000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Income (Loss) (Unaudited) link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Condensed Consolidated Statements of Stockholders' Deficit (Unaudited) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited) link:calculationLink link:definitionLink link:presentationLink 006 - Disclosure - Note 1 - Organization and Basis of Presentation link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 2 - Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 3 - Net Income (Loss) Per Share link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 4 - Fair-value Measurements link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 5 - Certain Balance Sheet Accounts link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 6 - Debt link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 7 - Discontinued Operations - Sale of OMIDRIA link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 8 - OMIDRIA Royalty Obligation link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 9 - Lease Liabilities link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 10 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 11 - Shareholders' Deficit link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 12 - Stock-based Compensation link:calculationLink link:definitionLink link:presentationLink 995445 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 995446 - Disclosure - Note 3 - Net Income (Loss) Per Share (Tables) link:calculationLink link:definitionLink link:presentationLink 995447 - Disclosure - Note 4 - Fair-value Measurements (Tables) link:calculationLink link:definitionLink link:presentationLink 995448 - Disclosure - Note 5 - Certain Balance Sheet Accounts (Tables) link:calculationLink link:definitionLink link:presentationLink 995449 - Disclosure - Note 6 - Debt (Tables) link:calculationLink link:definitionLink link:presentationLink 995450 - Disclosure - Note 7 - Discontinued Operations - Sale of OMIDRIA (Tables) link:calculationLink link:definitionLink link:presentationLink 995451 - Disclosure - Note 8 - OMIDRIA Royalty Obligation (Tables) link:calculationLink link:definitionLink link:presentationLink 995452 - Disclosure - Note 9 - Lease Liabilities (Tables) link:calculationLink link:definitionLink link:presentationLink 995453 - Disclosure - Note 12 - Stock-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 995454 - Disclosure - Note 1 - Organization and Basis of Presentation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995455 - Disclosure - Note 2 - Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995456 - Disclosure - Note 3 - Net Income (Loss) Per Share (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995457 - Disclosure - Note 3 - Net Income (Loss) Per Share - Schedule of Antidilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 995458 - Disclosure - Note 4 - Fair-value Measurements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995459 - Disclosure - Note 4 - Fair-value Measurements - Fair Value Hierarchy (Details) link:calculationLink link:definitionLink link:presentationLink 995460 - Disclosure - Note 4 - Fair-value Measurements - Embedded Derivative Assumptions (Details) link:calculationLink link:definitionLink link:presentationLink 995461 - Disclosure - Note 4 - Fair-value Measurements - Changes in Level 3 Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995462 - Disclosure - Note 5 - Certain Balance Sheet Accounts (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995463 - Disclosure - Note 5 - Certain Balance Sheet Accounts - Contract Royalty Asset (Details) link:calculationLink link:definitionLink link:presentationLink 995464 - Disclosure - Note 5 - Certain Balance Sheet Accounts - OMIDRIA Royalty Obligation (Details) link:calculationLink link:definitionLink link:presentationLink 995465 - Disclosure - Note 5 - Certain Balance Sheet Accounts - Schedule of Receivables (Details) link:calculationLink link:definitionLink link:presentationLink 995466 - Disclosure - Note 5 - Certain Balance Sheet Accounts - Property and Equipment, Net (Details) link:calculationLink link:definitionLink link:presentationLink 995467 - Disclosure - Note 5 - Certain Balance Sheet Accounts - Schedule of Accrued Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995468 - Disclosure - Note 6 - Debt (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995469 - Disclosure - Note 6 - Debt - Debt Balances (Details) link:calculationLink link:definitionLink link:presentationLink 995470 - Disclosure - Note 6 - Debt - Schedule of Convertible Debt (Details) link:calculationLink link:definitionLink link:presentationLink 995471 - Disclosure - Note 6 - Debt - Schedule of Debt Instruments (Details) link:calculationLink link:definitionLink link:presentationLink 995472 - Disclosure - Note 7 - Discontinued Operations - Sale of OMIDRIA - Net Income From Discontinued Operations (Details) link:calculationLink link:definitionLink link:presentationLink 995473 - Disclosure - Note 7 - Discontinued Operations - Sale of OMIDRIA - Contract Royalty Asset (Details) link:calculationLink link:definitionLink link:presentationLink 995474 - Disclosure - Note 7 - Discontinued Operations - Sale of OMIDRIA - Schedule of Discontinued Operations Cash Flows (Details) link:calculationLink link:definitionLink link:presentationLink 995475 - Disclosure - Note 8 - OMIDRIA Royalty Obligation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995476 - Disclosure - Note 8 - OMIDRIA Royalty Obligation - Schedule of Royalty Obligation (Details) link:calculationLink link:definitionLink link:presentationLink 995477 - Disclosure - Note 8 - OMIDRIA Royalty Obligation - Interest Expense (Details) link:calculationLink link:definitionLink link:presentationLink 995478 - Disclosure - Note 8 - OMIDRIA Royalty Obligation - Schedule of Principal and Interest Payments on Royalty Obligations (Details) link:calculationLink link:definitionLink link:presentationLink 995479 - Disclosure - Note 9 - Lease Liabilities (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995480 - Disclosure - Note 9 - Lease Liabilities - Lease Cost (Details) link:calculationLink link:definitionLink link:presentationLink 995481 - Disclosure - Note 10 - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995482 - Disclosure - Note 11 - Shareholders' Deficit (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995483 - Disclosure - Note 12 - Stock-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995484 - Disclosure - Note 12 - Stock-based Compensation - Schedule of Recognized Period Costs (Details) link:calculationLink link:definitionLink link:presentationLink 995485 - Disclosure - Note 12 - Stock-based Compensation - Schedule of Recognized Period Costs 2 (Details) link:calculationLink link:definitionLink link:presentationLink 995486 - Disclosure - Note 12 - Stock-based Compensation - Valuation Assumptions (Details) link:calculationLink link:definitionLink link:presentationLink 995487 - Disclosure - Note 12 - Stock-Based Compensation - Stock Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink