3.26.1 html 166 290 1 true 66 0 false 5 false false R1.htm 75000 - Document - Document and Entity Information Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DocumentDocumentAndEntityInformation Document and Entity Information Cover 1 false false R2.htm 75010 - Statement - Condensed Consolidated Balance Sheets (Unaudited) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/StatementCondensedConsolidatedBalanceSheetsUnaudited Condensed Consolidated Balance Sheets (Unaudited) Statements 2 false false R3.htm 75020 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/StatementCondensedConsolidatedBalanceSheetsParentheticalUnaudited Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited) Statements 3 false false R4.htm 75030 - Statement - Condensed Consolidated Statements of Operations (Unaudited) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/StatementCondensedConsolidatedStatementsOfOperationsUnaudited Condensed Consolidated Statements of Operations (Unaudited) Statements 4 false false R5.htm 75040 - Statement - Condensed Consolidated Statements of Shareholders' Equity (Unaudited) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/StatementCondensedConsolidatedStatementsOfShareholdersEquityUnaudited Condensed Consolidated Statements of Shareholders' Equity (Unaudited) Statements 5 false false R6.htm 75050 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/StatementCondensedConsolidatedStatementsOfCashFlowsUnaudited Condensed Consolidated Statements of Cash Flows (Unaudited) Statements 6 false false R7.htm 995410 - Disclosure - Pay vs Performance Disclosure Sheet http://xbrl.sec.gov/ecd/role/PvpDisclosure Pay vs Performance Disclosure Notes 7 false false R8.htm 995445 - Disclosure - Insider Trading Arrangements Sheet http://xbrl.sec.gov/ecd/role/InsiderTradingArrangements Insider Trading Arrangements Notes 8 false false R9.htm 995455 - Disclosure - Organization and Basis of Presentation Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureOrganizationAndBasisOfPresentation Organization and Basis of Presentation Notes 9 false false R10.htm 995465 - Disclosure - Summary of Significant Accounting Policies Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPolicies Summary of Significant Accounting Policies Notes 10 false false R11.htm 995475 - Disclosure - Fair Value Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureFairValue Fair Value Notes 11 false false R12.htm 995495 - Disclosure - Property and Equipment, Net Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosurePropertyAndEquipmentNet1 Property and Equipment, Net Notes 12 false false R13.htm 995505 - Disclosure - Equity Method Investment Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureEquityMethodInvestment Equity Method Investment Notes 13 false false R14.htm 995515 - Disclosure - Loan with First Citizens Bank (formerly with Silicon Valley Bank) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureLoanWithFirstCitizensBankFormerlyWithSiliconValleyBank Loan with First Citizens Bank (formerly with Silicon Valley Bank) Notes 14 false false R15.htm 995525 - Disclosure - Accrued Expenses Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureAccruedExpenses Accrued Expenses Notes 15 false false R16.htm 995535 - Disclosure - Einstein License Agreement Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureEinsteinLicenseAgreement Einstein License Agreement Notes 16 false false R17.htm 995545 - Disclosure - Stock-Based Compensation Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureStockbasedCompensation Stock-Based Compensation Notes 17 false false R18.htm 995555 - Disclosure - Warrants Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureWarrants Warrants Notes 18 false false R19.htm 995565 - Disclosure - Collaboration Revenue Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureCollaborationRevenue Collaboration Revenue Notes 19 false false R20.htm 995575 - Disclosure - Commitments and Contingencies Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureCommitmentsAndContingencies Commitments and Contingencies Notes 20 false false R21.htm 995585 - Disclosure - Leases Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureLeases Leases Notes 21 false false R22.htm 995595 - Disclosure - Subsequent Events Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSubsequentEvents Subsequent Events Notes 22 false false R23.htm 995605 - Disclosure - Summary of Significant Accounting Policies (Policies) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesPolicies Summary of Significant Accounting Policies (Policies) Policies http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPolicies 23 false false R24.htm 995615 - Disclosure - Summary of Significant Accounting Policies (Tables) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesTables Summary of Significant Accounting Policies (Tables) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPolicies 24 false false R25.htm 995625 - Disclosure - Fair Value (Tables) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureFairValueTables Fair Value (Tables) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureFairValue 25 false false R26.htm 995645 - Disclosure - Property and Equipment, Net (Tables) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosurePropertyAndEquipmentNetTables Property and Equipment, Net (Tables) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosurePropertyAndEquipmentNet1 26 false false R27.htm 995655 - Disclosure - Accrued Expenses (Tables) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureAccruedExpensesTables Accrued Expenses (Tables) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureAccruedExpenses 27 false false R28.htm 995665 - Disclosure - Stock-Based Compensation (Tables) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureStockbasedCompensationTables Stock-Based Compensation (Tables) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureStockbasedCompensation 28 false false R29.htm 995675 - Disclosure - Warrants (Table) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureWarrantsTable Warrants (Table) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureWarrants 29 false false R30.htm 995685 - Disclosure - Collaboration Revenue (Tables) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureCollaborationRevenueTables Collaboration Revenue (Tables) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureCollaborationRevenue 30 false false R31.htm 995695 - Disclosure - Leases (Tables) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureLeasesTables Leases (Tables) Tables http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureLeases 31 false false R32.htm 995705 - Disclosure - Organization and Basis of Presentation - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureOrganizationAndBasisOfPresentationAdditionalInformationDetails Organization and Basis of Presentation - Additional Information (Details) Details 32 false false R33.htm 995715 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesAdditionalInformationDetails Summary of Significant Accounting Policies - Additional Information (Details) Details 33 false false R34.htm 995725 - Disclosure - Summary of Significant Accounting Policies - Summary of Estimated Useful Lives of Assets (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesSummaryOfEstimatedUsefulLivesOfAssetsDetails Summary of Significant Accounting Policies - Summary of Estimated Useful Lives of Assets (Details) Details 34 false false R35.htm 995735 - Disclosure - Summary of Significant Accounting Policies - Schedule of Anti-dilutive Securities Excluded from Computation of Earnings Per Share (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSummaryOfSignificantAccountingPoliciesScheduleOfAntiDilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetails Summary of Significant Accounting Policies - Schedule of Anti-dilutive Securities Excluded from Computation of Earnings Per Share (Details) Details 35 false false R36.htm 995745 - Disclosure - Fair Value - Schedule of Fair Value Assets Measured on Recurring Basis (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureFairValueScheduleOfFairValueAssetsMeasuredOnRecurringBasisDetails Fair Value - Schedule of Fair Value Assets Measured on Recurring Basis (Details) Details 36 false false R37.htm 995755 - Disclosure - Fair Value - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureFairValueAdditionalInformationDetails Fair Value - Additional Information (Details) Details 37 false false R38.htm 995785 - Disclosure - Property and Equipment, Net - Summary of Property and Equipment (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosurePropertyAndEquipmentNetSummaryOfPropertyAndEquipmentDetails Property and Equipment, Net - Summary of Property and Equipment (Details) Details 38 false false R39.htm 995795 - Disclosure - Property and Equipment, Net - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosurePropertyAndEquipmentNetAdditionalInformationDetails Property and Equipment, Net - Additional Information (Details) Details 39 false false R40.htm 995805 - Disclosure - Property and Equipment, Net - Summary of Depriciation Expense (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosurePropertyAndEquipmentNetSummaryOfDepriciationExpenseDetails Property and Equipment, Net - Summary of Depriciation Expense (Details) Details 40 false false R41.htm 995815 - Disclosure - Loan with First Citizens Bank (formerly with Silicon Valley Bank) - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureLoanWithFirstCitizensBankFormerlyWithSiliconValleyBankAdditionalInformationDetails Loan with First Citizens Bank (formerly with Silicon Valley Bank) - Additional Information (Details) Details http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureLoanWithFirstCitizensBankFormerlyWithSiliconValleyBank 41 false false R42.htm 995845 - Disclosure - Equity Method Investment (Additional Information) (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureEquityMethodInvestmentAdditionalInformationDetails Equity Method Investment (Additional Information) (Details) Details http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureEquityMethodInvestment 42 false false R43.htm 995855 - Disclosure - Accrued Expenses - Summary of Accrued Expenses (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureAccruedExpensesSummaryOfAccruedExpensesDetails Accrued Expenses - Summary of Accrued Expenses (Details) Details 43 false false R44.htm 995865 - Disclosure - Einstein License Agreement (Additional Information) (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureEinsteinLicenseAgreementAdditionalInformationDetails Einstein License Agreement (Additional Information) (Details) Details http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureEinsteinLicenseAgreement 44 false false R45.htm 995875 - Disclosure - Stock Based Compensation - Schedule of Estimated Fair Value of Each Stock Option Award (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureStockBasedCompensationScheduleOfEstimatedFairValueOfEachStockOptionAwardDetails Stock Based Compensation - Schedule of Estimated Fair Value of Each Stock Option Award (Details) Details 45 false false R46.htm 995885 - Disclosure - Stock Based Compensation - Summary of Stock Option Activity (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureStockBasedCompensationSummaryOfStockOptionActivityDetails Stock Based Compensation - Summary of Stock Option Activity (Details) Details 46 false false R47.htm 995895 - Disclosure - Stock Based Compensation - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureStockBasedCompensationAdditionalInformationDetails Stock Based Compensation - Additional Information (Details) Details 47 false false R48.htm 995905 - Disclosure - Stock Based Compensation - Schedule of Stock-Based Compensation Included in Statement of Operations (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureStockBasedCompensationScheduleOfStockBasedCompensationIncludedInStatementOfOperationsDetails Stock Based Compensation - Schedule of Stock-Based Compensation Included in Statement of Operations (Details) Details 48 false false R49.htm 995915 - Disclosure - Warrants - Schedule of Number of Warrants Outstanding (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureWarrantsScheduleOfNumberOfWarrantsOutstandingDetails Warrants - Schedule of Number of Warrants Outstanding (Details) Details 49 false false R50.htm 995925 - Disclosure - Warrants - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureWarrantsAdditionalInformationDetails Warrants - Additional Information (Details) Details 50 false false R51.htm 995935 - Disclosure - Collaboration Revenue - Schedule of Collaboration revenue (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureCollaborationRevenueScheduleOfCollaborationRevenueDetails Collaboration Revenue - Schedule of Collaboration revenue (Details) Details 51 false false R52.htm 995945 - Disclosure - Collaboration Revenue - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureCollaborationRevenueAdditionalInformationDetails Collaboration Revenue - Additional Information (Details) Details 52 false false R53.htm 995965 - Disclosure - Commitments and Contingencies - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureCommitmentsAndContingenciesAdditionalInformationDetails Commitments and Contingencies - Additional Information (Details) Details 53 false false R54.htm 995975 - Disclosure - Leases - Additional Information (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureLeasesAdditionalInformationDetails Leases - Additional Information (Details) Details 54 false false R55.htm 995985 - Disclosure - Leases - Schedule of Future Minimum Lease Payments on Operating Leases (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureLeasesScheduleOfFutureMinimumLeasePaymentsOnOperatingLeasesDetails Leases - Schedule of Future Minimum Lease Payments on Operating Leases (Details) Details 55 false false R56.htm 996015 - Disclosure - Leases - Schedule of Other Information of Operating Leases (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureLeasesScheduleOfOtherInformationOfOperatingLeasesDetails Leases - Schedule of Other Information of Operating Leases (Details) Details 56 false false R57.htm 996025 - Disclosure - Subsequent Events (Additional Information) (Details) Sheet http://www.cuebiopharma.com/20260331/taxonomy/role/DisclosureSubsequentEventsAdditionalInformationDetails Subsequent Events (Additional Information) (Details) Details http://www.cuebiopharma.com/20260331/taxonomy/role/Role_DisclosureSubsequentEvents 57 false false All Reports Book All Reports cue-20260331.htm cue-20260331.xsd http://fasb.org/us-gaap/2025 http://xbrl.sec.gov/dei/2025 http://xbrl.sec.gov/ecd/2025 false false