Summary of Significant Accounting Policies - Additional Information (Detail) $ / shares in Units, $ in Thousands |
3 Months Ended | ||
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Mar. 31, 2026
USD ($)
Segment
$ / shares
shares
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Mar. 31, 2025
USD ($)
shares
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Dec. 31, 2025
USD ($)
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| Summary Of Significant Accounting Policies [Line Items] | |||
| Cash, cash equivalents and restricted cash, maturity period | three months or less | ||
| Net loss | $ (39,025) | $ (6,495) | |
| Cash and cash equivalents and short-term investments | 111,100 | ||
| Working capital | 100,100 | ||
| Accumulated deficit | $ (440,228) | $ (401,203) | |
| Common stock, par value | $ / shares | $ 0.001 | $ 0.001 | |
| Going concern conditions or events description | The Company expects that, based on its current operating plans, the Company’s existing cash, cash equivalents and marketable securities will be sufficient to fund its currently planned operations for at least the next 12 months from the filing date of these unaudited condensed consolidated financial statements. The Company anticipates it will require additional financing to fund its future operations. Even if the Company believes it has sufficient funds for its current or future operating plans, the Company may seek to raise additional capital if market conditions are favorable or in light of other strategic considerations. | ||
| Recognized expense of employer contributions to the plan | $ 100 | $ 100 | |
| Convertible preferred stock, par value | $ / shares | $ 0.001 | ||
| Weighted-average common shares outstanding, basic | shares | 112,424,211 | 77,126,763 | |
| Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration] | srt:ChiefExecutiveOfficerMember | ||
| Segment Reporting, Factors Used to Identify Entity's Reportable Segments | The CODM manages and allocates resources to the operations of the Company on a total company basis. Managing and allocating resources on a consolidated basis enables the CODM to assess the overall level of resources available and how to best deploy these resources across functions, therapeutic areas and research and development projects that are in line with the Company’s long-term company wide strategic goals. | ||
| Number of operating segments | Segment | 1 | ||
| Number of reportable segments | Segment | 1 | ||
| Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description | the CODM uses consolidated net income (loss) for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. Operating expenses are used to monitor budget versus actual results. | ||
| Pre-Funded Warrants [Member] | |||
| Summary Of Significant Accounting Policies [Line Items] | |||
| Weighted-average common shares outstanding, basic | shares | 36,629,572 | 17,274,293 | |
| Warrants exercise price | $ / shares | $ 0.001 | ||
| Series X and Series X1 Non-voting Convertible Preferred Stock [Member] | |||
| Summary Of Significant Accounting Policies [Line Items] | |||
| Convertible preferred stock, par value | $ / shares | $ 0.001 | ||
| Anelixis Therapeutics, LLC and Otic Pharma, Ltd. | |||
| Summary Of Significant Accounting Policies [Line Items] | |||
| Ownership interest percentage | 100.00% | ||
| Otic Pharma, Inc. [Member] | |||
| Summary Of Significant Accounting Policies [Line Items] | |||
| Ownership interest percentage | 100.00% | ||
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- Definition Cash cash equivalents and restricted cash maturity period. No definition available.
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- Definition Summary of significant accounting policies. No definition available.
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- Definition Working capital. No definition available.
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- Definition Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Short-term investments, exclusive of cash equivalents, generally consist of marketable securities intended to be sold within one year (or the normal operating cycle if longer) and may include trading securities, available-for-sale securities, or held-to-maturity securities (if maturing within one year), as applicable. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Exercise price per share or per unit of warrants or rights outstanding. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Face amount or stated value per share of common stock. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of contribution received by defined benefit plan from employer which increases plan assets. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Description of the factors used to identify reportable segments, including the basis of organization (for example, whether management has chosen to organize the enterprise around differences in products and services, geographic areas, regulatory environments, or a combination of factors and whether operating segments have been aggregated to reportable segments). Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Number of segments reported by the entity. A reportable segment is a component of an entity for which there is an accounting requirement to report separate financial information on that component in the entity's financial statements. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of accumulated undistributed earnings (deficit). Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Indicates title and position of individual or name of group identified as chief operating decision maker (CODM) for segment reporting. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Description of how chief operating decision maker (CODM) uses reported segment profit (loss) measure to assess performance and allocate resource. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Percentage of subsidiary's or equity method investee's stock owned by parent immediately after all stock transactions. No definition available.
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- Definition Description of principal conditions or events that raised substantial doubt about the ability to continue as a going concern. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Per share amount of par value or stated value of stock classified as temporary equity. Temporary equity is a security with redemption features that are outside the control of the issuer, is not classified as an asset or liability in conformity with GAAP, and is not mandatorily redeemable. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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