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Short-Term Investments, Total Short-Term Investments Short-term investments Total operating expenses Operating Expenses Research and Development Expense, Total Research and development Research and Development Expense Convertible Preferred Stock [Member] Convertible Preferred Stock [Member] Temporary equity earnings per basic. Basic earnings per share, of Series X and Series X1 non-voting convertible preferred stock, basic Basic net income (loss) per Net loss per share, basic Other Supplemental Cash Flow Information Related to Leases [Table Text Block] Other supplemental cash flow information related to leases. Schedule of Other Supplemental Cash Flow Information Related to Leases Statement of Cash Flows [Abstract] January Two Thousand And Twenty One Pre-funded Warrants [Member] January Two Thousand And Twenty One Pre-funded Warrants Member. January 2021 Pre-funded Warrants [Member] Working capital. Working Capital Working capital Working capital Stock Issued During Period, Value, New Issues Issuance of common stock in connection with 2023 Securities Purchase Agreement in Second and Third Closing, net of issuance costs Table Text Block Supplement [Abstract] Common Stock Warrants [Member] Common Stock Warrants [Member] Common stock warrants. Earnings Per Share [Text Block] Net Loss Per Share Net loss and comprehensive loss Net loss Net loss Operating lease cost Operating Lease, Cost Convertible preferred stock Preferred Stock, Convertible, Shares Issuable Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Proceeds from issuance of net of offering costs. Proceeds From Issuance Of Net Of Offering Costs Net proceeds after deducting offering costs Purchase Obligation Non-cancelable purchase obligations related to manufacturing Purchase Obligation, Total Operating Lease, Payments Operating cash flows from operating leases ASSETS Assets [Abstract] Risk-free interest rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Increase (Decrease) in Prepaid Expense and Other Assets, Total Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Document Fiscal Year Focus Document Fiscal Year Focus Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Cash flows from investing activities: Accounts Payable, Current, Total Accounts payable Accounts Payable, Current Rule 10b51 Arr Modified Flag Rule 10b51 arr modified flag. Rule 10b5-1 Arrangement Modified Research and Development Expense [Member] Research and Development [Member] Segment Reporting, Factors Used to Identify Entity's Reportable Segments Prepaid Expenses and Other Current Assets Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block] Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term, Simplified Method Expected life assumption using simplified method, description Issuance of common stock in connection with conversion of X1 non-voting convertible preferred stock value. Issuance Of Common Stock In Connection With Conversion Of X1 Non-voting Convertible Preferred Stock Value Issuance of common stock in connection with conversion of X1 non-voting convertible preferred stock, Value Proceeds from exercise of stock options Proceeds from Stock Options Exercised Fair Value Disclosures [Abstract] Commitments and Contingencies Disclosure [Abstract] Lessee, Operating Lease, Liability, to be Paid, Year One 2027 Net income attributable to common shares - basic Net Income (Loss) Available to Common Stockholders, Basic Net income (loss) attributable to common shares - basic Net loss available to common stock, basic Share-Based Payment Arrangement [Abstract] Assets, Fair Value Disclosure Total financial assets Underwritten Public Offering [Member] Underwritten public offering. Underwritten Public Offering [Member] Sale of Stock Sale of Stock [Axis] Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Net cash provided by investing activities Private Placement Warrants [Member] Private Placement [Member] Title of 12(b) Security Title of 12(b) Security Schedule of Segment Reporting Information, by Segment [Table] Money Market Funds [Member] Money Market Funds [Member] Temporary Equity, Shares Issued Convertible preferred stock, shares issued Class Of Warrant Or Right [Line Items] Class of Warrant or Right [Line Items] Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year 2026 (remainder of) Legal Entity Legal Entity [Axis] Changes in operating assets and liabilities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Summary Of Significant Accounting Policies [Table] Summary Of Significant Accounting Policies [Table] Summary of significant accounting policies. Fair Value, Recurring and Nonrecurring [Table] Accrued Liabilities and Other Liabilities [Abstract] Additional Paid-In Capital [Member] Additional Paid-in Capital [Member] Non Cash Lease Expense Non cash lease expense. Non-cash lease expense Measurement Frequency [Domain] Income Statement Location Statement of Income Location, Balance [Axis] Trading Symbol Trading Symbol Subsequent Event Type [Axis] Class of warrant subject to specified beneficial ownership limitations permitted percentage. Class of Warrant Subject to Specified Beneficial Ownership Limitations Permitted Percentage Class of Warrant Subject to Specified Beneficial Ownership Limitations Permitted Percentage Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Cash flows from financing activities: Expected term (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Fair Value, Recurring [Member] Fair Value, Recurring [Member] Total minimum lease payments Lessee, Operating Lease, Liability, to be Paid Issuance of common stock in connection with exercise of pre-funded warrants, shares. Issuance of common stock in connection with exercise of pre-funded warrants, Shares Issuance Of Common Stock In Connection With Exercise Of Pre-funded Warrants Shares Less imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Equity Components [Axis] Equity Components Equity Component Equity Component [Domain] Business Acquisition Business Combination [Axis] Prepaid insurance Prepaid Insurance Issuance of common stock in connection with vesting of restricted stock units Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total In-process research and development In Process Research And Development In-process research and development. Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items] Schedule of Other Information Related to Leases Other Information Related To Leases Table [Text Block] Other information related to leases. Maximum [Member] Maximum [Member] Grodd proceeds Proceeds from issuance offering Proceeds From Issuance Offering Proceeds from issuance offering Liabilities measured at fair value Liabilities, Fair Value Disclosure Liabilities, Fair Value Disclosure, Total Statistical Measurement Statistical Measurement [Axis] Common Stock, Value, Issued Common stock Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Common Stock, Value, Issued, Total Common stock, $0.001 par value, 300,000,000 shares authorized at March 31, 2026 and December 31, 2025; 75,851,722 and 75,430,033 shares issued and outstanding at March 31, 2026 and December 31, 2025, respectively Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds Change in Fair Value of Warrant Liabilities and Fair Value of Financial Instruments Issued in Excess of Proceeds Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds. Change in fair value of warrant liabilities and fair value of financial instruments issued in excess of proceeds Net loss used in the calculation of diluted loss per share Net income (loss) attributable to common shares - diluted Net loss available to common stock - diluted Net loss available to common stock, diluted Two Thousand And Twenty Three Securities Purchase Agreement Pre-funded Warrants [Member] Two Thousand And Twenty Three Securities Purchase Agreement Pre-funded Warrants Member. 2023 Securities Purchase Agreement Pre-funded Warrants [Member] Stock Issued During Period Shares Upon Cashless Conversion of Warrants Stock issued during period shares upon cashless conversion of warrants. Common stock issued upon cashless conversion of warrants Principles of Consolidation Consolidation, Policy [Policy Text Block] Warrant liabilities Balance as of June 30, 2024 Balance as of December 31, 2023 Warrant liabilities Warrants and Rights Outstanding Otic Pharma, Inc. [Member] Otic Pharma Inc [Member] Otic Pharma, Inc. Conversion of preferred stock, conversion blocker, percent. Conversion of Preferred Stock, Conversion Blocker, Percent Conversion of preferred stock, conversion blocker, percent Remaining milestone payments for first licensed product Remaining Milestone Payments For First Licensed Product Remaining milestone payments for first licensed product. Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Expected stock price volatility Other Comprehensive Income (Loss), before Tax, Portion Attributable to Parent [Abstract] Other comprehensive loss: Two Thousand Fourteen Stock Incentive Plan [Member] Two thousand fourteen stock incentive plan. 2014 Stock Incentive Plan [Member] Achievement of 500 Million Aggregate Sales [Member] Five Hundred Million Aggregate Net Sales [Member] Five hundred million aggregate net sales. Entity Registrant Name Entity Registrant Name Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Unrealized Losses Unrealized Losses Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Other Nonoperating Income (Expense), Total Other Nonoperating Income (Expense) Other income, net Other income, net Exercised Class Of Warrant Or Right Number Of Warrants Or Rights Exercised Class of warrant or right number of warrants exercised. Conversion of stock, shares issued Conversion of Stock, Shares Issued Subsequent Events [Abstract] Prepaid expenses and other current assets. Prepaid Expenses And Other Current Assets [Text Block] Prepaid Expenses and Other Current Assets Measurement Frequency [Axis] Proceeds from issuance of common stock Proceeds from Issuance of Common Stock Proceeds from Issuance of Common Stock Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income (loss) Consolidation Items [Axis] Total assets Assets Personnel-Related Expenses Personnel-related expenses. Personnel-related expenses Income Statement [Abstract] Share-Based Payment Arrangement [Policy Text Block] Stock-Based Compensation Common stock number of shares issued Stock Issued During Period, Shares, New Issues Issuance of common stock in connection with 2023 Securities Purchase Agreement in Second and Third Closing, net of issuance costs , Shares Convertible preferred stock, shares authorized Temporary Equity, Shares Authorized Earnings Per Share, Diluted, Total Diluted earnings per share of common stock Diluted net loss per common share Net loss per share, diluted Schedule of Segment Reporting Schedule of Segment Reporting Information, by Segment [Table Text Block] Operating Segments [Member] Title of Individual Title and Position [Domain] City Area Code City Area Code Other Comprehensive Income (Loss), Net of Tax, Total Other Comprehensive Income (Loss), Net of Tax Other comprehensive loss Other comprehensive (loss) income Counterparty Name Counterparty Name [Domain] Operating Lease, Weighted Average Remaining Lease Term Weighted-average remaining lease term (in years) Segment Reporting Information [Line Items] Lease expiration date Lease Expiration Date Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Operating Income (Loss) Loss from operations Loss from operations Ownership interest percentage Subsidiary or Equity Method Investee, Cumulative Percentage Ownership after All Transactions Accumulated Deficit [Member] Retained Earnings [Member] Cash and Cash Equivalents [Axis] Common Warrants [Member] Common Warrants [Member] Common warrants. Share-Based Payment Arrangement, Noncash Expense Share-Based Payment Arrangement, Noncash Expense, Total Stock-based compensation Tegoprubart - Kidney Transplantation Programs Tegoprubart kidney transplantation programs. Tegoprubart - kidney transplantation programs Operating Lease, Weighted Average Discount Rate, Percent Weighted-average discount rate Operating Lease, Liability, Noncurrent, Total Operating Lease, Liability, Noncurrent Non-current operating lease liabilities Operating lease liabilities (non-current) Operating lease liabilities (non-current) Fair Value, Inputs, Level 1 [Member] Fair Value, Inputs, Level 1 [Member] Class Of Stock [Line Items] Class of Stock [Line Items] Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash provided by financing activities Lease, Cost [Table Text Block] Components of Lease Expense Deferred Income Tax Liabilities, Net, Total Deferred Income Tax Liabilities, Net Deferred tax liabilities Investments, Fair Value Disclosure Total short-term investments Total short-term investments Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block] Schedule of Company's Outstanding Warrants to Purchase Shares of Common Stock Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Summary of Potentially Dilutive Securities Outstanding Based on Market Price of Common Stock that were Excluded from the Computation of Diluted Net Loss Per Share Achievement of 1 Billion Aggregate Sales [Member] One Billion Aggregate Net Sales [Member] One billion aggregate net sales. Debt Securities, Available-for-Sale [Table] Entity Interactive Data Current Entity Interactive Data Current Income Statement Location Statement of Income Location, Balance [Domain] Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Cash flows used in operating activities: Shares of common stock issued upon conversion of each share of preferred stock Convertible Preferred Stock, Shares Issued upon Conversion ALS Therapy Development Foundation, Inc. License Agreement [Member] A L S Therapy Development Foundation Inc License Agreement [Member] ALS therapy development foundation, Inc. license agreement. Accrued clinical Accrued Clinical Current Accrued clinical current. Entity Tax Identification Number Entity Tax Identification Number Share Price Share price Preferred Stock And Stockholders' Equity Disclosure [Text Block] Preferred Stock and Stockholders' Equity Disclosure. Preferred Stock and Stockholders' Equity Two Thousand And Twenty Four Underwritten Offering Pre-funded Warrants [Member] Two Thousand And Twenty Four Underwritten Offering Pre-funded Warrants Member. 2024 Underwritten Offering Pre-funded Warrants [Member] Prepaid Interest Interest income receivable Local Phone Number Local Phone Number Contingent liabilities Contingent liability. Contingent Liability Board of Directors Chairman [Member] Board of Directors [Member] Number of Milestones Achieved Number Of Milestones Achieved Number of milestones achieved. Accounting Policies [Abstract] Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table] eGenesis, Inc. Collaboration Agreement [Member] eGenesis, Inc. Collaboration Agreement [Member] Class of Stock Class of Stock [Domain] Prepaid manufacturing Prepaid Manufacturing Prepaid manufacturing. Accrued professional services Accrued Professional Fees, Current Cash and cash equivalents and short-term investments Cash, Cash Equivalents, and Short-Term Investments Cash, Cash Equivalents, and Short-Term Investments, Total Cash and cash equivalents and short-term investments Schedule Of Stock By Class [Table] Stock, Class of Stock [Table] Entity Emerging Growth Company Entity Emerging Growth Company