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Disclosure - In-Licensing and Supply - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 995985 - Disclosure - Common Stock and Stockholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 995995 - Disclosure - Common Stock and Stockholders' Equity - Summary of Common Stock Reserved for Future Issuance (Detail) link:presentationLink link:calculationLink link:definitionLink 996005 - Disclosure - Stock-Based Compensation - Summary of Share-based Compensation Expense (Detail) link:presentationLink link:calculationLink link:definitionLink 996015 - Disclosure - Stock-Based Compensation - Summary of Activity Related to Stock Option (Detail) link:presentationLink link:calculationLink link:definitionLink 996025 - Disclosure - Stock-Based Compensation - Summary of Fair Value of Each Option Grant Estimated Throughout Year Using Black-Scholes Option-pricing Model (Detail) link:presentationLink link:calculationLink link:definitionLink 996035 - 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Other Accrued Liabilities, Noncurrent Other accrued liabilities Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Upfront Payment. Upfront Payment. Upfront Payment Upfront payment Statement [Line Items] Statement [Line Items] OrbiMed Advisors LLC [Member] OrbiMed Advisors LLC. OrbiMed Other Expense [Member] Other [Member] Entity Filer Category Selling, General and Administrative Costs Selling, General and Administrative Expenses, Policy [Policy Text Block] Kathleen Scott [Member] Kathleen Scott. Kathleen Scott [Member] Liabilities and Equity Total liabilities and stockholders' equity Debt Instrument [Line Items] Remaining Regulatory Milestone Remaining regulatory milestone. 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Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Weighted- Average Remaining Contractual Life (Years) Administrative Fees Expense Fee Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum Expected volatility, Maximum U.S. Treasury securities, Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost U.S. Treasury securities, Amortized Cost Exercise of common stock options, Shares Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Shares Subject to Options Outstanding, Exercised Debt Disclosure [Abstract] Term A Loan [Member] Tranche One Term Loan [Member] Tranche one term loan. Fair Value Measurements Fair Value Measurement and Measurement Inputs, Recurring and Nonrecurring [Text Block] ALK Co-Promotion Agreement [Member] ALK Co-Promotion Agreement [Member] ALK co-promotion agreement member. Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Royalty Income Allocated To The EEA License Royalty income allocated to the EEA license. Sales-based royalties earned under the EEA License Current Fiscal Year End Date Schedule of Long-Term Debt Instruments [Table] Number of pediatricians Number of pediatricians Number of pediatricians Level 1 And Level 2 [Member] Fair Value Inputs Level 1 And Level 2 [Member] Fair value inputs level 1 and level 2. In Licensing And Supply [Table] Disclosure of information about in-licensing and supply. Document Quarterly Report Cash And Cash Equivalents Gross Unrealized Gains Cash and cash equivalents gross unrealized gains. 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