The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALKERMES PLC SHS G01767105 69,689,751 1,970,864 SH SOLE 1,970,864 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 43,559,036 131,650 SH SOLE 131,650 0 0
ANAPTYSBIO INC COM 032724106 332,760 6,000 SH SOLE 6,000 0 0
ANI PHARMACEUTICALS INC COM 00182C103 63,076,687 820,243 SH SOLE 820,243 0 0
ARCUS BIOSCIENCES INC COM 03969F109 9,762,833 451,983 SH SOLE 451,983 0 0
ARGENX SE SPONSORED ADR 04016X101 2,555,875 3,500 SH SOLE 3,500 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 1,785,633 28,479 SH SOLE 28,479 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306 6,598,732 441,978 SH SOLE 441,978 0 0
AXOGEN INC COM 05463X106 22,500,902 679,170 SH SOLE 679,170 0 0
BETA BIONICS INC COM 08659B102 43,632,100 4,354,501 SH SOLE 4,354,501 0 0
BIODESIX INC COM 09075X207 6,040,686 416,599 SH SOLE 416,599 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 36,750,812 650,572 SH SOLE 650,572 0 0
C4 THERAPEUTICS INC COM STK 12529R107 10,004,367 3,803,942 SH SOLE 3,803,942 0 0
CELCUITY INC COM 15102K100 146,598,905 1,284,378 SH SOLE 1,284,378 0 0
CERUS CORP COM 157085101 19,571,734 10,753,700 SH SOLE 10,753,700 0 0
CG ONCOLOGY INC COM 156944100 1,353,600 20,000 SH SOLE 20,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 384,900 10,000 SH SOLE 10,000 0 0
CONTEXT THERAPEUTICS INC COM 21077P108 18,243,429 6,963,141 SH SOLE 6,963,141 0 0
CORCEPT THERAPEUTICS INC COM 218352102 11,509,755 285,531 SH SOLE 285,531 0 0
CULLINAN THERAPEUTICS INC COM 230031106 5,828,942 410,200 SH SOLE 410,200 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105 1,410,000 300,000 SH SOLE 300,000 0 0
DEXCOM INC COM 252131107 8,792,000 140,000 SH SOLE 140,000 0 0
EDAP TMS S A SPONSORED ADR 268311107 27,190,425 7,309,254 SH SOLE 7,309,254 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 45,672,323 1,449,915 SH SOLE 1,449,915 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102 9,050,065 230,869 SH SOLE 230,869 0 0
ETON PHARMACEUTICALS INC COM 29772L108 4,106,283 166,381 SH SOLE 166,381 0 0
EVOLUS INC COM 30052C107 9,228,430 2,245,360 SH SOLE 2,245,360 0 0
GERON CORP COM 374163103 61,847,902 41,508,659 SH SOLE 41,508,659 0 0
GLOBUS MED INC CL A 379577208 62,850,877 729,467 SH SOLE 729,467 0 0
ICON PLC SHS G4705A100 21,246,720 192,000 SH SOLE 192,000 0 0
IMMUNIC INC COM 4525EP101 4,995,000 4,500,000 SH SOLE 4,500,000 0 0
IMMUNOVANT INC COM 45258J102 5,713,200 230,000 SH SOLE 230,000 0 0
INDIVIOR PHARMACEUTICALS INC COM 45579U109 38,831,520 1,274,000 SH SOLE 1,274,000 0 0
INHIBIKASE THERAPEUTICS INC COM NEW 45719W205 18,270,000 10,875,000 SH SOLE 10,875,000 0 0
INHIBRX BIOSCIENCES INC COM 45720N103 8,807,130 131,000 SH SOLE 131,000 0 0
INSMED INC COM PAR $.01 457669307 1,676,080 10,250 SH SOLE 10,250 0 0
INSPIRE MED SYS INC COM 457730109 29,725,502 576,299 SH SOLE 576,299 0 0
INSPIREMD INC COM 45779A846 1,704,504 1,045,708 SH SOLE 1,045,708 0 0
INSULET CORP COM 45784P101 118,035,000 562,500 SH SOLE 562,500 0 0
INVIVYD INC COM 00534A102 10,021,345 7,708,727 SH SOLE 7,708,727 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 3,510,000 1,000,000 SH SOLE 1,000,000 0 0
JADE BIOSCIENCES INC COM NEW 008064206 11,194,253 796,744 SH SOLE 796,744 0 0
JASPER THERAPEUTICS INC COM NEW 471871202 242,105 276,312 SH SOLE 276,312 0 0
KARYOPHARM THERAPEUTICS INC COM NEW 48576U205 2,450,800 440,000 SH SOLE 440,000 0 0
KINIKSA PHARMACEUTICALS INTL ORD SHS CL A G52694109 25,103,147 521,353 SH SOLE 521,353 0 0
KRYSTAL BIOTECH INC COM 501147102 297,865,434 1,153,087 SH SOLE 1,153,087 0 0
LARIMAR THERAPEUTICS INC COM 517125100 4,801,320 1,066,960 SH SOLE 1,066,960 0 0
LB PHARMACEUTICALS INC COM SHS 50180M108 246,600 10,000 SH SOLE 10,000 0 0
LIVANOVA PLC SHS G5509L101 37,023,700 582,500 SH SOLE 582,500 0 0
MBX BIOSCIENCES INC COM 55287L101 5,340,075 178,897 SH SOLE 178,897 0 0
MERCK & CO INC COM 58933Y105 24,418,870 203,000 SH SOLE 203,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 36,980,268 400,306 SH SOLE 400,306 0 0
NATERA INC COM 632307104 23,798,810 119,000 SH SOLE 119,000 0 0
NEOGENOMICS INC COM NEW 64049M209 1,298,500 175,000 SH SOLE 175,000 0 0
NEUROPACE INC COM 641288105 38,558,522 2,932,207 SH SOLE 2,932,207 0 0
NOVOCURE LTD ORD SHS G6674U108 114,367,062 10,492,391 SH SOLE 10,492,391 0 0
NURIX THERAPEUTICS INC COM 67080M103 14,541,527 938,163 SH SOLE 938,163 0 0
ORGANOGENESIS HLDGS INC COM 68621F102 23,903,704 10,085,951 SH SOLE 10,085,951 0 0
ORTHOPEDIATRICS CORP COM 68752L100 9,767,144 615,447 SH SOLE 615,447 0 0
ORUKA THERAPEUTICS INC COM 687604108 245,250 5,000 SH SOLE 5,000 0 0
PHARVARIS N V COM N69605108 19,832,969 702,052 SH SOLE 702,052 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 106,489,272 330,517 SH SOLE 330,517 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 4,001,600 160,000 SH SOLE 160,000 0 0
PROGYNY INC COM 74340E103 35,097,660 2,067,000 SH SOLE 2,067,000 0 0
PULMONX CORP COM 745848101 3,596,937 2,788,323 SH SOLE 2,788,323 0 0
QUOIN PHARMACEUTICALS LTD SPONSORED ADS 74907L409 480,018 72,730 SH SOLE 72,730 0 0
RAPPORT THERAPEUTICS INC COM 75383L102 312,900 10,000 SH SOLE 10,000 0 0
RELMADA THERAPEUTICS INC COM 75955J402 5,861,058 842,106 SH SOLE 842,106 0 0
RIGEL PHARMACEUTICALS INC COM 766559702 270,400 10,000 SH SOLE 10,000 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202 4,021,500 1,050,000 SH SOLE 1,050,000 0 0
SATELLOS BIOSCIENCE INC COM 80401L803 2,332,841 414,359 SH SOLE 414,359 0 0
SEPTERNA INC COM 81734D104 6,608,250 275,000 SH SOLE 275,000 0 0
SIONNA THERAPEUTICS INC COM 829401108 11,766,415 293,500 SH SOLE 293,500 0 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 9,157,500 1,850,000 SH SOLE 1,850,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 374,000 20,000 SH SOLE 20,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 3,856,000 80,000 SH SOLE 80,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 40,340,571 1,726,908 SH SOLE 1,726,908 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 15,010,110 783,000 SH SOLE 783,000 0 0
TANGO THERAPEUTICS INC COM 87583X109 9,414,000 450,000 SH SOLE 450,000 0 0
TECTONIC THERAPEUTIC INC COM 878972108 3,761,252 121,684 SH SOLE 121,684 0 0
TG THERAPEUTICS INC COM 88322Q108 133,853,977 4,029,319 SH SOLE 4,029,319 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 16,221,660 546,000 SH SOLE 546,000 0 0
TREVI THERAPEUTICS INC COM 89532M101 19,326,600 1,620,000 SH SOLE 1,620,000 0 0
TWIST BIOSCIENCE CORP COM 90184D100 58,289,410 1,226,629 SH SOLE 1,226,629 0 0
TYRA BIOSCIENCES INC COM 90240B106 383,000 10,000 SH SOLE 10,000 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 110,998,147 187,187 SH SOLE 187,187 0 0
UROGEN PHARMA LTD COM M96088105 13,071,460 727,000 SH SOLE 727,000 0 0
VAXCYTE INC COM 92243G108 22,399,778 385,472 SH SOLE 385,472 0 0
VERACYTE INC COM 92337F107 10,304,366 319,912 SH SOLE 319,912 0 0
VERICEL CORP COM 92346J108 82,003,871 2,549,079 SH SOLE 2,549,079 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 17,937,920 2,002,000 SH SOLE 2,002,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 16,979,800 292,000 SH SOLE 292,000 0 0
ZYMEWORKS INC COM 98985Y108 250,400 10,000 SH SOLE 10,000 0 0