarrantPercentage"/>
  <xs:element name="ClassOfWarrantOrRightBeneficialOwnershipLimitationNoticePeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ClassOfWarrantOrRightBeneficialOwnershipLimitationNoticePeriod"/>
  <xs:element name="WarrantsExpirationTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_WarrantsExpirationTerm"/>
  <xs:element name="IncreaseInWarrantPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_IncreaseInWarrantPercentage"/>
  <xs:element name="ConsecutiveTradingDays" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ConsecutiveTradingDays"/>
  <xs:element name="SignificantAccountingPoliciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_SignificantAccountingPoliciesDetailsTable"/>
  <xs:element name="StraightlineIncomeRecognition" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_StraightlineIncomeRecognition"/>
  <xs:element name="NonRefundableConsideration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_NonRefundableConsideration"/>
  <xs:element name="MarketableSecuritiesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_MarketableSecuritiesDetailsTable"/>
  <xs:element name="AgreementDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_AgreementDomainDomain"/>
  <xs:element name="InvestmentsatFairValueDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_InvestmentsatFairValueDetailsTable"/>
  <xs:element name="RefinancedAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_RefinancedAmount"/>
  <xs:element name="PercentageOfSeniorSecuredConvertibleNotesIssued" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfSeniorSecuredConvertibleNotesIssued"/>
  <xs:element name="DebtInstrumentIncreaseDecreaseInPrincipalBalance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_DebtInstrumentIncreaseDecreaseInPrincipalBalance"/>
  <xs:element name="PercentageOfTranchePurchased" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfTranchePurchased"/>
  <xs:element name="RoyaltyPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RoyaltyPercentage"/>
  <xs:element name="ExercisableWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ExercisableWarrants"/>
  <xs:element name="PercentageOfDiscountRate" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfDiscountRate"/>
  <xs:element name="PercentageOfBeneficialOwnership" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfBeneficialOwnership"/>
  <xs:element name="PercentageOfProjectProfits" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfProjectProfits"/>
  <xs:element name="FundedAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_FundedAmount"/>
  <xs:element name="LoantoanEquityMethodInvesteeDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_LoantoanEquityMethodInvesteeDetailsTable"/>
  <xs:element name="PercentageOfIssuedAndOutstandingCapitalStock" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfIssuedAndOutstandingCapitalStock"/>
  <xs:element name="LoanAgreementMeasuredinFairValueDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_LoanAgreementMeasuredinFairValueDetailsTable"/>
  <xs:element name="MaturityDaysOfLoan" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_MaturityDaysOfLoan"/>
  <xs:element name="RefundedAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_RefundedAmount"/>
  <xs:element name="PercentageOfWeightedAverageCashflowsOfLoanDiscounted" type="dtr:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfWeightedAverageCashflowsOfLoanDiscounted"/>
  <xs:element name="InvestmentinAssociateatFairValueDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_InvestmentinAssociateatFairValueDetailsTable"/>
  <xs:element name="PercentageOfOrdinaryShares" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfOrdinaryShares"/>
  <xs:element name="NonRefundableFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_NonRefundableFee"/>
  <xs:element name="PercentageOfVotingInterest" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfVotingInterest"/>
  <xs:element name="InvestmentinLifewardDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_InvestmentinLifewardDetailsTable"/>
  <xs:element name="OrdinarySharesClosingPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_OrdinarySharesClosingPercentage"/>
  <xs:element name="LifewardRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_LifewardRevenue"/>
  <xs:element name="PercentageOfBearingInterestPerAnnum" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PercentageOfBearingInterestPerAnnum"/>
  <xs:element name="PromissoryNote" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_PromissoryNote"/>
  <xs:element name="AdditionalPrincipalAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_AdditionalPrincipalAmount"/>
  <xs:element name="AnnumAndSecuredInterestPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_AnnumAndSecuredInterestPercentage"/>
  <xs:element name="AdditionalCashPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_AdditionalCashPayment"/>
  <xs:element name="CommitmentsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_CommitmentsDetailsTable"/>
  <xs:element name="ExpectedCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_ExpectedCost"/>
  <xs:element name="ActualCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_ActualCost"/>
  <xs:element name="StockholdersEquityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_StockholdersEquityDetailsTable"/>
  <xs:element name="IncomeLossPerShareofCommonStockDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_IncomeLossPerShareofCommonStockDetailsTable"/>
  <xs:element name="IncomeLossPerShareofCommonStockDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_IncomeLossPerShareofCommonStockDetailsLineItems"/>
  <xs:element name="RelatedPartyTransactionsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_RelatedPartyTransactionsDetailsTable"/>
  <xs:element name="ConsultingFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="ormp_ConsultingFee"/>
  <xs:element name="TrancheDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TrancheDomainDomain"/>
  <xs:element name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ormp_SubsequentEventsDetailsTable"/>
  <xs:element name="PurchaseOfAdditionalOrdinaryShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PurchaseOfAdditionalOrdinaryShares"/>
  <xs:element name="AggregatePurchasePrice" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_AggregatePurchasePrice"/>
  <xs:element name="AggregateProceedsAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="ormp_AggregateProceedsAmount"/>
  <xs:element name="AgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="ormp_AgreementAxis"/>
  <xs:element name="TrancheAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="ormp_TrancheAxis"/>
  <xs:element name="ALPHATauWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ALPHATauWarrantsMember"/>
  <xs:element name="APSeniorInvestorsLPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_APSeniorInvestorsLPMember"/>
  <xs:element name="AdditionalLoanAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_AdditionalLoanAgreementMember"/>
  <xs:element name="AlphaTauMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_AlphaTauMember"/>
  <xs:element name="BuybackProgramMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_BuybackProgramMember"/>
  <xs:element name="ChiefExecutiveOfficersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ChiefExecutiveOfficersMember"/>
  <xs:element name="ChiefScientificOfficerMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ChiefScientificOfficerMember"/>
  <xs:element name="ClinicalTrialManagementAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ClinicalTrialManagementAgreementMember"/>
  <xs:element name="ClosingPennyWarrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ClosingPennyWarrantMember"/>
  <xs:element name="ConsolidatedBalanceSheetsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ConsolidatedBalanceSheetsMember"/>
  <xs:element name="ConvertibleNoteMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ConvertibleNoteMember"/>
  <xs:element name="ConvertibleNotesSPAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ConvertibleNotesSPAMember"/>
  <xs:element name="DNAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_DNAMember"/>
  <xs:element name="DatavaultMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_DatavaultMember"/>
  <xs:element name="EnteraMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_EnteraMember"/>
  <xs:element name="ExecutiveOfficersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ExecutiveOfficersMember"/>
  <xs:element name="ExtensionAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ExtensionAgreementMember"/>
  <xs:element name="InitialNotesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InitialNotesMember"/>
  <xs:element name="InvestmentInAlphaTausSharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInAlphaTausSharesMember"/>
  <xs:element name="InvestmentInAlphaTausWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInAlphaTausWarrantsMember"/>
  <xs:element name="JuniorParticipationAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_JuniorParticipationAgreementMember"/>
  <xs:element name="KNRYMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_KNRYMember"/>
  <xs:element name="LidocaineTopicalSystemMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LidocaineTopicalSystemMember"/>
  <xs:element name="LifewardMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LifewardMember"/>
  <xs:element name="LifewardNotesPurchaseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LifewardNotesPurchaseAgreementMember"/>
  <xs:element name="LifewardOrdinarySharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LifewardOrdinarySharesMember"/>
  <xs:element name="LoanAgreementMeasuredInFairValueMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LoanAgreementMeasuredInFairValueMember"/>
  <xs:element name="LoanAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LoanAgreementMember"/>
  <xs:element name="LoanExtensionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LoanExtensionMember"/>
  <xs:element name="LoanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LoanMember"/>
  <xs:element name="LoanToAnEquityMethodInvesteeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LoanToAnEquityMethodInvesteeMember"/>
  <xs:element name="MeasurementInputCurveRateMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_MeasurementInputCurveRateMember"/>
  <xs:element name="MeasurementInputFloorRateMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_MeasurementInputFloorRateMember"/>
  <xs:element name="MeasurementInputYieldMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_MeasurementInputYieldMember"/>
  <xs:element name="MedicoxLicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_MedicoxLicenseAgreementMember"/>
  <xs:element name="NanoCommonStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NanoCommonStockMember"/>
  <xs:element name="NanoDimensionLtdMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NanoDimensionLtdMember"/>
  <xs:element name="NanoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NanoMember"/>
  <xs:element name="NanosPutOptionsAndWrittenCallOptionsNetMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NanosPutOptionsAndWrittenCallOptionsNetMember"/>
  <xs:element name="NewTalpiotLtdMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NewTalpiotLtdMember"/>
  <xs:element name="NoteWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NoteWarrantsMember"/>
  <xs:element name="NotesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_NotesMember"/>
  <xs:element name="OraTechLtdMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_OraTechLtdMember"/>
  <xs:element name="ParticipationAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ParticipationAgreementMember"/>
  <xs:element name="PelthosCommonStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PelthosCommonStockMember"/>
  <xs:element name="PelthosMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PelthosMember"/>
  <xs:element name="PelthosTherapeuticsIncMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PelthosTherapeuticsIncMember"/>
  <xs:element name="PerformanceRestrictedStockUnitsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PerformanceRestrictedStockUnitsMember"/>
  <xs:element name="PrefundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_PrefundedWarrantsMember"/>
  <xs:element name="ProfitSharingLoanAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ProfitSharingLoanAgreementMember"/>
  <xs:element name="RestrictedStockHoldersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RestrictedStockHoldersMember"/>
  <xs:element name="RevaluationOfAlphaTauNetMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfAlphaTauNetMember"/>
  <xs:element name="RevaluationOfConvertibleNoteMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfConvertibleNoteMember"/>
  <xs:element name="RevaluationOfHapisgaNetMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfHapisgaNetMember"/>
  <xs:element name="RevaluationOfLifewardMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfLifewardMember"/>
  <xs:element name="RevaluationOfMarketableSecuritiesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfMarketableSecuritiesMember"/>
  <xs:element name="RevaluationOfProfitSharingLoanAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfProfitSharingLoanAgreementMember"/>
  <xs:element name="RevaluationOfRoyaltyVestLoanNetMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfRoyaltyVestLoanNetMember"/>
  <xs:element name="RevaluationOfRubyCapitalMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfRubyCapitalMember"/>
  <xs:element name="RevaluationOfScilexNetMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RevaluationOfScilexNetMember"/>
  <xs:element name="RoyaltyPurchaseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RoyaltyPurchaseAgreementMember"/>
  <xs:element name="RoyaltyPurchaseAgreementPaymentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RoyaltyPurchaseAgreementPaymentMember"/>
  <xs:element name="RoyaltyVestMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RoyaltyVestMember"/>
  <xs:element name="RubyCapitalMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RubyCapitalMember"/>
  <xs:element name="RubySapphireIIMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_RubySapphireIIMember"/>
  <xs:element name="ScilexMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScilexMember"/>
  <xs:element name="ScilexTransactionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScilexTransactionMember"/>
  <xs:element name="SecuredPromissoryNoteMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_SecuredPromissoryNoteMember"/>
  <xs:element name="SeniorSecuredConvertibleNotesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_SeniorSecuredConvertibleNotesMember"/>
  <xs:element name="SharePurchaseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_SharePurchaseAgreementMember"/>
  <xs:element name="SharePurchaseWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_SharePurchaseWarrantsMember"/>
  <xs:element name="ShareholdersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ShareholdersMember"/>
  <xs:element name="TovaChochmaImNachalaLtdMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TovaChochmaImNachalaLtdMember"/>
  <xs:element name="TrancheAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TrancheAMember"/>
  <xs:element name="TrancheANoteMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TrancheANoteMember"/>
  <xs:element name="TrancheBMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TrancheBMember"/>
  <xs:element name="TrancheBNoteConsentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TrancheBNoteConsentMember"/>
  <xs:element name="TrancheBNoteMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TrancheBNoteMember"/>
  <xs:element name="TrancheBWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TrancheBWarrantsMember"/>
  <xs:element name="TwoThousandTwentyThreeScilexTransactionMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_TwoThousandTwentyThreeScilexTransactionMember"/>
  <xs:element name="WarrantHoldersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_WarrantHoldersMember"/>
  <xs:element name="WarrantsNoteBMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_WarrantsNoteBMember"/>
  <xs:element name="WarrenAtBayLoanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_WarrenAtBayLoanMember"/>
  <xs:element name="WytheLoanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_WytheLoanMember"/>
  <xs:element name="WytheSeniorInvestorsLPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_WytheSeniorInvestorsLPMember"/>
  <xs:element name="GeneralAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_GeneralAbstract"/>
  <xs:element name="InvestmentInLifewardLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_InvestmentInLifewardLineItems"/>
  <xs:element name="LoanToAnEquityMethodInvesteeAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_LoanToAnEquityMethodInvesteeAbstract"/>
  <xs:element name="ScheduleOfValuationOfTheNotesAndWarrantsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_ScheduleOfValuationOfTheNotesAndWarrantsLineItems"/>
<!-- [WMV7][WeJiO/iXbpyaGKoj0CNXpw17KNHSmVhdpqAqJWlvtDdJGqSJiHiXjpRJGCHHMOSNVUy3FU7cpTe7Up9Je5tTOSNOrIuz8yOo9LeOw9AvpOk5ZBc9PMzrwvg0NTRxyz1JoHNkso3v3pedjbYCO/Zgq+hCLEvlqF7s9HUx+P9+gVA/1z7l0hP/G7mt5wRYprKAtUztfPzyeWeKRrz+BOmAroJvmspHfa7AIJDuYTrqGa+Df7/oLXksY52zHFW/gl9HJhaxux9uTjjSIulbLVoFDt7TPAMAzv5Q8OOsBcO34eUrU4A42i1VPWzKpT4oKGQRrcZqYOl3gnpQShB/XfKp+WASI8yRyPwz7SkrNXZTeH7plL4FabY=] CSR-->
  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ormp_DocumentAndEntityInformationAbstract"/>
</xs:schema>
