<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019cfceb-171f-7340-a84d-e67975b2d9ca,g:253a6946-98d7-43f4-b883-c87ee561d41e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://darebioscience.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="dare-20260331.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019e0381-b740-709d-b6b6-5259b8306c71" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_StatementTable_019e0381-b740-709d-b6b6-5259b8306c71" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019e0381-b740-7253-a201-488974680c46" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019e0381-b740-709d-b6b6-5259b8306c71" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019e0381-b740-7253-a201-488974680c46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e0381-b740-7253-a201-488974680c46_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e0381-b740-7253-a201-488974680c46" xlink:to="loc_us-gaap_ClassOfStockDomain_019e0381-b740-7253-a201-488974680c46_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019e0381-b740-7bea-9eed-3d04dec5474c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019e0381-b740-7253-a201-488974680c46" xlink:to="loc_us-gaap_ClassOfStockDomain_019e0381-b740-7bea-9eed-3d04dec5474c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_019e0382-013c-774c-8516-c89bc5212c30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019e0381-b740-7bea-9eed-3d04dec5474c" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_019e0382-013c-774c-8516-c89bc5212c30" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019cfceb-18db-7f1f-8f4a-a8449e106709" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019cfceb-18db-7f1f-8f4a-a8449e106709" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_019cfceb-18db-7003-bb72-ebba029018f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_019cfceb-18db-7003-bb72-ebba029018f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_019cfceb-18db-7c83-be37-0ae01b31a347" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_PreferredStockSharesIssued_019cfceb-18db-7c83-be37-0ae01b31a347" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_019cfceb-18db-7c96-bf98-7cffccb94aaa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_019cfceb-18db-7c96-bf98-7cffccb94aaa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockLiquidationPreferenceValue_019e037d-a0d5-7c83-97ae-f56f7ee2ff9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockLiquidationPreferenceValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_PreferredStockLiquidationPreferenceValue_019e037d-a0d5-7c83-97ae-f56f7ee2ff9d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019cfceb-18db-770c-9058-a43b0f9b5d22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019cfceb-18db-770c-9058-a43b0f9b5d22" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_019cfceb-18db-7995-9f14-75d7458c8c2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_019cfceb-18db-7995-9f14-75d7458c8c2a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_019cfceb-18db-7ab1-a0dd-e7708b24637d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_CommonStockSharesIssued_019cfceb-18db-7ab1-a0dd-e7708b24637d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019cfceb-18db-712a-861c-39d2a5095759" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019e0381-b740-7356-bc6f-1aaac0a8feb6" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019cfceb-18db-712a-861c-39d2a5095759" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/CondensedConsolidatedStatementsofStockholdersEquityDeficitUnaudited" xlink:type="simple" xlink:href="dare-20260331.xsd#CondensedConsolidatedStatementsofStockholdersEquityDeficitUnaudited"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/CondensedConsolidatedStatementsofStockholdersEquityDeficitUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019cfceb-18db-7d0e-802f-ea45fbd68a6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019cfceb-18db-74b2-bd45-9abdf3e15e41" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019cfceb-18db-7d0e-802f-ea45fbd68a6b" xlink:to="loc_us-gaap_StatementTable_019cfceb-18db-74b2-bd45-9abdf3e15e41" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019cfceb-18db-71ae-b7e2-cec8ae40db4a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019cfceb-18db-74b2-bd45-9abdf3e15e41" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019cfceb-18db-71ae-b7e2-cec8ae40db4a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019cfceb-18db-71ae-b7e2-cec8ae40db4a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019cfceb-18db-71ae-b7e2-cec8ae40db4a" xlink:to="loc_us-gaap_EquityComponentDomain_019cfceb-18db-71ae-b7e2-cec8ae40db4a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019cfceb-18db-7b02-a263-184d9b68cb1f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019cfceb-18db-71ae-b7e2-cec8ae40db4a" xlink:to="loc_us-gaap_EquityComponentDomain_019cfceb-18db-7b02-a263-184d9b68cb1f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SeriesANonVotingConvertiblePreferredStockMember_019dab4a-5861-74d9-9567-8c8778eb0f10" xlink:href="dare-20260331.xsd#dare_SeriesANonVotingConvertiblePreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cfceb-18db-7b02-a263-184d9b68cb1f" xlink:to="loc_dare_SeriesANonVotingConvertiblePreferredStockMember_019dab4a-5861-74d9-9567-8c8778eb0f10" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019cfceb-18db-7eaf-9453-a1b1087bd9c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cfceb-18db-7b02-a263-184d9b68cb1f" xlink:to="loc_us-gaap_CommonStockMember_019cfceb-18db-7eaf-9453-a1b1087bd9c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019cfceb-18db-76d6-a6d8-200d62cdf6de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cfceb-18db-7b02-a263-184d9b68cb1f" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019cfceb-18db-76d6-a6d8-200d62cdf6de" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cfceb-18db-7cb9-bcc8-055ce4ea7069" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cfceb-18db-7b02-a263-184d9b68cb1f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cfceb-18db-7cb9-bcc8-055ce4ea7069" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019cfceb-18db-75a7-912e-b26119bb09e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cfceb-18db-7b02-a263-184d9b68cb1f" xlink:to="loc_us-gaap_RetainedEarningsMember_019cfceb-18db-75a7-912e-b26119bb09e2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cfceb-18db-7d0e-802f-ea45fbd68a6b" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019cfceb-18db-7e52-90f5-ad7aba04e556" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019cfceb-18db-7e52-90f5-ad7aba04e556" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cfceb-18db-7c37-8292-12766e1aa71d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_us-gaap_StockholdersEquity_019cfceb-18db-7c37-8292-12766e1aa71d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019cfceb-18db-7044-8169-035d6b79e155" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019cfceb-18db-7044-8169-035d6b79e155" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsShares_019df61e-27f4-722e-83c0-7b7795cea90f" xlink:href="dare-20260331.xsd#dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsShares_019df61e-27f4-722e-83c0-7b7795cea90f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsValue_019df61e-27f4-72ee-a622-9d2f8da0ecf5" xlink:href="dare-20260331.xsd#dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_dare_IssuanceOfSeriesAConvertiblePreferredStockAndWarrantsValue_019df61e-27f4-72ee-a622-9d2f8da0ecf5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019cfceb-18db-7e6d-b1c9-9e68ef5d62e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019cfceb-18db-7e6d-b1c9-9e68ef5d62e6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019cfceb-18db-739e-b1c0-b2677d678217" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019cfceb-18db-739e-b1c0-b2677d678217" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019cfceb-18db-7dbc-ba08-6a13c13d5b7b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_us-gaap_NetIncomeLoss_019cfceb-18db-7dbc-ba08-6a13c13d5b7b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019cfceb-18db-781e-b052-ec990c5e5623" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cfceb-18db-7223-a888-00a464277be0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019cfceb-18db-781e-b052-ec990c5e5623" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019cfceb-18db-7a5f-bae1-33dbe7a9ced5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cfceb-18db-7c8b-9553-793962aed931" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7c3f-9cad-cdd940e279a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7c3f-9cad-cdd940e279a8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019e15ab-8f29-78aa-8304-b70a244ce2ba" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7c3f-9cad-cdd940e279a8" xlink:to="loc_srt_RangeAxis_019e15ab-8f29-78aa-8304-b70a244ce2ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e15ab-8f29-78aa-8304-b70a244ce2ba_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019e15ab-8f29-78aa-8304-b70a244ce2ba" xlink:to="loc_srt_RangeMember_019e15ab-8f29-78aa-8304-b70a244ce2ba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019e15ab-8f29-7bcd-90ba-4600781d05f2" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019e15ab-8f29-78aa-8304-b70a244ce2ba" xlink:to="loc_srt_RangeMember_019e15ab-8f29-7bcd-90ba-4600781d05f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019e15ab-8f29-79b3-baf5-c230f1c1b667" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e15ab-8f29-7bcd-90ba-4600781d05f2" xlink:to="loc_srt_MinimumMember_019e15ab-8f29-79b3-baf5-c230f1c1b667" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019e15ab-8f29-757b-b799-111556cab650" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019e15ab-8f29-7bcd-90ba-4600781d05f2" xlink:to="loc_srt_MaximumMember_019e15ab-8f29-757b-b799-111556cab650" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019e15ab-e703-7d8f-83b6-540e5d8da0e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7c3f-9cad-cdd940e279a8" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019e15ab-e703-7d8f-83b6-540e5d8da0e4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e15ab-e703-7d8f-83b6-540e5d8da0e4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e15ab-e703-7d8f-83b6-540e5d8da0e4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e15ab-e703-7d8f-83b6-540e5d8da0e4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e15ab-e703-7350-bd81-955170a7f70b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019e15ab-e703-7d8f-83b6-540e5d8da0e4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e15ab-e703-7350-bd81-955170a7f70b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreeclampsiaAgreementMember_019e15ab-e703-71da-8537-48be53b3ef18" xlink:href="dare-20260331.xsd#dare_PreeclampsiaAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e15ab-e703-7350-bd81-955170a7f70b" xlink:to="loc_dare_PreeclampsiaAgreementMember_019e15ab-e703-71da-8537-48be53b3ef18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraceptiveLandscapeReviewAgreementMember_019e15ab-e703-7176-8ce3-206a21d5e9a1" xlink:href="dare-20260331.xsd#dare_ContraceptiveLandscapeReviewAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e15ab-e703-7350-bd81-955170a7f70b" xlink:to="loc_dare_ContraceptiveLandscapeReviewAgreementMember_019e15ab-e703-7176-8ce3-206a21d5e9a1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentServicesMember_019e15ab-e703-7f16-b13c-776e4bd92197" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentServicesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019e15ab-e703-7350-bd81-955170a7f70b" xlink:to="loc_dare_ResearchAndDevelopmentServicesMember_019e15ab-e703-7f16-b13c-776e4bd92197" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_019e17ad-f60a-7c35-847f-f4f96f33c03c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7c3f-9cad-cdd940e279a8" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_019e17ad-f60a-7c35-847f-f4f96f33c03c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_019e17ad-f60a-7c35-847f-f4f96f33c03c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_019e17ad-f60a-7c35-847f-f4f96f33c03c" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_019e17ad-f60a-7c35-847f-f4f96f33c03c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_019e17ad-f60a-7889-93b5-23ae6c2e6e4b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_019e17ad-f60a-7c35-847f-f4f96f33c03c" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_019e17ad-f60a-7889-93b5-23ae6c2e6e4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OtherReceivablesCurrentMember_019e17ae-8dee-7760-997f-09b8db56b31e" xlink:href="dare-20260331.xsd#dare_OtherReceivablesCurrentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_019e17ad-f60a-7889-93b5-23ae6c2e6e4b" xlink:to="loc_dare_OtherReceivablesCurrentMember_019e17ae-8dee-7760-997f-09b8db56b31e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentAssetsMember_019e17ae-c031-7678-9cbd-e626c35d7cd9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoncurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_019e17ad-f60a-7889-93b5-23ae6c2e6e4b" xlink:to="loc_us-gaap_OtherNoncurrentAssetsMember_019e17ae-c031-7678-9cbd-e626c35d7cd9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e15ab-8f29-73eb-8e1b-e99331d1eb19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e15ab-8f29-73eb-8e1b-e99331d1eb19" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_WorkingCapitalIncreaseDeficit_019e15ab-8f29-7f8e-9843-a6ee05f92abf" xlink:href="dare-20260331.xsd#dare_WorkingCapitalIncreaseDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_dare_WorkingCapitalIncreaseDeficit_019e15ab-8f29-7f8e-9843-a6ee05f92abf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_GrantAwardsIndirectCostAllowancePercentage_019e15ab-8f29-7f36-b946-6e02a6657d9e" xlink:href="dare-20260331.xsd#dare_GrantAwardsIndirectCostAllowancePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_dare_GrantAwardsIndirectCostAllowancePercentage_019e15ab-8f29-7f36-b946-6e02a6657d9e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DeferredGrantFundingCurrent_019e15ab-8f29-7d52-b180-989445cfd213" xlink:href="dare-20260331.xsd#dare_DeferredGrantFundingCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_dare_DeferredGrantFundingCurrent_019e15ab-8f29-7d52-b180-989445cfd213" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e15ab-bf34-7299-83bf-ba36676a80f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e15ab-bf34-7299-83bf-ba36676a80f6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e15ab-bf34-742d-9196-5db830176434" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_NetIncomeLoss_019e15ab-bf34-742d-9196-5db830176434" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019e15ab-bf34-79c0-881e-c5d4a8ad29c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations_019e15ab-bf34-79c0-881e-c5d4a8ad29c0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_019e15ab-e703-7c92-917a-1ea4183ed755" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_NumberOfOperatingSegments_019e15ab-e703-7c92-917a-1ea4183ed755" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_019e15ab-e703-7111-933f-f7d1c8d1ef95" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_NumberOfReportableSegments_019e15ab-e703-7111-933f-f7d1c8d1ef95" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e15ab-e703-7e08-bb4f-198a3e8fef17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e15ab-e703-7e08-bb4f-198a3e8fef17" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TransactionPriceAllocatedToRemainingPerformanceObligations_019e15ab-e703-7fe2-b767-37cb1dcf4dc1" xlink:href="dare-20260331.xsd#dare_TransactionPriceAllocatedToRemainingPerformanceObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_dare_TransactionPriceAllocatedToRemainingPerformanceObligations_019e15ab-e703-7fe2-b767-37cb1dcf4dc1" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OutstandingAdvancesRepaymentPeriod_019e17af-ce45-7c0d-b57d-f0fe1e6e3d04" xlink:href="dare-20260331.xsd#dare_OutstandingAdvancesRepaymentPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_dare_OutstandingAdvancesRepaymentPeriod_019e17af-ce45-7c0d-b57d-f0fe1e6e3d04" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvancesOnInventoryPurchases_019e17ad-7c0d-7a37-8d32-b3122b7498c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdvancesOnInventoryPurchases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_AdvancesOnInventoryPurchases_019e17ad-7c0d-7a37-8d32-b3122b7498c4" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivables_019e15ac-0a14-72e6-a46c-f139dc775332" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_OtherReceivables_019e15ac-0a14-72e6-a46c-f139dc775332" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019e15ac-3a43-74b5-9904-c9c52c2ead78" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019e15ab-8f29-7a67-8089-bc1fd5582741" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_019e15ac-3a43-74b5-9904-c9c52c2ead78" xlink:type="arc" order="14"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesFinancialAssetsandLiabilitiesRemeasuredonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cfceb-18db-77bc-adce-969ce034bf9c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7eb9-9237-b3a80f06071e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cfceb-18db-77bc-adce-969ce034bf9c" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7eb9-9237-b3a80f06071e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cfceb-18db-7457-a7a9-8762ce30281c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cfceb-18db-7eb9-9237-b3a80f06071e" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cfceb-18db-7457-a7a9-8762ce30281c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cfceb-18db-7457-a7a9-8762ce30281c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cfceb-18db-7457-a7a9-8762ce30281c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cfceb-18db-7457-a7a9-8762ce30281c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cfceb-18db-7de1-966f-e07cba60cbe0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cfceb-18db-7457-a7a9-8762ce30281c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cfceb-18db-7de1-966f-e07cba60cbe0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019cfceb-18db-7c0e-858f-cabf140b0720" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cfceb-18db-7de1-966f-e07cba60cbe0" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019cfceb-18db-7c0e-858f-cabf140b0720" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019cfceb-18db-7fc3-8a5c-3c8e802bdd45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cfceb-18db-7de1-966f-e07cba60cbe0" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019cfceb-18db-7fc3-8a5c-3c8e802bdd45" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019cfceb-18db-7bec-bbe1-7e3562f1989a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cfceb-18db-7de1-966f-e07cba60cbe0" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019cfceb-18db-7bec-bbe1-7e3562f1989a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019cfceb-18db-7828-83b5-47b4bcf8ece7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cfceb-18db-77bc-adce-969ce034bf9c" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019cfceb-18db-7828-83b5-47b4bcf8ece7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StrategicAgreementsDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#StrategicAgreementsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StrategicAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019dab9c-46d0-7367-8ef4-b50e1ae5110f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_srt_CounterpartyNameAxis_019dab9c-46d0-7367-8ef4-b50e1ae5110f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-7367-8ef4-b50e1ae5110f_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019dab9c-46d0-7367-8ef4-b50e1ae5110f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-7367-8ef4-b50e1ae5110f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-774b-9a69-3238926b92c8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019dab9c-46d0-7367-8ef4-b50e1ae5110f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-774b-9a69-3238926b92c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OrganonMember_019dab9c-46d0-71d9-a2d4-71a9fba20e19" xlink:href="dare-20260331.xsd#dare_OrganonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-774b-9a69-3238926b92c8" xlink:to="loc_dare_OrganonMember_019dab9c-46d0-71d9-a2d4-71a9fba20e19" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_BayerHealthcareLLCMember_019dab9c-67ed-7bb8-a53f-b05787b1e47c" xlink:href="dare-20260331.xsd#dare_BayerHealthcareLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-774b-9a69-3238926b92c8" xlink:to="loc_dare_BayerHealthcareLLCMember_019dab9c-67ed-7bb8-a53f-b05787b1e47c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FormerStockholdersOfMBIMember_019dab9c-8b73-7485-aedf-0704a9794b1a" xlink:href="dare-20260331.xsd#dare_FormerStockholdersOfMBIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-774b-9a69-3238926b92c8" xlink:to="loc_dare_FormerStockholdersOfMBIMember_019dab9c-8b73-7485-aedf-0704a9794b1a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CatalentAndMilanaPharmMember_019dab9c-b029-7d8d-8b38-88cf62b57c3f" xlink:href="dare-20260331.xsd#dare_CatalentAndMilanaPharmMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dab9c-46d0-774b-9a69-3238926b92c8" xlink:to="loc_dare_CatalentAndMilanaPharmMember_019dab9c-b029-7d8d-8b38-88cf62b57c3f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019dab9c-67ed-77ef-82fd-11c17d602751" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_srt_ProductOrServiceAxis_019dab9c-67ed-77ef-82fd-11c17d602751" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019dab9c-67ed-77ef-82fd-11c17d602751_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019dab9c-67ed-77ef-82fd-11c17d602751" xlink:to="loc_srt_ProductsAndServicesDomain_019dab9c-67ed-77ef-82fd-11c17d602751_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019dab9c-67ed-7ea3-b427-1533dd9c21c4" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019dab9c-67ed-77ef-82fd-11c17d602751" xlink:to="loc_srt_ProductsAndServicesDomain_019dab9c-67ed-7ea3-b427-1533dd9c21c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyRevenueMember_019dab9c-67ed-7251-a0f7-8fd4d9708b01" xlink:href="dare-20260331.xsd#dare_RoyaltyRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019dab9c-67ed-7ea3-b427-1533dd9c21c4" xlink:to="loc_dare_RoyaltyRevenueMember_019dab9c-67ed-7251-a0f7-8fd4d9708b01" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019dab9c-67ed-751a-93b9-0a6302147214" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019dab9c-67ed-751a-93b9-0a6302147214" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-751a-93b9-0a6302147214_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019dab9c-67ed-751a-93b9-0a6302147214" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-751a-93b9-0a6302147214_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019dab9c-67ed-751a-93b9-0a6302147214" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_019dab9c-67ed-76f4-aeb4-f02bbff09694" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_us-gaap_CollaborativeArrangementMember_019dab9c-67ed-76f4-aeb4-f02bbff09694" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DouglasLicenseAgreementMember_019dab9c-67ed-71d9-865a-4dff8bd9489e" xlink:href="dare-20260331.xsd#dare_DouglasLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_dare_DouglasLicenseAgreementMember_019dab9c-67ed-71d9-865a-4dff8bd9489e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_HennepinLicenseAgreementMember_019dab9c-8b73-7bd6-a31e-bbea380927b4" xlink:href="dare-20260331.xsd#dare_HennepinLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_dare_HennepinLicenseAgreementMember_019dab9c-8b73-7bd6-a31e-bbea380927b4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_019dab9c-8b73-7b14-8dd3-deee5f14ab0e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_us-gaap_LicensingAgreementsMember_019dab9c-8b73-7b14-8dd3-deee5f14ab0e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AssignmentAgreementMember_019dab9c-b029-7136-ab48-81e3ecbb7225" xlink:href="dare-20260331.xsd#dare_AssignmentAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_dare_AssignmentAgreementMember_019dab9c-b029-7136-ab48-81e3ecbb7225" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MergerAgreementMember_019dab9c-b029-7038-81c5-16300b57dcc6" xlink:href="dare-20260331.xsd#dare_MergerAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_dare_MergerAgreementMember_019dab9c-b029-7038-81c5-16300b57dcc6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PearTreePharmaceuticalsIncMember_019dab9c-b029-7884-9efa-87405fda2557" xlink:href="dare-20260331.xsd#dare_PearTreePharmaceuticalsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_dare_PearTreePharmaceuticalsIncMember_019dab9c-b029-7884-9efa-87405fda2557" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_JuniperPharmaceuticalsInc.Member_019dab9c-b029-79b3-9ba7-323b78b1e0cb" xlink:href="dare-20260331.xsd#dare_JuniperPharmaceuticalsInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_dare_JuniperPharmaceuticalsInc.Member_019dab9c-b029-79b3-9ba7-323b78b1e0cb" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndCollaborationAgreementMember_019dab9c-d4e5-7709-908f-6832adb79545" xlink:href="dare-20260331.xsd#dare_LicenseAndCollaborationAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dab9c-67ed-7b42-9f65-97b0c4ce0cd7" xlink:to="loc_dare_LicenseAndCollaborationAgreementMember_019dab9c-d4e5-7709-908f-6832adb79545" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_019dab9c-67ed-7853-9031-9c78992edcfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_019dab9c-67ed-7853-9031-9c78992edcfc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7853-9031-9c78992edcfc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019dab9c-67ed-7853-9031-9c78992edcfc" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7853-9031-9c78992edcfc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7317-8d58-09d54d62c189" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_019dab9c-67ed-7853-9031-9c78992edcfc" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7317-8d58-09d54d62c189" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievingCertainDevelopmentMilestonesMember_019dab9c-67ed-766f-82ca-25de007d8b8f" xlink:href="dare-20260331.xsd#dare_UponAchievingCertainDevelopmentMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7317-8d58-09d54d62c189" xlink:to="loc_dare_UponAchievingCertainDevelopmentMilestonesMember_019dab9c-67ed-766f-82ca-25de007d8b8f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievingCertainCommercialMilestonesMember_019dab9c-67ed-7345-adb7-670667afafba" xlink:href="dare-20260331.xsd#dare_UponAchievingCertainCommercialMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7317-8d58-09d54d62c189" xlink:to="loc_dare_UponAchievingCertainCommercialMilestonesMember_019dab9c-67ed-7345-adb7-670667afafba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicensedProductOrProcessForVaginalOrUrologicalUseMember_019dab9c-8b73-7fb5-b0c6-f9dda1dd581e" xlink:href="dare-20260331.xsd#dare_LicensedProductOrProcessForVaginalOrUrologicalUseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7317-8d58-09d54d62c189" xlink:to="loc_dare_LicensedProductOrProcessForVaginalOrUrologicalUseMember_019dab9c-8b73-7fb5-b0c6-f9dda1dd581e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievingCertainClinicalAndRegulatoryDevelopmentMilestonesMember_019dab9c-b029-71b9-a3eb-3b66a195bcb3" xlink:href="dare-20260331.xsd#dare_UponAchievingCertainClinicalAndRegulatoryDevelopmentMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_019dab9c-67ed-7317-8d58-09d54d62c189" xlink:to="loc_dare_UponAchievingCertainClinicalAndRegulatoryDevelopmentMilestonesMember_019dab9c-b029-71b9-a3eb-3b66a195bcb3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019dab9c-8b73-724d-ad11-32a1ac477cfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019dab9c-8b73-724d-ad11-32a1ac477cfc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019dab9c-8b73-724d-ad11-32a1ac477cfc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019dab9c-8b73-724d-ad11-32a1ac477cfc" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019dab9c-8b73-724d-ad11-32a1ac477cfc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019dab9c-8b73-70b0-a2b6-7dcc9c3cf8c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_019dab9c-8b73-724d-ad11-32a1ac477cfc" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019dab9c-8b73-70b0-a2b6-7dcc9c3cf8c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClinicalAndRegulatoryMilestonesMember_019dab9c-8b73-7f1d-855b-6da4df1ac842" xlink:href="dare-20260331.xsd#dare_ClinicalAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019dab9c-8b73-70b0-a2b6-7dcc9c3cf8c6" xlink:to="loc_dare_ClinicalAndRegulatoryMilestonesMember_019dab9c-8b73-7f1d-855b-6da4df1ac842" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SalesMilestonesMember_019dab9c-8b73-71dc-a88a-16388715069d" xlink:href="dare-20260331.xsd#dare_SalesMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019dab9c-8b73-70b0-a2b6-7dcc9c3cf8c6" xlink:to="loc_dare_SalesMilestonesMember_019dab9c-8b73-71dc-a88a-16388715069d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ADVATecAgreementMember_019dab9c-d4e5-732e-a9b8-f59357e22399" xlink:href="dare-20260331.xsd#dare_ADVATecAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_019dab9c-8b73-70b0-a2b6-7dcc9c3cf8c6" xlink:to="loc_dare_ADVATecAgreementMember_019dab9c-d4e5-732e-a9b8-f59357e22399" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019dab9c-8b73-7111-9135-34eb3c743760" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019dab9c-8b73-7111-9135-34eb3c743760" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019dab9c-8b73-7111-9135-34eb3c743760_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019dab9c-8b73-7111-9135-34eb3c743760" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019dab9c-8b73-7111-9135-34eb3c743760_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019dab9c-8b73-7b9e-997f-71a797e8246f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019dab9c-8b73-7111-9135-34eb3c743760" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019dab9c-8b73-7b9e-997f-71a797e8246f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MicrochipsBiotechInc.Member_019dab9c-8b73-7fdf-a582-c3645129bdde" xlink:href="dare-20260331.xsd#dare_MicrochipsBiotechInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019dab9c-8b73-7b9e-997f-71a797e8246f" xlink:to="loc_dare_MicrochipsBiotechInc.Member_019dab9c-8b73-7fdf-a582-c3645129bdde" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_019dab9c-8b73-78a7-a677-a3c8061d00ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_019dab9c-8b73-78a7-a677-a3c8061d00ae" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_019dab9c-8b73-78a7-a677-a3c8061d00ae_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_019dab9c-8b73-78a7-a677-a3c8061d00ae" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_019dab9c-8b73-78a7-a677-a3c8061d00ae_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_019dab9c-8b73-7768-aaa8-f31a569a6a77" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_019dab9c-8b73-78a7-a677-a3c8061d00ae" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_019dab9c-8b73-7768-aaa8-f31a569a6a77" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019dab9c-8b73-7bbf-8e36-cac6fa52a752" xlink:href="dare-20260331.xsd#dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_019dab9c-8b73-7768-aaa8-f31a569a6a77" xlink:to="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019dab9c-8b73-7bbf-8e36-cac6fa52a752" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019dab9c-8b73-7b1e-b186-4d50de092e7b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_srt_RangeAxis_019dab9c-8b73-7b1e-b186-4d50de092e7b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019dab9c-8b73-7b1e-b186-4d50de092e7b_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019dab9c-8b73-7b1e-b186-4d50de092e7b" xlink:to="loc_srt_RangeMember_019dab9c-8b73-7b1e-b186-4d50de092e7b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019dab9c-8b73-755b-8360-8957d899de83" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019dab9c-8b73-7b1e-b186-4d50de092e7b" xlink:to="loc_srt_RangeMember_019dab9c-8b73-755b-8360-8957d899de83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019dab9c-8b73-7ba6-8b27-e3b1fe10696c" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019dab9c-8b73-755b-8360-8957d899de83" xlink:to="loc_srt_MaximumMember_019dab9c-8b73-7ba6-8b27-e3b1fe10696c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019dab9c-d4e5-7f24-8e57-40abb25c9231" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019dab9c-8b73-755b-8360-8957d899de83" xlink:to="loc_srt_MinimumMember_019dab9c-d4e5-7f24-8e57-40abb25c9231" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019dab9c-8b73-7962-875c-31327f62b387" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019dab9c-8b73-7962-875c-31327f62b387" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019dab9c-8b73-7962-875c-31327f62b387_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019dab9c-8b73-7962-875c-31327f62b387" xlink:to="loc_us-gaap_RelatedPartyDomain_019dab9c-8b73-7962-875c-31327f62b387_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019dab9c-8b73-7f31-86ff-ab053ec6e87b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019dab9c-8b73-7962-875c-31327f62b387" xlink:to="loc_us-gaap_RelatedPartyDomain_019dab9c-8b73-7f31-86ff-ab053ec6e87b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyMember_019dab9c-8b73-7929-97c2-4a38212595d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019dab9c-8b73-7f31-86ff-ab053ec6e87b" xlink:to="loc_us-gaap_RelatedPartyMember_019dab9c-8b73-7929-97c2-4a38212595d9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019dab9c-d4e5-78e7-8dcd-deafe348988e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cfceb-18db-77f5-877c-c48d996b4687" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019dab9c-d4e5-78e7-8dcd-deafe348988e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProjectMember_019dab9c-d4e5-78e7-8dcd-deafe348988e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProjectMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019dab9c-d4e5-78e7-8dcd-deafe348988e" xlink:to="loc_us-gaap_ProjectMember_019dab9c-d4e5-78e7-8dcd-deafe348988e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProjectMember_019dab9c-d4e5-748e-9242-f0bd155b6fef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProjectMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_019dab9c-d4e5-78e7-8dcd-deafe348988e" xlink:to="loc_us-gaap_ProjectMember_019dab9c-d4e5-748e-9242-f0bd155b6fef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019dab9c-d4e5-71a7-99ee-dc169234b10a" xlink:href="dare-20260331.xsd#dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProjectMember_019dab9c-d4e5-748e-9242-f0bd155b6fef" xlink:to="loc_dare_UponAchievementOfSpecifiedDevelopmentAndRegulatoryMilestonesMember_019dab9c-d4e5-71a7-99ee-dc169234b10a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UponReachingCertainWorldwideNetSalesMilestonesMember_019dab9c-d4e5-7f79-b592-101344f93203" xlink:href="dare-20260331.xsd#dare_UponReachingCertainWorldwideNetSalesMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProjectMember_019dab9c-d4e5-748e-9242-f0bd155b6fef" xlink:to="loc_dare_UponReachingCertainWorldwideNetSalesMilestonesMember_019dab9c-d4e5-7f79-b592-101344f93203" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UpfrontLicenseFeeAmountPaid_019dab9c-46d0-7537-8413-f9a080102ec2" xlink:href="dare-20260331.xsd#dare_UpfrontLicenseFeeAmountPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_UpfrontLicenseFeeAmountPaid_019dab9c-46d0-7537-8413-f9a080102ec2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsContingentAmountSalesBasedMilestonesAmount_019dab9c-46d0-7867-b031-8b3e0233dae3" xlink:href="dare-20260331.xsd#dare_MilestonePaymentsContingentAmountSalesBasedMilestonesAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_MilestonePaymentsContingentAmountSalesBasedMilestonesAmount_019dab9c-46d0-7867-b031-8b3e0233dae3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsReimburseAmountPDUFAFeesAndOtherManufacturingExpenses_019dab9c-46d0-7365-a464-1cd1f4521d63" xlink:href="dare-20260331.xsd#dare_MilestonePaymentsReimburseAmountPDUFAFeesAndOtherManufacturingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_MilestonePaymentsReimburseAmountPDUFAFeesAndOtherManufacturingExpenses_019dab9c-46d0-7365-a464-1cd1f4521d63" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsContingentAmountFirstCommercialSaleAmount_019dab9c-46d0-7034-b78d-388a4af2463d" xlink:href="dare-20260331.xsd#dare_MilestonePaymentsContingentAmountFirstCommercialSaleAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_MilestonePaymentsContingentAmountFirstCommercialSaleAmount_019dab9c-46d0-7034-b78d-388a4af2463d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UpfrontLicenseFeeAdvancedWrittenNoticePeriod_019dab9c-67ed-773f-b1e1-f447f0cc9b7f" xlink:href="dare-20260331.xsd#dare_UpfrontLicenseFeeAdvancedWrittenNoticePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_UpfrontLicenseFeeAdvancedWrittenNoticePeriod_019dab9c-67ed-773f-b1e1-f447f0cc9b7f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MaximumPotentialMilestonePayments_019dab9c-8b73-7ca1-a023-d2d12c29f77e" xlink:href="dare-20260331.xsd#dare_MaximumPotentialMilestonePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_MaximumPotentialMilestonePayments_019dab9c-8b73-7ca1-a023-d2d12c29f77e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentMilestonePayment_019dab9c-8b73-7377-b8f8-4de0bfa437a3" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentMilestonePayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_ResearchAndDevelopmentMilestonePayment_019dab9c-8b73-7377-b8f8-4de0bfa437a3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AssetAcquisitionContingentConsiderationCurrent_019dab9c-8b73-791f-891b-adfe2a5aeb44" xlink:href="dare-20260331.xsd#dare_AssetAcquisitionContingentConsiderationCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_AssetAcquisitionContingentConsiderationCurrent_019dab9c-8b73-791f-891b-adfe2a5aeb44" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PaymentOfAdditionalConsiderationInBusinessCombination_019dab9c-8b73-7e32-a6f3-b9c12ea05eea" xlink:href="dare-20260331.xsd#dare_PaymentOfAdditionalConsiderationInBusinessCombination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_PaymentOfAdditionalConsiderationInBusinessCombination_019dab9c-8b73-7e32-a6f3-b9c12ea05eea" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PaymentsToStockholdersRepresentativeInBusinessCombination_019dab9c-8b73-76f1-88ea-ce0024095954" xlink:href="dare-20260331.xsd#dare_PaymentsToStockholdersRepresentativeInBusinessCombination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_PaymentsToStockholdersRepresentativeInBusinessCombination_019dab9c-8b73-76f1-88ea-ce0024095954" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MilestonePaymentsContingentAmount_019dab9c-8b73-77c2-a9da-47404d3babde" xlink:href="dare-20260331.xsd#dare_MilestonePaymentsContingentAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_MilestonePaymentsContingentAmount_019dab9c-8b73-77c2-a9da-47404d3babde" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PotentialAnnualLicenseMaintenanceFeePaymentsThereafter_019dab9c-b029-7bcf-b798-8050ce2fd5fa" xlink:href="dare-20260331.xsd#dare_PotentialAnnualLicenseMaintenanceFeePaymentsThereafter"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_PotentialAnnualLicenseMaintenanceFeePaymentsThereafter_019dab9c-b029-7bcf-b798-8050ce2fd5fa" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyRatePercentage_019dab9c-d4e5-7a3b-bd1e-c6043708ee25" xlink:href="dare-20260331.xsd#dare_RoyaltyRatePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019dab9c-46d0-7e3f-97a7-5176fc23e673" xlink:to="loc_dare_RoyaltyRatePercentage_019dab9c-d4e5-7a3b-bd1e-c6043708ee25" xlink:type="arc" order="12"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#StockholdersEquityAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockholdersEquityAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019df678-d24e-7b23-82a4-b3e41530385b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:to="loc_srt_CounterpartyNameAxis_019df678-d24e-7b23-82a4-b3e41530385b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df678-d24e-7b23-82a4-b3e41530385b_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019df678-d24e-7b23-82a4-b3e41530385b" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df678-d24e-7b23-82a4-b3e41530385b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df678-d24e-7e68-985e-9f7e247f0d75" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019df678-d24e-7b23-82a4-b3e41530385b" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df678-d24e-7e68-985e-9f7e247f0d75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LincolnParkCapitalFundLLCMember_019df678-d24e-78e8-837a-51b261f073ac" xlink:href="dare-20260331.xsd#dare_LincolnParkCapitalFundLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df678-d24e-7e68-985e-9f7e247f0d75" xlink:to="loc_dare_LincolnParkCapitalFundLLCMember_019df678-d24e-78e8-837a-51b261f073ac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DigitalOfferingLLCMember_019df679-9be6-77e6-87e8-1a4f1e3b6c2a" xlink:href="dare-20260331.xsd#dare_DigitalOfferingLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df678-d24e-7e68-985e-9f7e247f0d75" xlink:to="loc_dare_DigitalOfferingLLCMember_019df679-9be6-77e6-87e8-1a4f1e3b6c2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019df678-d24e-7356-aabf-be96bed367d4" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:to="loc_srt_RangeAxis_019df678-d24e-7356-aabf-be96bed367d4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019df678-d24e-7356-aabf-be96bed367d4_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019df678-d24e-7356-aabf-be96bed367d4" xlink:to="loc_srt_RangeMember_019df678-d24e-7356-aabf-be96bed367d4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019df678-d24e-761e-a81c-710f2457a5ff" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019df678-d24e-7356-aabf-be96bed367d4" xlink:to="loc_srt_RangeMember_019df678-d24e-761e-a81c-710f2457a5ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019df678-d24e-76e0-8370-884cf4d48011" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019df678-d24e-761e-a81c-710f2457a5ff" xlink:to="loc_srt_MaximumMember_019df678-d24e-76e0-8370-884cf4d48011" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019df678-d24e-7a87-b4e2-85aa86d303b5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019df678-d24e-761e-a81c-710f2457a5ff" xlink:to="loc_srt_MinimumMember_019df678-d24e-7a87-b4e2-85aa86d303b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019df678-d24e-763f-a73f-b3738098a667" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019df678-d24e-763f-a73f-b3738098a667" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019df678-d24e-763f-a73f-b3738098a667_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019df678-d24e-763f-a73f-b3738098a667" xlink:to="loc_us-gaap_EquityComponentDomain_019df678-d24e-763f-a73f-b3738098a667_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019df678-d24e-7697-8325-4a923180112e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019df678-d24e-763f-a73f-b3738098a667" xlink:to="loc_us-gaap_EquityComponentDomain_019df678-d24e-7697-8325-4a923180112e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019df678-d24e-71ed-a681-b950a747bf76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019df678-d24e-7697-8325-4a923180112e" xlink:to="loc_us-gaap_CommonStockMember_019df678-d24e-71ed-a681-b950a747bf76" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019df678-d24e-7cc7-af48-3f4e59367638" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019df678-d24e-7cc7-af48-3f4e59367638" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df678-d24e-7cc7-af48-3f4e59367638_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019df678-d24e-7cc7-af48-3f4e59367638" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df678-d24e-7cc7-af48-3f4e59367638_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df678-d24e-7f02-9e51-7602ccd6f634" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019df678-d24e-7cc7-af48-3f4e59367638" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df678-d24e-7f02-9e51-7602ccd6f634" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PurchaseAndRegistrationRightsAgreementMember_019df678-d24e-7f02-bdf6-be08e8445102" xlink:href="dare-20260331.xsd#dare_PurchaseAndRegistrationRightsAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df678-d24e-7f02-9e51-7602ccd6f634" xlink:to="loc_dare_PurchaseAndRegistrationRightsAgreementMember_019df678-d24e-7f02-bdf6-be08e8445102" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_March2023AtTheMarketSalesAgreementMember_019df678-f52c-71d7-9d48-25572ec5c1e6" xlink:href="dare-20260331.xsd#dare_March2023AtTheMarketSalesAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df678-d24e-7f02-9e51-7602ccd6f634" xlink:to="loc_dare_March2023AtTheMarketSalesAgreementMember_019df678-f52c-71d7-9d48-25572ec5c1e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RegulationAOfferingMember_019df679-52c4-76d9-abc1-34635eea9be9" xlink:href="dare-20260331.xsd#dare_RegulationAOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df678-d24e-7f02-9e51-7602ccd6f634" xlink:to="loc_dare_RegulationAOfferingMember_019df679-52c4-76d9-abc1-34635eea9be9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019df678-f52c-7120-b187-5411fad261d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:to="loc_us-gaap_AwardTypeAxis_019df678-f52c-7120-b187-5411fad261d8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019df678-f52c-7120-b187-5411fad261d8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019df678-f52c-7120-b187-5411fad261d8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019df678-f52c-7120-b187-5411fad261d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019df678-f52c-7a3d-93ff-44be13e5bc28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019df678-f52c-7120-b187-5411fad261d8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019df678-f52c-7a3d-93ff-44be13e5bc28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019df678-f52c-7000-9d14-0e9acd00a388" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019df678-f52c-7a3d-93ff-44be13e5bc28" xlink:to="loc_us-gaap_WarrantMember_019df678-f52c-7000-9d14-0e9acd00a388" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019df678-f52c-7484-8565-38267903348a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019df678-f52c-7484-8565-38267903348a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7484-8565-38267903348a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019df678-f52c-7484-8565-38267903348a" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7484-8565-38267903348a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7295-b17b-a0b5e710ca6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019df678-f52c-7484-8565-38267903348a" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7295-b17b-a0b5e710ca6c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019df678-f52c-707d-92ea-fc5a2f5dad11" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7295-b17b-a0b5e710ca6c" xlink:to="loc_us-gaap_WarrantMember_019df678-f52c-707d-92ea-fc5a2f5dad11" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_InvestorWarrantsMember_019df679-52c4-7235-af4b-ade2e341dabb" xlink:href="dare-20260331.xsd#dare_InvestorWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7295-b17b-a0b5e710ca6c" xlink:to="loc_dare_InvestorWarrantsMember_019df679-52c4-7235-af4b-ade2e341dabb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AgentUnitWarrantsMember_019df679-9be6-7283-b8a5-f6fc63002756" xlink:href="dare-20260331.xsd#dare_AgentUnitWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7295-b17b-a0b5e710ca6c" xlink:to="loc_dare_AgentUnitWarrantsMember_019df679-9be6-7283-b8a5-f6fc63002756" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AgentCommonWarrantMember_019df679-9be6-7b27-97e5-74d6f6d37c18" xlink:href="dare-20260331.xsd#dare_AgentCommonWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019df678-f52c-7295-b17b-a0b5e710ca6c" xlink:to="loc_dare_AgentCommonWarrantMember_019df679-9be6-7b27-97e5-74d6f6d37c18" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019df679-14ea-734c-b3e3-e62db930c665" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019cfceb-18db-7c89-990f-65d13daf53e4" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019df679-14ea-734c-b3e3-e62db930c665" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019df679-14ea-734c-b3e3-e62db930c665_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019df679-14ea-734c-b3e3-e62db930c665" xlink:to="loc_us-gaap_ClassOfStockDomain_019df679-14ea-734c-b3e3-e62db930c665_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019df679-14ea-7803-94a8-9c60a639db6e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019df679-14ea-734c-b3e3-e62db930c665" xlink:to="loc_us-gaap_ClassOfStockDomain_019df679-14ea-7803-94a8-9c60a639db6e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_019df679-14ea-79a9-bd31-a6419e67ce8e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019df679-14ea-7803-94a8-9c60a639db6e" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_019df679-14ea-79a9-bd31-a6419e67ce8e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockAuthorizedAmount_019df678-d24e-710e-835e-53584bce0a53" xlink:href="dare-20260331.xsd#dare_SaleOfStockAuthorizedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_SaleOfStockAuthorizedAmount_019df678-d24e-710e-835e-53584bce0a53" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockRegistrationStatementPeriod_019df678-d24e-7d49-9916-97cd4269e4ee" xlink:href="dare-20260331.xsd#dare_SaleOfStockRegistrationStatementPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_SaleOfStockRegistrationStatementPeriod_019df678-d24e-7d49-9916-97cd4269e4ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssuedPricePerShare_019df678-d24e-799b-a9f7-760f07e326b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharesIssuedPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_SharesIssuedPricePerShare_019df678-d24e-799b-a9f7-760f07e326b9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_019df678-d24e-73a5-866f-22c9ef41135c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_019df678-d24e-73a5-866f-22c9ef41135c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NumberOfLowestSalePrices_019df678-d24e-7c2f-a265-532b220355ae" xlink:href="dare-20260331.xsd#dare_NumberOfLowestSalePrices"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_NumberOfLowestSalePrices_019df678-d24e-7c2f-a265-532b220355ae" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NumberOfProceedingBusinessPeriod_019df678-d24e-7104-b435-09aec818aa72" xlink:href="dare-20260331.xsd#dare_NumberOfProceedingBusinessPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_NumberOfProceedingBusinessPeriod_019df678-d24e-7104-b435-09aec818aa72" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PurchaseCommitmentMaximumAmountCommitted_019df678-d24e-7b3b-a08e-7e78f29a06a4" xlink:href="dare-20260331.xsd#dare_PurchaseCommitmentMaximumAmountCommitted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PurchaseCommitmentMaximumAmountCommitted_019df678-d24e-7b3b-a08e-7e78f29a06a4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockSharesAvailableNotToIssueOrSell_019df678-d24e-781a-aa14-648f5a8a611f" xlink:href="dare-20260331.xsd#dare_SaleOfStockSharesAvailableNotToIssueOrSell"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_SaleOfStockSharesAvailableNotToIssueOrSell_019df678-d24e-781a-aa14-648f5a8a611f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NumberOfConsecutiveTradingDays_019df678-d24e-71bd-8d81-47cea3c50495" xlink:href="dare-20260331.xsd#dare_NumberOfConsecutiveTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_NumberOfConsecutiveTradingDays_019df678-d24e-71bd-8d81-47cea3c50495" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightExtentHolderOwnPercentage_019df678-d24e-7d87-a2ab-ec4f0be43445" xlink:href="dare-20260331.xsd#dare_ClassOfWarrantOrRightExtentHolderOwnPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_ClassOfWarrantOrRightExtentHolderOwnPercentage_019df678-d24e-7d87-a2ab-ec4f0be43445" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_BeneficialOwnershipPercentage_019df678-d24e-70f6-9241-aef776ae7dfd" xlink:href="dare-20260331.xsd#dare_BeneficialOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_BeneficialOwnershipPercentage_019df678-d24e-70f6-9241-aef776ae7dfd" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019df678-d24e-7888-b385-bdbb1870e658" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019df678-d24e-7888-b385-bdbb1870e658" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019df678-d24e-7824-8cd4-1b40393fe77f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019df678-d24e-7824-8cd4-1b40393fe77f" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PercentageOfAggregateCommission_019df678-f52c-7c67-b548-56636069a364" xlink:href="dare-20260331.xsd#dare_PercentageOfAggregateCommission"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PercentageOfAggregateCommission_019df678-f52c-7c67-b548-56636069a364" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019df678-f52c-72a5-9c31-b29375861d0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019df678-f52c-72a5-9c31-b29375861d0f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019df678-f52c-7ded-9370-e2a89f4001f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_019df678-f52c-7ded-9370-e2a89f4001f3" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_019df679-14ea-7265-85f8-45c50c6cbaf6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_019df679-14ea-7265-85f8-45c50c6cbaf6" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019df679-14ea-7911-bb10-5bcd149cc201" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019df679-14ea-7911-bb10-5bcd149cc201" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockInitialStatedValuePerShare_019df679-14ea-7504-bd97-2babf9b29f68" xlink:href="dare-20260331.xsd#dare_PreferredStockInitialStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockInitialStatedValuePerShare_019df679-14ea-7504-bd97-2babf9b29f68" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockNonCompoundedRateOfReturnPercentage_019df679-52c4-755d-bb62-45b65c0a4865" xlink:href="dare-20260331.xsd#dare_PreferredStockNonCompoundedRateOfReturnPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockNonCompoundedRateOfReturnPercentage_019df679-52c4-755d-bb62-45b65c0a4865" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockPercentageOfStatedValuePerShare_019df679-52c4-71b7-bbcc-118caa4ecea2" xlink:href="dare-20260331.xsd#dare_PreferredStockPercentageOfStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockPercentageOfStatedValuePerShare_019df679-52c4-71b7-bbcc-118caa4ecea2" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockConvertibleConversionPrice_019df679-52c4-7916-af3c-eba6ad8b5fa7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockConvertibleConversionPrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_PreferredStockConvertibleConversionPrice_019df679-52c4-7916-af3c-eba6ad8b5fa7" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_019df679-52c4-717f-bd24-b9339ad54c0a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_019df679-52c4-717f-bd24-b9339ad54c0a" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertibleSharePriceTrigger_019df679-52c4-7f88-ae07-750af07f2a22" xlink:href="dare-20260331.xsd#dare_PreferredStockConvertibleSharePriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockConvertibleSharePriceTrigger_019df679-52c4-7f88-ae07-750af07f2a22" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertibleThresholdTradingDays_019df679-52c4-7886-b654-47933468a79c" xlink:href="dare-20260331.xsd#dare_PreferredStockConvertibleThresholdTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockConvertibleThresholdTradingDays_019df679-52c4-7886-b654-47933468a79c" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertibleThresholdConsecutiveTradingDays_019df679-52c4-706b-8e67-aa3e1093bdc8" xlink:href="dare-20260331.xsd#dare_PreferredStockConvertibleThresholdConsecutiveTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockConvertibleThresholdConsecutiveTradingDays_019df679-52c4-706b-8e67-aa3e1093bdc8" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertiblePublicOfferingProceedsTrigger_019df679-52c4-7e59-a8ea-76c7c89e3c8b" xlink:href="dare-20260331.xsd#dare_PreferredStockConvertiblePublicOfferingProceedsTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockConvertiblePublicOfferingProceedsTrigger_019df679-52c4-7e59-a8ea-76c7c89e3c8b" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreferredStockConvertiblePublicOfferingSharePriceTrigger_019df679-52c4-7abf-95e0-8a6373774846" xlink:href="dare-20260331.xsd#dare_PreferredStockConvertiblePublicOfferingSharePriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_PreferredStockConvertiblePublicOfferingSharePriceTrigger_019df679-52c4-7abf-95e0-8a6373774846" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByEachWarrantOrRight_019df679-52c4-77e2-9688-19cc10b525bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByEachWarrantOrRight"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByEachWarrantOrRight_019df679-52c4-77e2-9688-19cc10b525bc" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_019df679-52c4-7811-859c-01c6c9166f5c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_SharePrice_019df679-52c4-7811-859c-01c6c9166f5c" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance_019df679-52c4-7db6-bf47-0bd4706833fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_ConvertiblePreferredStockSharesReservedForFutureIssuance_019df679-52c4-7db6-bf47-0bd4706833fa" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockPlacementFeePercentage_019df679-9be6-7660-8e79-87f4ba6273d0" xlink:href="dare-20260331.xsd#dare_SaleOfStockPlacementFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_SaleOfStockPlacementFeePercentage_019df679-9be6-7660-8e79-87f4ba6273d0" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockPercentageOfWarrantsIssuable_019df679-9be6-78e2-b8bd-522caddf9ade" xlink:href="dare-20260331.xsd#dare_SaleOfStockPercentageOfWarrantsIssuable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_SaleOfStockPercentageOfWarrantsIssuable_019df679-9be6-78e2-b8bd-522caddf9ade" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_019df679-9be6-73d7-86f3-35c19d4cd9fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_019df679-9be6-73d7-86f3-35c19d4cd9fd" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfStockReimbursedAndReimbursableIssuanceCosts_019df679-9be6-7ad9-b53d-7602110cc878" xlink:href="dare-20260331.xsd#dare_SaleOfStockReimbursedAndReimbursableIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_SaleOfStockReimbursedAndReimbursableIssuanceCosts_019df679-9be6-7ad9-b53d-7602110cc878" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingTerm_019df679-9be6-718a-8c65-f98ed967eab7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantsAndRightsOutstandingTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingTerm_019df679-9be6-718a-8c65-f98ed967eab7" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightPercentageCommonStockOwnershipAfterExercise_019df679-9be6-77db-ab02-5dd5a4e25ec5" xlink:href="dare-20260331.xsd#dare_ClassOfWarrantOrRightPercentageCommonStockOwnershipAfterExercise"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_dare_ClassOfWarrantOrRightPercentageCommonStockOwnershipAfterExercise_019df679-9be6-77db-ab02-5dd5a4e25ec5" xlink:type="arc" order="36"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019df679-9be6-77ea-b071-d07fee2b8ba1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019df679-9be6-77ea-b071-d07fee2b8ba1" xlink:type="arc" order="37"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpenseOfferingCost_019e0348-b120-71a1-9873-737b60f12f0b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NoninterestExpenseOfferingCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019df678-d24e-73c0-88eb-d70bb609d8fc" xlink:to="loc_us-gaap_NoninterestExpenseOfferingCost_019e0348-b120-71a1-9873-737b60f12f0b" xlink:type="arc" order="38"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityScheduleofWarrantActivityDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#StockholdersEquityScheduleofWarrantActivityDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockholdersEquityScheduleofWarrantActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019dabb3-4eb7-7dc3-aa23-33e59fbeeae2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019dabb3-4eb7-7e5f-89ae-6455d2c78191" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019dabb3-4eb7-7dc3-aa23-33e59fbeeae2" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019dabb3-4eb7-7e5f-89ae-6455d2c78191" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabb3-4eb7-7721-8dc6-e35a4de90bf3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019dabb3-4eb7-7e5f-89ae-6455d2c78191" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabb3-4eb7-7721-8dc6-e35a4de90bf3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabb3-4eb7-7721-8dc6-e35a4de90bf3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabb3-4eb7-7721-8dc6-e35a4de90bf3" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabb3-4eb7-7721-8dc6-e35a4de90bf3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabb3-4eb7-785d-827e-73664f61d22e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabb3-4eb7-7721-8dc6-e35a4de90bf3" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabb3-4eb7-785d-827e-73664f61d22e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019dabb3-4eb7-72c7-9a8c-9d02a89b25f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabb3-4eb7-785d-827e-73664f61d22e" xlink:to="loc_us-gaap_WarrantMember_019dabb3-4eb7-72c7-9a8c-9d02a89b25f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_December2023WarrantsMember_019dabb3-4eb7-795e-a765-50b1e3c893a6" xlink:href="dare-20260331.xsd#dare_December2023WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019dabb3-4eb7-72c7-9a8c-9d02a89b25f8" xlink:to="loc_dare_December2023WarrantsMember_019dabb3-4eb7-795e-a765-50b1e3c893a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_September2023WarrantsMember_019dabb3-4eb7-725b-ba22-48f4609cb460" xlink:href="dare-20260331.xsd#dare_September2023WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019dabb3-4eb7-72c7-9a8c-9d02a89b25f8" xlink:to="loc_dare_September2023WarrantsMember_019dabb3-4eb7-725b-ba22-48f4609cb460" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_October2016WarrantsMember_019dabb3-4eb7-7bc2-a616-ec1aab6b865d" xlink:href="dare-20260331.xsd#dare_October2016WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019dabb3-4eb7-72c7-9a8c-9d02a89b25f8" xlink:to="loc_dare_October2016WarrantsMember_019dabb3-4eb7-7bc2-a616-ec1aab6b865d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RegulationAOfferingInvestorWarrantsMember_019df633-375c-74d5-8383-c2487fcd5939" xlink:href="dare-20260331.xsd#dare_RegulationAOfferingInvestorWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WarrantMember_019dabb3-4eb7-72c7-9a8c-9d02a89b25f8" xlink:to="loc_dare_RegulationAOfferingInvestorWarrantsMember_019df633-375c-74d5-8383-c2487fcd5939" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019dabb3-4eb7-7837-b7a8-2ea875e6f41d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019dabb3-4eb7-7dc3-aa23-33e59fbeeae2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019dabb3-4eb7-7837-b7a8-2ea875e6f41d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019dabb3-4eb7-7fd7-b816-a0f7b79780b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019dabb3-4eb7-7dc3-aa23-33e59fbeeae2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019dabb3-4eb7-7fd7-b816-a0f7b79780b9" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockholdersEquityScheduleofCommonStockWarrantsOutstandingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019dabcf-a7d1-728d-a5fe-e2c0844bbfdc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019dabcf-a7d1-7c41-a89b-afc166f03488" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019dabcf-a7d1-728d-a5fe-e2c0844bbfdc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019dabcf-a7d1-7c41-a89b-afc166f03488" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabcf-a7d1-76ef-9ecf-9e8cda600ecd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019dabcf-a7d1-7c41-a89b-afc166f03488" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabcf-a7d1-76ef-9ecf-9e8cda600ecd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabcf-a7d1-76ef-9ecf-9e8cda600ecd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabcf-a7d1-76ef-9ecf-9e8cda600ecd" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabcf-a7d1-76ef-9ecf-9e8cda600ecd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabcf-a7d1-7e7a-8566-c420f3ca3017" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019dabcf-a7d1-76ef-9ecf-9e8cda600ecd" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabcf-a7d1-7e7a-8566-c420f3ca3017" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_WarrantsMember_019dabcf-a7d1-7d0b-a884-661302b8c105" xlink:href="dare-20260331.xsd#dare_WarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019dabcf-a7d1-7e7a-8566-c420f3ca3017" xlink:to="loc_dare_WarrantsMember_019dabcf-a7d1-7d0b-a884-661302b8c105" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019dabcf-a7d1-715e-adb9-9bda1308f6a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019dabcf-a7d1-728d-a5fe-e2c0844bbfdc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019dabcf-a7d1-715e-adb9-9bda1308f6a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019dabcf-a7d1-7c9c-8b9a-47676b5b0328" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019dabcf-a7d1-715e-adb9-9bda1308f6a9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019dabcf-a7d1-7c9c-8b9a-47676b5b0328" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_019dabcf-a7d1-7dc8-8fdc-b65abaec1581" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019dabcf-a7d1-715e-adb9-9bda1308f6a9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_019dabcf-a7d1-7dc8-8fdc-b65abaec1581" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_019dabcf-a7d1-726a-ab9b-eb7bfdd65aa5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019dabcf-a7d1-715e-adb9-9bda1308f6a9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercised_019dabcf-a7d1-726a-ab9b-eb7bfdd65aa5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirations_019dabcf-a7d1-7526-afcb-f962c717cf6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019dabcf-a7d1-715e-adb9-9bda1308f6a9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsForfeituresAndExpirations_019dabcf-a7d1-7526-afcb-f962c717cf6b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_019dabcf-a7d1-7954-9569-f22c7d808560" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019dabcf-a7d1-727d-a963-82dc5253ed2e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019dabcf-a7d1-728d-a5fe-e2c0844bbfdc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019dabcf-a7d1-727d-a963-82dc5253ed2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019dabcf-a7d1-7656-b5cf-829e58812304" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019dabcf-a7d1-727d-a963-82dc5253ed2e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019dabcf-a7d1-7656-b5cf-829e58812304" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019dabcf-a7d1-7185-9e4c-3b1f2c741493" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019dabcf-a7d1-727d-a963-82dc5253ed2e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019dabcf-a7d1-7185-9e4c-3b1f2c741493" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue_019dabcf-a7d1-73f6-8039-7901d22a144e" xlink:href="dare-20260331.xsd#dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019dabcf-a7d1-727d-a963-82dc5253ed2e" xlink:to="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisedWeightedAverageGrantDateFairValue_019dabcf-a7d1-73f6-8039-7901d22a144e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpiredWeightedAverageGrantDateFairValue_019dabcf-a7d1-74fa-bfbe-8cc4f1f5f4bd" xlink:href="dare-20260331.xsd#dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpiredWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019dabcf-a7d1-727d-a963-82dc5253ed2e" xlink:to="loc_dare_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedAndExpiredWeightedAverageGrantDateFairValue_019dabcf-a7d1-74fa-bfbe-8cc4f1f5f4bd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019dabcf-a7d1-75c7-a6e7-09cbefb50234" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_019dabcf-a7d1-71d2-8b3c-c1d7d2619f43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019dabcf-a7d1-728d-a5fe-e2c0844bbfdc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_019dabcf-a7d1-71d2-8b3c-c1d7d2619f43" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_019dabcf-a7d1-75ac-9627-55ce1ae357db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_019dabcf-a7d1-71d2-8b3c-c1d7d2619f43" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_019dabcf-a7d1-75ac-9627-55ce1ae357db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_019dabcf-a7d1-7419-9a2e-a57a487f8d07" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019dabcf-a7d1-728d-a5fe-e2c0844bbfdc" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_019dabcf-a7d1-7419-9a2e-a57a487f8d07" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding_019dabcf-a7d1-7a2c-9b14-ffa93b0d4f6a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_019dabcf-a7d1-7419-9a2e-a57a487f8d07" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding_019dabcf-a7d1-7a2c-9b14-ffa93b0d4f6a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#StockBasedCompensationAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-79ff-8122-6eeb5a258258" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-79ff-8122-6eeb5a258258" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019cfceb-18db-708f-b791-1701849aa3f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-79ff-8122-6eeb5a258258" xlink:to="loc_us-gaap_PlanNameAxis_019cfceb-18db-708f-b791-1701849aa3f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cfceb-18db-708f-b791-1701849aa3f1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019cfceb-18db-708f-b791-1701849aa3f1" xlink:to="loc_us-gaap_PlanNameDomain_019cfceb-18db-708f-b791-1701849aa3f1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cfceb-18db-76b3-8cac-c6687dbf0911" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019cfceb-18db-708f-b791-1701849aa3f1" xlink:to="loc_us-gaap_PlanNameDomain_019cfceb-18db-76b3-8cac-c6687dbf0911" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TwoThousandAndFourteenEmployeeStockPurchasePlanMember_019cfceb-18db-70f8-a3d1-e394d31b5393" xlink:href="dare-20260331.xsd#dare_TwoThousandAndFourteenEmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cfceb-18db-76b3-8cac-c6687dbf0911" xlink:to="loc_dare_TwoThousandAndFourteenEmployeeStockPurchasePlanMember_019cfceb-18db-70f8-a3d1-e394d31b5393" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019cfceb-18db-73bb-a20b-51cee55c4d3f" xlink:href="dare-20260331.xsd#dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cfceb-18db-76b3-8cac-c6687dbf0911" xlink:to="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019cfceb-18db-73bb-a20b-51cee55c4d3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019cfceb-18db-7937-8971-17eab08a8961" xlink:href="dare-20260331.xsd#dare_TwoThousandTwentyTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cfceb-18db-76b3-8cac-c6687dbf0911" xlink:to="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019cfceb-18db-7937-8971-17eab08a8961" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UnderlyingAwardsGrantedTwoThousandTwentyTwoStockIncentivePlanMember_019cfceb-18db-7c38-9d5a-295e06175422" xlink:href="dare-20260331.xsd#dare_UnderlyingAwardsGrantedTwoThousandTwentyTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cfceb-18db-76b3-8cac-c6687dbf0911" xlink:to="loc_dare_UnderlyingAwardsGrantedTwoThousandTwentyTwoStockIncentivePlanMember_019cfceb-18db-7c38-9d5a-295e06175422" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UnderlyingAwardsGrantedUnderTheAmendedTwoThousandFourteenPlanMember_019cfceb-18db-7664-a60d-d3edc6d11bdc" xlink:href="dare-20260331.xsd#dare_UnderlyingAwardsGrantedUnderTheAmendedTwoThousandFourteenPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cfceb-18db-76b3-8cac-c6687dbf0911" xlink:to="loc_dare_UnderlyingAwardsGrantedUnderTheAmendedTwoThousandFourteenPlanMember_019cfceb-18db-7664-a60d-d3edc6d11bdc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7f9f-acc0-85f53c5a9194" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-79ff-8122-6eeb5a258258" xlink:to="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7f9f-acc0-85f53c5a9194" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7f9f-acc0-85f53c5a9194_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7f9f-acc0-85f53c5a9194" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7f9f-acc0-85f53c5a9194_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7431-a95c-e1ff5918401d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7f9f-acc0-85f53c5a9194" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7431-a95c-e1ff5918401d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019cfceb-18db-7921-bd68-7e2930e60b41" xlink:href="dare-20260331.xsd#dare_TwoThousandTwentyTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7431-a95c-e1ff5918401d" xlink:to="loc_dare_TwoThousandTwentyTwoStockIncentivePlanMember_019cfceb-18db-7921-bd68-7e2930e60b41" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019cfceb-18db-7712-9235-3002c61538f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7431-a95c-e1ff5918401d" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019cfceb-18db-7712-9235-3002c61538f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019cfceb-18db-731c-b467-fda888bf3e86" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019cfceb-18db-731c-b467-fda888bf3e86" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019cfceb-18db-794a-8eb2-a7f3a04a7c87" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019cfceb-18db-794a-8eb2-a7f3a04a7c87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_019cfceb-18db-78b7-8c1e-ede14fa3ce30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_019cfceb-18db-78b7-8c1e-ede14fa3ce30" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019cfceb-18db-7dc1-b621-1eb5ccba4c07" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_019cfceb-18db-7dc1-b621-1eb5ccba4c07" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019cfceb-18db-77a7-bf66-38ca086d9877" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019cfceb-18db-77a7-bf66-38ca086d9877" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent_019cfceb-18db-7de3-8a80-5cf89f092561" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_DeferredCompensationSharebasedArrangementsLiabilityCurrentAndNoncurrent_019cfceb-18db-7de3-8a80-5cf89f092561" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_WeightedAverageAmortizationPeriod_019cfceb-18db-7f35-a291-1833ee8f86b2" xlink:href="dare-20260331.xsd#dare_WeightedAverageAmortizationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_dare_WeightedAverageAmortizationPeriod_019cfceb-18db-7f35-a291-1833ee8f86b2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019cfceb-18db-7589-a175-b74220696937" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-74e4-b018-c89861b39460" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019cfceb-18db-7589-a175-b74220696937" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationScheduleofStockOptionActivityforAmended2014PlanandRelatedInformationDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#StockBasedCompensationScheduleofStockOptionActivityforAmended2014PlanandRelatedInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationScheduleofStockOptionActivityforAmended2014PlanandRelatedInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-7ec7-982d-3515ff96f03e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-723f-ada4-23e873e1517b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-7ec7-982d-3515ff96f03e" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-723f-ada4-23e873e1517b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019cfceb-18db-7105-8f8a-02708d3b4814" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-723f-ada4-23e873e1517b" xlink:to="loc_us-gaap_PlanNameAxis_019cfceb-18db-7105-8f8a-02708d3b4814" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cfceb-18db-7105-8f8a-02708d3b4814_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019cfceb-18db-7105-8f8a-02708d3b4814" xlink:to="loc_us-gaap_PlanNameDomain_019cfceb-18db-7105-8f8a-02708d3b4814_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cfceb-18db-7c7d-bfc6-b2cc34ebe5e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019cfceb-18db-7105-8f8a-02708d3b4814" xlink:to="loc_us-gaap_PlanNameDomain_019cfceb-18db-7c7d-bfc6-b2cc34ebe5e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019cfceb-18db-7d37-b384-f803902c0d9e" xlink:href="dare-20260331.xsd#dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cfceb-18db-7c7d-bfc6-b2cc34ebe5e1" xlink:to="loc_dare_AmendedAndRestatedTwoThousandFourteenStockIncentivePlanMember_019cfceb-18db-7d37-b384-f803902c0d9e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7146-9101-fe6bcd3fd6a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cfceb-18db-723f-ada4-23e873e1517b" xlink:to="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7146-9101-fe6bcd3fd6a3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7146-9101-fe6bcd3fd6a3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7146-9101-fe6bcd3fd6a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-7146-9101-fe6bcd3fd6a3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-77f7-92da-fbed57b970f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019cfceb-18db-7146-9101-fe6bcd3fd6a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-77f7-92da-fbed57b970f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019cfceb-18db-7f07-a3a7-a8c40d8f3d18" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cfceb-18db-77f7-92da-fbed57b970f4" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019cfceb-18db-7f07-a3a7-a8c40d8f3d18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019cfceb-18db-7722-b2db-0f6251577486" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-7ec7-982d-3515ff96f03e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019cfceb-18db-7722-b2db-0f6251577486" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019cfceb-18db-77bb-817a-5a7db39f02b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019cfceb-18db-7722-b2db-0f6251577486" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019cfceb-18db-77bb-817a-5a7db39f02b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019cfceb-18db-773f-9021-7576b960ea82" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019cfceb-18db-7722-b2db-0f6251577486" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019cfceb-18db-773f-9021-7576b960ea82" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019cfceb-18db-7ca1-9be4-79bd771cf54d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019cfceb-18db-7722-b2db-0f6251577486" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019cfceb-18db-7ca1-9be4-79bd771cf54d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_019cfceb-18db-726c-ad31-f5f3f1880836" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019cfceb-18db-7722-b2db-0f6251577486" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_019cfceb-18db-726c-ad31-f5f3f1880836" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_019cfceb-18db-7973-ae71-0b41fb8b54cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_019cfceb-18db-7722-b2db-0f6251577486" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_019cfceb-18db-7973-ae71-0b41fb8b54cb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019cfceb-18db-738d-9403-9fce12475705" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_019cfceb-18db-76e9-95fa-9f2d5910d207" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-7ec7-982d-3515ff96f03e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_019cfceb-18db-76e9-95fa-9f2d5910d207" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019cfceb-18db-73de-9e9d-b36ac0d60b22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-7ec7-982d-3515ff96f03e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019cfceb-18db-73de-9e9d-b36ac0d60b22" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019cfceb-18db-7fb4-9635-1441b23178b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019cfceb-18db-73de-9e9d-b36ac0d60b22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019cfceb-18db-7fb4-9635-1441b23178b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_019cfceb-18db-7586-89b1-c795940879b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019cfceb-18db-73de-9e9d-b36ac0d60b22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_019cfceb-18db-7586-89b1-c795940879b8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_019cfceb-18db-7ec3-86a6-e6970f7aa87f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019cfceb-18db-73de-9e9d-b36ac0d60b22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_019cfceb-18db-7ec3-86a6-e6970f7aa87f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_019cfceb-18db-7455-adc0-4c8169c42e0a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019cfceb-18db-73de-9e9d-b36ac0d60b22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_019cfceb-18db-7455-adc0-4c8169c42e0a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_019cfceb-18db-7d8f-aa4a-0b9895b63b95" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_019cfceb-18db-73de-9e9d-b36ac0d60b22" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_019cfceb-18db-7d8f-aa4a-0b9895b63b95" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_019cfceb-18db-75a4-811d-f4c2e6d3f2fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_019cfceb-18db-7d16-a1c9-5d67fc07df6f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cfceb-18db-7ec7-982d-3515ff96f03e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_019cfceb-18db-7d16-a1c9-5d67fc07df6f" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/StockBasedCompensationScheduleofRecognizedStockBasedCompensationExpenseRelatedtoStockOptionsGrantedtoEmployeesandDirectorsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019cfceb-18db-7136-8ca3-ea8b3374d99e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019cfceb-18db-757a-bd73-34c246b9d036" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019cfceb-18db-7136-8ca3-ea8b3374d99e" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019cfceb-18db-757a-bd73-34c246b9d036" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019cfceb-18db-7303-a851-22087da9f476" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019cfceb-18db-757a-bd73-34c246b9d036" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019cfceb-18db-7303-a851-22087da9f476" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cfceb-18db-7303-a851-22087da9f476_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cfceb-18db-7303-a851-22087da9f476" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cfceb-18db-7303-a851-22087da9f476_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cfceb-18db-76a6-bdeb-d855cfe7d6e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cfceb-18db-7303-a851-22087da9f476" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cfceb-18db-76a6-bdeb-d855cfe7d6e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019cfceb-18db-79cf-9152-1466614b22c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cfceb-18db-76a6-bdeb-d855cfe7d6e3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019cfceb-18db-79cf-9152-1466614b22c0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019cfceb-18db-7a89-b435-cc152725b402" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cfceb-18db-76a6-bdeb-d855cfe7d6e3" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019cfceb-18db-7a89-b435-cc152725b402" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019cfceb-18db-7e9c-8a91-a3da6ca6769b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019cfceb-18db-7136-8ca3-ea8b3374d99e" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019cfceb-18db-7e9c-8a91-a3da6ca6769b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/LeasedPropertiesAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#LeasedPropertiesAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/LeasedPropertiesAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_019cfceb-18db-74cb-9fa9-b9b0cc7bd6a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_019cfceb-18db-74cb-9fa9-b9b0cc7bd6a1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_019dae1a-e62a-79f5-9740-7107fb3ff2cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019cfceb-18db-74cb-9fa9-b9b0cc7bd6a1" xlink:to="loc_us-gaap_LeaseContractualTermAxis_019dae1a-e62a-79f5-9740-7107fb3ff2cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019dae1a-e62a-79f5-9740-7107fb3ff2cb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019dae1a-e62a-79f5-9740-7107fb3ff2cb" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019dae1a-e62a-79f5-9740-7107fb3ff2cb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019dae1a-e62a-789e-8eb3-70f6dcbfc4ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019dae1a-e62a-79f5-9740-7107fb3ff2cb" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019dae1a-e62a-789e-8eb3-70f6dcbfc4ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CleanRoomSpaceMember_019dae1a-e62a-7b3a-89a9-a814f6e9f72c" xlink:href="dare-20260331.xsd#dare_CleanRoomSpaceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_019dae1a-e62a-789e-8eb3-70f6dcbfc4ae" xlink:to="loc_dare_CleanRoomSpaceMember_019dae1a-e62a-7b3a-89a9-a814f6e9f72c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019dae1a-e62a-70e8-809e-732a1c9a32a7" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019cfceb-18db-74cb-9fa9-b9b0cc7bd6a1" xlink:to="loc_srt_RangeAxis_019dae1a-e62a-70e8-809e-732a1c9a32a7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019dae1a-e62a-70e8-809e-732a1c9a32a7_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019dae1a-e62a-70e8-809e-732a1c9a32a7" xlink:to="loc_srt_RangeMember_019dae1a-e62a-70e8-809e-732a1c9a32a7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019dae1a-e62a-747b-88eb-95e3418fef74" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019dae1a-e62a-70e8-809e-732a1c9a32a7" xlink:to="loc_srt_RangeMember_019dae1a-e62a-747b-88eb-95e3418fef74" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019dae1a-e62a-77f8-90f4-9a45159f87ce" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019dae1a-e62a-747b-88eb-95e3418fef74" xlink:to="loc_srt_MaximumMember_019dae1a-e62a-77f8-90f4-9a45159f87ce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_019dae1b-1b68-7cb9-a238-cab0ad8244ba" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019cfceb-18db-74cb-9fa9-b9b0cc7bd6a1" xlink:to="loc_dei_LegalEntityAxis_019dae1b-1b68-7cb9-a238-cab0ad8244ba" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019dae1b-1b68-7cb9-a238-cab0ad8244ba_default" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_019dae1b-1b68-7cb9-a238-cab0ad8244ba" xlink:to="loc_dei_EntityDomain_019dae1b-1b68-7cb9-a238-cab0ad8244ba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_019dae1b-1b68-7b41-8d91-934745e7eaa6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_019dae1b-1b68-7cb9-a238-cab0ad8244ba" xlink:to="loc_dei_EntityDomain_019dae1b-1b68-7b41-8d91-934745e7eaa6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MBIMember_019dae1b-1b68-719d-b9f2-8d3538289ed6" xlink:href="dare-20260331.xsd#dare_MBIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_019dae1b-1b68-7b41-8d91-934745e7eaa6" xlink:to="loc_dare_MBIMember_019dae1b-1b68-719d-b9f2-8d3538289ed6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019dae1c-40a5-7fa2-a0c8-2b250c710a32" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019cfceb-18db-74cb-9fa9-b9b0cc7bd6a1" xlink:to="loc_srt_ProductOrServiceAxis_019dae1c-40a5-7fa2-a0c8-2b250c710a32" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019dae1c-40a5-7fa2-a0c8-2b250c710a32_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019dae1c-40a5-7fa2-a0c8-2b250c710a32" xlink:to="loc_srt_ProductsAndServicesDomain_019dae1c-40a5-7fa2-a0c8-2b250c710a32_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019dae1c-40a5-7cc8-b5c0-a01d0fb50d82" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019dae1c-40a5-7fa2-a0c8-2b250c710a32" xlink:to="loc_srt_ProductsAndServicesDomain_019dae1c-40a5-7cc8-b5c0-a01d0fb50d82" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseMember_019dae1c-79ca-7a3a-80b9-e92f9a00a8de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LicenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019dae1c-40a5-7cc8-b5c0-a01d0fb50d82" xlink:to="loc_us-gaap_LicenseMember_019dae1c-79ca-7a3a-80b9-e92f9a00a8de" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndServicesAgreementTerm_019dae1a-e62a-700f-a529-db6dd48019ef" xlink:href="dare-20260331.xsd#dare_LicenseAndServicesAgreementTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_dare_LicenseAndServicesAgreementTerm_019dae1a-e62a-700f-a529-db6dd48019ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndServicesAgreementAmountPayableUponExecution_019dae1a-e62a-7a35-b392-79063390bf5d" xlink:href="dare-20260331.xsd#dare_LicenseAndServicesAgreementAmountPayableUponExecution"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_dare_LicenseAndServicesAgreementAmountPayableUponExecution_019dae1a-e62a-7a35-b392-79063390bf5d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_LicenseAndServicesAgreementMaximumFeeIncreasePercentage_019dae1a-e62a-75df-91ce-3739d33bde9a" xlink:href="dare-20260331.xsd#dare_LicenseAndServicesAgreementMaximumFeeIncreasePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_dare_LicenseAndServicesAgreementMaximumFeeIncreasePercentage_019dae1a-e62a-75df-91ce-3739d33bde9a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_019dae1a-e62a-72cc-a2af-09fcd9d2cf69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_019dae1a-e62a-72cc-a2af-09fcd9d2cf69" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019dae1a-e62a-787b-a60e-d0a9d443d13e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_us-gaap_FinanceLeaseLiability_019dae1a-e62a-787b-a60e-d0a9d443d13e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_019dae1a-e62a-7084-8267-fa9bb7f89d45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_019dae1a-e62a-7084-8267-fa9bb7f89d45" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FinanceLeaseIncrementalBorrowingRatePrimeRate_019dae1a-e62a-74a3-a92d-a1a979548cd7" xlink:href="dare-20260331.xsd#dare_FinanceLeaseIncrementalBorrowingRatePrimeRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_dare_FinanceLeaseIncrementalBorrowingRatePrimeRate_019dae1a-e62a-74a3-a92d-a1a979548cd7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_019dae1a-e62a-7deb-aa58-65998221b1b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_019dae1a-e62a-7deb-aa58-65998221b1b3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetRentableArea_019dae1b-1b68-7010-8a8e-3bca441f40aa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetRentableArea"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_us-gaap_NetRentableArea_019dae1b-1b68-7010-8a8e-3bca441f40aa" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019dae1b-1b68-727b-95d8-e3b0d7b0f843" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019dae1b-1b68-727b-95d8-e3b0d7b0f843" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OperatingLeaseIncrementalBorrowingRatePrimeRate_019dae1b-1b68-7caf-a4e8-181f81eab30c" xlink:href="dare-20260331.xsd#dare_OperatingLeaseIncrementalBorrowingRatePrimeRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019dae1a-e62a-750b-b377-5c408598975e" xlink:to="loc_dare_OperatingLeaseIncrementalBorrowingRatePrimeRate_019dae1b-1b68-7caf-a4e8-181f81eab30c" xlink:type="arc" order="10"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/RoyaltyInterestFinancingAdditionalInformationDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#RoyaltyInterestFinancingAdditionalInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/RoyaltyInterestFinancingAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7224-8282-54ac2aa59f00" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7224-8282-54ac2aa59f00" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cfceb-18db-7833-be56-2592db1dad66" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7224-8282-54ac2aa59f00" xlink:to="loc_srt_CounterpartyNameAxis_019cfceb-18db-7833-be56-2592db1dad66" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-7833-be56-2592db1dad66_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cfceb-18db-7833-be56-2592db1dad66" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-7833-be56-2592db1dad66_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-741e-9533-07de3d2bb70b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cfceb-18db-7833-be56-2592db1dad66" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-741e-9533-07de3d2bb70b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_UnitedInEndeavorLLCMember_019cfceb-18db-7b14-a859-ea891c51e64f" xlink:href="dare-20260331.xsd#dare_UnitedInEndeavorLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-741e-9533-07de3d2bb70b" xlink:to="loc_dare_UnitedInEndeavorLLCMember_019cfceb-18db-7b14-a859-ea891c51e64f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019cfceb-18db-79f6-8715-af439b6d484b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7224-8282-54ac2aa59f00" xlink:to="loc_srt_RangeAxis_019cfceb-18db-79f6-8715-af439b6d484b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019cfceb-18db-79f6-8715-af439b6d484b_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019cfceb-18db-79f6-8715-af439b6d484b" xlink:to="loc_srt_RangeMember_019cfceb-18db-79f6-8715-af439b6d484b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019cfceb-18db-7cd3-942d-fdc19691730f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019cfceb-18db-79f6-8715-af439b6d484b" xlink:to="loc_srt_RangeMember_019cfceb-18db-7cd3-942d-fdc19691730f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019cfceb-18db-7d19-a028-5449371b15fb" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019cfceb-18db-7cd3-942d-fdc19691730f" xlink:to="loc_srt_MinimumMember_019cfceb-18db-7d19-a028-5449371b15fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019cfceb-18db-714d-90df-af97c79990be" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019cfceb-18db-7cd3-942d-fdc19691730f" xlink:to="loc_srt_MaximumMember_019cfceb-18db-714d-90df-af97c79990be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019cfceb-18db-7202-bb21-d1fe459f3e3e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7224-8282-54ac2aa59f00" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019cfceb-18db-7202-bb21-d1fe459f3e3e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019cfceb-18db-7202-bb21-d1fe459f3e3e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019cfceb-18db-7202-bb21-d1fe459f3e3e" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019cfceb-18db-7202-bb21-d1fe459f3e3e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019cfceb-18db-77ac-98b9-d3151653b840" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019cfceb-18db-7202-bb21-d1fe459f3e3e" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019cfceb-18db-77ac-98b9-d3151653b840" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_019cfceb-18db-7589-863a-4f5f4f6440f9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019cfceb-18db-77ac-98b9-d3151653b840" xlink:to="loc_us-gaap_WarrantMember_019cfceb-18db-7589-863a-4f5f4f6440f9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_019cfceb-18db-7784-ad36-0686bab889e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7224-8282-54ac2aa59f00" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_019cfceb-18db-7784-ad36-0686bab889e3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019cfceb-18db-7784-ad36-0686bab889e3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019cfceb-18db-7784-ad36-0686bab889e3" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019cfceb-18db-7784-ad36-0686bab889e3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019cfceb-18db-7f3e-9bf0-80c41d6f5057" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019cfceb-18db-7784-ad36-0686bab889e3" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019cfceb-18db-7f3e-9bf0-80c41d6f5057" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019cfceb-18db-7e8d-a3f9-dc4761c903d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019cfceb-18db-7f3e-9bf0-80c41d6f5057" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019cfceb-18db-7e8d-a3f9-dc4761c903d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019cfceb-18db-7aa8-b16f-d5875718936e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019cfceb-18db-7e8d-a3f9-dc4761c903d5" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019cfceb-18db-7aa8-b16f-d5875718936e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_019cfceb-18db-79f9-bd6e-beb17239c6c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_019cfceb-18db-79f9-bd6e-beb17239c6c9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementNumberOfAdditionalPayments_019cfceb-18db-7fe8-a167-4cfae82bd23d" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementNumberOfAdditionalPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementNumberOfAdditionalPayments_019cfceb-18db-7fe8-a167-4cfae82bd23d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementSupplementInvestmentPayment_019cfceb-18db-7d38-b7e1-693b47ca16dd" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementSupplementInvestmentPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementSupplementInvestmentPayment_019cfceb-18db-7d38-b7e1-693b47ca16dd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementInternalRateOfReturn_019cfceb-18db-7cb7-92a8-673cd979c214" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementInternalRateOfReturn"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementInternalRateOfReturn_019cfceb-18db-7cb7-92a8-673cd979c214" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementHardCapPercentage_019cfceb-18db-7843-a91c-87fea8ed36ff" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementHardCapPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementHardCapPercentage_019cfceb-18db-7843-a91c-87fea8ed36ff" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019cfceb-18db-7b59-9cd5-fda313910002" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019cfceb-18db-7b59-9cd5-fda313910002" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019cfceb-18db-7f09-83b8-9f4a138266f6" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementMilestonePaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019cfceb-18db-7f09-83b8-9f4a138266f6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementQuarterlyPaymentsPeriod_019cfceb-18db-73de-bdce-017fd3bc699d" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementQuarterlyPaymentsPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementQuarterlyPaymentsPeriod_019cfceb-18db-73de-bdce-017fd3bc699d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementEffectiveAnnualInterestRatePercentage_019cfceb-18db-76c8-b97a-c253a4f113a3" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementEffectiveAnnualInterestRatePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementEffectiveAnnualInterestRatePercentage_019cfceb-18db-76c8-b97a-c253a4f113a3" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementEstimatedAmountOfRoyaltyObligation_019cfceb-18db-79ee-bb3a-2bc2d32e3798" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementEstimatedAmountOfRoyaltyObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_RoyaltyAgreementEstimatedAmountOfRoyaltyObligation_019cfceb-18db-79ee-bb3a-2bc2d32e3798" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightInitialRoyaltyWarrantIssued_019cfceb-18db-781d-a16b-b69c39d60f9b" xlink:href="dare-20260331.xsd#dare_ClassOfWarrantOrRightInitialRoyaltyWarrantIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_ClassOfWarrantOrRightInitialRoyaltyWarrantIssued_019cfceb-18db-781d-a16b-b69c39d60f9b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightSupplementInvestment_019cfceb-18db-7be7-9fa0-d4b1753aab59" xlink:href="dare-20260331.xsd#dare_ClassOfWarrantOrRightSupplementInvestment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_ClassOfWarrantOrRightSupplementInvestment_019cfceb-18db-7be7-9fa0-d4b1753aab59" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ClassOfWarrantOrRightSupplementInvestmentShareAmount_019cfceb-18db-7e4a-bab9-ab258e50faab" xlink:href="dare-20260331.xsd#dare_ClassOfWarrantOrRightSupplementInvestmentShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_dare_ClassOfWarrantOrRightSupplementInvestmentShareAmount_019cfceb-18db-7e4a-bab9-ab258e50faab" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_019cfceb-18db-73b9-b6e8-9e8b87dfb75a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7fae-9fa2-4f7fbca70e5e" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_019cfceb-18db-73b9-b6e8-9e8b87dfb75a" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/RoyaltyInterestFinancingScheduleofChangesintheLiabilityRelatedtotheSaleofFutureRoyaltiesDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#RoyaltyInterestFinancingScheduleofChangesintheLiabilityRelatedtotheSaleofFutureRoyaltiesDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/RoyaltyInterestFinancingScheduleofChangesintheLiabilityRelatedtotheSaleofFutureRoyaltiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7f06-b00c-aa7753c225e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7f06-b00c-aa7753c225e9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cfceb-18db-7922-9f3c-9adc6a065cba" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_019cfceb-18db-7f06-b00c-aa7753c225e9" xlink:to="loc_srt_ProductOrServiceAxis_019cfceb-18db-7922-9f3c-9adc6a065cba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7922-9f3c-9adc6a065cba_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cfceb-18db-7922-9f3c-9adc6a065cba" xlink:to="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7922-9f3c-9adc6a065cba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cfceb-18db-77f2-a75b-603f73b46cc8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cfceb-18db-7922-9f3c-9adc6a065cba" xlink:to="loc_srt_ProductsAndServicesDomain_019cfceb-18db-77f2-a75b-603f73b46cc8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_019cfceb-18db-740b-b05a-82722ac23cfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-77f2-a75b-603f73b46cc8" xlink:to="loc_us-gaap_RoyaltyMember_019cfceb-18db-740b-b05a-82722ac23cfb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_019cfceb-18db-73be-8220-30bd676f3fa3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_019cfceb-18db-73be-8220-30bd676f3fa3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019cfceb-18db-7c13-ad44-b0ed7d252150" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019cfceb-18db-7c13-ad44-b0ed7d252150" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_019cfceb-18db-7cac-9907-68afe47448d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_019cfceb-18db-7cac-9907-68afe47448d3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRoyalties_019cfceb-18db-7dfb-b112-310fc9b8358d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRoyalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:to="loc_us-gaap_PaymentsForRoyalties_019cfceb-18db-7dfb-b112-310fc9b8358d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties_019cfceb-18db-7722-af5c-1f5a2a2aa664" xlink:href="dare-20260331.xsd#dare_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:to="loc_dare_NonCashInterestExpenseOnLiabilityRelatedToSaleOfFutureRoyalties_019cfceb-18db-7722-af5c-1f5a2a2aa664" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyGuaranteesCommitmentsGrossAmount_019cfceb-18db-731c-87c0-b7e85c3d8994" xlink:href="dare-20260331.xsd#dare_RoyaltyGuaranteesCommitmentsGrossAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_019cfceb-18db-7086-a183-372a76fd4567" xlink:to="loc_dare_RoyaltyGuaranteesCommitmentsGrossAmount_019cfceb-18db-731c-87c0-b7e85c3d8994" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/RoyaltyPurchaseAgreementsDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#RoyaltyPurchaseAgreementsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/RoyaltyPurchaseAgreementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:href="dare-20260331.xsd#dare_CommitmentsAndContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CommitmentsAndContingenciesTable_019cfceb-18db-7745-a4cf-a60a87195f33" xlink:href="dare-20260331.xsd#dare_CommitmentsAndContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_CommitmentsAndContingenciesTable_019cfceb-18db-7745-a4cf-a60a87195f33" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cfceb-18db-7fdd-8717-d099d50aca14" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019cfceb-18db-7745-a4cf-a60a87195f33" xlink:to="loc_srt_CounterpartyNameAxis_019cfceb-18db-7fdd-8717-d099d50aca14" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-7fdd-8717-d099d50aca14_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cfceb-18db-7fdd-8717-d099d50aca14" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-7fdd-8717-d099d50aca14_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-79e0-b6de-b941475e652d" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cfceb-18db-7fdd-8717-d099d50aca14" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-79e0-b6de-b941475e652d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_XOMAUSLLCMember_019cfceb-18db-724a-a052-9c3ff12d06d7" xlink:href="dare-20260331.xsd#dare_XOMAUSLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-79e0-b6de-b941475e652d" xlink:to="loc_dare_XOMAUSLLCMember_019cfceb-18db-724a-a052-9c3ff12d06d7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_BayerHealthcareLLCMember_019cfceb-18db-7b1d-be48-3db259e1166b" xlink:href="dare-20260331.xsd#dare_BayerHealthcareLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cfceb-18db-79e0-b6de-b941475e652d" xlink:to="loc_dare_BayerHealthcareLLCMember_019cfceb-18db-7b1d-be48-3db259e1166b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019cfceb-18db-7238-97e5-e4c592a79c6e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019cfceb-18db-7745-a4cf-a60a87195f33" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019cfceb-18db-7238-97e5-e4c592a79c6e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cfceb-18db-7238-97e5-e4c592a79c6e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019cfceb-18db-7238-97e5-e4c592a79c6e" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cfceb-18db-7238-97e5-e4c592a79c6e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cfceb-18db-739e-b981-93e863c1bbe6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019cfceb-18db-7238-97e5-e4c592a79c6e" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cfceb-18db-739e-b981-93e863c1bbe6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyPurchaseAgreementMember_019cfceb-18db-7305-b5ce-6124f467cbe7" xlink:href="dare-20260331.xsd#dare_RoyaltyPurchaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cfceb-18db-739e-b981-93e863c1bbe6" xlink:to="loc_dare_RoyaltyPurchaseAgreementMember_019cfceb-18db-7305-b5ce-6124f467cbe7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cfceb-18db-7c8d-8799-059e6bfc91e2" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019cfceb-18db-7745-a4cf-a60a87195f33" xlink:to="loc_srt_ProductOrServiceAxis_019cfceb-18db-7c8d-8799-059e6bfc91e2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7c8d-8799-059e6bfc91e2_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cfceb-18db-7c8d-8799-059e6bfc91e2" xlink:to="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7c8d-8799-059e6bfc91e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cfceb-18db-743d-b8bc-87d8d6356ee5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cfceb-18db-7c8d-8799-059e6bfc91e2" xlink:to="loc_srt_ProductsAndServicesDomain_019cfceb-18db-743d-b8bc-87d8d6356ee5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_XACIATOMember_019cfceb-18db-779b-8cf1-85d82f3281c2" xlink:href="dare-20260331.xsd#dare_XACIATOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-743d-b8bc-87d8d6356ee5" xlink:to="loc_dare_XACIATOMember_019cfceb-18db-779b-8cf1-85d82f3281c2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OvapreneMember_019cfceb-18db-7923-bc72-a924d961e14c" xlink:href="dare-20260331.xsd#dare_OvapreneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-743d-b8bc-87d8d6356ee5" xlink:to="loc_dare_OvapreneMember_019cfceb-18db-7923-bc72-a924d961e14c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SildenafilCream2.0Member_019cfceb-18db-74b2-bf0d-a0c87a28e4ca" xlink:href="dare-20260331.xsd#dare_SildenafilCream2.0Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-743d-b8bc-87d8d6356ee5" xlink:to="loc_dare_SildenafilCream2.0Member_019cfceb-18db-74b2-bf0d-a0c87a28e4ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SildenafilCream3.6Member_019cfceb-18db-7573-98dd-95d73bfa72e9" xlink:href="dare-20260331.xsd#dare_SildenafilCream3.6Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-743d-b8bc-87d8d6356ee5" xlink:to="loc_dare_SildenafilCream3.6Member_019cfceb-18db-7573-98dd-95d73bfa72e9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SyntheticMember_019cfceb-18db-7905-875d-1a5eff7caa91" xlink:href="dare-20260331.xsd#dare_SyntheticMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-743d-b8bc-87d8d6356ee5" xlink:to="loc_dare_SyntheticMember_019cfceb-18db-7905-875d-1a5eff7caa91" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019cfceb-18db-7559-a12a-144d93aed2b6" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dare_CommitmentsAndContingenciesTable_019cfceb-18db-7745-a4cf-a60a87195f33" xlink:to="loc_srt_RangeAxis_019cfceb-18db-7559-a12a-144d93aed2b6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019cfceb-18db-7559-a12a-144d93aed2b6_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019cfceb-18db-7559-a12a-144d93aed2b6" xlink:to="loc_srt_RangeMember_019cfceb-18db-7559-a12a-144d93aed2b6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019cfceb-18db-77f6-8838-b37ee3c7972b" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019cfceb-18db-7559-a12a-144d93aed2b6" xlink:to="loc_srt_RangeMember_019cfceb-18db-77f6-8838-b37ee3c7972b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019cfceb-18db-72a2-9372-fd95f8870d22" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019cfceb-18db-77f6-8838-b37ee3c7972b" xlink:to="loc_srt_MaximumMember_019cfceb-18db-72a2-9372-fd95f8870d22" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019cfceb-18db-7c31-8533-a3b1878bf8b4" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019cfceb-18db-77f6-8838-b37ee3c7972b" xlink:to="loc_srt_MinimumMember_019cfceb-18db-7c31-8533-a3b1878bf8b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_019cfceb-18db-79a8-a149-1897adc0eb95" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_019cfceb-18db-79a8-a149-1897adc0eb95" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMaximumRoyaltyPayments_019cfceb-18db-714f-a66d-a1a0d75837dc" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementMaximumRoyaltyPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementMaximumRoyaltyPayments_019cfceb-18db-714f-a66d-a1a0d75837dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementContingentPurchasePricePayments_019cfceb-18db-7541-b349-e985af793336" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementContingentPurchasePricePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementContingentPurchasePricePayments_019cfceb-18db-7541-b349-e985af793336" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementRevenueTierThresholdIncrementalAmount_019cfceb-18db-7cb7-a29f-34b89fb05ec5" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementRevenueTierThresholdIncrementalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementRevenueTierThresholdIncrementalAmount_019cfceb-18db-7cb7-a29f-34b89fb05ec5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019cfceb-18db-7038-9b1c-2549db294df2" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementMilestonePaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementMilestonePaymentsPercentage_019cfceb-18db-7038-9b1c-2549db294df2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMilestonePaymentsSalesBasedPotentialFutureMilestones_019cfceb-18db-7d27-8212-a2feb300e8a2" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementMilestonePaymentsSalesBasedPotentialFutureMilestones"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementMilestonePaymentsSalesBasedPotentialFutureMilestones_019cfceb-18db-7d27-8212-a2feb300e8a2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementMaximumPotentialMilestonePayments_019cfceb-18db-7139-97dc-4ed2135b681d" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementMaximumPotentialMilestonePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementMaximumPotentialMilestonePayments_019cfceb-18db-7139-97dc-4ed2135b681d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019cfceb-18db-79ad-9105-37b5eebab137" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementNetRoyaltyPaymentsPercentage_019cfceb-18db-79ad-9105-37b5eebab137" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyAgreementFutureNetSalesPercentage_019cfceb-18db-76f0-90d5-f79f0853e559" xlink:href="dare-20260331.xsd#dare_RoyaltyAgreementFutureNetSalesPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyAgreementFutureNetSalesPercentage_019cfceb-18db-76f0-90d5-f79f0853e559" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RoyaltyRatePercentage_019cfceb-18db-73ec-80a2-fd4035120a40" xlink:href="dare-20260331.xsd#dare_RoyaltyRatePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_RoyaltyRatePercentage_019cfceb-18db-73ec-80a2-fd4035120a40" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromSaleOfRoyaltyAndMilestoneRights_019cfceb-18db-74ba-b20f-cd0695096b74" xlink:href="dare-20260331.xsd#dare_ProceedsFromSaleOfRoyaltyAndMilestoneRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_ProceedsFromSaleOfRoyaltyAndMilestoneRights_019cfceb-18db-74ba-b20f-cd0695096b74" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SaleOfRoyaltyAndMilestoneRightsNetOfTransactionCosts_019cfceb-18db-7626-afec-1c1c2d7f5d52" xlink:href="dare-20260331.xsd#dare_SaleOfRoyaltyAndMilestoneRightsNetOfTransactionCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_CommitmentsAndContingenciesLineItems_019cfceb-18db-7ff0-9018-772417dc2074" xlink:to="loc_dare_SaleOfRoyaltyAndMilestoneRightsNetOfTransactionCosts_019cfceb-18db-7626-afec-1c1c2d7f5d52" xlink:type="arc" order="11"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/GrantAwardsDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#GrantAwardsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/GrantAwardsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019cfceb-18db-7491-957b-867734c453c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019cfceb-18db-7491-957b-867734c453c4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019dae35-d212-735a-82cf-b1bd4511dd8e" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019cfceb-18db-7491-957b-867734c453c4" xlink:to="loc_srt_CounterpartyNameAxis_019dae35-d212-735a-82cf-b1bd4511dd8e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dae35-d212-735a-82cf-b1bd4511dd8e_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019dae35-d212-735a-82cf-b1bd4511dd8e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dae35-d212-735a-82cf-b1bd4511dd8e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dae35-d212-720a-9656-a5c2bdec854c" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019dae35-d212-735a-82cf-b1bd4511dd8e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dae35-d212-720a-9656-a5c2bdec854c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember_019dae35-d212-7c38-a649-2c2b3d55cb61" xlink:href="dare-20260331.xsd#dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dae35-d212-720a-9656-a5c2bdec854c" xlink:to="loc_dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember_019dae35-d212-7c38-a649-2c2b3d55cb61" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FoundationMember_019dae35-f4ae-7751-902e-e6fbed6babb9" xlink:href="dare-20260331.xsd#dare_FoundationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019dae35-d212-720a-9656-a5c2bdec854c" xlink:to="loc_dare_FoundationMember_019dae35-f4ae-7751-902e-e6fbed6babb9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019dae35-d212-7b40-a4c2-1c1a479066fd" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019cfceb-18db-7491-957b-867734c453c4" xlink:to="loc_srt_ProductOrServiceAxis_019dae35-d212-7b40-a4c2-1c1a479066fd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019dae35-d212-7b40-a4c2-1c1a479066fd_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019dae35-d212-7b40-a4c2-1c1a479066fd" xlink:to="loc_srt_ProductsAndServicesDomain_019dae35-d212-7b40-a4c2-1c1a479066fd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019dae35-d212-73e7-867b-0ba74b07bbb0" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019dae35-d212-7b40-a4c2-1c1a479066fd" xlink:to="loc_srt_ProductsAndServicesDomain_019dae35-d212-73e7-867b-0ba74b07bbb0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_FederalSubawardMember_019dae35-d212-73bc-95ad-64597f195180" xlink:href="dare-20260331.xsd#dare_FederalSubawardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019dae35-d212-73e7-867b-0ba74b07bbb0" xlink:to="loc_dare_FederalSubawardMember_019dae35-d212-73bc-95ad-64597f195180" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DAREHPVMember_019dae35-f4ae-77a0-9690-53ee527d4191" xlink:href="dare-20260331.xsd#dare_DAREHPVMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019dae35-d212-73e7-867b-0ba74b07bbb0" xlink:to="loc_dare_DAREHPVMember_019dae35-f4ae-77a0-9690-53ee527d4191" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_GrantDAREPTB1Member_019dae35-f4ae-7fee-9585-81c5feec75b0" xlink:href="dare-20260331.xsd#dare_GrantDAREPTB1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019dae35-d212-73e7-867b-0ba74b07bbb0" xlink:to="loc_dare_GrantDAREPTB1Member_019dae35-f4ae-7fee-9585-81c5feec75b0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraceptiveProductGrantAgreementMember_019dae35-f4ae-7de2-a581-0b9d76b35def" xlink:href="dare-20260331.xsd#dare_ContraceptiveProductGrantAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019dae35-d212-73e7-867b-0ba74b07bbb0" xlink:to="loc_dare_ContraceptiveProductGrantAgreementMember_019dae35-f4ae-7de2-a581-0b9d76b35def" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DARELARC1Member_019dae36-1508-74ae-8348-4d1d909e362c" xlink:href="dare-20260331.xsd#dare_DARELARC1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019dae35-d212-73e7-867b-0ba74b07bbb0" xlink:to="loc_dare_DARELARC1Member_019dae36-1508-74ae-8348-4d1d909e362c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019dae35-f4ae-74f1-98bc-ebc3a475afd4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019cfceb-18db-7491-957b-867734c453c4" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019dae35-f4ae-74f1-98bc-ebc3a475afd4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dae35-f4ae-74f1-98bc-ebc3a475afd4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019dae35-f4ae-74f1-98bc-ebc3a475afd4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dae35-f4ae-74f1-98bc-ebc3a475afd4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dae35-f4ae-786d-aae9-735162f9a29d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019dae35-f4ae-74f1-98bc-ebc3a475afd4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dae35-f4ae-786d-aae9-735162f9a29d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PhaseIISegmentMember_019dae35-f4ae-7cc1-9544-56c4a12ad528" xlink:href="dare-20260331.xsd#dare_PhaseIISegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019dae35-f4ae-786d-aae9-735162f9a29d" xlink:to="loc_dare_PhaseIISegmentMember_019dae35-f4ae-7cc1-9544-56c4a12ad528" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019dae35-f4ae-79ca-a7b9-2316a17ea5d1" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_019cfceb-18db-7491-957b-867734c453c4" xlink:to="loc_srt_RangeAxis_019dae35-f4ae-79ca-a7b9-2316a17ea5d1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019dae35-f4ae-79ca-a7b9-2316a17ea5d1_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019dae35-f4ae-79ca-a7b9-2316a17ea5d1" xlink:to="loc_srt_RangeMember_019dae35-f4ae-79ca-a7b9-2316a17ea5d1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019dae35-f4ae-7e77-b838-66d6acc0afa5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019dae35-f4ae-79ca-a7b9-2316a17ea5d1" xlink:to="loc_srt_RangeMember_019dae35-f4ae-7e77-b838-66d6acc0afa5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019dae35-f4ae-7e4c-b97b-b4f5dbcd0c99" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019dae35-f4ae-7e77-b838-66d6acc0afa5" xlink:to="loc_srt_MinimumMember_019dae35-f4ae-7e4c-b97b-b4f5dbcd0c99" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019dae35-f4ae-7b13-9c6b-d573d6b5078d" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019dae35-f4ae-7e77-b838-66d6acc0afa5" xlink:to="loc_srt_MaximumMember_019dae35-f4ae-7b13-9c6b-d573d6b5078d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromAwardOfGrants_019dae35-d212-73b3-bdee-585659468d49" xlink:href="dare-20260331.xsd#dare_ProceedsFromAwardOfGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_dare_ProceedsFromAwardOfGrants_019dae35-d212-73b3-bdee-585659468d49" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentArrangementPerformancePeriod_019dae35-d212-75c2-a0e1-f7354bf1f2b5" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentArrangementPerformancePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_dare_ResearchAndDevelopmentArrangementPerformancePeriod_019dae35-d212-75c2-a0e1-f7354bf1f2b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurredForGeneralAndAdministrativeExpensesPercentage_019dae35-d212-748e-b93e-4803dda359ed" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurredForGeneralAndAdministrativeExpensesPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_dare_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurredForGeneralAndAdministrativeExpensesPercentage_019dae35-d212-748e-b93e-4803dda359ed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromResearchAndDevelopmentArrangementWithFederalGovernment_019dae35-d212-79a1-b0e6-8ef626fe75d0" xlink:href="dare-20260331.xsd#dare_ProceedsFromResearchAndDevelopmentArrangementWithFederalGovernment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_dare_ProceedsFromResearchAndDevelopmentArrangementWithFederalGovernment_019dae35-d212-79a1-b0e6-8ef626fe75d0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurred_019dae35-d212-7edb-a686-3ac0e8ff5457" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementWithFederalGovernmentCustomerFundingToOffsetCostsIncurred_019dae35-d212-7edb-a686-3ac0e8ff5457" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ReceivableForExpensesEligibleForReimbursement_019e03ea-3a3c-7246-bf93-bbf33699776f" xlink:href="dare-20260331.xsd#dare_ReceivableForExpensesEligibleForReimbursement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_dare_ReceivableForExpensesEligibleForReimbursement_019e03ea-3a3c-7246-bf93-bbf33699776f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DeferredGrantFundingCurrent_019dae35-d212-7403-87aa-22cf77a5512e" xlink:href="dare-20260331.xsd#dare_DeferredGrantFundingCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_dare_DeferredGrantFundingCurrent_019dae35-d212-7403-87aa-22cf77a5512e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NonDilutiveGrantFundingPercentageExcluded_019dae35-f4ae-7aad-bfea-06935118fd03" xlink:href="dare-20260331.xsd#dare_NonDilutiveGrantFundingPercentageExcluded"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_dare_NonDilutiveGrantFundingPercentageExcluded_019dae35-f4ae-7aad-bfea-06935118fd03" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantsReceivable_019dae35-f4ae-72ff-800b-ef13aea6d1de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrantsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_us-gaap_GrantsReceivable_019dae35-f4ae-72ff-800b-ef13aea6d1de" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019dae36-1508-79a3-b376-978c48931da5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_019dae35-d212-7458-8cf2-c85d85b6abe6" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019dae36-1508-79a3-b376-978c48931da5" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/NetLossPerShareDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#NetLossPerShareDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/NetLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019cfceb-18db-7193-b1a5-d4af262dbabb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019cfceb-18db-7fac-a1bb-06ad407b0aed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019cfceb-18db-7193-b1a5-d4af262dbabb" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019cfceb-18db-7fac-a1bb-06ad407b0aed" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019cfceb-18db-7692-b0e0-f71353227b51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019cfceb-18db-7fac-a1bb-06ad407b0aed" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019cfceb-18db-7692-b0e0-f71353227b51" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7692-b0e0-f71353227b51_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019cfceb-18db-7692-b0e0-f71353227b51" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7692-b0e0-f71353227b51_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7f3e-aff8-67ecf02e8705" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019cfceb-18db-7692-b0e0-f71353227b51" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7f3e-aff8-67ecf02e8705" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_StockOptionsMember_019dae3a-327c-77d4-9ccd-8711bdb0e535" xlink:href="dare-20260331.xsd#dare_StockOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7f3e-aff8-67ecf02e8705" xlink:to="loc_dare_StockOptionsMember_019dae3a-327c-77d4-9ccd-8711bdb0e535" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019dae3a-a75e-7e54-b9aa-8360d1819272" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7f3e-aff8-67ecf02e8705" xlink:to="loc_us-gaap_CommonStockMember_019dae3a-a75e-7e54-b9aa-8360d1819272" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockMember_019dae3b-005b-75ca-a5ba-2c41fbceaece" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7f3e-aff8-67ecf02e8705" xlink:to="loc_us-gaap_PreferredStockMember_019dae3b-005b-75ca-a5ba-2c41fbceaece" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SellingAgentUnitWarrantsMember_019dae3b-735a-7052-937e-bb9741e13345" xlink:href="dare-20260331.xsd#dare_SellingAgentUnitWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019cfceb-18db-7f3e-aff8-67ecf02e8705" xlink:to="loc_dare_SellingAgentUnitWarrantsMember_019dae3b-735a-7052-937e-bb9741e13345" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019cfceb-18db-72cf-a84b-83fbdf43c2ba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019cfceb-18db-7193-b1a5-d4af262dbabb" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019cfceb-18db-72cf-a84b-83fbdf43c2ba" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/SegmentInformationDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#SegmentInformationDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/SegmentInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019cfceb-18db-758a-ba2d-8ae98f4a7a9c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019cfceb-18db-7a71-af23-750703bd9c63" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019cfceb-18db-758a-ba2d-8ae98f4a7a9c" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019cfceb-18db-7a71-af23-750703bd9c63" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019cfceb-18db-7688-b39a-0e80832844c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019cfceb-18db-7a71-af23-750703bd9c63" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019cfceb-18db-7688-b39a-0e80832844c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019cfceb-18db-7688-b39a-0e80832844c3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019cfceb-18db-7688-b39a-0e80832844c3" xlink:to="loc_us-gaap_SegmentDomain_019cfceb-18db-7688-b39a-0e80832844c3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019cfceb-18db-7747-9aec-90969b927878" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019cfceb-18db-7688-b39a-0e80832844c3" xlink:to="loc_us-gaap_SegmentDomain_019cfceb-18db-7747-9aec-90969b927878" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ReportableSegmentMember_019cfceb-18db-76df-a587-a2f1c492b7e0" xlink:href="dare-20260331.xsd#dare_ReportableSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019cfceb-18db-7747-9aec-90969b927878" xlink:to="loc_dare_ReportableSegmentMember_019cfceb-18db-76df-a587-a2f1c492b7e0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cfceb-18db-73f3-a48f-91f58b66db7e" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019cfceb-18db-7a71-af23-750703bd9c63" xlink:to="loc_srt_ProductOrServiceAxis_019cfceb-18db-73f3-a48f-91f58b66db7e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cfceb-18db-73f3-a48f-91f58b66db7e_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cfceb-18db-73f3-a48f-91f58b66db7e" xlink:to="loc_srt_ProductsAndServicesDomain_019cfceb-18db-73f3-a48f-91f58b66db7e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cfceb-18db-73f3-a48f-91f58b66db7e" xlink:to="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_019cfceb-18db-77d3-b8aa-d7d54643d9ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_us-gaap_RoyaltyMember_019cfceb-18db-77d3-b8aa-d7d54643d9ce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OvapreneMember_019cfceb-18db-7b83-87a4-93ae9bfb33f0" xlink:href="dare-20260331.xsd#dare_OvapreneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_dare_OvapreneMember_019cfceb-18db-7b83-87a4-93ae9bfb33f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_SildenafilCream3.6Member_019cfceb-18db-794f-9456-836c7293aaac" xlink:href="dare-20260331.xsd#dare_SildenafilCream3.6Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_dare_SildenafilCream3.6Member_019cfceb-18db-794f-9456-836c7293aaac" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OtherAdvancedClinicalStageProgramsMember_019cfceb-18db-783b-bf69-46ea9e20c2c6" xlink:href="dare-20260331.xsd#dare_OtherAdvancedClinicalStageProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_dare_OtherAdvancedClinicalStageProgramsMember_019cfceb-18db-783b-bf69-46ea9e20c2c6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_Phase1AndPhase1ReadyClinicalStageProgramsMember_019cfceb-18db-7e17-af8e-33f9199e0d92" xlink:href="dare-20260331.xsd#dare_Phase1AndPhase1ReadyClinicalStageProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_dare_Phase1AndPhase1ReadyClinicalStageProgramsMember_019cfceb-18db-7e17-af8e-33f9199e0d92" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PreclinicalStageProgramsMember_019cfceb-18db-7c94-a98e-34d08c4bc690" xlink:href="dare-20260331.xsd#dare_PreclinicalStageProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_dare_PreclinicalStageProgramsMember_019cfceb-18db-7c94-a98e-34d08c4bc690" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_PersonnelRelatedIncludingStockBasedCompensationMember_019cfceb-18db-7e96-bd76-81e179d09fd9" xlink:href="dare-20260331.xsd#dare_PersonnelRelatedIncludingStockBasedCompensationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_dare_PersonnelRelatedIncludingStockBasedCompensationMember_019cfceb-18db-7e96-bd76-81e179d09fd9" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_OtherIndirectCostsMember_019cfceb-18db-7c44-ae3c-1f2c7b0d87f3" xlink:href="dare-20260331.xsd#dare_OtherIndirectCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cfceb-18db-7a5b-a5d7-29c95350bf49" xlink:to="loc_dare_OtherIndirectCostsMember_019cfceb-18db-7c44-ae3c-1f2c7b0d87f3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019cfceb-18db-7a67-918e-1c8f7086b9cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019cfceb-18db-758a-ba2d-8ae98f4a7a9c" xlink:to="loc_us-gaap_RevenuesAbstract_019cfceb-18db-7a67-918e-1c8f7086b9cb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cfceb-18db-7755-80e9-ec86f1bcf744" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019cfceb-18db-7a67-918e-1c8f7086b9cb" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cfceb-18db-7755-80e9-ec86f1bcf744" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019dd864-d07c-7279-b3ec-268c4a84bcc4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019cfceb-18db-7a67-918e-1c8f7086b9cb" xlink:to="loc_us-gaap_CostOfRevenue_019dd864-d07c-7279-b3ec-268c4a84bcc4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019cfceb-18db-758a-ba2d-8ae98f4a7a9c" xlink:to="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019cfceb-18db-7dc6-b50f-569b8db4c6e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019cfceb-18db-7dc6-b50f-569b8db4c6e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019cfceb-18db-74b9-95da-52ecd9f30b07" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentDirectProgramCostsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019cfceb-18db-7dc6-b50f-569b8db4c6e9" xlink:to="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019cfceb-18db-74b9-95da-52ecd9f30b07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCosts_019cfceb-18db-7f33-bb65-bd3f4de63df3" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentExpenseDirectProgramCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019cfceb-18db-74b9-95da-52ecd9f30b07" xlink:to="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCosts_019cfceb-18db-7f33-bb65-bd3f4de63df3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts_019cfceb-18db-7a69-8776-c4231ecb0263" xlink:href="dare-20260331.xsd#dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019cfceb-18db-74b9-95da-52ecd9f30b07" xlink:to="loc_dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts_019cfceb-18db-7a69-8776-c4231ecb0263" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCostsNet_019cfceb-18db-72a8-af98-313fafc78ffd" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentExpenseDirectProgramCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentDirectProgramCostsAbstract_019cfceb-18db-74b9-95da-52ecd9f30b07" xlink:to="loc_dare_ResearchAndDevelopmentExpenseDirectProgramCostsNet_019cfceb-18db-72a8-af98-313fafc78ffd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019cfceb-18db-7175-bd39-6c874b2f8cae" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentIndirectCostsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019cfceb-18db-7dc6-b50f-569b8db4c6e9" xlink:to="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019cfceb-18db-7175-bd39-6c874b2f8cae" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseIndirectCosts_019cfceb-18db-75e5-8d0b-cdb6ea4d8125" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentExpenseIndirectCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019cfceb-18db-7175-bd39-6c874b2f8cae" xlink:to="loc_dare_ResearchAndDevelopmentExpenseIndirectCosts_019cfceb-18db-75e5-8d0b-cdb6ea4d8125" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraResearchAndDevelopmentExpenseIndirectCosts_019cfceb-18db-7a70-b760-63cdbf1ffbd6" xlink:href="dare-20260331.xsd#dare_ContraResearchAndDevelopmentExpenseIndirectCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019cfceb-18db-7175-bd39-6c874b2f8cae" xlink:to="loc_dare_ContraResearchAndDevelopmentExpenseIndirectCosts_019cfceb-18db-7a70-b760-63cdbf1ffbd6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ResearchAndDevelopmentExpenseIndirectCostsNet_019cfceb-18db-7b9b-a8e6-caa7d2383790" xlink:href="dare-20260331.xsd#dare_ResearchAndDevelopmentExpenseIndirectCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dare_ResearchAndDevelopmentIndirectCostsAbstract_019cfceb-18db-7175-bd39-6c874b2f8cae" xlink:to="loc_dare_ResearchAndDevelopmentExpenseIndirectCostsNet_019cfceb-18db-7b9b-a8e6-caa7d2383790" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e06b6-c56a-704a-a9da-d5b600763aa1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019cfceb-18db-7dc6-b50f-569b8db4c6e9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e06b6-c56a-704a-a9da-d5b600763aa1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019dae92-6498-731c-9a56-a0993cfeb48b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019cfceb-18db-7dc6-b50f-569b8db4c6e9" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019dae92-6498-731c-9a56-a0993cfeb48b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019cfceb-18db-72cf-a265-561ac57ed520" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_019cfceb-18db-7dc6-b50f-569b8db4c6e9" xlink:to="loc_us-gaap_OperatingExpenses_019cfceb-18db-72cf-a265-561ac57ed520" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019cfceb-18db-77db-82e2-0e380ef52546" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:to="loc_us-gaap_OperatingIncomeLoss_019cfceb-18db-77db-82e2-0e380ef52546" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019cfceb-18db-75e8-b421-5de388beece0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019cfceb-18db-75e8-b421-5de388beece0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019cfceb-18db-71ef-83e4-36d09dbef5bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019cfceb-18db-71ef-83e4-36d09dbef5bc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019cfceb-18db-73b0-8358-f15bcea77d45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019cfceb-18db-73b0-8358-f15bcea77d45" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019cfceb-18db-76a9-afdc-d7b8a330c61f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019cfceb-18db-7fd4-b48e-1a8fc8537f55" xlink:to="loc_us-gaap_NetIncomeLoss_019cfceb-18db-76a9-afdc-d7b8a330c61f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts_019e0409-9de7-7022-a2c6-5196458c1826" xlink:href="dare-20260331.xsd#dare_ContraResearchAndDevelopmentExpenseDirectProgramCosts"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://darebioscience.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="dare-20260331.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://darebioscience.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_019df6cc-abe0-7181-94ff-ea142d150559" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_019df6cc-abe0-7181-94ff-ea142d150559" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019df6cc-abe0-7181-94ff-ea142d150559_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019df6cc-abe0-7181-94ff-ea142d150559" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019df6cc-abe0-7181-94ff-ea142d150559_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_019df6cc-abe0-7046-8a80-8b32c8f48b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_019df6cc-abe0-7181-94ff-ea142d150559" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_019df6cc-abe0-7046-8a80-8b32c8f48b6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_019df6cc-abe0-7bf6-b465-cd6cde67edc5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_019df6cc-abe0-7046-8a80-8b32c8f48b6a" xlink:to="loc_us-gaap_SubsequentEventMember_019df6cc-abe0-7bf6-b465-cd6cde67edc5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019df6cc-abe0-7f32-ac1e-891420edcf7a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019df6cc-abe0-7f32-ac1e-891420edcf7a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df6cc-abe0-7f32-ac1e-891420edcf7a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019df6cc-abe0-7f32-ac1e-891420edcf7a" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df6cc-abe0-7f32-ac1e-891420edcf7a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df6cc-abe0-7917-923a-247308a86a1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019df6cc-abe0-7f32-ac1e-891420edcf7a" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df6cc-abe0-7917-923a-247308a86a1e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_RegulationAOfferingMember_019df6cc-abe0-79fd-be4d-e9fe28ed502e" xlink:href="dare-20260331.xsd#dare_RegulationAOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019df6cc-abe0-7917-923a-247308a86a1e" xlink:to="loc_dare_RegulationAOfferingMember_019df6cc-abe0-79fd-be4d-e9fe28ed502e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019df6cc-abe0-7754-b756-cf9b83010871" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019df6cc-abe0-7754-b756-cf9b83010871" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019df6cc-abe0-7754-b756-cf9b83010871_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019df6cc-abe0-7754-b756-cf9b83010871" xlink:to="loc_us-gaap_ClassOfStockDomain_019df6cc-abe0-7754-b756-cf9b83010871_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019df6cc-abe0-7437-be8d-8c6544d0a3b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019df6cc-abe0-7754-b756-cf9b83010871" xlink:to="loc_us-gaap_ClassOfStockDomain_019df6cc-abe0-7437-be8d-8c6544d0a3b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_019df6cc-abe0-78ed-a7a9-3e9b66574ad6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019df6cc-abe0-7437-be8d-8c6544d0a3b1" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_019df6cc-abe0-78ed-a7a9-3e9b66574ad6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019df6cc-abe0-7e7f-9567-353be3d6b78c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019df6cc-abe0-7e7f-9567-353be3d6b78c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019df6cc-abe0-7e7f-9567-353be3d6b78c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019df6cc-abe0-7e7f-9567-353be3d6b78c" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019df6cc-abe0-7e7f-9567-353be3d6b78c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019df6cc-abe0-7acf-8dfa-84edab9888a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019df6cc-abe0-7e7f-9567-353be3d6b78c" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019df6cc-abe0-7acf-8dfa-84edab9888a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_AgentUnitWarrantsMember_019df6cc-abe0-7d07-b005-a784bc1b8918" xlink:href="dare-20260331.xsd#dare_AgentUnitWarrantsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019df6cc-abe0-7acf-8dfa-84edab9888a7" xlink:to="loc_dare_AgentUnitWarrantsMember_019df6cc-abe0-7d07-b005-a784bc1b8918" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019df6cd-1168-7214-9d91-91f37da23ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019df6cd-1168-7214-9d91-91f37da23ffc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019df6cd-1168-7214-9d91-91f37da23ffc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019df6cd-1168-7214-9d91-91f37da23ffc" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019df6cd-1168-7214-9d91-91f37da23ffc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019df6cd-1168-798d-9fcf-d876c8b1c021" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019df6cd-1168-7214-9d91-91f37da23ffc" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019df6cd-1168-798d-9fcf-d876c8b1c021" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_DAREHPVMember_019df6cd-388e-7148-b6a0-b62efea38775" xlink:href="dare-20260331.xsd#dare_DAREHPVMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019df6cd-1168-798d-9fcf-d876c8b1c021" xlink:to="loc_dare_DAREHPVMember_019df6cd-388e-7148-b6a0-b62efea38775" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019df6cd-388e-73ce-977b-ec9e8bf50e39" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_019cfceb-18db-73b0-966a-cda18796af4c" xlink:to="loc_srt_CounterpartyNameAxis_019df6cd-388e-73ce-977b-ec9e8bf50e39" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df6cd-388e-73ce-977b-ec9e8bf50e39_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019df6cd-388e-73ce-977b-ec9e8bf50e39" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df6cd-388e-73ce-977b-ec9e8bf50e39_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df6cd-388e-7f0f-93e4-dd1b74e34d4f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019df6cd-388e-73ce-977b-ec9e8bf50e39" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df6cd-388e-7f0f-93e4-dd1b74e34d4f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember_019df6cd-388e-7e3f-9896-e8b763b5deb7" xlink:href="dare-20260331.xsd#dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019df6cd-388e-7f0f-93e4-dd1b74e34d4f" xlink:to="loc_dare_NationalCollegiateInventorsAndInnovatorsAllianceInc.DbaVentureWellMember_019df6cd-388e-7e3f-9896-e8b763b5deb7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019df6cc-abe0-74e2-91d2-ec9c2f17db2c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019df6cc-abe0-74e2-91d2-ec9c2f17db2c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019df6cc-abe0-7bb8-abd5-548a2a29ed53" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_019df6cc-abe0-7bb8-abd5-548a2a29ed53" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019df6cc-abe0-746b-838f-c336025fdef7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019df6cc-abe0-746b-838f-c336025fdef7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockSharesConverted1_019df6cd-1168-7590-8bb8-407f3a94de3f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConversionOfStockSharesConverted1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_ConversionOfStockSharesConverted1_019df6cd-1168-7590-8bb8-407f3a94de3f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockSharesIssued1_019df6cd-1168-7835-84e0-b2dca1d95288" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConversionOfStockSharesIssued1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_ConversionOfStockSharesIssued1_019df6cd-1168-7835-84e0-b2dca1d95288" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019e03aa-af5d-7506-8417-ce13c34f25ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019e03aa-af5d-7506-8417-ce13c34f25ec" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_019e03c6-e2e7-7a59-b279-17b35c9efcf0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_019e03c6-e2e7-7a59-b279-17b35c9efcf0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_019df6cd-1168-7e01-a58d-a9ef640a113a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_019df6cd-1168-7e01-a58d-a9ef640a113a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_ProceedsFromAwardOfGrants_019df6cd-388e-746f-a146-eee5507f4c19" xlink:href="dare-20260331.xsd#dare_ProceedsFromAwardOfGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_dare_ProceedsFromAwardOfGrants_019df6cd-388e-746f-a146-eee5507f4c19" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_CumulativeTotalReceivedFromGrants_019df6cd-388e-71af-ba43-447ecddebd2b" xlink:href="dare-20260331.xsd#dare_CumulativeTotalReceivedFromGrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_dare_CumulativeTotalReceivedFromGrants_019df6cd-388e-71af-ba43-447ecddebd2b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dare_MaximumPotentialMilestonePayments_019df6cd-1168-7dc6-a1aa-ece54306eb9c" xlink:href="dare-20260331.xsd#dare_MaximumPotentialMilestonePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_019df6cc-abe0-7596-a1e3-0baec08027de" xlink:to="loc_dare_MaximumPotentialMilestonePayments_019df6cd-1168-7dc6-a1aa-ece54306eb9c" xlink:type="arc" order="10"/>
  </link:definitionLink>
</link:linkbase>
