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  <xsd:element name="ZenasBiopharmaHkLimitedMember" id="zbio_ZenasBiopharmaHkLimitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RightsObtainedDevelopManufactureAndCommercializeNumberOfProducts" id="zbio_RightsObtainedDevelopManufactureAndCommercializeNumberOfProducts" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InnocarePharmaInc.Member" id="zbio_InnocarePharmaInc.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfSharesToBeIssued" id="zbio_NumberOfSharesToBeIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="InducementPlan2026Member" id="zbio_InducementPlan2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonStockToBeIssuedToRelatedPartyMember" id="zbio_CommonStockToBeIssuedToRelatedPartyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentNumberOfTranches" id="zbio_DebtInstrumentNumberOfTranches" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="RoyaltyObligationNonCurrent" id="zbio_RoyaltyObligationNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InterestExpenseRoyalty" id="zbio_InterestExpenseRoyalty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EquityOfferingMember" id="zbio_EquityOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NoncashInterestExpenseOnDebt" id="zbio_NoncashInterestExpenseOnDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredOfferingCostsAndDebtIssuanceCostsIncludedInAccountsPayableAndAccruedExpenses" id="zbio_DeferredOfferingCostsAndDebtIssuanceCostsIncludedInAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ConvertibleDebtPolicyPolicyTextBlock" id="zbio_ConvertibleDebtPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="OtherProgramsZb002Zb004Zb014Zb021Zb022Member" id="zbio_OtherProgramsZb002Zb004Zb014Zb021Zb022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAndOptionAgreementsFoodAndDrugAdministrationMarketAuthorizationPayable" id="zbio_LicenseAndOptionAgreementsFoodAndDrugAdministrationMarketAuthorizationPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAndOptionAgreementsFoodAndDrugAdministrationMarketApprovalPayable" id="zbio_LicenseAndOptionAgreementsFoodAndDrugAdministrationMarketApprovalPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ScheduleOfAmortizationOfDebtDiscountsAndIssuanceCostsAmortizationTableTextBlock" id="zbio_ScheduleOfAmortizationOfDebtDiscountsAndIssuanceCostsAmortizationTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SeniorSecuredTermLoanMember" id="zbio_SeniorSecuredTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeniorSecuredTermLoanTrancheTermLoanMember" id="zbio_SeniorSecuredTermLoanTrancheTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeniorSecuredTermLoanTrancheBTermLoanMember" id="zbio_SeniorSecuredTermLoanTrancheBTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeniorSecuredTermLoanTrancheCTermLoanMember" id="zbio_SeniorSecuredTermLoanTrancheCTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SeniorSecuredTermLoanTrancheETermLoanMember" id="zbio_SeniorSecuredTermLoanTrancheETermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScenarioPeriodOfFirst24MonthsFollowingTrancheLoanFundingDateMember" id="zbio_ScenarioPeriodOfFirst24MonthsFollowingTrancheLoanFundingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScenarioImmediatelyFollowingTrancheClosingDateUntilSatisfactionOfTrancheBCApprovalConditionMember" id="zbio_ScenarioImmediatelyFollowingTrancheClosingDateUntilSatisfactionOfTrancheBCApprovalConditionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScenarioIfPrepaymentOccursPriorsToThirdYearAnniversaryOfEachTrancheSClosingDateMember" id="zbio_ScenarioIfPrepaymentOccursPriorsToThirdYearAnniversaryOfEachTrancheSClosingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScenarioIfPrepaymentOccursAfter3rdYearButPriorTo4thAnniversaryOfEachTrancheSClosingDateMember" id="zbio_ScenarioIfPrepaymentOccursAfter3rdYearButPriorTo4thAnniversaryOfEachTrancheSClosingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScenarioIfPrepaymentOccursAfter4thYearAnniversaryButPriorToLoanMaturityDateMember" id="zbio_ScenarioIfPrepaymentOccursAfter4thYearAnniversaryButPriorToLoanMaturityDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScenarioAggregatePrincipalOutstandingOfTermsLoansExceeds200MillionMember" id="zbio_ScenarioAggregatePrincipalOutstandingOfTermsLoansExceeds200MillionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentMaximumBorrowingCapacity" id="zbio_DebtInstrumentMaximumBorrowingCapacity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentNumberOfCommittedTranches" id="zbio_DebtInstrumentNumberOfCommittedTranches" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentMaximumAdditionalBorrowingCapacity" id="zbio_DebtInstrumentMaximumAdditionalBorrowingCapacity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentNumberOfDiscretionalTranches" id="zbio_DebtInstrumentNumberOfDiscretionalTranches" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfInterestToBePaidInKind" id="zbio_PercentageOfInterestToBePaidInKind" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentFundingFeePercentage" id="zbio_DebtInstrumentFundingFeePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PaymentOfDebtFundingFee" id="zbio_PaymentOfDebtFundingFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MinimumLiquidityAmountToBeMaintain" id="zbio_MinimumLiquidityAmountToBeMaintain" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LoanPrepaymentPremiumPercentageOfMultiplierOnPrepaidPrincipal" id="zbio_LoanPrepaymentPremiumPercentageOfMultiplierOnPrepaidPrincipal" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ExitConsiderationFeesPercentageOfMultiplierOnPrincipalRepaidOrPrepaid" id="zbio_ExitConsiderationFeesPercentageOfMultiplierOnPrincipalRepaidOrPrepaid" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentNumberOfEqualRepayment" id="zbio_DebtInstrumentNumberOfEqualRepayment" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtCovenantMinimumTrailing12MonthsConsolidatedNetRevenueThreshold" id="zbio_DebtCovenantMinimumTrailing12MonthsConsolidatedNetRevenueThreshold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SeniorSecuredTermLoanTrancheDTermLoanMember" id="zbio_SeniorSecuredTermLoanTrancheDTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RoyaltyObligationAbstract" id="zbio_RoyaltyObligationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FollowOnPublicEquityOfferingMember" id="zbio_FollowOnPublicEquityOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentCashInterestExpense" id="zbio_DebtInstrumentCashInterestExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TwoPointFiveZeroConvertibleSeniorNotesDue2032Member" id="zbio_TwoPointFiveZeroConvertibleSeniorNotesDue2032Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentAverageTradingPriceNumberOfBusinessDays" id="zbio_DebtInstrumentAverageTradingPriceNumberOfBusinessDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentAverageTradingPriceLengthOfConsecutiveTradingDayPeriod" id="zbio_DebtInstrumentAverageTradingPriceLengthOfConsecutiveTradingDayPeriod" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentAverageTradingPricePercentageOfAverageConversionValueOfNote" id="zbio_DebtInstrumentAverageTradingPricePercentageOfAverageConversionValueOfNote" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedeemableScheduledTradingDaysBeforeMaturity" id="zbio_DebtInstrumentRedeemableScheduledTradingDaysBeforeMaturity" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentRedeemableMinimumOutstandingPrincipalAmountAfterPartialRedemption" id="zbio_DebtInstrumentRedeemableMinimumOutstandingPrincipalAmountAfterPartialRedemption" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentConvertibleMakeWholeAdjustmentMaximumSharePriceThreshold" id="zbio_DebtInstrumentConvertibleMakeWholeAdjustmentMaximumSharePriceThreshold" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentConvertibleMakeWholeAdjustmentMinimumSharePriceThreshold" id="zbio_DebtInstrumentConvertibleMakeWholeAdjustmentMinimumSharePriceThreshold" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentConvertibleNumberOfTradingDaysForVolumeWeightedAveragePriceForConvertibleDebtSettlements" id="zbio_DebtInstrumentConvertibleNumberOfTradingDaysForVolumeWeightedAveragePriceForConvertibleDebtSettlements" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentCovenantDebtDefaultCurePeriod" id="zbio_DebtInstrumentCovenantDebtDefaultCurePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentCrossDefaultThresholdAmount" id="zbio_DebtInstrumentCrossDefaultThresholdAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentConvertibleCapitalSharesReservedForFutureIssuance" id="zbio_DebtInstrumentConvertibleCapitalSharesReservedForFutureIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ScheduleOfActivityOfRoyaltyObligation" id="zbio_ScheduleOfActivityOfRoyaltyObligation" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
</xsd:schema>
