0001479615 2026-05-15 2026-05-15 0001479615 1 2026-05-15 2026-05-15 0001479615 2 2026-05-15 2026-05-15 iso4217:USD pure S-3 S-3 EX-FILING FEES 0001479615 Silence Therapeutics plc N/A N/A 0.0001381 S-3 Silence Therapeutics plc Equity Ordinary Shares, nominal value GBP0.05 per share true false Unallocated (Universal) Shelf true 300000000.00 0.0001381 41430.00 300000000.00 41430.00 0.00 0.00 41430.00 (A) These ordinary shares, nominal value GBP0.05 per share, are represented by American Depositary Shares, or ADSs, each of which represents three ordinary shares of the Registrant. ADSs issuable on deposit of the ordinary shares registered hereby have been registered pursuant to a separate registration statement on Form F-6 (File No. 333-248217). (B) There are being registered hereunder such indeterminate number of the securities of ADSs as may be sold by the Registrant from time to time at indeterminate prices, with the maximum aggregate offering price not to exceed $300,000,000. The proposed maximum initial offering price per unit will be determined, from time to time, by the Registrant in connection with the issuance by the Registrant of the securities registered hereunder. The securities registered also include such indeterminate number of ordinary shares represented by ADSs. In addition, pursuant to Rule 416 under the Securities Act of 1933, as amended, or the Securities Act, the ordinary shares represented by ADSs being registered hereunder include such indeterminate number of ordinary shares as may be issuable with respect to the ordinary shares being registered hereunder as a result of stock splits, stock dividends or similar transactions. (C) The proposed maximum aggregate offering price per share will be determined from time to time by the Registrant in connection with the issuance by the Registrant of the securities registered hereunder and is not specified as to each class of security pursuant to Instruction 2.A.iii.b. to the Calculation of Filing Fee Tables and Related Disclosure on Item 16(b) of Form S-3 under the Securities Act. (D) The registration fee is calculated pursuant to Rule 457(o) of the Securities Act based on the maximum aggregate offering price.