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  <xsd:element id="casi_ScheduleOfLongTermInvestmentsTable" name="ScheduleOfLongTermInvestmentsTable" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_ScheduleOfLongTermInvestmentsLineItems" name="ScheduleOfLongTermInvestmentsLineItems" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_LicenseAgreementMilestonePayment" name="LicenseAgreementMilestonePayment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="casi_LoanToBeAdvanced" name="LoanToBeAdvanced" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="casi_OfficeSpaceLeaseMember" name="OfficeSpaceLeaseMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_UnrecognizedShareBasedCompensationCostExpectedToRecognizeOverWeightedAveragePeriod" name="UnrecognizedShareBasedCompensationCostExpectedToRecognizeOverWeightedAveragePeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="casi_ChairmanAndChiefExecutiveOfficerMember" name="ChairmanAndChiefExecutiveOfficerMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_NumberOfWarrantsSubscribedPerShare" name="NumberOfWarrantsSubscribedPerShare" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="casi_RedeemableNoncontrollingInterestEquityCommonForeignCurrencyTranslationAdjustments" name="RedeemableNoncontrollingInterestEquityCommonForeignCurrencyTranslationAdjustments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="casi_NumberMilestonesAchieved" name="NumberMilestonesAchieved" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="casi_NumberMilestonesPaymentsOutstanding" name="NumberMilestonesPaymentsOutstanding" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="casi_FurnitureAndEquipmentMember" name="FurnitureAndEquipmentMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_CleaveTherapeuticsIncMember" name="CleaveTherapeuticsIncMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_InvestmentInConvertibleNote" name="InvestmentInConvertibleNote" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="casi_PotentialMilestonePaymentAndRoyalty" name="PotentialMilestonePaymentAndRoyalty" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="casi_FairValueCarryingAmount" name="FairValueCarryingAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="casi_InvestmentsFairValueDisclosureWarrantsMeasuredAtFairValueThroughProfitAndLoss" name="InvestmentsFairValueDisclosureWarrantsMeasuredAtFairValueThroughProfitAndLoss" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="casi_LongTermIncentivePlan2021Member" name="LongTermIncentivePlan2021Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_AlestaTxMember" name="AlestaTxMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="casi_EquityMethodInvestmentsContribution" name="EquityMethodInvestmentsContribution" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="casi_EquityMethodInvestmentsExchangeOfCommonStocks" name="EquityMethodInvestmentsExchangeOfCommonStocks" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ConstructionAgreementsAxis" id="casi_ConstructionAgreementsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConstructionAgreementsDomain" id="casi_ConstructionAgreementsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FullyDilutedCapitalPercentage" id="casi_FullyDilutedCapitalPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AccruedAndOtherCurrentLiabilitiesAndOtherLiabilitiesDisclosureTextBlock" id="casi_AccruedAndOtherCurrentLiabilitiesAndOtherLiabilitiesDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ScheduleOfAccruedAndOtherCurrentLiabilitiesAndOtherLiabilitiesTableTextBlock" id="casi_ScheduleOfAccruedAndOtherCurrentLiabilitiesAndOtherLiabilitiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="TimeBasedStockOptionsMember" id="casi_TimeBasedStockOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TaxCreditCarryforwardExpirationPeriod" id="casi_TaxCreditCarryforwardExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NonRoyaltyExclusiveDistributionAdditionalPeriod" id="casi_NonRoyaltyExclusiveDistributionAdditionalPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EquitySecuritiesWithoutReadilyDeterminableFairValueMember" id="casi_EquitySecuritiesWithoutReadilyDeterminableFairValueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnrealizedGains" id="casi_UnrealizedGains" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="UnrealizedLoss" id="casi_UnrealizedLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredTaxAssetsTaxDeferredExpenseImpairmentLossOfLongTermInvestments" id="casi_DeferredTaxAssetsTaxDeferredExpenseImpairmentLossOfLongTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NumberOfInstallmentsForUpfrontPayment" id="casi_NumberOfInstallmentsForUpfrontPayment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PercentageOfEquityHeldInJointVenture" id="casi_PercentageOfEquityHeldInJointVenture" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AggregateConsiderationForEquityInvestment" id="casi_AggregateConsiderationForEquityInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PrecisionAutoimmuneTherapeuticsCo.LtdMember" id="casi_PrecisionAutoimmuneTherapeuticsCo.LtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsNoncontrollingInterestAfterTax" id="casi_IncomeLossFromContinuingOperationsBeforeEquityMethodInvestmentsNoncontrollingInterestAfterTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PercentageOfInterestInBoardSeats" id="casi_PercentageOfInterestInBoardSeats" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EquityMethodInvestmentShares" id="casi_EquityMethodInvestmentShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LicenseAgreementDevelopmentMilestonePaymentPayable" id="casi_LicenseAgreementDevelopmentMilestonePaymentPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAgreementSalesMilestonePaymentPayable" id="casi_LicenseAgreementSalesMilestonePaymentPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAgreementRefundFromTerminationOfAgreement" id="casi_LicenseAgreementRefundFromTerminationOfAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InvestmentInSubsidiaries" id="casi_InvestmentInSubsidiaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IntercompanyOperatingExpenses" id="casi_IntercompanyOperatingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RestrictedNetAssetsAbstract" id="casi_RestrictedNetAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestrictedNetAssetsTextBlock" id="casi_RestrictedNetAssetsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GrantsRelatedToLandUseRightCurrent" id="casi_GrantsRelatedToLandUseRightCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SalesAndMarketingServicesPayableCurrent" id="casi_SalesAndMarketingServicesPayableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ClinicalStudyServicePayableCurrent" id="casi_ClinicalStudyServicePayableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IntercompanyPayablesCurrent" id="casi_IntercompanyPayablesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OwnershipPercentage" id="casi_OwnershipPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DeferredTaxAssetsTaxDeferredExpenseCapitalizedResearchAndDevelopmentAmortization" id="casi_DeferredTaxAssetsTaxDeferredExpenseCapitalizedResearchAndDevelopmentAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TotalUnrecognizedShareBasedCompensationCostExpectedToBeRecognizedOverWeightedAveragePeriod" id="casi_TotalUnrecognizedShareBasedCompensationCostExpectedToBeRecognizedOverWeightedAveragePeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ChinaResourcesPharmaceuticalCommercialGroupInternationalTradingCo.Ltd.Member" id="casi_ChinaResourcesPharmaceuticalCommercialGroupInternationalTradingCo.Ltd.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SublicensingRevenueFromRelatedParty" id="casi_SublicensingRevenueFromRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ResearchAndDevelopmentInProcess1" id="casi_ResearchAndDevelopmentInProcess1" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProceedsFromReimbursementOfLaborPreclinicalAndClinalExpense" id="casi_ProceedsFromReimbursementOfLaborPreclinicalAndClinalExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="MachineryAndLabEquipmentMember" id="casi_MachineryAndLabEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FolotynMember" id="casi_FolotynMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FiniteLivedIntangibleAssetsAccumulatedImpairment" id="casi_FiniteLivedIntangibleAssetsAccumulatedImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PercentageOfValuationAllowanceRecognized" id="casi_PercentageOfValuationAllowanceRecognized" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfGuaranteeAgreements" id="casi_NumberOfGuaranteeAgreements" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="InvestmentPrincipalReturned" id="casi_InvestmentPrincipalReturned" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InvestmentPrincipal" id="casi_InvestmentPrincipal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="WuxiLpMember" id="casi_WuxiLpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InvestmentReturnPayableInInstallments" id="casi_InvestmentReturnPayableInInstallments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ConvertibleLoanMember" id="casi_ConvertibleLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TermOfAnniversaryAfterMaturityOfLoan" id="casi_TermOfAnniversaryAfterMaturityOfLoan" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ReductionInRegisteredCapital" id="casi_ReductionInRegisteredCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LicenseAgreementAmountPayable" id="casi_LicenseAgreementAmountPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAgreementWithMundipharmaInternationalCorporationLimitedMember" id="casi_LicenseAgreementWithMundipharmaInternationalCorporationLimitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementOneTimePaymentPayableUponCompletionOfQualityAudit" id="casi_LicenseAgreementOneTimePaymentPayableUponCompletionOfQualityAudit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PercentageOfNetSales" id="casi_PercentageOfNetSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LicenseAgreementAggregateAmountPayableInQuarterlyInstallment" id="casi_LicenseAgreementAggregateAmountPayableInQuarterlyInstallment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TermOfAgreement" id="casi_TermOfAgreement" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ExclusiveDistributionAgreementMember" id="casi_ExclusiveDistributionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssignmentAgreementWithCleaveMember" id="casi_AssignmentAgreementWithCleaveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssignmentAgreementCommercialAndSalesMilestonePaymentsPayable" id="casi_AssignmentAgreementCommercialAndSalesMilestonePaymentsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssignmentAgreementPercentageOfRoyaltyOnNetSalesPayable" id="casi_AssignmentAgreementPercentageOfRoyaltyOnNetSalesPayable" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PurchaseOfShortTermInvestmentsAndTermDeposits" id="casi_PurchaseOfShortTermInvestmentsAndTermDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ProceedsFromSalesOrMaturityOfShortTermInvestmentsAndTermDeposits" id="casi_ProceedsFromSalesOrMaturityOfShortTermInvestmentsAndTermDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProceedsFromExtinguishmentOfInvestmentInConvertibleLoan" id="casi_ProceedsFromExtinguishmentOfInvestmentInConvertibleLoan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AcrotechBiopharmaL.l.c.Member" id="casi_AcrotechBiopharmaL.l.c.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EstimatedShareBasedCompensationExpense" id="casi_EstimatedShareBasedCompensationExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationExpenseToBePaidOverRemainingVestingPeriod" id="casi_ShareBasedCompensationExpenseToBePaidOverRemainingVestingPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProfitSharingLiabilityNonCurrent" id="casi_ProfitSharingLiabilityNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RightOfUseAssetsRemeasured" id="casi_RightOfUseAssetsRemeasured" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ImpairmentLossOfLongTermInvestments" id="casi_ImpairmentLossOfLongTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtAndEquitySecuritiesUnrealizedGainLossIncludingImpairment" id="casi_DebtAndEquitySecuritiesUnrealizedGainLossIncludingImpairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InvestmentEquitySecuritiesFairValue" id="casi_InvestmentEquitySecuritiesFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeemedDividendsAdjustment" id="casi_DeemedDividendsAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InterestAndDividendsPayableNonCurrent" id="casi_InterestAndDividendsPayableNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RedeemableNonControllingInterestAndLongTermBorrowingAbstract" id="casi_RedeemableNonControllingInterestAndLongTermBorrowingAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RedeemableNonControllingInterestAndLongTermBorrowingTextBlock" id="casi_RedeemableNonControllingInterestAndLongTermBorrowingTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LicenseAgreementAmountPayableOnCompletionOfAuditAndDeferredQuarterlyPaymentsBecomesDueImmediatelyUponEventOfNonPayment" id="casi_LicenseAgreementAmountPayableOnCompletionOfAuditAndDeferredQuarterlyPaymentsBecomesDueImmediatelyUponEventOfNonPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IncreaseDecreaseInDeferredTaxAssets" id="casi_IncreaseDecreaseInDeferredTaxAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DeferredTaxAssetsForeignCurrencyTranslationAdjustment" id="casi_DeferredTaxAssetsForeignCurrencyTranslationAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredTaxAssetsLeaseLiabilities" id="casi_DeferredTaxAssetsLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredTaxLiabilitiesRightOfUseAssets" id="casi_DeferredTaxLiabilitiesRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="UnderpaymentOfTaxesStatueOfLimitationExtendedTerm" id="casi_UnderpaymentOfTaxesStatueOfLimitationExtendedTerm" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IntercompanyReceivables" id="casi_IntercompanyReceivables" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="July2024PrivateInvestmentInPublicEquityFinancingMember" id="casi_July2024PrivateInvestmentInPublicEquityFinancingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PrefundedWarrantsMember" id="casi_PrefundedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SaleOfStockMaximumAggregateOfferingPrice" id="casi_SaleOfStockMaximumAggregateOfferingPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PaymentsForUnderwriterSSalesCommissions" id="casi_PaymentsForUnderwriterSSalesCommissions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SharesIssuedPricePerShareNetOfExercisePriceOfWarrants" id="casi_SharesIssuedPricePerShareNetOfExercisePriceOfWarrants" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AtMarketOffering2024Member" id="casi_AtMarketOffering2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EquityMethodInvestmentAggregateNumberOfInstallments" id="casi_EquityMethodInvestmentAggregateNumberOfInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="HeFamilyGratMember" id="casi_HeFamilyGratMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InterestLoanPrincipalAndDividendsPayableCurrent" id="casi_InterestLoanPrincipalAndDividendsPayableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LongTermIncentivePlan2024Member" id="casi_LongTermIncentivePlan2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsPlanModificationInPeriodWeightedAverageModificationDateFairValue" id="casi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsPlanModificationInPeriodWeightedAverageModificationDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CurrentAssetsNet" id="casi_CurrentAssetsNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtSecuritiesConversionGainLossOnFairValue" id="casi_DebtSecuritiesConversionGainLossOnFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MaximumValueOfEntityAssetsFreezed" id="casi_MaximumValueOfEntityAssetsFreezed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EquityMethodInvestmentOwnershipPercentageAcquiredDuringPeriod" id="casi_EquityMethodInvestmentOwnershipPercentageAcquiredDuringPeriod" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="HumanLongevityIncMember" id="casi_HumanLongevityIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ServiceFeePerMonth" id="casi_ServiceFeePerMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InvestmentsFairValueDisclosureEquitySecuritiesInOrdinaryShares" id="casi_InvestmentsFairValueDisclosureEquitySecuritiesInOrdinaryShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="InvestmentReturnPayableAsDividendYearOne" id="casi_InvestmentReturnPayableAsDividendYearOne" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InvestmentReturnPayableAsDividendYearTwo" id="casi_InvestmentReturnPayableAsDividendYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InvestmentReturnPayableAsDividendYearThree" id="casi_InvestmentReturnPayableAsDividendYearThree" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InvestmentReturnPayableAsDividendYearFour" id="casi_InvestmentReturnPayableAsDividendYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InvestmentReturnPayableAsDividendNumberOfInstallments" id="casi_InvestmentReturnPayableAsDividendNumberOfInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ChinaNationalMedicinesCorporationLtd.Member" id="casi_ChinaNationalMedicinesCorporationLtd.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="GuangzhouGloriaBiosciencesCo.Ltd.Member" id="casi_GuangzhouGloriaBiosciencesCo.Ltd.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredTaxAssetsTaxDeferredExpenseInventoryWriteDown" id="casi_DeferredTaxAssetsTaxDeferredExpenseInventoryWriteDown" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriodWeightedAverageExercisePrice" id="casi_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedInPeriodWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EtpGlobalIiiFundLpMember" id="casi_EtpGlobalIiiFundLpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConvertibleNotesTrancheOneMember" id="casi_ConvertibleNotesTrancheOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConvertibleNotesTrancheTwoMember" id="casi_ConvertibleNotesTrancheTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConvertibleNotesTrancheThreeMember" id="casi_ConvertibleNotesTrancheThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentConvertibleVolumeWeightedAverageClosingPriceConsecutiveTradingDaysPrecedingMaturityDate" id="casi_DebtInstrumentConvertibleVolumeWeightedAverageClosingPriceConsecutiveTradingDaysPrecedingMaturityDate" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="HuiyingMemorialFoundationMember" id="casi_HuiyingMemorialFoundationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PanaceaVentureHealthcareFundIiLpMember" id="casi_PanaceaVentureHealthcareFundIiLpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InterestRateOnEquityConsiderationPayable" id="casi_InterestRateOnEquityConsiderationPayable" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfWhollyOwnedSubsidiaries" id="casi_NumberOfWhollyOwnedSubsidiaries" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AdjustmentsToAdditionalPaidInCapitalIssuanceOfConvertibleNotes" id="casi_AdjustmentsToAdditionalPaidInCapitalIssuanceOfConvertibleNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NumberOfMajorSuppliers" id="casi_NumberOfMajorSuppliers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ProvisionForExcessLossInSubsidiaries" id="casi_ProvisionForExcessLossInSubsidiaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ConvertibleNotesTrancheFourMember" id="casi_ConvertibleNotesTrancheFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationAttributeExpirationAmount" id="casi_EffectiveIncomeTaxRateReconciliationAttributeExpirationAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationAttributeExpirationPercent" id="casi_EffectiveIncomeTaxRateReconciliationAttributeExpirationPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ConvertibleNotesCurrent" id="casi_ConvertibleNotesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DeferredTaxAssetsAccruedInterestExpense" id="casi_DeferredTaxAssetsAccruedInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TotalMilestoneConsideration" id="casi_TotalMilestoneConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
</xsd:schema>
