Exhibit 8.1

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List of Significant Subsidiaries

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CASI Pharmaceuticals (China) Co., Ltd, a company of limited liability, incorporated and existing under the laws of the People’s Republic of China

CASI Pharmaceuticals (WUXI) Co., Ltd., a company of limited liability, incorporated and existing under the laws of the People’s Republic of China

CASI Biopharmaceuticals (WUXI) Co., Ltd., a company of limited liability, incorporated and existing under the laws of the People’s Republic of China

CASI Pharmaceuticals Co., Limited, a company of limited liability, incorporated and existing under the laws of Hong Kong