v3.26.1
Document and Entity Information - shares
 3 Months Ended
Mar. 31, 2026
May 13, 2026
Document and Entity Information    
Document Type 10-Q  
Document Quarterly Report true  
Document Period End Date Mar. 31, 2026  
Document Transition Report false  
Entity File Number 001-38365  
Entity Registrant Name HYPERION DEFI, INC.  
Entity Incorporation, State or Country Code DE  
Entity Tax Identification Number 47-1178401  
Entity Address, Address Line One 3090 Nowitzki Way, Suite 300  
Entity Address, City or Town Dallas  
Entity Address, State or Province TX  
Entity Address, Postal Zip Code 75219  
City Area Code 833  
Local Phone Number 393-6684  
Title of 12(b) Security Common Stock, par value $0.0001 per share  
Trading Symbol HYPD  
Security Exchange Name NASDAQ  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Non-accelerated Filer  
Entity Small Business true  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   15,157,747
Entity Central Index Key 0001682639  
Current Fiscal Year End Date --12-31  
Document Fiscal Year Focus 2026  
Document Fiscal Period Focus Q1  
Amendment Flag false